Sodium Channel
Sodium channel are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell plasma membrane.
Products for Sodium Channel
- Cat.No. Product Name Information
- GC11271 Oxybuprocaine HCl Oxybuprocaine HCl (Benoxinate hydrochloride) reversibly blocks sodium channels and prevents propagation of painful nerve impulses in the cornea, conjunctiva, and sclera.
- GC31206 PF 04531083 PF 04531083 is a selective NaV1.8 blocker, and used for the research of neuropathic/inflammatory pain.
- GC12109 PF 04885614 NaV1.8 inhibitor
- GC36877 PF 05089771 PF 05089771 is a potent, orally active and selective arylsulfonamide Nav1.7 inhibitor, with IC50 values of 11 nM, 12 nM, 13 nM, 171 nM and 8 nM for hNav1.7, cynNav1.7, dogNav1.7,ratNav1.7, and musNav1.7, respectively.
- GC19281 PF-01247324 PF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker with an IC50 of 196 nM for recombinant human Nav1.8 channel.
- GC18947 PF-05089771 (tosylate) PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50s = 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively).
- GC67799 PF-05198007
- GC30322 PF-05241328 PF-05241328 is a potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channels (Nav1.7), with an IC50 of 31 nM.
- GC31095 PF-06305591 PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC50 of 15 nM.
- GC61175 PF-06305591 dihydrate PF-06305591 dihydrate is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC50 of 15 nM.
- GC66038 PF-06649298 PF-06649298 is a sodium-coupled citrate transporter (NaCT or SLC13A5) inhibitor. PF-06649298 specifically interacts with NaCT with an IC50 value of 16.2 μM to inhibits the transport of citrate in human hepatocytes. PF-06649298 can be used for the research of regulating glucose metabolism and lipid metabolism.
- GC68011 PF-06761281
- GC19289 PF-06869206 PF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1) with an IC50 of 380 nM.
- GC16086 Phenytoin inactive voltage-gated sodium channel stabilizer
- GC12858 Phenytoin sodium Sodium channel stabilizer
- GC13494 Phrixotoxin 3 voltage-gated sodium channels blocker
- GC12805 Procainamide HCl Procainamide HCl is an anti-arrhythmic agent and is used to treat cardiac arrhythmia; induces rapid block of the batrachotoxin(BTX)-activated sodium channels of the heart muscle and acts as antagonist to long gating closures.
- GC16173 Procaine HCl inhibitor of sodium channel, NMDA receptor and nAChR
- GC30415 Propafenone D7 hydrochloride (SA-79 (D7 hydrochloride)) Propafenone D7 (SA-79 D7) hydrochloride is the deuterium labeled Propafenone, which is a classic anti-arrhythmic agent.
- GC10639 Propafenone HCl Propafenone (hydrochloride) (SA-79 (hydrochloride)) is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.
- GC13397 Proparacaine HCl voltage-gated sodium channels antagonist
- GC33729 Proparacaine Hydrochloride (Proxymetacaine Hydrochloride)
-
GC30957
Propoxycaine hydrochloride
Propoxycaine hydrochloride inhibits voltage-gated sodium channels, and thereby inhibits the ionic flux required for the initiation and conduction of impulses.
- GC11904 ProTx II NaV1.7 channel blocker
- GC50264 ProTx III Potent Nav1.7 blocker; analgesic
- GC50174 QAQ dichloride Photoswitchable Nav, Kv and Cav channel blocker
-
GC12439
Quinacrine (hydrochloride hydrate)
voltage-dependent sodium channels blocker
- GC25812 Quinidine sulfate Quinidine (Chinidin, Pitayine, β-quinine, (+)-quinidine) acts as a blocker of voltage-gated sodium channels, also an antimuscarinic and antimalarial.
- GC11446 QX 222 QX 222, a trimethyl analogue of Lignocaine, is a potent Na+ channel blocker.
- GC16648 QX 314 bromide voltage-activated Na+ channels blocker
- GC17495 QX 314 chloride voltage-activated Na+ channel blocker
- GC13781 QX-314 QX-314 is a membrane-impermeable permanently charged sodium channel blocker.
- GC16645 Rabeprazole proton pump inhibitor
- GC37069 Ralfinamide Ralfinamide (FCE-26742A) is an orally available Na+ blocker derived from α-aminoamide, with function of suppressing pain.
- GC13283 Ralfinamide mesylate Sodium channel blocker
- GC14487 Ranolazine Anti-ischemic
- GC13882 Ranolazine 2HCl Ranolazine 2HCl (CVT 303 dihydrochloride) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP).
- GC68425 Ranolazine-d3
- GC63295 Ranolazine-d8
- GC30813 Raxatrigine hydrochloride (GSK-1014802 hydrochloride) Raxatrigine hydrochloride (GSK-1014802 hydrochloride) (GSK-1014802 hydrochloride) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor.
- GC13802 Riluzole Sodium channel protein inhibitor
- GC44841 Riluzole (hydrochloride) Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 μM).
- GC31387 Rimeporide (EMD-87580) Rimeporide (EMD-87580) (EMD-87580) is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1).
- GC31449 Rimeporide hydrochloride (EMD-87580 hydrochloride) Rimeporide hydrochloride (EMD-87580 hydrochloride) (EMD-87580 hydrochloride) is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1).
- GC61250 Ropivacaine Ropivacain is a potent?sodium channel?blocker.
- GC16390 Ropivacaine hydrochloride monohydrate anaesthetic, long-acting and local
- GC39843 Ropivacaine mesylate Ropivacaine mesylate is a long-acting amide local anaesthetic agent for a spinal block and effectively blocks neuropathic pain.
- GC12413 Rostafuroxin (PST 2238) Rostafuroxin (PST 2238) (PST 2238), a digitoxigenin derivative, is an orally active and potent Na+,K+-ATPase (ATP1A1) antognist.
- GC44858 RY785 RY785 is a selective inhibitor of Kv2.1 voltage-gated potassium channels (IC50 = 0.05 μM) that does not affect Cav2 calcium channels.
- GC64691 RY796 RY796 is a potent and selective voltage-gated potassium (KV2) channel inhibitor with IC50s of 0.25 μM and 0.09 μM for KV2.1 and KV2.2.
- GC63821 S-Bioallethrin S-Bioallethrin is a pyrethroid insecticide.
- GC10615 S0859 A selective sodium/bicarbonate cotransporter blocker
- GC11041 Sipatrigine voltage-dependent sodium channels (NaV) blocker
- GC25936 SLC13A5-IN-1 SLC13A5-IN-1 is a selective inhibitor of sodium-citrate co-transporter (SLC13A5/NaCT). It completely blocks the uptake of 14 C-citrate and has the potential for the treatment of metabolic and/or cardiovascular diseases.
- GC37659 Sodium Channel inhibitor 1 Sodium Channel inhibitor1, one of 3-Oxoisoindoline-1-carboxamides, is a novel and selective voltage-gated sodium channel for pain treatment.
-
GC31167
Sodium Channel inhibitor 2
Sodium Channel inhibitor 2 is a sodium channel blocker extracted from patent WO 2004011439 A2, compound 3c.
- GC31279 Sodium ionophore III (ETH2120) Sodium ionophore III (ETH2120) (ETH2120) is a Na+ ionophore suitable for the assay of sodium activity in blood, plasma, serum.
-
GC69989
Taplucainium chloride
Taplucainium chloride is a sodium channel blocker. It exhibits 70-95% inhibition at 10 μ M concentration. Taplucainium chloride can be used as an analgesic.
- GC12676 TC-N 1752 human NaV1.7 channels blocker
- GC19352 Tenapanor Tenapanor is an inhibitor of the Na+/H+ exchanger NHE3 with IC50 values of 5 and 10 nM against human and Rat NHE3, respectively.
- GC38865 Tocainide hydrochloride Tocainide hydrochloride is a sodium channel blocker, it blocks the sodium channels in the pain-producing foci in the nerve membranes.
- GC16149 Topiramate An anticonvulsant
- GC50198 Topiramate - d12 Deuterated topiramate
- GC63234 TPC2-A1-P TPC2-A1-P is a powerful and membrane permeable agonist of?two pore?channel?2?(TPC2) with an EC50 of 10.5 μM.
- GC12254 Triamterene Sodium channel inhibitor
- GC37824 Triamterene D5 Triamterene D5 is deuterium labeled Triamterene, which can block epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic.
- GC11213 Trichlormethiazide thiazide diuretic
-
GC14730
Veratridine
Voltage-gated Na+ channel opener
- GC26033 Veratrine Veratridine (Cevadine, Cevadin, Cevadene), a steroidal alkaloid found in plants of the lily family, is a voltage-gated sodium channel activator. Veratridine induces anxiogenic-like behaviors in rats.
- GC16658 Vinpocetine PDE inhibitor
- GC63259 VX-150 VX-150 is an orally active, highly selective NaV1.8 inhibitor.
- GC30984 XEN907 XEN907 is a potent and spirooxindole blocker of NaV1.7, with an IC50 of 3 nM.
- GC63261 XPC-6444 XPC-6444 is a highly potent, isoform-selective, and CNS-penetrant NaV1.6 inhibitor (IC50=41 nM for hNaV1.6).
- GC32501 YM758 YM758 is a “funny” If current channel (If channel) inhibitor.
- GC65940 Zandatrigine Zandatrigine (NBI-921352) is a sodium channel protein type 8 subunit alpha (Scn8α) blocker.
- GC38872 Zoniporide hydrochloride hydrate Zoniporide (CP-597396) hydrochloride hydrate is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1).
- GC11735 Zonisamide Antiepileptic with anticonvulsant and mechanistic effect
- GC17952 Zonisamide sodium Antiepileptic drug