PKA
PKA (protein kinase A), also known as cAMP-dependent protein kinase, has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism.
Products for PKA
- Cat.No. Product Name Information
- GC16929 8-Bromo-cAMP, sodium salt Cell-permeable cAMP analog that activates PKA
- GC64460 8-Chloro-cAMP 8-Chloro-cAMP is a cAMP analogue that induces growth arrest, and modulates cAMP-dependent PKA activity. 8-Chloro-cAMP has anticancer activity.
- GC15352 8-CPT-Cyclic AMP (sodium salt) 8-CPT-Cyclic AMP (8-CPT-cAMP) sodium is a selective activator of cyclic AMP-dependent protein kinase (PKA).
- GC60037 A-3 hydrochloride A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases.
- GC17712 AT13148 Multi-AGC kinase inhibitor,ATP-competitive
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GC12297
AT7867
Akt1/2/3 and p70S6K/PKA inhibitor
- GC10918 AT7867 dihydrochloride A potent and orally bioavailable pan-Akt inhibitor
- GC35518 Bilobetin A biflavonoid with diverse biological activities
- GC35565 Bucladesine calcium salt Bucladesine calcium salt salt (Dibutyryl-cAMP calcium salt;DC2797 calcium salt) is a cell-permeable cyclic AMP (cAMP) analog and selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP.
- GC11605 C-1 C-1 is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. C-1 also used as a ROCK inhibitor.
- GC10941 cAMPS-Rp, triethylammonium salt cAMPS-Rp, triethylammonium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist.
- GC19090 CCG215022 CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 uM, 0.38±0.06 uM and 3.9±1 uM for GRK2, GRK5 and GRK1, respectively.
- GC15525 cGMP Dependent Kinase Inhibitor Peptide cGMP Dependent Kinase Inhibitor Peptide is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a Ki of 86 μM.
- GC31525 CREBtide A PKA substrate
- GC50181 CW 008 PKA signaling activator; promotes osteogenesis from hMSCs
- GN10336 Daphnetin
- GC12824 Dibutyryl-cAMP, sodium salt Dibutyryl-cAMP, sodium salt salt (Dibutyryl-cAMP sodium salt) is a stabilized cyclic AMP (cAMP) analog and a selective PKA activator.
- GC13869 Fasudil Calcium antagonist
- GC14289 Fasudil (HA-1077) HCl Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil (HA-1077) HCl is also a potent Ca2+ channel antagonist and vasodilator.
- GC17255 Gliotoxin An immunosuppressive mycotoxin with diverse biological effects
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GC19396
H 89
A potent inhibitor of cyclic AMP-dependent protein kinase
- GC10074 H 89 2HCl H 89 2HCl is a potent and selective inhibitor of protein kinase A (PKA) with an IC50 of 48 nM and has weak inhibition on PKG, PKC, Casein Kinase.
- GC12799 H-8 (hydrochloride) H-8 (dihydrochloride) is a cell-permeable, reversible and ATP-competitive PKA inhibitor.
- GC65303 Jaspamycin Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5 nM and Kd of 8 nM in Trypanosoma brucei.
- GC11362 K 252a A protein kinase inhibitor
- GC13640 Kemptide substrate for cAMP-dependent protein kinase (PKA)
- GC36391 Kemptide Phospho-Ser5 Kemptide (Phospho-Ser5) is a phosphate acceptor peptide that serves as a specific substrate for cAMP-dependent protein kinase (PKA).
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GC14648
KT 5720
protein kinase A inhibitor, potent and selective
- GC17346 KT 5823 A protein kinase G inhibitor
- GC30545 Malantide Malantide is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide is a highly specific substrate for PKA with a Km of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts. Malantide is also an efficient substrate for PKC with a Km of 16 μM.
- GC33771 Metadoxine Metadoxine blocks adipocyte differentiation in association with inhibition of the protein kinase A-cAMP response element binding protein (PKA-CREB) pathway.
- GC49440 ML-9 A PKB/Akt inhibitor
- GC44653 PKA Inhibitor (5-24) PKA Inhibitor (5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM.
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GP10075
PKA inhibitor fragment (6-22) amide
A synthetic peptide inhibitor of PKA
- GC61512 PKA Inhibitor Fragment (6-22) amide TFA PKA Inhibitor Fragment (6-22) amide TFA is an inhibitor of cAMP-dependent protein kinase A (PKA), with a Ki of 2.8 nM.
- GC49265 PKI (14-22) amide (myristoylated) (trifluoroacetate salt) A PKA inhibitor
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GC69715
PKI (14-24)amide TFA
PKI (14-24)amide TFA is an effective inhibitor of PKA. In cell cytosol, PKI (14-24)amide strongly inhibits the activity of cyclic AMP-dependent protein kinase.
- GC12321 PKI 14-22 amide, myristoylated PKA inhibitor
- GC61849 PKI 14-22 amide,myristoylated TFA PKI 14-22 amide,myristoylated TFA is a potent cAMP-dependent PKA inhibitor. PKI 14-22 amide,myristoylated TFA reduces the IgG-mediated phagocytic response and also inhibits neutrophil adhesion.
- GC50502 RI-STAD 2 AKAP disruptor; selectively binds PKA-RI with high affinity and blocks its interaction with AKAP; cell permeable
- GC44853 Rp-8-CPT-Cyclic AMP (sodium salt) Rp-8-CPT-Cyclic AMP (sodium salt), a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependent PKA I and II.
- GC63176 Rp-cAMPS sodium salt Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 ?M and 4.5 ?M, respectively) antagonist.
- GC10428 Sp-5,6-dichloro-cBIMPS (sodium salt) PKA activator
- GC61747 Sp-cAMPS Sp-cAMPS, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II.
- GC50406 st-Ht31 Inhibits PKA/AKAP interactions; cell permeable
- GC50407 st-Ht31 P Negative control for st-Ht31
- GC50501 STAD 2 AKAP disruptor; selectively binds PKA-RII and blocks its interaction with AKAP; cell permeable
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GC15299
Staurosporine(CGP 41251)
A potent inhibitor of protein kinase C
- GC16678 UCN-02 protein kinase C inhibitor
- GC30857 Warangalone (Scandenolone) Warangalone (Scandenolone) is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC50s of 4.8 μg/mL and 3.7 μg/mL, respectively.