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Home >> Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

TRP Channel

TRP (transient receptor potential) channels are a family of cation channels that sense various external and celluar signals such as mechanical stress, temperature, cellular messengers and exogenous chemicals. It is implicated in vascular tone , neurological disorders, kidney diseases, hypomagnesemia and hypocalcemia etc.

Products for  TRP Channel

  1. Cat.No. Product Name Information
  2. GC10873 α-Spinasterol TRPV1 antagonist α-Spinasterol Chemical Structure
  3. GC40808 (+)-Menthol (+)-Menthol is a monoterpene alcohol that has been found in Cannabis and has antifungal activity. (+)-Menthol Chemical Structure
  4. GC34951 (-)-Menthol A monoterpene with diverse biological activities (-)-Menthol Chemical Structure
  5. GC64062 (1R,2R)-ML-SI3

    (1R,2R)-ML-SI3 is a potent inhibitor of both TRPML1 and TRPML2 (IC50 values of 1.6 and 2.3 μM) and a weak inhibitor (IC50 12.5 μM) of TRPML3.

     (1R,2R)-ML-SI3 Chemical Structure
  6. GC40696 (R)-(+)-Pulegone (R)-(+)-Pulegone, the major chemical constituent of Calamintha nepeta (L. (R)-(+)-Pulegone Chemical Structure
  7. GC35010 (Z)-Capsaicin (Z)-Capsaicin is the cis isomer of capsaicin, acts as an orally active TRPV1 agonist, and is used in the research of neuropathic pain. (Z)-Capsaicin Chemical Structure
  8. GC38726 1,4-Cineole 1,4-Cineole is a widely distributed, natural, oxygenated monoterpene. 1,4-Cineole Chemical Structure
  9. GC17562 2-APB

    2-APB is an antagonist of the Ins(1,4,5)P3 receptor, with an IC50 value of 42μM when the concentration of InsP3 is 100 nm. 2-APB is also an inhibitor of TRPV6 and a modulator of various TRP channels.

     2-APB Chemical Structure
  10. GC68080 4-(Phenyldiazenyl)benzoic acid 4-(Phenyldiazenyl)benzoic acid Chemical Structure
  11. GC16801 5'-Iodoresiniferatoxin TRPV1 (VR1) receptor antagonist 5'-Iodoresiniferatoxin Chemical Structure
  12. GC10188 6'-Iodoresiniferatoxin TRPV1 (VR1) vanilloid receptor partial agonist 6'-Iodoresiniferatoxin Chemical Structure
  13. GC13679 6-Iodonordihydrocapsaicin Vanilloid receptor antagonist 6-Iodonordihydrocapsaicin Chemical Structure
  14. GC60542 8-Gingerol A natural TRPV1 agonist 8-Gingerol Chemical Structure
  15. GC10221 9-Phenanthrol TRPM4 blocker 9-Phenanthrol Chemical Structure
  16. GC50261 A 425619 Potent TRPV1 antagonist A 425619 Chemical Structure
  17. GC17091 A 784168 TRPV1 antagonist,potent and selective A 784168 Chemical Structure
  18. GC11701 A 967079 Selective TRPA1 channel blocker A 967079 Chemical Structure
  19. GC30837 A-1165442 A-1165442 is a potent, competitive and orally available TRPV1 antagonist with an IC50 of 9 nM for human TRPV1. A-1165442 Chemical Structure
  20. GC35222 ABT-239 ABT-239 is a novel, highly efficacious, non-imidazole?class of H3R antagonist and a transient receptor potential vanilloid type 1 (TRPV1) antagonist. ABT-239 Chemical Structure
  21. GC40860 AC1903 AC1903 is an inhibitor of transient receptor potential canonical channel 5 (TRPC5; IC50 = 14.7 μM). AC1903 Chemical Structure
  22. GC19729 Adenosine 5′-diphosphoribose sodium Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose sodium Chemical Structure
  23. GC50475 AM 12 TRPC5 inhibitor AM 12 Chemical Structure
  24. GC19025 AM-0902 AM-0902 is a potent, selective transient receptor potential A1 (TRPA1) antagonist with IC50s of 71 and 131 nM for rTRPA1 and hTRPA1, respectively. AM-0902 Chemical Structure
  25. GC50058 AMG 21629 Potent and selective TRPV1 antagonist AMG 21629 Chemical Structure
  26. GC65611 AMG 333 AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM. AMG 333 Chemical Structure
  27. GC11926 AMG 9810 TRPV1 antagonist AMG 9810 Chemical Structure
  28. GC13003 AMG-517 TRPV1 antagonist,potent and highly selective AMG-517 Chemical Structure
  29. GC35316 AMG2850 AMG2850 is a potent, orally bioavailable and selective transient receptor potential melastatin 8 (TRPM8) antagonist. AMG2850 Chemical Structure
  30. GC14537 AMTB hydrochloride TRPM8 channel blocker AMTB hydrochloride Chemical Structure
  31. GC18020 AP 18

    Reversible TRPA1 channel blocker

     AP 18 Chemical Structure
  32. GC35407 Asivatrep Asivatrep (PAC-14028) is a potent and selective transient receptor potential vanilloid type I (TRPV1) antagonist. Asivatrep Chemical Structure
  33. GC50115 ASP 7663 Selective TRPA1 activator ASP 7663 Chemical Structure
  34. GC14276 BCTC vanilloid receptor 1 (TRPV1 receptor) antagonist BCTC Chemical Structure
  35. GC35501 Beta-Eudesmol A sesquiterpene with diverse biological activities Beta-Eudesmol Chemical Structure
  36. GC34489 BI-749327 BI-749327 is a potent, high selectivity and orally bioavailable TRPC6 antagonist, with IC50s of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively. BI-749327 Chemical Structure
  37. GC50617 BTD Selective TRPC5 activator BTD Chemical Structure
  38. GN10792 Caffeic acid Caffeic acid Chemical Structure
  39. GC31953 Camphor ((±)-Camphor) Camphor ((±)-Camphor) ((±)-Camphor ((±)-Camphor)) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. Camphor ((±)-Camphor) Chemical Structure
  40. GC14065 Capsaicin A terpene alkaloid with diverse biological activities Capsaicin Chemical Structure
  41. GC17918 Capsazepine A TRPV1 antagonist Capsazepine Chemical Structure
  42. GC18069 Cardamonin Cardamonin ((E)-Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM. Cardamonin Chemical Structure
  43. GC50557 CBA CBA (CBA) is a potent and selective inhibitor of the cation channel TRPM4, with an IC50 of 1.5 μM. CBA Chemical Structure
  44. GC50188 CIM 0216 Selective TRPM3 agonist CIM 0216 Chemical Structure
  45. GC62179 Cyclic ADP-ribose Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD+ by an ADP-ribosyl cyclase. Cyclic ADP-ribose Chemical Structure
  46. GC61792 Cyclic ADP-ribose ammonium Cyclic ADP-ribose ammonium Chemical Structure
  47. GC33158 D-3263 D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity. D-3263 Chemical Structure
  48. GC32961 D-3263 hydrochloride D-3263 hydrochloride is an enteric-coated, orally bioavailable (transient receptor potential melastatin member 8) TRPM8 agonist. D-3263 hydrochloride Chemical Structure
  49. GC67739 D-erythro-Sphingosine hydrochloride D-erythro-Sphingosine hydrochloride Chemical Structure
  50. GC50670 D-GsMTx4 D-GsMTx4 Chemical Structure
  51. GC67924 Dihydrocapsiate Dihydrocapsiate Chemical Structure
  52. GC12520 Diphenyleneiodonium chloride

    Diphenyleneiodonium (DPI) chloride (DPIC), as a NADH/NADPH oxidase inhibitor, has possessing potent antimicrobial activity against Mtb and S. aureus.

     Diphenyleneiodonium chloride Chemical Structure
  53. GC15893 EIPA

    EIPA inhibited TRPP3-mediated Ca2+-activated currents with IC50 values of 10.5 µM.

     EIPA Chemical Structure
  54. GC35970 EIPA hydrochloride

    EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM.

     EIPA hydrochloride Chemical Structure
  55. GC64459 Englerin A Englerin A is a potent and selective activator of TRPC4 and TRPC5 channels, with EC50s of 11.2 and 7.6 nM, respectively. Englerin A can induce renal carcinoma cells death by elevated Ca2+ influx and Ca2+ cell overload. Englerin A Chemical Structure
  56. GC66016 Evifacotrep Evifacotrep, a short transient receptor potential channel 5 (TRPC5) antagonist (WO2020061162, compound 100), can be used for the research of neurological diseases. Evifacotrep Chemical Structure
  57. GC66436 FEMA 4809 FEMA 4809 is a TRPM8 receptor agonist (EC50=0.2 nM) for use as a cooling agent. TRPM8 is the ion channel responsible for the cool perception. FEMA 4809 Chemical Structure
  58. GC16917 GSK 2193874 TRPV4 antagonist, potent and selective GSK 2193874 Chemical Structure
  59. GC17940 GSK1016790A A TRPV4 agonist GSK1016790A Chemical Structure
  60. GC39198 GSK1702934A A TRPC3 and TRPC6 activator GSK1702934A Chemical Structure
  61. GC38501 GSK205 GSK205 is a potent, selective TRPV4 antagonist with an IC50 of 4.19? μM for inhibiting TRPV4-mediated Ca2+ influx. GSK205 Chemical Structure
  62. GC38465 GsMTx4

    GsMTx4 selectively inhibits cation-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families.

     GsMTx4 Chemical Structure
  63. GC12260 HC 067047 TRPV4 antagonist HC 067047 Chemical Structure
  64. GC15947 HC-030031

    TRPA1 channel blocker,potent and selective

     HC-030031 Chemical Structure
  65. GC30799 HC-070 HC-070 is an antagonist of TRPC4/TRPC5, with IC50s of 9.3 nM and 46 nM for hTRPC5 and hTRPC4 in cells, respectively. HC-070 Chemical Structure
  66. GC36277 Hydroxy-α-sanshool

    Hydroxy-α-sanshool is a transient receptor potential ankyrin 1 (TRPA1) and TRP vanilloid 1 (TRPV1) agonist with EC50s of 69 and 1.1 uM, respectively.

     Hydroxy-α-sanshool Chemical Structure
  67. GC43884 Hyperforin (dicyclohexylammonium salt) Hyperforin is a natural activator of the steroid X receptor (active at 0.1 to 0.5 μg/ml) and inhibitor of several cytochrome P450 (CYP) isoforms (IC50 = 10 μg/ml for CYP2D6). Hyperforin (dicyclohexylammonium salt) Chemical Structure
  68. GC50641 IA-Alkyne Broad spectrum cysteine reactive probe IA-Alkyne Chemical Structure
  69. GC16882 Icilin TRPM8/ hENaCδ agonist Icilin Chemical Structure
  70. GN10437 Imperatorin Imperatorin Chemical Structure
  71. GC65006 JNc-440 JNc-440 is a potent antihypertensive agent. JNc-440 Chemical Structure
  72. GC15427 JNJ 17203212 TRPV1 antagonist JNJ 17203212 Chemical Structure
  73. GC69317 JNJ-28583113

    JNJ-28583113 is a brain-penetrant TRPM2 antagonist. It inhibits the phosphorylation of GSK3α and β subunits by blocking TRPM2. JNJ-28583113 protects cells from oxidative stress-induced cell death. It also inhibits the release of cytokines from microglia in response to pro-inflammatory stimuli.

     JNJ-28583113 Chemical Structure
  74. GC33423 JT010 A TRPA1 channel agonist JT010 Chemical Structure
  75. GC31236 JYL 1421 (SC 0030) JYL 1421 (SC 0030) is a TRPV1 receptor antagonist, with an IC50 of 8 nM. JYL 1421 (SC 0030) Chemical Structure
  76. GC11613 L-R4W2 Vanilloid TRPV1 (VR1) receptor antagonist peptide L-R4W2 Chemical Structure
  77. GC44075 Linopirdine Linopirdine is an enhancer of the stimulus-evoked but not basal release of several neurotransmitters, including acetylcholine, dopamine, serotonin, and glutamate. Linopirdine Chemical Structure
  78. GC50268 M 084 hydrochloride TRPC4/5 channel blocker; antidepressant and anxiolytic M 084 hydrochloride Chemical Structure
  79. GC18296 M8-B (hydrochloride) M8-B is an antagonist of transient receptor potential melastatin 8 (TRPM8) that blocks activation by cold, icilin , or menthol in vitro (IC50s = 7.8, 26.9, and 64.3 nM, respectively). M8-B (hydrochloride) Chemical Structure
  80. GC14761 Mavatrep TRPV1 antagonist Mavatrep Chemical Structure
  81. GC39117 Methyl syringate Methyl syringate, a chemical marker of asphodel monofloral honey, is an efficient phenolic mediator for bacterial and fungal laccases. Methyl syringate Chemical Structure
  82. GC36609 Mifamurtide Mifamurtide (MTP-PE), an analog of the muramyl dipeptide (MDP), is a nonspecific immunomodulator by stimulating the immune response activating macrophages and monocytes. Mifamurtide Chemical Structure
  83. GC18564 MK6-83 MK6-83 is an activator of the transient receptor potential cation channel, mucolipin subfamily (TRPML1). MK6-83 Chemical Structure
  84. GC13457 ML 204 TRPC4 channels blocker ML 204 Chemical Structure
  85. GC16850 ML SA1 activator of TRPML channels ML SA1 Chemical Structure
  86. GC67784 ML-SI3 ML-SI3 Chemical Structure
  87. GC36627 ML204 hydrochloride ML204 hydrochloride is a novel, potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca2+ channels. ML204 hydrochloride Chemical Structure
  88. GC69508 MSP-3

    MSP-3 is an effective TRPV1 agonist with an EC50 value of 0.87 μM. MSP-3 has neuroprotective effects.

     MSP-3 Chemical Structure
  89. GC13930 N-(p-amylcinnamoyl) Anthranilic Acid

    phospholipase A2 (PLA2) inhibitor and TRP channel blocker

     N-(p-amylcinnamoyl) Anthranilic Acid Chemical Structure
  90. GC12769 Nonivamide

    agonist of the VR1 (TRPV1)

     Nonivamide Chemical Structure
  91. GC17879 OLDA OLDA (OLDA) is a product of condensation of oleic acid and dopamine (DA) and an endogenous TRPV1 selective agonist. OLDA Chemical Structure
  92. GC16467 Olvanil vanilloid receptor agonist Olvanil Chemical Structure
  93. GC11906 Ononetin TRPM3 channel blocker Ononetin Chemical Structure
  94. GC50640 OptoBI-1 Photoswitchable TRPC3/6/7 agonist OptoBI-1 Chemical Structure
  95. GC12597 Optovin photoactivator of TRPA1 Optovin Chemical Structure
  96. GC16700 PALDA PALDA (PALDA) is a endogenous, long-chain, linear fatty acid dopamide, which is inactive on TRPV1. PALDA Chemical Structure
  97. GC64573 PF-04745637 PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1. PF-04745637 Chemical Structure
  98. GC46199 PF-05105679 A TRPM8 antagonist PF-05105679 Chemical Structure
  99. GC19291 PF-4840154 PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel with EC50s of 97 and 23 nM, respectively. PF-4840154 Chemical Structure
  100. GC13994 Phenamil Phenamil, an analog of Amiloride, is a more potent and less reversible epithelial sodium channel (ENaC) blocker with an IC50 of 400 nM. Phenamil Chemical Structure
  101. GC32849 Pico145 (HC-608) Pico145 (HC-608) (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels, inhibits (-)-englerin A-activated TRPC4/TRPC5 channels, with IC50s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8. Pico145 (HC-608) Chemical Structure

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