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Home >> Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

Potassium Channel

Potassium channels are voltage-gated ion channels that selectively permeate potassium ion through the excitable membrane. It regulates the release of neurotransmitters, insulin secretion, smooth muscle contraction and heart rate etc.

Products for  Potassium Channel

  1. Cat.No. Product Name Information
  2. GC14044 (-)-[3R,4S]-Chromanol 293B (-)-[3R,4S]-Chromanol 293B is a potent and selective inhibitor of the slow component of delayed rectifier K+ current (IKs). (-)-[3R,4S]-Chromanol 293B Chemical Structure
  3. GC16717 1-EBIO Activator of epithelial KCa channels 1-EBIO Chemical Structure
  4. GC60455 2,2,2-Trichloroethanol 2,2,2-Trichloroethanol, the active form of Chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4). 2,2,2-Trichloroethanol Chemical Structure
  5. GC35075 20-HETE A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications 20-HETE Chemical Structure
  6. GC17469 4-Aminopyridine potassium channel-blocking agent 4-Aminopyridine Chemical Structure
  7. GC42414 4-hydroxy Tolbutamide 4-hydroxy Tolbutamide is a cytochrome P450 2C8 (CYP2C8) and CYP2C9 metabolite of tolbutamide, a first-generation potassium channel blocker. 4-hydroxy Tolbutamide Chemical Structure
  8. GC60029 5-Hydroxydecanoate sodium 5-Hydroxydecanoate sodium is a selective ATP-sensitive K+ (KATP) channel blocker (IC50 of ~30 μM). 5-Hydroxydecanoate sodium Chemical Structure
  9. GC50632 A 1899 Potent K2P3.1 (TASK-1) and K2P9.1 (TASK-3) blocker A 1899 Chemical Structure
  10. GC39335 A2764 dihydrochloride A2764 dihydrochloride is a highly selective inhibitor of TRESK (TWIK-related spinal cord K+ channel, K2P18.1), which has moderate inhibitory effects on TREK-1 and TALK-1. A2764 dihydrochloride Chemical Structure
  11. GC60545 A2793 A2793 is an efficient dual TWIK-related acid-sensitive K+ channel (TASK)-1/TRESK inhibitor, with an IC50 of 6.8 μM for mTRESK. A2793 Chemical Structure
  12. GN10812 Acacetin Acacetin Chemical Structure
  13. GC11315 ADWX 1 Kv1.3 channel blocker,potent and selective ADWX 1 Chemical Structure
  14. GC14867 Agitoxin 2 Shaker K+ channel blocker, potent Agitoxin 2 Chemical Structure
  15. GC35273 Ajmaline Ajmaline Chemical Structure
  16. GC35293 Allocryptopine Allocryptopine, a derivative of tetrahydropalmatine, is extracted from Corydalis decumbens (Thunb. Allocryptopine Chemical Structure
  17. GC30891 Almitrine mesylate (Almitrine bismesylate) Almitrine mesylate (Almitrine bismesylate), a peripheral chemoreceptor agonist, inhibits selectively the Ca2+-dependent K+ channel. Almitrine mesylate (Almitrine bismesylate) Chemical Structure
  18. GC32673 Almokalant (H 234/09) Almokalant (H 234/09) is a class III antiarrhythmic drug, acts as a potassium channel blocker, and inhibits a specific component (Ikr) of the time-dependent delayed rectifier K+ current. Almokalant (H 234/09) Chemical Structure
  19. GC10943 AM 92016 hydrochloride Potassium channel blocker AM 92016 hydrochloride Chemical Structure
  20. GC35322 Amiodarone Amiodarone is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM. Amiodarone Chemical Structure
  21. GC11432 Amiodarone HCl Amiodarone HCl, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERG tails with an IC50 of ~45 nM. Amiodarone HCl Chemical Structure
  22. GC50334 AMP PNP AMP PNP (Adenylyl-imidodiphosphate tetralithium) is a non-hydrolysable analogue of ATP and inhibits KATP channels. AMP PNP Chemical Structure
  23. GC18203 Annonacin Annonacin is a potent and lipophilic acetogenin from A. Annonacin Chemical Structure
  24. GC31141 Antihistamine-1 Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively. Antihistamine-1 Chemical Structure
  25. GC50471 AP 14145 hydrochloride KCa2 channel negative allosteric modulator AP 14145 hydrochloride Chemical Structure
  26. GC14893 Apamin small-conductance Ca2+-activated K+-channel (KCa2, SK) inhibitor Apamin Chemical Structure
  27. GC38557 Apamin TFA Apamin TFA (Apamine TFA) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity. Apamin TFA Chemical Structure
  28. GC61960 ASP2905 ASP2905 is a potent and selective potassium channel Kv12.2 inhibitor encoded by the Kcnh3/BEC1 gene. ASP2905 Chemical Structure
  29. GC16945 Astemizole anti-histamine compound, potent Astemizole Chemical Structure
  30. GC19480 AUT1

    Cell permeant modulator

     AUT1 Chemical Structure
  31. GC64274 AZD-5672 AZD-5672 is an orally active, potent, and selective CCR5 antagonist (IC50=0.32 nM). AZD-5672 Chemical Structure
  32. GC14515 Azimilide class III anti-arrhythmic drug Azimilide Chemical Structure
  33. GC35453 Azimilide Dihydrochloride A class III antiarrhythmic agent Azimilide Dihydrochloride Chemical Structure
  34. GC13323 BDS I Kv3.4 potassium channel blocker, potent and reversible BDS I Chemical Structure
  35. GC50661 BeKm 1 BeKm 1 is a HERG (human ether-a-go-go-related gene) blocking compound. BeKm 1 Chemical Structure
  36. GC10094 BL 1249 K2P2.1 (TREK-1) channel opener BL 1249 Chemical Structure
  37. GC14239 BMS 191011 BKCa channel opener BMS 191011 Chemical Structure
  38. GC31405 BMS-191095 BMS-191095 is an activators of mitochondrial ATP-sensitive potassium (mitoKATP) channels. BMS-191095 Chemical Structure
  39. GC30914 Butamben (Butyl 4-aminobenzoate) Butamben (Butyl 4-aminobenzoate) (Butyl 4-aminobenzoate) results in long-lasting relief from pain, without impairing motor function or other sensory functions. Butamben (Butyl 4-aminobenzoate) Chemical Structure
  40. GC17272 Charybdotoxin inhibitor of the big conductance Ca2+-activated K+ channel Charybdotoxin Chemical Structure
  41. GC61534 Charybdotoxin TFA Charybdotoxin TFA, a 37-amino acid peptide, is a K+ channel blocker. Charybdotoxin TFA Chemical Structure
  42. GC30280 Chlorpromazine D6 hydrochloride An internal standard for the quantification of chlorpromazine Chlorpromazine D6 hydrochloride Chemical Structure
  43. GC14216 Chlorpromazine HCl

    dopamine receptor antagonist

     Chlorpromazine HCl Chemical Structure
  44. GC43261 Cholesteryl Myristate Cholesteryl Myristate is a natural steroid present in traditional Chinese medicine. Cholesteryl Myristate binds to several ion channels such as the nicotinic acetylcholine receptor, GABAA receptor, and the inward-rectifier potassium ion channel. Cholesteryl Myristate Chemical Structure
  45. GC10213 Chromanol 293B slow delayed rectifier K+ current (IKs) blocker Chromanol 293B Chemical Structure
  46. GC64925 Cibenzoline Cibenzoline is a potent inhibitor of KATP channel with directly affecting the pore-forming Kir6.2 subunit rather than the SUR1 subunit. Cibenzoline Chemical Structure
  47. GC32587 Clofilium tosylate Clofilium tosylate, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3. Clofilium tosylate Chemical Structure
  48. GC33851 Cloperastine fendizoate Cloperastine fendizoate inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM. Cloperastine fendizoate Chemical Structure
  49. GC60718 Cloperastine hydrochloride Cloperastine hydrochloride inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM. Cloperastine hydrochloride Chemical Structure
  50. GC50127 CLP 257 Selective KCC2 activator CLP 257 Chemical Structure
  51. GC35713 CLP290 A prodrug form of CLP 257 CLP290 Chemical Structure
  52. GC17595 CP 339818 hydrochloride KV1.3 channel antagonist CP 339818 hydrochloride Chemical Structure
  53. GC14116 Cromakalim Kir6 (KATP) channel opener Cromakalim Chemical Structure
  54. GC16144 CyPPA Activator of small conductance Ca2+-activated K+ channels CyPPA Chemical Structure
  55. GC67747 Dalazatide TFA Dalazatide TFA Chemical Structure
  56. GC33003 Daurisoline ((R,R)-Daurisoline) Daurisoline ((R,R)-Daurisoline) is a hERG inhibitor and also an autophagy blocker. Daurisoline ((R,R)-Daurisoline) Chemical Structure
  57. GC15750 DCEBIO Stimulates Cl- secretion DCEBIO Chemical Structure
  58. GC14073 DCPIB volume-sensitive anion channel (VSAC) and and ICl,swell blocker DCPIB Chemical Structure
  59. GC60750 Dehydrosoyasaponin I Dehydrosoyasaponin I Chemical Structure
  60. GC64863 Dendrotoxin K Dendrotoxin K is a Kv1.1 channel blocker. Dendrotoxin K Chemical Structure
  61. GC16354 Dequalinium Chloride anti-tumor agent and PKC inhibitor Dequalinium Chloride Chemical Structure
  62. GC11598 Diazoxide

    positive allosteric modulator of the AMPA and kainate receptors

     Diazoxide Chemical Structure
  63. GC43442 Dibutyryl-Cyclic GMP (sodium salt) Dibutyryl-Cyclic GMP (sodium salt) (Bt2cGMP sodium) is a cell-permeable cGMP analogue. Dibutyryl-Cyclic GMP (sodium salt) Chemical Structure
  64. GC38223 Dihydroberberine Dihydroberberine Chemical Structure
  65. GC66836 Dimethyl L-glutamate Dimethyl L-glutamate (Dimethyl glutamate), a membrane-permeable analog of Glutamate, can stimulate insulin release induced by Glucose. Dimethyl L-glutamate suppresses the KATP channel activities. Dimethyl L-glutamate inhibits E. gracilis growth and causes abnormal cell division. Dimethyl L-glutamate can be used in the research of diabetes, glucose transport, phosphorylation, and further metabolism. Dimethyl L-glutamate Chemical Structure
  66. GC43478 Disopyramide Disopyramide is a sodium channel blocker that, in rabbit ventricular myocytes, binds and dissociates from open channels more quickly than from resting channels. Disopyramide Chemical Structure
  67. GC11429 DMP 543 K+ channel blocker and acetylcholine release stimulator DMP 543 Chemical Structure
  68. GC17152 Dofetilide Potassium channel inhibitor Dofetilide Chemical Structure
  69. GC47260 Dofetilide-d4 An internal standard for the quantification of dofetilide Dofetilide-d4 Chemical Structure
  70. GC10861 Domiphen Bromide Quaternary ammonium antiseptic Domiphen Bromide Chemical Structure
  71. GC16537 Doxapram Respiratory stimulant Doxapram Chemical Structure
  72. GC13976 Doxapram HCl Potassium channel inhibitor Doxapram HCl Chemical Structure
  73. GC12575 DPO-1 Blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels DPO-1 Chemical Structure
  74. GC12234 Dronedarone HCl Dronedarone HCl is a non-iodinated amiodarone derivative that inhibits Na+, K+ and Ca2+ currents. Dronedarone HCl Chemical Structure
  75. GC13490 E-4031 antiarrhythmic agent blocking the ATP-sensitive potassium channel E-4031 Chemical Structure
  76. GC17661 E-4031 dihydrochloride KV11.1 (hERG) channels blocker E-4031 dihydrochloride Chemical Structure
  77. GC12140 Endoxifen Endoxifen Z-isomer is the most important Tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha (ERα). Endoxifen Chemical Structure
  78. GC35991 Endoxifen Z-isomer hydrochloride Endoxifen Z-isomer hydrochloride is the most important Tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha (ERα). Endoxifen Z-isomer hydrochloride Chemical Structure
  79. GC63367 Enflurane Enflurane Chemical Structure
  80. GC30910 Eucalyptol (1,8-Cineole) A bicyclic monoterpene with diverse biological activities Eucalyptol (1,8-Cineole) Chemical Structure
  81. GC65416 Flecainide Flecainide is a potent and orally active antiarrhythmic agent. Flecainide Chemical Structure
  82. GC65150 Flecainide hydrochloride Flecainide hydrochloride is a potent and orally active antiarrhythmic agent. Flecainide hydrochloride Chemical Structure
  83. GC13466 Flufenamic acid

    TRPC activator

     Flufenamic acid Chemical Structure
  84. GC36060 Flupirtine Flupirtine(D 9998) is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties. Flupirtine Chemical Structure
  85. GC11470 Flupirtine maleate NMDA receptor antagonist Flupirtine maleate Chemical Structure
  86. GC18210 GAL-021 GAL-021 is a large-conductance Ca2+-activated potassium channel (BKCa/KCa1.1) blocker. GAL-021 Chemical Structure
  87. GC64418 GAL-021 sulfate GAL-021 sulfate is a potent BKCa-channel blocker. GAL-021 sulfate Chemical Structure
  88. GC50547 GI 530159 K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channel activator GI 530159 Chemical Structure
  89. GN10799 Ginsenoside Rg3 Ginsenoside Rg3 Chemical Structure
  90. GC12356 Glibenclamide Insulin production modulator Glibenclamide Chemical Structure
  91. GC63568 Glibornuride Glibornuride is a blocker of ATP-sensitive K+ channels (KATP channel) with a pKi of 5.75. Glibornuride Chemical Structure
  92. GC13527 Gliclazide Potassium channel inhibitor Gliclazide Chemical Structure
  93. GC15419 Glipizide Oral anti-diabetic medication Glipizide Chemical Structure
  94. GC16561 Gliquidone ATP-sensitive K+ channel antagonist Gliquidone Chemical Structure
  95. GC50702 GoSlo SR 5-69 GoSlo SR 5-69 is a potent activator of large conductance Ca2+-activated K+ (BK) channels, with an EC50 of 251 nM. GoSlo SR 5-69 Chemical Structure
  96. GC19183 GSK369796 Dihydrochloride GSK369796 Dihydrochloride is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization with an IC50 of 7.5 uM. GSK369796 Dihydrochloride Chemical Structure
  97. GC64448 Guanfu base A Guanfu base A is an antiarrhythmic alkaloid isolated from Aconitum coreanum and is a potent noncompetitive CYP2D6 inhibitor, with a Ki of 1.20 μM in human liver microsomes (HLMs) and a Ki of 0.37 μM for the human recombinant form (rCYP2D6). Guanfu base A Chemical Structure
  98. GC50231 Guangxitoxin 1E Potent Kv2.1 and Kv2.2 channel blocker Guangxitoxin 1E Chemical Structure
  99. GC10352 GW 542573X Activator of small-conductance Ca2+-activated K+ channels (KCa2) GW 542573X Chemical Structure
  100. GC39648 H3B-120 H3B-120 is a highly selective, competitive and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor with an IC50 of 1.5 μM and a Ki of 1.4 μM. H3B-120 has anti-cancer activity. H3B-120 Chemical Structure
  101. GC63001 Halothane Halothane Chemical Structure

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