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Home >> Signaling Pathways >> MAPK Signaling >> ERK

ERK

ERK (extracellular-signal-regulated kinase), also known as MAPK, is involved in the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells.

Products for  ERK

  1. Cat.No. Product Name Information
  2. GC63903 (E)-Osmundacetone (E)-Osmundacetone is the isomer of Osmundacetone. (E)-Osmundacetone Chemical Structure
  3. GC39325 2,5-Dihydroxyacetophenone 2,5-Dihydroxyacetophenone, isolated from Rehmanniae Radix Preparata, inhibits the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and NF-κB signaling pathways. 2,5-Dihydroxyacetophenone Chemical Structure
  4. GA20623 Ac-muramyl-Ala-D-Glu-NH₂ Ac-muramyl-Ala-D-Glu-NH₂ (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Ac-muramyl-Ala-D-Glu-NH₂ Chemical Structure
  5. GC68597 ACA-28

    ACA-28 (compound 2a) is an effective ERK MAPK signaling regulator. ACA-28 induces apoptosis through excessive activation of ERK and selectively inhibits cancer cell growth. ACA-28 inhibits the growth of melanoma cells (SK-MEL-28) and normal melanocytes (NHEM), with IC50 values of 5.3 and 10.1 μM, respectively.

     ACA-28 Chemical Structure
  6. GC17265 AG-126 ERK1 (p44) and ERK2 (p42) inhibitor AG-126 Chemical Structure
  7. GC35412 Asperulosidic Acid Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd. Asperulosidic Acid Chemical Structure
  8. GN10494 Astragaloside IV Astragaloside IV Chemical Structure
  9. GC31667 AX-15836 AX-15836 is a potent and selective ERK5 inhibitor with an IC50 of 8 nM. AX-15836 Chemical Structure
  10. GC19048 AZD-0364 AZD-0364 (AZD0364) is a potent and selective ERK2 inhibitor extracted from patent WO2017080979A1, compound example 18, has an IC50 of 0.6 nM. AZD-0364 Chemical Structure
  11. GC34342 BAY885 An ERK5 inhibitor BAY885 Chemical Structure
  12. GC15693 BIX 02188 MEK5 inhibitor,potent and selective BIX 02188 Chemical Structure
  13. GC12220 BIX 02189 Selective MEK5 inhibitor BIX 02189 Chemical Structure
  14. GC40352 Cafestol Cafestol is a natural diterpene which is abundant in unfiltered coffee. Cafestol Chemical Structure
  15. GC32900 CC-90003 CC-90003 is an irreversible and selective inhibitor of ERK 1/2 with antitumor activity. CC-90003 Chemical Structure
  16. GC61865 Cearoin Cearoin increases autophagy and apoptosis through the production of ROS and the activation of ERK. Cearoin Chemical Structure
  17. GC35674 Chicanine Chicanine is a lignan compound of Schisandra chinesis, inhibits LPS-induced phosphorylation of p38 MAPK, ERK 1/2 and IκB-α, with anti-inflammatory activity. Chicanine Chemical Structure
  18. GC12532 CHPG mGlu5 metabotropic glutamate receptor agonist CHPG Chemical Structure
  19. GC17963 CHPG Sodium salt mGlu5 agonist CHPG Sodium salt Chemical Structure
  20. GC39485 CK2/ERK8-IN-1 A dual inhibitor of CK2 and ERK8 CK2/ERK8-IN-1 Chemical Structure
  21. GN10481 Corynoxeine Corynoxeine Chemical Structure
  22. GC16214 DEL-22379 inhibitor of the dimerization of ERK DEL-22379 Chemical Structure
  23. GC32254 Deltonin Deltonin, a steroidal saponin, isolated from Dioscorea zingiberensis Wright, with antitumor activity; Deltonin inhibits ERK1/2 and AKT activation. Deltonin Chemical Structure
  24. GC61466 DMU-212 DMU-212 is a methylated derivative of Resveratrol, with antimitotic, anti-proliferative, antioxidant and apoptosis promoting activities. DMU-212 induces mitotic arrest via induction of apoptosis and activation of ERK1/2 protein. DMU-212 has orally active. DMU-212 Chemical Structure
  25. GC64496 EF24 EF24 is a curcumin analogue with greater anti-tumor efficacy and oral bioavailability via deactivation of the MAPK/ERK signaling pathway in oral squamous cell carcinoma (OSCC). EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK. EF24 Chemical Structure
  26. GC43610 Enniatin A1 Enniatins are cyclohexadepsipeptides commonly isolated from fungi that are known to have antibiotic properties and to induce apoptosis in several cancer lines. Enniatin A1 Chemical Structure
  27. GC17693 Enniatin B ionophore with some capacity to facilitate import of K+ and Na+ across membranes Enniatin B Chemical Structure
  28. GC43611 Enniatin B1 Enniatins are cyclohexadepsipeptides commonly isolated from fungi and are known to have antibiotic properties. Enniatin B1 Chemical Structure
  29. GC33206 ERK-IN-1 ERK-IN-1 (compound B) is an orally available ERK1 and ERK2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. The activity is particularly related to the treatment of KRAS-mutant NSCLC, BRAF-mutant NSCLC, KRAS-mutant pancreatic cancer, KRAS-mutant colorectal cancer (CRC) and KRAS-mutant ovarian cancer. ERK-IN-1 hydrochloride can also inhibit RAF. ERK-IN-1 Chemical Structure
  30. GC62229 ERK-IN-3 ERK-IN-3 is a potent and orally active inhibitor of ERK. ERK-IN-3 inhibits ERK1/2 with low single-digit nM IC50 values. ERK-IN-3 can be used for the research of cancers driven by RAS mutations. ERK-IN-3 Chemical Structure
  31. GC63459 ERK-IN-3 benzenesulfonate ERK-IN-3 benzenesulfonate is a potent and orally active inhibitor of ERK. ERK-IN-3 benzenesulfonate inhibits ERK1/2 with low single-digit nM IC50 values. ERK-IN-3 benzenesulfonate can be used for the research of cancers driven by RAS mutations. ERK-IN-3 benzenesulfonate Chemical Structure
  32. GC65510 ERK1/2 inhibitor 1 ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively. ERK1/2 inhibitor 1 Chemical Structure
  33. GC67905 ERK1/2 inhibitor 7 ERK1/2 inhibitor 7 Chemical Structure
  34. GC32796 ERK5-IN-1 An ERK5 inhibitor ERK5-IN-1 Chemical Structure
  35. GC36002 ERK5-IN-2 ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively. ERK5-IN-2 Chemical Structure
  36. GC10647 FR 180204

    ERK inhibitor

     FR 180204 Chemical Structure
  37. GC12006 GDC-0994 GDC-0994 (GDC-0994) is an orally active ERK kinase inhibitor with an IC50 of 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively. GDC-0994 Chemical Structure
  38. GC64035 Hirsutenone Hirsutenone is an active botanical diarylheptanoid present in Alnus species and exhibits many biological activities, including anti-inflammatory, anti-tumor promoting and anti-atopic dermatitis effects. Hirsutenone Chemical Structure
  39. GN10664 Honokiol Honokiol Chemical Structure
  40. GC43885 Hypothemycin A resorcylic acid lactone polyketide Hypothemycin Chemical Structure
  41. GC38804 JWG-071 JWG-071 is the first reported kinase-selective chemical probe for ERK5. JWG-071 improves ERK5 activity and BRD4 selectivity. JWG-071 will be a much-needed chemical probe for deconvoluting ERK5 and BRD4 pharmacology. JWG-071 Chemical Structure
  42. GC33051 KO-947 An ERK inhibitor KO-947 Chemical Structure
  43. GC44085 L-Sulforaphene L-Sulforaphene, isolated from radish seeds, exhibits an ED50 against velvetleaf seedlings approximately 2 x 10-4 M. L-Sulforaphene promotes cancer cells apoptosis and inhibits migration via inhibiting EGFR, p-ERK1/2, NF‐κB and other signals. L-Sulforaphene Chemical Structure
  44. GC17608 Lidocaine Anasthetic and class Ib antiarrhythmic agent Lidocaine Chemical Structure
  45. GC33831 Lidocaine hydrochloride (Lignocaine hydrochloride) Lidocaine hydrochloride (Lignocaine hydrochloride) (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence. Lidocaine hydrochloride (Lignocaine hydrochloride) Chemical Structure
  46. GC30770 LM22B-10 An activator of TrkB and TrkC LM22B-10 Chemical Structure
  47. GC34650 Longdaysin

    Longdaysin is a inhibitor of the Wnt/β-catenin signaling pathway, which exerts antitumor effect through blocking CK1δ/ε-dependent Wnt signaling. Longdaysin inhibits CK1α, CK1δ, CDK7, and ERK2 with IC50s of? 5.6 ?M, 8.8 ?M, 29 ?M, and 52 ?M, respectively.

     Longdaysin Chemical Structure
  48. GN10267 Loureirin B Loureirin B Chemical Structure
  49. GC19235 LY3214996 LY3214996 (LY3214996) is a highly selective inhibitor of ERK1 and ERK2, with IC50 of 5 nM for both enzymes in biochemical assays. LY3214996 potently inhibits cellular p-RSK1 in BRAF and RAS mutant cancer cell lines. LY3214996 shows potent antitumor activities in cancer models with MAPK pathway alterations. LY3214996 Chemical Structure
  50. GC31735 Magnolin A lignan with anti-inflammatory and anticancer activities Magnolin Chemical Structure
  51. GC36596 Methylnissolin Methylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC50 of 10 μM. Methylnissolin Chemical Structure
  52. GC16007 Methylthiouracil antithyroid preparation Methylthiouracil Chemical Structure
  53. GC18156 MK8353

    Selective and orally available ERK1/2 inhibitor

     MK8353 Chemical Structure
  54. GC32789 Mogrol Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling. Mogrol Chemical Structure
  55. GC33857 Omtriptolide Omtriptolide (PG490-88) is a derivative prodrug of triptolide purified from the Chinese herb. Omtriptolide Chemical Structure
  56. GN10752 Pachymic acid Pachymic acid Chemical Structure
  57. GC10282 Piperlongumine An alkaloid with anticancer and antioxidant activities Piperlongumine Chemical Structure
  58. GC17407 Pluripotin dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP Pluripotin Chemical Structure
  59. GC37071 Ravoxertinib hydrochloride Ravoxertinib hydrochloride (GDC-0994 hydrochloride) is an orally bioavailable inhibitor selective for ERK kinase activity with IC50 of 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively. Ravoxertinib hydrochloride Chemical Structure
  60. GC62448 Rineterkib hydrochloride Rineterkib hydrochloride (compound B) is an orally available ERK1 and ERK2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. The activity is particularly related to the treatment of KRAS-mutant NSCLC, BRAF-mutant NSCLC, KRAS-mutant pancreatic cancer, KRAS-mutant colorectal cancer (CRC) and KRAS-mutant ovarian cancer. Rineterkib hydrochloride can also inhibit RAF. Rineterkib hydrochloride Chemical Structure
  61. GC69821 RLX-33

    RLX-33 is an effective and selective relaxin family peptide 3 (RXFP3) antagonist with blood-brain barrier permeability. It also blocks the phosphorylation of ERK1/2 induced by relaxin 3, with IC50 values for RXFP3, ERK1, and ERK2 phosphorylation being 2.36 μM, 7.82 μM, and 13.86 μM respectively. RLX-33 can block the increase in food intake induced by the RXFP3 selective agonist R3/I5 in rats. RLX-33 can be used for research on metabolic syndrome.

     RLX-33 Chemical Structure
  62. GC16001 SCH772984

    A selective inhibitor of ERK1/2

     SCH772984 Chemical Structure
  63. GC17425 Sodium Tauroursodeoxycholate (TUDC) Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK. Sodium Tauroursodeoxycholate (TUDC) Chemical Structure
  64. GC34181 Tauroursodeoxycholate (TUDCA) Tauroursodeoxycholate (TUDCA) (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate (TUDCA) significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate (TUDCA) also inhibits ERK. Tauroursodeoxycholate (TUDCA) Chemical Structure
  65. GC34831 Tauroursodeoxycholate dihydrate Tauroursodeoxycholate (Tauroursodeoxycholic acid; TDUCA) dihydrate is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK. Tauroursodeoxycholate dihydrate Chemical Structure
  66. GC34057 TBHQ (tert-Butylhydroquinone) TBHQ (tert-Butylhydroquinone) (tert-Butylhydroquinone) is a widely used Nrf2 activator, protects against Doxorubicin (DOX)-induced cardiotoxicity through activation of Nrf2. TBHQ (tert-Butylhydroquinone) (tert-Butylhydroquinone) is also an ERK activator; rescues Dehydrocorydaline (DHC)-induced cell proliferation inhibitionin melanoma. TBHQ (tert-Butylhydroquinone) Chemical Structure
  67. GC39074 Tenuifoliside A Tenuifoliside A is isolated from Polygala tenuifolia, has anti-apoptotic and antidepressant-like effects. Tenuifoliside A Chemical Structure
  68. GC41573 Theaflavin 3,3'-digallate

    Theaflavin-3,3'-digallate (TFDG) is a major polyphenol found in black tea with diverse biological activities.

     Theaflavin 3,3'-digallate Chemical Structure
  69. GC30162 trans-Zeatin A cytokinin plant growth regulator trans-Zeatin Chemical Structure
  70. GC11422 Ulixertinib (hydrochloride) reversible ERK1/2 inhibitor Ulixertinib (hydrochloride) Chemical Structure
  71. GC38679 Urolithin B A metabolite of ellagic acid Urolithin B Chemical Structure
  72. GC17031 VRT752271 VRT752271 (BVD-523; VRT752271) is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC50 of <0.3 nM against ERK2. VRT752271 (BVD-523; VRT752271) inhibits the phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) in an A375 melanoma cell line. VRT752271 Chemical Structure
  73. GC13115 VX-11e A selective ERK inhibitor VX-11e Chemical Structure
  74. GC12691 XMD17-109 A selective ERK5 inhibitor XMD17-109 Chemical Structure
  75. GC11076 XMD8-92 A selective ERK5 inhibitor XMD8-92 Chemical Structure

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