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Sodium Channel

Sodium channel are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell plasma membrane.

Products for  Sodium Channel

  1. Cat.No. Product Name Information
  2. GC11271 Oxybuprocaine HCl Oxybuprocaine HCl (Benoxinate hydrochloride) reversibly blocks sodium channels and prevents propagation of painful nerve impulses in the cornea, conjunctiva, and sclera. Oxybuprocaine HCl  Chemical Structure
  3. GC31206 PF 04531083 PF 04531083 is a selective NaV1.8 blocker, and used for the research of neuropathic/inflammatory pain. PF 04531083  Chemical Structure
  4. GC12109 PF 04885614 NaV1.8 inhibitor PF 04885614  Chemical Structure
  5. GC36877 PF 05089771 PF 05089771 is a potent, orally active and selective arylsulfonamide Nav1.7 inhibitor, with IC50 values of 11 nM, 12 nM, 13 nM, 171 nM and 8 nM for hNav1.7, cynNav1.7, dogNav1.7,ratNav1.7, and musNav1.7, respectively. PF 05089771  Chemical Structure
  6. GC19281 PF-01247324 PF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker with an IC50 of 196 nM for recombinant human Nav1.8 channel. PF-01247324  Chemical Structure
  7. GC18947 PF-05089771 (tosylate) PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50s = 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively). PF-05089771 (tosylate)  Chemical Structure
  8. GC67799 PF-05198007 PF-05198007  Chemical Structure
  9. GC30322 PF-05241328 PF-05241328 is a potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channels (Nav1.7), with an IC50 of 31 nM. PF-05241328  Chemical Structure
  10. GC31095 PF-06305591 PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC50 of 15 nM. PF-06305591  Chemical Structure
  11. GC61175 PF-06305591 dihydrate PF-06305591 dihydrate is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC50 of 15 nM. PF-06305591 dihydrate  Chemical Structure
  12. GC66038 PF-06649298 PF-06649298 is a sodium-coupled citrate transporter (NaCT or SLC13A5) inhibitor. PF-06649298 specifically interacts with NaCT with an IC50 value of 16.2 μM to inhibits the transport of citrate in human hepatocytes. PF-06649298 can be used for the research of regulating glucose metabolism and lipid metabolism. PF-06649298  Chemical Structure
  13. GC68011 PF-06761281 PF-06761281  Chemical Structure
  14. GC19289 PF-06869206 PF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1) with an IC50 of 380 nM. PF-06869206  Chemical Structure
  15. GC16086 Phenytoin inactive voltage-gated sodium channel stabilizer Phenytoin  Chemical Structure
  16. GC12858 Phenytoin sodium Sodium channel stabilizer Phenytoin sodium  Chemical Structure
  17. GC13494 Phrixotoxin 3 voltage-gated sodium channels blocker Phrixotoxin 3  Chemical Structure
  18. GC12805 Procainamide HCl Procainamide HCl is an anti-arrhythmic agent and is used to treat cardiac arrhythmia; induces rapid block of the batrachotoxin(BTX)-activated sodium channels of the heart muscle and acts as antagonist to long gating closures. Procainamide HCl  Chemical Structure
  19. GC16173 Procaine HCl inhibitor of sodium channel, NMDA receptor and nAChR Procaine HCl  Chemical Structure
  20. GC30415 Propafenone D7 hydrochloride (SA-79 (D7 hydrochloride)) Propafenone D7 (SA-79 D7) hydrochloride is the deuterium labeled Propafenone, which is a classic anti-arrhythmic agent. Propafenone D7 hydrochloride (SA-79 (D7 hydrochloride))  Chemical Structure
  21. GC10639 Propafenone HCl Propafenone (hydrochloride) (SA-79 (hydrochloride)) is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias. Propafenone HCl  Chemical Structure
  22. GC13397 Proparacaine HCl voltage-gated sodium channels antagonist Proparacaine HCl  Chemical Structure
  23. GC33729 Proparacaine Hydrochloride (Proxymetacaine Hydrochloride) Proparacaine Hydrochloride (Proxymetacaine Hydrochloride)  Chemical Structure
  24. GC30957 Propoxycaine hydrochloride

    Propoxycaine hydrochloride inhibits voltage-gated sodium channels, and thereby inhibits the ionic flux required for the initiation and conduction of impulses.

    Propoxycaine hydrochloride  Chemical Structure
  25. GC11904 ProTx II NaV1.7 channel blocker ProTx II  Chemical Structure
  26. GC50264 ProTx III Potent Nav1.7 blocker; analgesic ProTx III  Chemical Structure
  27. GC50174 QAQ dichloride Photoswitchable Nav, Kv and Cav channel blocker QAQ dichloride  Chemical Structure
  28. GC12439 Quinacrine (hydrochloride hydrate)

    voltage-dependent sodium channels blocker

    Quinacrine (hydrochloride hydrate)  Chemical Structure
  29. GC25812 Quinidine sulfate Quinidine (Chinidin, Pitayine, β-quinine, (+)-quinidine) acts as a blocker of voltage-gated sodium channels, also an antimuscarinic and antimalarial. Quinidine sulfate  Chemical Structure
  30. GC11446 QX 222 QX 222, a trimethyl analogue of Lignocaine, is a potent Na+ channel blocker. QX 222  Chemical Structure
  31. GC16648 QX 314 bromide voltage-activated Na+ channels blocker QX 314 bromide  Chemical Structure
  32. GC17495 QX 314 chloride voltage-activated Na+ channel blocker QX 314 chloride  Chemical Structure
  33. GC13781 QX-314 QX-314 is a membrane-impermeable permanently charged sodium channel blocker. QX-314  Chemical Structure
  34. GC16645 Rabeprazole proton pump inhibitor Rabeprazole  Chemical Structure
  35. GC37069 Ralfinamide Ralfinamide (FCE-26742A) is an orally available Na+ blocker derived from α-aminoamide, with function of suppressing pain. Ralfinamide  Chemical Structure
  36. GC13283 Ralfinamide mesylate Sodium channel blocker Ralfinamide mesylate  Chemical Structure
  37. GC14487 Ranolazine Anti-ischemic Ranolazine  Chemical Structure
  38. GC13882 Ranolazine 2HCl Ranolazine 2HCl (CVT 303 dihydrochloride) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP). Ranolazine 2HCl  Chemical Structure
  39. GC68425 Ranolazine-d3 Ranolazine-d3  Chemical Structure
  40. GC63295 Ranolazine-d8 Ranolazine-d8  Chemical Structure
  41. GC30813 Raxatrigine hydrochloride (GSK-1014802 hydrochloride) Raxatrigine hydrochloride (GSK-1014802 hydrochloride) (GSK-1014802 hydrochloride) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor. Raxatrigine hydrochloride (GSK-1014802 hydrochloride)  Chemical Structure
  42. GC13802 Riluzole Sodium channel protein inhibitor Riluzole  Chemical Structure
  43. GC44841 Riluzole (hydrochloride) Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 μM). Riluzole (hydrochloride)  Chemical Structure
  44. GC31387 Rimeporide (EMD-87580) Rimeporide (EMD-87580) (EMD-87580) is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1). Rimeporide (EMD-87580)  Chemical Structure
  45. GC31449 Rimeporide hydrochloride (EMD-87580 hydrochloride) Rimeporide hydrochloride (EMD-87580 hydrochloride) (EMD-87580 hydrochloride) is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1). Rimeporide hydrochloride (EMD-87580 hydrochloride)  Chemical Structure
  46. GC61250 Ropivacaine Ropivacain is a potent?sodium channel?blocker. Ropivacaine  Chemical Structure
  47. GC16390 Ropivacaine hydrochloride monohydrate anaesthetic, long-acting and local Ropivacaine hydrochloride monohydrate  Chemical Structure
  48. GC39843 Ropivacaine mesylate Ropivacaine mesylate is a long-acting amide local anaesthetic agent for a spinal block and effectively blocks neuropathic pain. Ropivacaine mesylate  Chemical Structure
  49. GC12413 Rostafuroxin (PST 2238) Rostafuroxin (PST 2238) (PST 2238), a digitoxigenin derivative, is an orally active and potent Na+,K+-ATPase (ATP1A1) antognist. Rostafuroxin (PST 2238)  Chemical Structure
  50. GC44858 RY785 RY785 is a selective inhibitor of Kv2.1 voltage-gated potassium channels (IC50 = 0.05 μM) that does not affect Cav2 calcium channels. RY785  Chemical Structure
  51. GC64691 RY796 RY796 is a potent and selective voltage-gated potassium (KV2) channel inhibitor with IC50s of 0.25 μM and 0.09 μM for KV2.1 and KV2.2. RY796  Chemical Structure
  52. GC63821 S-Bioallethrin S-Bioallethrin is a pyrethroid insecticide. S-Bioallethrin  Chemical Structure
  53. GC10615 S0859 A selective sodium/bicarbonate cotransporter blocker S0859  Chemical Structure
  54. GC11041 Sipatrigine voltage-dependent sodium channels (NaV) blocker Sipatrigine  Chemical Structure
  55. GC25936 SLC13A5-IN-1 SLC13A5-IN-1 is a selective inhibitor of sodium-citrate co-transporter (SLC13A5/NaCT). It completely blocks the uptake of 14 C-citrate and has the potential for the treatment of metabolic and/or cardiovascular diseases. SLC13A5-IN-1  Chemical Structure
  56. GC37659 Sodium Channel inhibitor 1 Sodium Channel inhibitor1, one of 3-Oxoisoindoline-1-carboxamides, is a novel and selective voltage-gated sodium channel for pain treatment. Sodium Channel inhibitor 1  Chemical Structure
  57. GC31167 Sodium Channel inhibitor 2

    Sodium Channel inhibitor 2 is a sodium channel blocker extracted from patent WO 2004011439 A2, compound 3c.

    Sodium Channel inhibitor 2  Chemical Structure
  58. GC31279 Sodium ionophore III (ETH2120) Sodium ionophore III (ETH2120) (ETH2120) is a Na+ ionophore suitable for the assay of sodium activity in blood, plasma, serum. Sodium ionophore III (ETH2120)  Chemical Structure
  59. GC69989 Taplucainium chloride

    Taplucainium chloride is a sodium channel blocker. It exhibits 70-95% inhibition at 10 μ M concentration. Taplucainium chloride can be used as an analgesic.

    Taplucainium chloride  Chemical Structure
  60. GC12676 TC-N 1752 human NaV1.7 channels blocker TC-N 1752  Chemical Structure
  61. GC19352 Tenapanor Tenapanor is an inhibitor of the Na+/H+ exchanger NHE3 with IC50 values of 5 and 10 nM against human and Rat NHE3, respectively. Tenapanor  Chemical Structure
  62. GC38865 Tocainide hydrochloride Tocainide hydrochloride is a sodium channel blocker, it blocks the sodium channels in the pain-producing foci in the nerve membranes. Tocainide hydrochloride  Chemical Structure
  63. GC16149 Topiramate An anticonvulsant Topiramate  Chemical Structure
  64. GC50198 Topiramate - d12 Deuterated topiramate Topiramate - d12  Chemical Structure
  65. GC63234 TPC2-A1-P TPC2-A1-P is a powerful and membrane permeable agonist of?two pore?channel?2?(TPC2) with an EC50 of 10.5 μM. TPC2-A1-P  Chemical Structure
  66. GC12254 Triamterene Sodium channel inhibitor Triamterene  Chemical Structure
  67. GC37824 Triamterene D5 Triamterene D5 is deuterium labeled Triamterene, which can block epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic. Triamterene D5  Chemical Structure
  68. GC11213 Trichlormethiazide thiazide diuretic Trichlormethiazide  Chemical Structure
  69. GC14730 Veratridine

    Voltage-gated Na+ channel opener

    Veratridine  Chemical Structure
  70. GC26033 Veratrine Veratridine (Cevadine, Cevadin, Cevadene), a steroidal alkaloid found in plants of the lily family, is a voltage-gated sodium channel activator. Veratridine induces anxiogenic-like behaviors in rats. Veratrine  Chemical Structure
  71. GC16658 Vinpocetine PDE inhibitor Vinpocetine  Chemical Structure
  72. GC63259 VX-150 VX-150 is an orally active, highly selective NaV1.8 inhibitor. VX-150  Chemical Structure
  73. GC30984 XEN907 XEN907 is a potent and spirooxindole blocker of NaV1.7, with an IC50 of 3 nM. XEN907  Chemical Structure
  74. GC63261 XPC-6444 XPC-6444 is a highly potent, isoform-selective, and CNS-penetrant NaV1.6 inhibitor (IC50=41 nM for hNaV1.6). XPC-6444  Chemical Structure
  75. GC32501 YM758 YM758 is a “funny” If current channel (If channel) inhibitor. YM758  Chemical Structure
  76. GC65940 Zandatrigine Zandatrigine (NBI-921352) is a sodium channel protein type 8 subunit alpha (Scn8α) blocker. Zandatrigine  Chemical Structure
  77. GC38872 Zoniporide hydrochloride hydrate Zoniporide (CP-597396) hydrochloride hydrate is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1). Zoniporide hydrochloride hydrate  Chemical Structure
  78. GC11735 Zonisamide Antiepileptic with anticonvulsant and mechanistic effect Zonisamide  Chemical Structure
  79. GC17952 Zonisamide sodium Antiepileptic drug Zonisamide sodium  Chemical Structure

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