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Proton Pump

Proton pump is a protein complex that transport the H+ ion across the membranes of lysosomes and vacuoles to generate an electrical and chemical gradient that provide energy for ATP synthesis from ADP.

Products for  Proton Pump

  1. Cat.No. Product Name Information
  2. GC69839 (R)-Tegoprazan

    (R)-CJ-12420; (R)-RQ-00000004

    (R)-Tegoprazan ((R)-CJ-12420; example 3) is a benzimidazole derivative and an effective inhibitor of gastric H+/K+-ATPase. Its IC50 for canine kidney Na+/K+-ATPase is 98 nM. (R)-Tegoprazan has potential in the research of gastrointestinal diseases.

    (R)-Tegoprazan  Chemical Structure
  3. GC60530 5-Hydroxylansoprazole 5-Hydroxylansoprazole (AG1908) is an active metabolite of Lansoprazole in plasma. 5-Hydroxylansoprazole  Chemical Structure
  4. GC62823 Abeprazan Abeprazan (DWP14012) is a potassium-competitive acid blocker. Abeprazan  Chemical Structure
  5. GC65377 Abeprazan hydrochloride

    DWP14012 hydrochloride; Fexuprazan hydrochloride

    Abeprazan hydrochloride (DWP14012 hydrochloride) is a potassium-competitive acid blocker. Abeprazan hydrochloride  Chemical Structure
  6. GC17597 Bafilomycin A1

    NSC 381866

    Bafilomycin A1, a macrolide antibiotic isolated from the Streptomyces species, is an inhibitor of vacuolar H ATPase (V-ATPase).

    Bafilomycin A1  Chemical Structure
  7. GC31426 Bamaquimast (F 10126)

    F 10126; L 0042

    Bamaquimast (F 10126) (F 10126; L 0042) is a potent antiasthmatic drug. Bamaquimast (F 10126)  Chemical Structure
  8. GC16516 BCH

    2-amino-2-Norbornanecarboxylic Acid

    BCH (BCH) is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis. BCH  Chemical Structure
  9. GC62885 Caloxin 2A1 TFA Caloxin 2A1 TFA is an extracellular plasma membrane Ca2+-ATPase (PMCA) peptide inhibitor. Caloxin 2A1 TFA  Chemical Structure
  10. GC32250 Chebulinic acid

    Eutannin, NSC 69862

    An ellagitannin with diverse biological activities Chebulinic acid  Chemical Structure
  11. GC17519 Concanamycin A

    Antibiotic X 4357B; NSC 674620; X 4357B

    Concanamycin A is a specific inhibitor of vacuolar-type ATPase (V-ATPase) with IC50 value of 10 nM [1]. Concanamycin A  Chemical Structure
  12. GC16622 Dexlansoprazole

    (+)-Lansoprazole, T-168390, TAK-390

    Dexlansoprazole is the R enantiomer of Lansoprazole, Lansoprazole (AG 1749) is an orally active proton pump inhibitor which prevents the stomach from producing acid. Dexlansoprazole  Chemical Structure
  13. GC39734 Diphyllin

    NSC 309691

    Diphyllin is an arylnaphthalene lignan isolated from Justicia procumbens and is a potent HIV-1 inhibitor with an IC50 of 0.38 μM. Diphyllin  Chemical Structure
  14. GC35982 EN6 An activator of autophagy EN6  Chemical Structure
  15. GC14313 Esomeprazole Magnesium

    (–)-Omeprazole Magnesium, (S)-Omeprazole Magnesium

    Proton pump inhibitor Esomeprazole Magnesium  Chemical Structure
  16. GC36009 Esomeprazole magnesium salt

    (S)-Omeprazole magnesium salt; (-)-Omeprazole magnesium salt

    Esomeprazole magnesium salt ((S)-Omeprazole magnesium salt) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole magnesium salt  Chemical Structure
  17. GC13022 Esomeprazole Magnesium trihydrate An H+/K+-ATPase inhibitor Esomeprazole Magnesium trihydrate  Chemical Structure
  18. GC33575 Esomeprazole potassium salt ((S)-Omeprazole potassium) Esomeprazole potassium salt ((S)-Omeprazole potassium) ((S)-Omeprazole potassium salt) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole potassium salt ((S)-Omeprazole potassium)  Chemical Structure
  19. GC10599 Esomeprazole Sodium

    An H+/K+-ATPase inhibitor

    Esomeprazole Sodium  Chemical Structure
  20. GC25386 Ethacrynate Sodium

    ethacrynic acid sodium

    Ethacrynate Sodium (ethacrynic acid sodium) is the sodium salt form of ethacrynic acid, which inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. Ethacrynate Sodium  Chemical Structure
  21. GC31347 Ilaprazole (IY-81149)

    (R,S)-Ilaprazole, IY-81149

    Ilaprazole (IY-81149) (IY-81149) is an orally active proton pump inhibitor. Ilaprazole (IY-81149)  Chemical Structure
  22. GC60929 Ilaprazole sodium Ilaprazole (IY-81149) sodium is an orally active proton pump inhibitor. Ilaprazole sodium  Chemical Structure
  23. GC63954 KM91104 KM91104, a cell-permeable V-ATPase inhibitor, specifically targets the a3-b2 subunits of V-ATPase. KM91104  Chemical Structure
  24. GC16570 Lansoprazole

    AG1749

    H+,K+-ATPase inhibitor Lansoprazole  Chemical Structure
  25. GC12112 Lansoprazole sodium PPI/cytochrome P450 inhibitor Lansoprazole sodium  Chemical Structure
  26. GC60975 Lansoprazole Sulfide D4 Lansoprazole Sulfide D4 is a deuterium labeled Lansoprazole Sulfide. Lansoprazole Sulfide D4  Chemical Structure
  27. GC47537 Lansoprazole-d4 An internal standard for the quantification of lansoprazole Lansoprazole-d4  Chemical Structure
  28. GC32924 Linaprazan (AZD0865)

    Linaprazan

    Linaprazan (AZD0865) (AZD0865) inhibits gastric H+,K+-ATPase by K+-competitive binding. Linaprazan (AZD0865)  Chemical Structure
  29. GC15334 N2-Methyl-L-arginine Selective L-arginine uptake inhibitor N2-Methyl-L-arginine  Chemical Structure
  30. GC13166 Omeprazole

    OMEP, OMP, OMZ

    H+,K+-ATPase inhibitor Omeprazole  Chemical Structure
  31. GC36806 Omeprazole D3

    OMEP-d3, OMP-d3, OMZ-d3

    Omeprazole D3 (H 16868-d3) is deuterium labeled Omeprazole. Omeprazole D3  Chemical Structure
  32. GC61155 Omeprazole sodium Omeprazole sodium (H 16868 sodium), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole sodium  Chemical Structure
  33. GC63335 Omeprazole-13CD3

    H 16868-13CD3

    Omeprazole-13CD3  Chemical Structure
  34. GC64070 Omeprazole-d3-1

    OMEP-d3, OMP-d3, OMZ-d3

    Omeprazole-d3-1  Chemical Structure
  35. GC12718 Pantoprazole

    BY 1023, SKF 96022

    H+/K+-ATPase inhibitor Pantoprazole  Chemical Structure
  36. GC36847 Pantoprazole sodium Pantoprazole sodium (BY10232 sodium) is an orally active and potent proton pump inhibitor (PPI). Pantoprazole sodium  Chemical Structure
  37. GC36848 Pantoprazole sodium hydrate Pantoprazole sodium hydrate (BY10232 sodium hydrate) is an orally active and potent proton pump inhibitor (PPI). Pantoprazole sodium hydrate  Chemical Structure
  38. GC31466 Picoprazole Picoprazole is a specific inhibitor of H+/K+-ATPase with IC50 of 3.1±0.4 μM. Picoprazole  Chemical Structure
  39. GC31969 Pumaprazole (BY-841)

    BY-841

    Pumaprazole (BY-841) is a reversible proton pump antagonist. Pumaprazole (BY-841)  Chemical Structure
  40. GC16645 Rabeprazole proton pump inhibitor Rabeprazole  Chemical Structure
  41. GC15670 Rabeprazole sodium

    E 3810, LY307640

    proton pump inhibitor Rabeprazole sodium  Chemical Structure
  42. GC39429 Rabeprazole Sulfide

    Rabeprazole Thioether

    Rabeprazole Sulfide is an active metabolite of Rabeprazole. Rabeprazole Sulfide  Chemical Structure
  43. GC63687 Rabeprazole-d4 Rabeprazole D4 (LY307640 D4) is a deuterium labeled Rabeprazole. Rabeprazole-d4  Chemical Structure
  44. GC31987 S3337 S3337 is an H+, K+-ATPase inhibitor. S3337  Chemical Structure
  45. GC11151 SCH 28080 H+,K+-ATPase inhibitor SCH 28080  Chemical Structure
  46. GC30418 SKF96067 SKF96067 is a reversible inhibitor of the gastric H+/K+-ATPase. SKF96067  Chemical Structure
  47. GC30130 Soraprazan (BYK61359)

    BYK61359

    Soraprazan (BYK61359) (BYK61359) is a selective, reversible K-competitive inhibitor of the H,K-ATPase (Ki=6.4 nM), with an IC50 of 0.19 μM in gastric glands. Soraprazan (BYK61359)  Chemical Structure
  48. GC15418 TAK-438

    TAK-438

    Blocker of potassium-competitive acid TAK-438  Chemical Structure
  49. GC31566 Tegoprazan

    CJ-12420

    A proton pump inhibitor

    Tegoprazan  Chemical Structure
  50. GC37756 Tenatoprazole sodium Tenatoprazole sodium (TU-199 sodium) is a proton pump inhibitor; inhibits hog gastric H+/K+-ATPase with an IC50 of 6.2 μM. Tenatoprazole sodium  Chemical Structure
  51. GC61863 Verucopeptin Verucopeptin is a potent?HIF-1 (IC50=0.22 μM) inhibitor and decreases the expression of HIF-1 target genes and HIF-1α protein levels. Verucopeptin strongly inhibits v-ATPase activity?by directly targeting the v-ATPase ATP6V1G subunit but not ATP1V1B2 or ATP6V1D. Verucopeptin exhibits antitumor activity against multidrug resistance (MDR)?cancers and can be used for cancer research. Verucopeptin  Chemical Structure
  52. GC37920 Vonoprazan Vonoprazan (TAK-438 free base), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan  Chemical Structure
  53. GC63472 Zastaprazan

    JP-1366

    Zastaprazan is a proton pump inhibitor (WO2018008929). Zastaprazan  Chemical Structure
  54. GC16453 Zinc Pyrithione Proton pump inhibitor Zinc Pyrithione  Chemical Structure

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