Proton Pump
Proton pump is a protein complex that transport the H+ ion across the membranes of lysosomes and vacuoles to generate an electrical and chemical gradient that provide energy for ATP synthesis from ADP.
Products for Proton Pump
- Cat.No. Product Name Information
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GC69839
(R)-Tegoprazan
(R)-Tegoprazan ((R)-CJ-12420; example 3) is a benzimidazole derivative and an effective inhibitor of gastric H+/K+-ATPase. Its IC50 for canine kidney Na+/K+-ATPase is 98 nM. (R)-Tegoprazan has potential in the research of gastrointestinal diseases.
- GC60530 5-Hydroxylansoprazole 5-Hydroxylansoprazole (AG1908) is an active metabolite of Lansoprazole in plasma.
- GC62823 Abeprazan Abeprazan (DWP14012) is a potassium-competitive acid blocker.
- GC65377 Abeprazan hydrochloride Abeprazan hydrochloride (DWP14012 hydrochloride) is a potassium-competitive acid blocker.
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GC17597
Bafilomycin A1
Bafilomycin A1, a macrolide antibiotic isolated from the Streptomyces species, is an inhibitor of vacuolar H ATPase (V-ATPase).
- GC31426 Bamaquimast (F 10126) Bamaquimast (F 10126) (F 10126; L 0042) is a potent antiasthmatic drug.
- GC16516 BCH BCH (BCH) is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis.
- GC62885 Caloxin 2A1 TFA Caloxin 2A1 TFA is an extracellular plasma membrane Ca2+-ATPase (PMCA) peptide inhibitor.
- GC32250 Chebulinic acid An ellagitannin with diverse biological activities
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GC17519
Concanamycin A
V-type (vacuolar) H+-ATPase inhibitor
- GC16622 Dexlansoprazole Dexlansoprazole is the R enantiomer of Lansoprazole, Lansoprazole (AG 1749) is an orally active proton pump inhibitor which prevents the stomach from producing acid.
- GC39734 Diphyllin Diphyllin is an arylnaphthalene lignan isolated from Justicia procumbens and is a potent HIV-1 inhibitor with an IC50 of 0.38 μM.
- GC35982 EN6 An activator of autophagy
- GC14313 Esomeprazole Magnesium Proton pump inhibitor
- GC36009 Esomeprazole magnesium salt Esomeprazole magnesium salt ((S)-Omeprazole magnesium salt) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells.
- GC13022 Esomeprazole Magnesium trihydrate An H+/K+-ATPase inhibitor
- GC33575 Esomeprazole potassium salt ((S)-Omeprazole potassium) Esomeprazole potassium salt ((S)-Omeprazole potassium) ((S)-Omeprazole potassium salt) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells.
- GC10599 Esomeprazole Sodium Proton pump inhibitor
- GC25386 Ethacrynate Sodium Ethacrynate Sodium (ethacrynic acid sodium) is the sodium salt form of ethacrynic acid, which inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules.
- GC31347 Ilaprazole (IY-81149) Ilaprazole (IY-81149) (IY-81149) is an orally active proton pump inhibitor.
- GC60929 Ilaprazole sodium Ilaprazole (IY-81149) sodium is an orally active proton pump inhibitor.
- GC63954 KM91104 KM91104, a cell-permeable V-ATPase inhibitor, specifically targets the a3-b2 subunits of V-ATPase.
- GC16570 Lansoprazole H+,K+-ATPase inhibitor
- GC12112 Lansoprazole sodium PPI/cytochrome P450 inhibitor
- GC60975 Lansoprazole Sulfide D4 Lansoprazole Sulfide D4 is a deuterium labeled Lansoprazole Sulfide.
- GC47537 Lansoprazole-d4 An internal standard for the quantification of lansoprazole
- GC32924 Linaprazan (AZD0865) Linaprazan (AZD0865) (AZD0865) inhibits gastric H+,K+-ATPase by K+-competitive binding.
- GC15334 N2-Methyl-L-arginine Selective L-arginine uptake inhibitor
- GC13166 Omeprazole H+,K+-ATPase inhibitor
- GC36806 Omeprazole D3 Omeprazole D3 (H 16868-d3) is deuterium labeled Omeprazole.
- GC61155 Omeprazole sodium Omeprazole sodium (H 16868 sodium), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders.
- GC63335 Omeprazole-13CD3
- GC64070 Omeprazole-d3-1
- GC12718 Pantoprazole H+/K+-ATPase inhibitor
- GC36847 Pantoprazole sodium Pantoprazole sodium (BY10232 sodium) is an orally active and potent proton pump inhibitor (PPI).
- GC36848 Pantoprazole sodium hydrate Pantoprazole sodium hydrate (BY10232 sodium hydrate) is an orally active and potent proton pump inhibitor (PPI).
- GC31466 Picoprazole Picoprazole is a specific inhibitor of H+/K+-ATPase with IC50 of 3.1±0.4 μM.
- GC31969 Pumaprazole (BY-841) Pumaprazole (BY-841) is a reversible proton pump antagonist.
- GC16645 Rabeprazole proton pump inhibitor
- GC15670 Rabeprazole sodium proton pump inhibitor
- GC39429 Rabeprazole Sulfide Rabeprazole Sulfide is an active metabolite of Rabeprazole.
- GC63687 Rabeprazole-d4 Rabeprazole D4 (LY307640 D4) is a deuterium labeled Rabeprazole.
- GC31987 S3337 S3337 is an H+, K+-ATPase inhibitor.
- GC11151 SCH 28080 H+,K+-ATPase inhibitor
- GC30418 SKF96067 SKF96067 is a reversible inhibitor of the gastric H+/K+-ATPase.
- GC30130 Soraprazan (BYK61359) Soraprazan (BYK61359) (BYK61359) is a selective, reversible K-competitive inhibitor of the H,K-ATPase (Ki=6.4 nM), with an IC50 of 0.19 μM in gastric glands.
- GC15418 TAK-438 Blocker of potassium-competitive acid
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GC31566
Tegoprazan
A proton pump inhibitor
- GC37756 Tenatoprazole sodium Tenatoprazole sodium (TU-199 sodium) is a proton pump inhibitor; inhibits hog gastric H+/K+-ATPase with an IC50 of 6.2 μM.
- GC61863 Verucopeptin Verucopeptin is a potent?HIF-1 (IC50=0.22 μM) inhibitor and decreases the expression of HIF-1 target genes and HIF-1α protein levels. Verucopeptin strongly inhibits v-ATPase activity?by directly targeting the v-ATPase ATP6V1G subunit but not ATP1V1B2 or ATP6V1D. Verucopeptin exhibits antitumor activity against multidrug resistance (MDR)?cancers and can be used for cancer research.
- GC37920 Vonoprazan Vonoprazan (TAK-438 free base), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity.
- GC63472 Zastaprazan Zastaprazan is a proton pump inhibitor (WO2018008929).
- GC16453 Zinc Pyrithione Proton pump inhibitor