JNK

JNK (c-Jun N-terminal kinase) is a group of kinases belong to the mitogen-activated protein kinase family and also play a role in T cell differentiation and the cellular apoptosis pathway.

Products for JNK

Cat.No. Product Name Information
GC60393 (-)-Zuonin A (-)-Zuonin A (D-Epigalbacin), a naturally occurring lignin, is a potent, selective JNKs inhibitor, with IC50s of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively.
GC63903 (E)-Osmundacetone (E)-Osmundacetone is the isomer of Osmundacetone.
GA20623 Ac-muramyl-Ala-D-Glu-NH₂ Ac-muramyl-Ala-D-Glu-NH₂ (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln.
GC35242 Actein Actein is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in human bladder cancer. Actein has little toxicity in vivo.
GC10204 AEG 3482 inhibitor of Jun kinase (JNK)-dependent apoptosis
GC11559 Anisomycin
JNK agonist, potent and specific
GC12882 AS 602801 A selective, orally bioavailable JNK inhibitor
GC10010 AS601245 A c-Jun NH2-terminal protein kinase inhibitor
GN10494 Astragaloside IV
GC12904 BI 78D3 Competitive JNK inhibitor
GC10693 c-JUN peptide JNK/c-Jun interaction inhibitor
GC50400 CC 401 dihydrochloride High affinity JNK inhibitor; also inhibits HCMV replication
GC13529 CC-401 JNK inhibitor,ATP-competitive
GC14197 CC-401 hydrochloride A potent, specific pan-JNK inhibitor
GC62492 CC-90001 CC-90001 is a potent, selective and orally active inhibitor of c-Jun N-terminal kinase (JNK).
GC10446 CC-930 A potent JNK inhibitor
GC12841 CEP 1347 JNK inhibitor
GC30057 D-JNKI-1 (AM-111) D-JNKI-1 (AM-111) (AM-111) is a highly potent and cell-permeable peptide inhibitor of JNK.
GC14114 DB07268 A potent inhibitor of JNK1
GC13244 DTP3 inhibitor of GADD45β/MKK7 complex
GC38202 DTP3 TFA DTP3 TFA is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor. DTP3 TFA targets an essential, cancer-selective cell-survival module downstream of the NF-κB pathway.
GC36006 Esculentoside H Thalidomide-O-PEG4-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
GN10307 Ginsenoside Re
GC17658 Guggulsterone Broad spectrum steroid receptor ligand
GC25521 IMM-H007 IMM-H007, an adenosine derivative, is an activator of AMP-Activated Protein Kinase (AMPK). IMM-H007 is a potential drug for treating cardiac dysfunction. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 (ATP binding cassette subfamily a member 1) degradation and facilitates its cell-surface localization in macrophages, thereby promotes cholesterol efflux.
GC12674 IQ 3 Selective JNK3 inhibitor
GC36327 IQ-1S free acid An inhibitor of NF-κB/AP-1
GN10804 Isovitexin
GC33844 Isovitexin (Saponaretin) A C-glycosylated flavone with diverse biological activities
GC36359 J30-8 J30-8 is a potent and isoform-selective inhibitor of c-Jun N-terminal kinase 3 (JNK3) with an IC50 of 40 nM, which 2500-fold isoform selectivity against JNK1α1 and JNK2α2.
GC13724 JIP-1 (153-163) Peptide inhibitor of c-Jun N-terminal kinase (JNK)
GC15028 JNK-IN-7 A non-selective JNK inhibitor
GC13841 JNK-IN-8 JNK-IN-8 is the first irreversible inhibitor of JNK, targeting JNK1, JNK2, and JNK3 with IC₅₀values of 4.7 nM, 18.7 nM, and 1 nM, respectively, in the A375 cell line.

GC32983 Juglanin Juglanin, a natural occurring flavonoid, is a JNK acticator, with inflammation and anti-tumor activities.

GC46015 KY 05009 A TNIK inhibitor

GC34275 L-JNKI-1 L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK.

GC11157 LL-Z 1640-4 A signal-specific JNK/p38 pathway and TAK 1 inhibitor

GN10267 Loureirin B

GC49241 Methyl Diethyldithiocarbamate An active metabolite of disulfiram

GC36652 MPT0B392 MPT0B392, an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation, leading to apoptosis. MPT0B392 inhibits tubulin polymerization and triggers induction of the mitotic arrest, followed by mitochondrial membrane potential loss and caspases cleavage by activation of JNK and ultimately leads to apoptosis. MPT0B392 is demonstrated to be a novel microtubule-depolymerizing agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line.

GC44587 PDMP (hydrochloride) PDMP is a ceramide analog first prepared in a search for inhibitors of glucosylceramide synthase.

GC14938 PF-03394197(Oclacitinib) Novel Janus kinase inhibitor

GN10709 Polyphyllin A

GC16652 SR 3576
JNK3 inhibitor, potent and selective

GC30864 SR-3306 SR-3306 is a selective, potent, highly brain penetrant JNK inhibitor.

GC11542 SU 3327 JNK inhibitor

GC25982 Tanzisertib(CC-930) Tanzisertib (CC-930, JNK-930, JNKI-1) is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively.

GC11488 TCS JNK 5a JNK2 and JNK3 inhibitor

GC17282 TCS JNK 6o TCS JNK 6o (TCS JNK 6o) is a c-Jun N-terminal kinases (JNK-1, -2, and -3) inhibitor with Ki values of 2 nM, 4 nM, 52 nM, respectively, and has IC50 values of 45 nM and 160 nM for JNK-1 and -2, respectively.

GC31647 Tomatidine Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling.

GC45064 Tomatidine (hydrochloride) Tomatidine is a steroidal alkaloid that has been found in the skins and leaves of tomatoes.

GC38679 Urolithin B A metabolite of ellagic acid

GC38053 WHI-P258 A negative control for JAK3 inhibition

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