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MAPK Signaling

Targets for  MAPK Signaling

Products for  MAPK Signaling

  1. Cat.No. Product Name Information
  2. GC32900 CC-90003 CC-90003 is an irreversible and selective inhibitor of ERK 1/2 with antitumor activity. CC-90003  Chemical Structure
  3. GC10446 CC-930 A potent JNK inhibitor CC-930  Chemical Structure
  4. GC63441 CC-99677 CC-99677 is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) pathway in both biochemical (IC50=156.3 nM) and cell based assays (EC50=89 nM). CC-99677  Chemical Structure
  5. GC19090 CCG215022 CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 uM, 0.38±0.06 uM and 3.9±1 uM for GRK2, GRK5 and GRK1, respectively. CCG215022  Chemical Structure
  6. GC19091 CCT196969 CCT196969, a pan-Raf inhibitor, inhibits B-Raf with an IC50 of 0.1 uM. CCT196969  Chemical Structure
  7. GC40054 CCT241161 CCT241161 is a multi-kinase inhibitor that inhibits B-RAF, B-RAFV600E, C-RAF, Src, and LCK (IC50s = 252, 15, 6, 15, and 3 nM, respectively). CCT241161  Chemical Structure
  8. GC61865 Cearoin Cearoin increases autophagy and apoptosis through the production of ROS and the activation of ERK. Cearoin  Chemical Structure
  9. GC12841 CEP 1347 JNK inhibitor CEP 1347  Chemical Structure
  10. GC16845 CEP-32496 CEP-32496 (CEP-32496; RXDX-105) is a highly potent and orally efficacious inhibitor of BRAFV600E with a Kd of 14 nM. CEP-32496  Chemical Structure
  11. GC17860 CEP-32496 hydrochloride A potent inhibitor of B-Raf CEP-32496 hydrochloride  Chemical Structure
  12. GC15525 cGMP Dependent Kinase Inhibitor Peptide cGMP Dependent Kinase Inhibitor Peptide is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a Ki of 86 μM. cGMP Dependent Kinase Inhibitor Peptide  Chemical Structure
  13. GC10666 CGP 57380 MNK1 inhibitor, specific and selective CGP 57380  Chemical Structure
  14. GC35674 Chicanine Chicanine is a lignan compound of Schisandra chinesis, inhibits LPS-induced phosphorylation of p38 MAPK, ERK 1/2 and IκB-α, with anti-inflammatory activity. Chicanine  Chemical Structure
  15. GC35684 CHMFL-EGFR-202 CHMFL-EGFR-202 is a potent, irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant kinase, with IC50s of 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases, respectively. CHMFL-EGFR-202 exhibits ?10-fold selectivity for EGFR L858R/T790M against the EGFR wild-type in cells. CHMFL-EGFR-202 adopts a covalent “DFG-in-C-helix-out” inactive binding conformation with EGFR, with strong antiproliferative effects against EGFR mutant-driven nonsmall-cell lung cancer (NSCLC) cell lines. CHMFL-EGFR-202  Chemical Structure
  16. GC12532 CHPG mGlu5 metabotropic glutamate receptor agonist CHPG  Chemical Structure
  17. GC17963 CHPG Sodium salt mGlu5 agonist CHPG Sodium salt  Chemical Structure
  18. GC47088 Cilostazol-d4 An internal standard for the quantification of cilostazol Cilostazol-d4  Chemical Structure
  19. GC39485 CK2/ERK8-IN-1 A dual inhibitor of CK2 and ERK8 CK2/ERK8-IN-1  Chemical Structure
  20. GC38755 CKI-7 CKI-7 is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC50 of 6 μM and a Ki of 8.5 μM. CKI-7 is a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 has a much weaker effect on casein kinase II and other protein kinases. CKI-7  Chemical Structure
  21. GC14693 CMK CMK  Chemical Structure
  22. GC11180 CMPD-1 inhibitor of p38α-mediated MK2a phosphorylation CMPD-1  Chemical Structure
  23. GC10033 Cobimetinib A potent, orally available MEK1 inhibitor Cobimetinib  Chemical Structure
  24. GC14337 Cobimetinib (R-enantiomer) Cobimetinib (R-enantiomer)  Chemical Structure
  25. GC17426 Cobimetinib (racemate) Cobimetinib (racemate)  Chemical Structure
  26. GC35719 Cobimetinib hemifumarate Cobimetinib hemifumarate is a novel selective MEK1 inhibitor, and the IC50 value against MEK1 is 4.2 nM. Cobimetinib hemifumarate  Chemical Structure
  27. GC25289 CompK CompK (compound K), a potent and selective hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) small molecule inhibitor, significantly improves human T-cell functions, with enhanced T-cell receptor avidity to recognize tumor-associated antigens and tumor cytolytic activity by CD8+ T cells. CompK  Chemical Structure
  28. GC46123 Comprehensive Kinase Screening Library For screening of a variety of kinase inhibitors Comprehensive Kinase Screening Library  Chemical Structure
  29. GN10409 cor-nuside cor-nuside  Chemical Structure
  30. GN10481 Corynoxeine Corynoxeine  Chemical Structure
  31. GC35734 Cot inhibitor-1 Cot inhibitor-1 (compound 28) is a selective tumor progression loci-2 (Tpl2) kinase inhibitor with an IC50 of 28 nM. Cot inhibitor-1  Chemical Structure
  32. GC35735 Cot inhibitor-2 Cot inhibitor-2 is a potent, selective and orally active cot (Tpl2/MAP3K8) inhibitor with an IC50 of 1.6 nM. Cot inhibitor-2 inhibts TNF-α production in LPS-stimulated human whole blood with an IC50 of 0.3 μM. Cot inhibitor-2  Chemical Structure
  33. GC31525 CREBtide A PKA substrate CREBtide  Chemical Structure
  34. GC43332 Cuspin-1 The Survival of Motor Neurons (SMN) protein participates in RNA splicing. Cuspin-1  Chemical Structure
  35. GC50181 CW 008 PKA signaling activator; promotes osteogenesis from hMSCs CW 008  Chemical Structure
  36. GC43339 Cyclic di-AMP (sodium salt) Cyclic di-AMP (c-di-AMP) is a second messenger produced by bacteria but not by mammals. Cyclic di-AMP (sodium salt)  Chemical Structure
  37. GC43341 Cyclic GMP

    Guanosine 3',5'-cyclic monophosphate (cyclic GMP or cGMP) is a second messenger that is biosynthesized from GTP by guanylate cyclases.

    Cyclic GMP  Chemical Structure
  38. GC30057 D-JNKI-1 (AM-111) D-JNKI-1 (AM-111) (AM-111) is a highly potent and cell-permeable peptide inhibitor of JNK. D-JNKI-1 (AM-111)  Chemical Structure
  39. GC15187 Dabrafenib (GSK2118436) Dabrafenib (GSK2118436) (GSK2118436A) is an ATP-competitive inhibitor of Raf with IC50s of 5 nM and 0.6 nM for C-Raf and B-RafV600E, respectively. Dabrafenib (GSK2118436)  Chemical Structure
  40. GC12486 Dabrafenib Mesylate (GSK-2118436) A Raf kinase inhibitor Dabrafenib Mesylate (GSK-2118436)  Chemical Structure
  41. GC47166 Dabrafenib-d9 An internal standard for the quantification of dabrafenib Dabrafenib-d9  Chemical Structure
  42. GN10336 Daphnetin Daphnetin  Chemical Structure
  43. GC14114 DB07268 A potent inhibitor of JNK1 DB07268  Chemical Structure
  44. GC15477 DBM 1285 dihydrochloride p38 MAPK inhibitor DBM 1285 dihydrochloride  Chemical Structure
  45. GC16795 DCA DCA is a metabolic regulator in cancer cells' mitochondria with anticancer activity. DCA inhibits PDHK, resulting in decreased lactic acid in the tumor microenvironment. DCA increases reactive oxygen species (ROS) generation and promotes cancer cell apoptosis. DCA also works as NKCC inhibitor. DCA  Chemical Structure
  46. GC18666 Debromohymenialdisine Damaged DNA in humans is detected by sensor proteins that transmit a signal through checkpoint kinases (Chks) Chk1 and Chk2. Debromohymenialdisine  Chemical Structure
  47. GC35832 Dehydrocorydaline chloride An alkaloid with diverse biological activities Dehydrocorydaline chloride  Chemical Structure
  48. GC16214 DEL-22379 inhibitor of the dimerization of ERK DEL-22379  Chemical Structure
  49. GC32254 Deltonin Deltonin, a steroidal saponin, isolated from Dioscorea zingiberensis Wright, with antitumor activity; Deltonin inhibits ERK1/2 and AKT activation. Deltonin  Chemical Structure
  50. GC12824 Dibutyryl-cAMP, sodium salt Dibutyryl-cAMP, sodium salt salt (Dibutyryl-cAMP sodium salt) is a stabilized cyclic AMP (cAMP) analog and a selective PKA activator. Dibutyryl-cAMP, sodium salt  Chemical Structure
  51. GC38319 Dihydrocaffeic acid Dihydrocaffeic acid is a phenolic acid found in Gynura bicolor, reduces phosphorylation of MAPK p38 and prevent UVB-induced skin damage. Dihydrocaffeic acid  Chemical Structure
  52. GC31697 Dilmapimod (SB-681323) Dilmapimod (SB-681323) (SB-681323) is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease. Dilmapimod (SB-681323)  Chemical Structure
  53. GC30913 DLK-IN-1 DLK-IN-1 is a selective, orally active inhibitor of dual leucine zipper kinase (DLK, MAP3K12), with a Ki of 3 nM. DLK-IN-1  Chemical Structure
  54. GC61466 DMU-212 DMU-212 is a methylated derivative of Resveratrol, with antimitotic, anti-proliferative, antioxidant and apoptosis promoting activities. DMU-212 induces mitotic arrest via induction of apoptosis and activation of ERK1/2 protein. DMU-212 has orally active. DMU-212  Chemical Structure
  55. GC65298 DMX-5804 DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC50 of 3 nM, a pIC50 of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC50, 8.18), and TNIK/MAP4K7 (pIC50, 7.96). DMX-5804  Chemical Structure
  56. GC13244 DTP3 inhibitor of GADD45β/MKK7 complex DTP3  Chemical Structure
  57. GC38202 DTP3 TFA DTP3 TFA is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor. DTP3 TFA targets an essential, cancer-selective cell-survival module downstream of the NF-κB pathway. DTP3 TFA  Chemical Structure
  58. GC64496 EF24 EF24 is a curcumin analogue with greater anti-tumor efficacy and oral bioavailability via deactivation of the MAPK/ERK signaling pathway in oral squamous cell carcinoma (OSCC). EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK. EF24  Chemical Structure
  59. GC10030 EHop-016 Rac1/Rac3 GTPase inhibitor,potent and specific EHop-016  Chemical Structure
  60. GC43610 Enniatin A1 Enniatins are cyclohexadepsipeptides commonly isolated from fungi that are known to have antibiotic properties and to induce apoptosis in several cancer lines. Enniatin A1  Chemical Structure
  61. GC17693 Enniatin B ionophore with some capacity to facilitate import of K+ and Na+ across membranes Enniatin B  Chemical Structure
  62. GC43611 Enniatin B1 Enniatins are cyclohexadepsipeptides commonly isolated from fungi and are known to have antibiotic properties. Enniatin B1  Chemical Structure
  63. GC10403 EO 1428 p38α and p38β2 inhibitor EO 1428  Chemical Structure
  64. GC43624 ERK Inhibitor ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 μM). ERK Inhibitor  Chemical Structure
  65. GC33206 ERK-IN-1 ERK-IN-1 (compound B) is an orally available ERK1 and ERK2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. The activity is particularly related to the treatment of KRAS-mutant NSCLC, BRAF-mutant NSCLC, KRAS-mutant pancreatic cancer, KRAS-mutant colorectal cancer (CRC) and KRAS-mutant ovarian cancer. ERK-IN-1 hydrochloride can also inhibit RAF. ERK-IN-1  Chemical Structure
  66. GC62229 ERK-IN-3 ERK-IN-3 is a potent and orally active inhibitor of ERK. ERK-IN-3 inhibits ERK1/2 with low single-digit nM IC50 values. ERK-IN-3 can be used for the research of cancers driven by RAS mutations. ERK-IN-3  Chemical Structure
  67. GC63459 ERK-IN-3 benzenesulfonate ERK-IN-3 benzenesulfonate is a potent and orally active inhibitor of ERK. ERK-IN-3 benzenesulfonate inhibits ERK1/2 with low single-digit nM IC50 values. ERK-IN-3 benzenesulfonate can be used for the research of cancers driven by RAS mutations. ERK-IN-3 benzenesulfonate  Chemical Structure
  68. GC65510 ERK1/2 inhibitor 1 ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively. ERK1/2 inhibitor 1  Chemical Structure
  69. GC60812 ERK1/2 inhibitor 2 ERK1/2 inhibitor 2 (Example 1) is a potent dual ERK1/2 inhibitor. ERK1/2 inhibitor 2 has anti-cancer activity. ERK1/2 inhibitor 2  Chemical Structure
  70. GC67905 ERK1/2 inhibitor 7 ERK1/2 inhibitor 7  Chemical Structure
  71. GC32796 ERK5-IN-1 An ERK5 inhibitor ERK5-IN-1  Chemical Structure
  72. GC36002 ERK5-IN-2 ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively. ERK5-IN-2  Chemical Structure
  73. GP23419 ESAT6 Early Secretory Target Mycobacterium Tuberculosis Recombinant ESAT6  Chemical Structure
  74. GC36006 Esculentoside H Thalidomide-O-PEG4-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Esculentoside H  Chemical Structure
  75. GC38708 Esculin Esculin  Chemical Structure
  76. GC33033 ETC-206 ETC-206 is a selective MNK1 and MNK2 inhibitor with IC50s of 64 nM and 86 nM, respectively. ETC-206  Chemical Structure
  77. GC61941 Eudesmin Eudesmin ((-)-Eudesmin) impairs adipogenic differentiation via inhibition of S6K1 signaling pathway. Eudesmin  Chemical Structure
  78. GC65329 EW-7195 EW-7195 is a potent and selective ALK5 (TGFβR1) inhibitor with an IC50 of 4.83 nM. EW-7195 has >300-fold selectivity for ALK5 over p38α. EW-7195 efficiently inhibits TGF-β1-induced Smad signaling, epithelial-to-mesenchymal transition (EMT) and breast tumour metastasis to the lung. EW-7195  Chemical Structure
  79. GC67964 Exarafenib Exarafenib  Chemical Structure
  80. GC13869 Fasudil Calcium antagonist Fasudil  Chemical Structure
  81. GC14289 Fasudil (HA-1077) HCl Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil (HA-1077) HCl is also a potent Ca2+ channel antagonist and vasodilator. Fasudil (HA-1077) HCl  Chemical Structure
  82. GC40484 Ferulic Acid methyl ester Ferulic acid is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F. Ferulic Acid methyl ester  Chemical Structure
  83. GC25420 Fipexide hydrochloride Fipexide (hydrochloride) is a psychoactive drug of the piperazine class. Fipexide hydrochloride  Chemical Structure
  84. GP23504 FLRT3 Human Fibronectin Leucine Rich Transmembrane Protein 3 Human Recombinant FLRT3 Human  Chemical Structure
  85. GC14125 FMK An inhibitor of RSK2 FMK  Chemical Structure
  86. GC34197 FMK-MEA

    A potent and selective p90 Ribosomal S6 Kinase (RSK) inhibitor

    FMK-MEA  Chemical Structure
  87. GC32411 FR 167653 (FR 167653 sulfate) FR 167653 (FR 167653 sulfate) (FR 167653 (FR 167653 sulfate) sulfate), an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 (FR 167653 sulfate)  Chemical Structure
  88. GC31058 FR 167653 free base FR 167653 free base, an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 free base  Chemical Structure
  89. GC10647 FR 180204

    ERK inhibitor

    FR 180204  Chemical Structure
  90. GC12970 Furosemide GABAA receptors antagonist Furosemide  Chemical Structure
  91. GC36091 Furosemide sodium A loop diuretic inhibitor of Na+/2Cl-/K+ (NKCC) cotransporter Furosemide sodium  Chemical Structure
  92. GC43734 Ganglioside GQ1b Mixture (sodium salt) Ganglioside GQ1b is a tetrasialoganglioside that contains two sialic acid residues linked to an inner galactose unit. Ganglioside GQ1b Mixture (sodium salt)  Chemical Structure
  93. GC14247 GDC-0623 MEK1 inhibitor, potent and ATP-uncompetitive GDC-0623  Chemical Structure
  94. GC10505 GDC-0879 B-Raf inhibitor,potent and selective GDC-0879  Chemical Structure
  95. GC12006 GDC-0994 GDC-0994 (GDC-0994) is an orally active ERK kinase inhibitor with an IC50 of 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively. GDC-0994  Chemical Structure
  96. GN10307 Ginsenoside Re Ginsenoside Re  Chemical Structure
  97. GC17255 Gliotoxin An immunosuppressive mycotoxin with diverse biological effects Gliotoxin  Chemical Structure
  98. GC33123 GNE 220 GNE-220 is a potent and selective inhibitor of MAP4K4 with an IC50 of 7 nM. GNE 220  Chemical Structure
  99. GC34208 GNE 220 Hydrochloride GNE 220 (hydrochloride) is a potent and selective inhibitor of MAP4K4, with an IC50 of 7 nM. GNE 220 Hydrochloride  Chemical Structure
  100. GC19173 GNE-3511 GNE-3511 is a dual leucine zipper kinase (DLK) inhibitor with a Ki of 0.5 nM. GNE-3511  Chemical Structure
  101. GC18257 GNE-495 GNE-495 is an orally bioavailable, potent, and selective MAP4K4 inhibitor (IC50 = 3.7 nM). GNE-495  Chemical Structure

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