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MAPK Signaling

Targets for  MAPK Signaling

Products for  MAPK Signaling

  1. Cat.No. Product Name Information
  2. GC13142 RWJ 67657 orally active inhibitor of the MAP kinases p38α and p38β RWJ 67657  Chemical Structure
  3. GC18273 SB 202190 (hydrochloride) SB 202190 is a potent, selective, and cell-permeable inhibitor of p38 MAP kinases, inhibiting p38α (SAPK2A, MAPK14) and p38β (SAPK2B, MAPK11) with IC50 values of 50 and 100 nM, respectively. SB 202190 (hydrochloride)  Chemical Structure
  4. GC16019 SB 202474 a negative control in studies of p38 inhibition SB 202474  Chemical Structure
  5. GC13001 SB 203580 hydrochloride Adezmapimod (SB 203580) hydrochloride is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. SB 203580 hydrochloride  Chemical Structure
  6. GC10054 SB 239063 A selective p38 MAPK inhibitor SB 239063  Chemical Structure
  7. GC37595 SB 242235 SB-242235 is a potent and selective p38 MAP kinase inhibitor, with an IC50 of 1.0 μM in primary human chondrocytes. SB 242235  Chemical Structure
  8. GC11922 SB 706504 p38 MAPK inhibitor SB 706504  Chemical Structure
  9. GC13968 SB202190 (FHPI) SB202190 (FHPI) is a selective p38 MAP kinase inhibitor with IC50s of 50 nM and 100 nM for p38α and p38β2, respectively. SB202190 (FHPI)  Chemical Structure
  10. GC11890 SB590885 Potent B-Raf inhibitor SB590885  Chemical Structure
  11. GC16001 SCH772984

    A selective inhibitor of ERK1/2

    SCH772984  Chemical Structure
  12. GC14647 SCH772984 HCl

    ERK1/2 inhibitor

    SCH772984 HCl  Chemical Structure
  13. GC15044 SCH772984 TFA

    ERK1/2 inhibitor

    SCH772984 TFA  Chemical Structure
  14. GC19325 SD 0006 SD-06 is a p38 MAP kinase inhibitor; inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats (83% inhibition at 1mg/kg, po).IC50 value: 170 nM. SD 0006  Chemical Structure
  15. GC14982 SD 169 selective ATP competitive inhibitor of the MAP kinases p38α and p38β SD 169  Chemical Structure
  16. GC12124 Selonsertib (GS-4997) Selonsertib (GS-4997) (GS-4997), an orally bioavailable, selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8.3, has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis. Selonsertib (GS-4997)  Chemical Structure
  17. GC38653 Selumetinib sulfate Selumetinib (AZD6244) is selective, non-ATP-competitive oral?MEK1/2?inhibitor, with an IC50 of 14 nM for MEK1. Selumetinib (AZD6244) inhibits ERK1/2 phosphorylation. Selumetinib sulfate  Chemical Structure
  18. GC39815 Semapimod tetrahydrochloride Semapimod tetrahydrochloride (CNI-1493), an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6. Semapimod tetrahydrochloride  Chemical Structure
  19. GC10005 SEP-0372814 A PDE10A inhibitor SEP-0372814  Chemical Structure
  20. GC33229 SJFα SJFα is a 13-atom linker PROTAC based on von Hippel-Lindau ligand. SJFα degrades p38α with a DC50 of 7.16nM, but is far less effective at degrading p38δ (DC50=299nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5μM. SJFα  Chemical Structure
  21. GC33238 SJFδ SJFδ is a 10-atom linker PROTAC based on von Hippel-Lindau ligand. SJFδ degrades p38δ with a DC50 of 46.17nM, but does not degrade p38α, p38β, or p38γ. SJFδ  Chemical Structure
  22. GC30646 Skatole(3-Methylindole) Skatole(3-Methylindole) is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38. Skatole(3-Methylindole)   Chemical Structure
  23. GC13578 Skepinone-L An inhibitor of p38 MAPK Skepinone-L  Chemical Structure
  24. GC17725 SKF 86002 dihydrochloride p38 MAP kinase inhibitor SKF 86002 dihydrochloride  Chemical Structure
  25. GC37646 SKF-86002 SKF-86002 is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002  Chemical Structure
  26. GC18532 Skyrin Skyrin is a fungal metabolite characterized by a bisanthraquinone structure. Skyrin  Chemical Structure
  27. GC16313 SL 0101-1 ribosomal S6 kinase inhibitor SL 0101-1  Chemical Structure
  28. GC15359 SL-327 Selective MEK1/2 inhibitor SL-327  Chemical Structure
  29. GC32937 SLV-2436 (SEL201-88) SLV-2436 (SEL201-88) is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC50s of 10.8 nM and 5.4 nM, respectively. SLV-2436 (SEL201-88)  Chemical Structure
  30. GC62675 SM1-71 SM1-71 (compound 5) is a potent TAK1 inhibitor, with a Ki of 160 nM, it also can covalently inhibit MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1 and RSK2. SM1-71 can inhibit proliferation of multiple cancer cell lines. SM1-71  Chemical Structure
  31. GC17425 Sodium Tauroursodeoxycholate (TUDC) Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK. Sodium Tauroursodeoxycholate (TUDC)  Chemical Structure
  32. GC17369 Sorafenib

    Sorafenib acts as a multi-kinase inhibitor, targeting Raf-1 and B-Raf with IC50 values of 6 nM and 22 nM, respectively.

    Sorafenib  Chemical Structure
  33. GC37664 Sorafenib (D3) An internal standard for the quantification of sorafenib Sorafenib (D3)  Chemical Structure
  34. GC37665 Sorafenib (D4) Sorafenib (D4) (Bay 43-9006-d4) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively. Sorafenib (D4)  Chemical Structure
  35. GC44917 Sorafenib N-oxide Sorafenib N-oxide is an active metabolite of sorafenib, an inhibitor of Raf-1, B-RAF, and receptor tyrosine kinases. Sorafenib N-oxide  Chemical Structure
  36. GC10428 Sp-5,6-dichloro-cBIMPS (sodium salt) PKA activator Sp-5,6-dichloro-cBIMPS (sodium salt)  Chemical Structure
  37. GC44920 Sp-8-bromo-Cyclic AMPS (sodium salt) Sp-8-bromo-cyclic AMPS (Sp-8-bromo-cAMPS) is a cell-permeable, cAMP analog that combines an exocyclic sulfur substitution in the axial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP. Sp-8-bromo-Cyclic AMPS (sodium salt)  Chemical Structure
  38. GC61747 Sp-cAMPS Sp-cAMPS, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS  Chemical Structure
  39. GC16652 SR 3576

    JNK3 inhibitor, potent and selective

    SR 3576  Chemical Structure
  40. GC30864 SR-3306 SR-3306 is a selective, potent, highly brain penetrant JNK inhibitor. SR-3306  Chemical Structure
  41. GC64287 SR15006 SR15006 is a inhibitor of Krüppel-like factor 5 (KLF5) with an IC50 of 41.6 nM in DLD-1/pGL4.18hKLF5p cells). SR15006  Chemical Structure
  42. GC50406 st-Ht31 Inhibits PKA/AKAP interactions; cell permeable st-Ht31  Chemical Structure
  43. GC50407 st-Ht31 P Negative control for st-Ht31 st-Ht31 P  Chemical Structure
  44. GC50501 STAD 2 AKAP disruptor; selectively binds PKA-RII and blocks its interaction with AKAP; cell permeable STAD 2  Chemical Structure
  45. GC15299 Staurosporine(CGP 41251)

    A potent inhibitor of protein kinase C

    Staurosporine(CGP 41251)  Chemical Structure
  46. GC11542 SU 3327 JNK inhibitor SU 3327  Chemical Structure
  47. GC13825 TA 01

    CK1ε, CK1δ,and p38α inhibitor

    TA 01  Chemical Structure
  48. GC11635 TA 02 p38 MAPK inhibitor TA 02  Chemical Structure
  49. GC16543 TAK-715 A p38 MAPK inhibitor TAK-715  Chemical Structure
  50. GC10209 TAK-733 MEK allosteric site inhibitor TAK-733  Chemical Structure
  51. GC62497 TAK1-IN-2 TAK1-IN-2 is a potent and selective TAK1 inhibitor, with an IC50> of 2 nM. TAK1-IN-2  Chemical Structure
  52. GC69984 TAK1-IN-4

    TAK1-IN-4 (Compound 14) is a TAK1 inhibitor.

    TAK1-IN-4  Chemical Structure
  53. GC49700 Takeda-6d Takeda-6d  Chemical Structure
  54. GC32687 Takinib A TAK1 inhibitor Takinib  Chemical Structure
  55. GC34072 Talmapimod (SCIO-469) Talmapimod (SCIO-469) (SCIO-469) is an orally active, selective, and ATP-competitive p38α inhibitor with an IC50 of 9 nM. Talmapimod (SCIO-469) shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs. Talmapimod (SCIO-469)  Chemical Structure
  56. GC25982 Tanzisertib(CC-930) Tanzisertib (CC-930, JNK-930, JNKI-1) is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively. Tanzisertib(CC-930)  Chemical Structure
  57. GC34181 Tauroursodeoxycholate (TUDCA) Tauroursodeoxycholate (TUDCA) (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate (TUDCA) significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate (TUDCA) also inhibits ERK. Tauroursodeoxycholate (TUDCA)  Chemical Structure
  58. GC34831 Tauroursodeoxycholate dihydrate Tauroursodeoxycholate (Tauroursodeoxycholic acid; TDUCA) dihydrate is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK. Tauroursodeoxycholate dihydrate  Chemical Structure
  59. GC34057 TBHQ (tert-Butylhydroquinone) TBHQ (tert-Butylhydroquinone) (tert-Butylhydroquinone) is a widely used Nrf2 activator, protects against Doxorubicin (DOX)-induced cardiotoxicity through activation of Nrf2. TBHQ (tert-Butylhydroquinone) (tert-Butylhydroquinone) is also an ERK activator; rescues Dehydrocorydaline (DHC)-induced cell proliferation inhibitionin melanoma. TBHQ (tert-Butylhydroquinone)  Chemical Structure
  60. GC14853 TC ASK 10 ASK1 inhibitor TC ASK 10  Chemical Structure
  61. GC34140 TC13172 TC13172 is a mixed lineage kinase domain-like protein (MLKL) inhibitor with an EC50 value of 2 nM for HT-29 cells. TC13172  Chemical Structure
  62. GC11488 TCS JNK 5a JNK2 and JNK3 inhibitor TCS JNK 5a  Chemical Structure
  63. GC17282 TCS JNK 6o TCS JNK 6o (TCS JNK 6o) is a c-Jun N-terminal kinases (JNK-1, -2, and -3) inhibitor with Ki values of 2 nM, 4 nM, 52 nM, respectively, and has IC50 values of 45 nM and 160 nM for JNK-1 and -2, respectively. TCS JNK 6o  Chemical Structure
  64. GC39074 Tenuifoliside A Tenuifoliside A is isolated from Polygala tenuifolia, has anti-apoptotic and antidepressant-like effects. Tenuifoliside A  Chemical Structure
  65. GC41573 Theaflavin 3,3'-digallate

    Theaflavin-3,3'-digallate (TFDG) is a major polyphenol found in black tea with diverse biological activities.

    Theaflavin 3,3'-digallate  Chemical Structure
  66. GC68350 Tinlorafenib Tinlorafenib  Chemical Structure
  67. GC50295 TL4-12 Potent MAP4K2 (GCK) inhibitor TL4-12  Chemical Structure
  68. GC31647 Tomatidine Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. Tomatidine  Chemical Structure
  69. GC45064 Tomatidine (hydrochloride) Tomatidine is a steroidal alkaloid that has been found in the skins and leaves of tomatoes. Tomatidine (hydrochloride)  Chemical Structure
  70. GC19131 Tomivosertib eFT508 is a potent, highly selective, and orally bioavailable MNK1 and MNK2 inhibitor, with IC50s of 1-2 nM against both isoforms. Tomivosertib  Chemical Structure
  71. GC45067 Tpl2 Kinase Inhibitor Tpl2 Kinase Inhibitor (Compound 1) is a potent and selective Tpl2 (COT kinase, MAP3K8) inhibitor, plays an important role in the regulation of the inflammatory response and the progression of some cancers. Tpl2 Kinase Inhibitor  Chemical Structure
  72. GC49150 Tpl2 Kinase Inhibitor (hydrochloride) A Tpl2 inhibitor Tpl2 Kinase Inhibitor (hydrochloride)  Chemical Structure
  73. GC70053 Trametiglue

    Trametiglue is a derivative of Trametinib that binds to KSR-MEK and RAF-MEK with unprecedented potency and selectivity through a unique interface interaction.

    Trametiglue  Chemical Structure
  74. GC13508 Trametinib (GSK1120212)

    An inhibitor of MEK1 and MEK2

    Trametinib (GSK1120212)  Chemical Structure
  75. GC15260 Trametinib DMSO solvate Trametinib DMSO solvate  Chemical Structure
  76. GC30162 trans-Zeatin A cytokinin plant growth regulator trans-Zeatin  Chemical Structure
  77. GC45099 U-0126

    A MEK inhibitor

    U-0126  Chemical Structure
  78. GC15061 U0124 Inactive analog of U0126(MEK-1/2 inhibitor), used as a negative control U0124  Chemical Structure
  79. GC12807 U0126-EtOH

    U0126-EtOH-EtOH (U0126 has potent inhibition on MEK1 and MEK2 with IC50s of 72 nM and 58 nM, respectively

    U0126-EtOH  Chemical Structure
  80. GC16678 UCN-02 protein kinase C inhibitor UCN-02  Chemical Structure
  81. GC11422 Ulixertinib (hydrochloride) reversible ERK1/2 inhibitor Ulixertinib (hydrochloride)  Chemical Structure
  82. GC19366 UM-164 UM-164 is a highly potent inhibitor of c-Src with a Kd of 2.7 nM. UM-164  Chemical Structure
  83. GC15004 URMC-099

    URMC-099, as a 7‐azaindole‐based MLK3 inhibitor with IC50 of 14 nM, could specifically affect specific Aβ species engaged in disease pathobiology[1].

    URMC-099  Chemical Structure
  84. GC38679 Urolithin B A metabolite of ellagic acid Urolithin B  Chemical Structure
  85. GC17818 Vacquinol-1 Vacquinol-1 (NSC13316) is a MKK4-specific activator that activates MAPK pathways. Vacquinol-1 specifically induces human glioblastoma cell (GC) death, attenuates tumor progression and prolongs survival in a glioblastoma multiforme (GBM) mouse model. Vacquinol-1 also induces apoptosis in hepatocellular carcinoma (HCC)cell. Vacquinol-1  Chemical Structure
  86. GC13412 Vemurafenib (PLX4032, RG7204)

    An inhibitor of mutant V600E and wild type B-Raf

    Vemurafenib (PLX4032, RG7204)  Chemical Structure
  87. GC17031 VRT752271 VRT752271 (BVD-523; VRT752271) is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC50 of <0.3 nM against ERK2. VRT752271 (BVD-523; VRT752271) inhibits the phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) in an A375 melanoma cell line. VRT752271  Chemical Structure
  88. GC13115 VX-11e A selective ERK inhibitor VX-11e  Chemical Structure
  89. GC17508 VX-702 P38α MAPK inhibitor,highly selective and ATP-competitive VX-702  Chemical Structure
  90. GC12926 VX-745 VX-745 (VX-745) is a potent, blood-brain barrier penetrant, highly selective inhibitor of p38α inhibitor with an IC50 for p38α of 10 nM and for p38β of 220 nM. VX-745  Chemical Structure
  91. GC30857 Warangalone (Scandenolone) Warangalone (Scandenolone) is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC50s of 4.8 μg/mL and 3.7 μg/mL, respectively. Warangalone (Scandenolone)  Chemical Structure
  92. GC38053 WHI-P258 A negative control for JAK3 inhibition WHI-P258  Chemical Structure
  93. GC12691 XMD17-109 A selective ERK5 inhibitor XMD17-109  Chemical Structure
  94. GC11076 XMD8-92 A selective ERK5 inhibitor XMD8-92  Chemical Structure
  95. GC16169 XRP44X Ras-Net (Elk-3) pathway inhibitor XRP44X  Chemical Structure
  96. GC62146 XST-14 XST-14 is a potent, competitive and highly selective ULK1 inhibitor with an IC50 of 26.6 nM. XST-14 induces autophagy inhibition by reducing the phosphorylation of the ULK1 downstream substrate. XST-14 induces apoptosis in hepatocellular carcinoma (HCC) cells and has antitumor effects. XST-14  Chemical Structure
  97. GC63264 Zapnometinib Zapnometinib (PD0184264), an active metabolite of CI-1040, is a MEK inhibitor, with an IC50 of 5.7 nM. Zapnometinib  Chemical Structure
  98. GC13286 ZM336372 C-Raf inhibitor, potent and selective ZM336372  Chemical Structure
  99. GC63425 Zunsemetinib Zunsemetinib (CDD-450) is an orally active and selective p38α mitogen-activated protein kinase-activated protein kinase 2 (MK2) pathway inhibitor. Zunsemetinib  Chemical Structure

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