Metabolism
- Sterol Biosynthesis(26)
- PPAR(216)
- 5-alpha Reductase(9)
- 5-Lipoxygenase(11)
- Adenosine Deaminase(8)
- Aminopeptidase(10)
- C14ɑ demethylase(2)
- Carbonic Anhydrase(63)
- CETP(13)
- Cholesterol absorption(1)
- CPT1(3)
- CYP3A/CYP450(26)
- Dehydrogenase(139)
- DHFR(11)
- DGAT(13)
- Dopamine β-hydroxylase(14)
- Enolase(11)
- FAAH(40)
- Factor Xa(49)
- Ferroptosis(200)
- Folate Analogue(3)
- Glucokinase(17)
- HLE(1)
- HMG-CoA Reductase(39)
- HSP(77)
- IDO(52)
- KRAS-PDEδ(4)
- MAO(9)
- Metabolic Enzymes(0)
- Neuronal Metabolism(8)
- Oxidative Phosphorylation(17)
- P450(146)
- PDE(254)
- Phospholipase(117)
- Procollagen C Proteinase(2)
- Saccharometabolism(1)
- SCD(19)
- SGLT(31)
- TPH(6)
- Transferase(183)
- Energy Metabolism(0)
- Inorganic Ions(0)
- ALP(1)
- Carbohydrates(18)
- Uric Acid(0)
- Muscle Metabolism(0)
- MDA(0)
- MPO(0)
- Transaminase(20)
- Glutathione Reductase(0)
- Thioredoxin Reductase(0)
- Catalase(8)
- monooxygenase(1)
- PKM2(1)
- aldehyde dehydrogenase(1)
- Squalene synthase(1)
- Hydrolase(47)
- ornithine decarboxylase(1)
- Amino acid metabolism(3)
- phosphatases(98)
- Pyruvate kinase(9)
- Others(4)
- MGL(1)
- Galactosidase(6)
- 12-Lipoxygenase(1)
- Fatty Acid Synthase (FASN)(9)
- Dihydroorotate Dehydrogenase(12)
- Bile Acids & Microbiome(94)
- Bone Growth & Remodeling(35)
- Carbohydrate Metabolism(126)
- Cofactors & Vitamins(64)
- Dyslipidemias(73)
- Inborn Errors of Metabolism(80)
- Metabolic Syndrome(16)
- Necroptosis(10)
- Necrosis(15)
- Nutrient Sensing(12)
- Phosphodiesterase(27)
- Reproductive Biology(126)
- Thermogenesis(6)
- Prolyl Hydroxylation Enzymes(1)
- Biliary System(4)
- Metabolic Disease(4)
- Fat Mass and Obesity-associated Protein (FTO)(2)
- SHIP(1)
Products for Metabolism
- Cat.No. Product Name Information
- GC14781 ABT (1-Aminobenzotriazole) ABT (1-Aminobenzotriazole) is a nonspecific and irreversible inhibitor of cytochrome P450 (P450).
- GC46777 AC-262536 A selective androgen receptor modulator
- GC42690 Acecainide (hydrochloride) Acecainide is an active metabolite of the class III antiarrhythmic procainamide.
- GC42691 Aceclofenac ethyl ester A potential impurity found in commercial preparations of aceclofenac
- GC42692 Aceclofenac methyl ester A potential impurity in commercial preparations of aceclofenac
- GC49614 Acenocoumarol-d4 Acenocoumarol-d4 is deuterium labeled Acenocoumarol.
- GC46780 Acesulfame-d4 (potassium salt) An internal standard for the quantification of acesulfame
- GC42693 Acetaminophen Glucuronide (sodium salt) Acetaminophen glucuronide is an inactive metabolite of the analgesic and antipyretic agent acetaminophen.
- GC42694 Acetaminophen sulfate (potassium salt) Acetaminophen sulfate is a metabolite of acetaminophen.
-
GC11567
Acetazolamide
carbonic anhydrase (CA) inhibitor
- GC33491 Acetazolamide D3 Acetazolamide D3 is deuterium labeled Acetazolamide, which is a potent carbonic anhydrase (CA) inhibitor.
- GC65612 Acetazolamide sodium Acetazolamide sodium is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Acetazolamide sodium has diuretic, antihypertensive and anti-gonococcal activities.
- GC41269 Acetildenafil Acetildenafil is an analog of the phosphodiesterase inhibitor sildenafil, named for a substitution of an acetyl group for a sulfonyl group.
-
GC42695
Acetoacetyl Coenzyme A (sodium salt hydrate)
Acetoacetyl coenzyme A (acetoacetyl-CoA) is a precursor to HMG-CoA in the isoprenoid pathway.
- GC46782 Acetochlor An herbicide
-
GC11786
Acetylcysteine
Acetylcysteine is the N-acetyl derivative of CYSTEINE.
- GC35236 Acetylshikonin Acetylshikonin, derived from the root of Lithospermum erythrorhizon, has anti-cancer and antiinflammation activity.
- GC49406 ACT-373898 A metabolite of macitentan
-
GC16350
Actinonin
Peptidomimetic antibiotic that inhibits aminopeptidases
- GC31693 Adelmidrol Adelmidrol exerts important anti-inflammatory effects that are partly dependent on PPARγ.
- GC42734 Adenosine 5'-phosphosulfate (sodium salt) Adenosine 5'-phosphosulfate is an ATP and sulfate competitive inhibitor of ATP sulfurylase in humans, S.
-
GC35250
Adenosine deaminase
Involved in metabolism of purines
- GC11969 Adenosine-5'-diphosphate Agonist of purinergic receptors
- GC42735 Adipostatin A Adipostatin A (Adipostatin A) is a glycerol-3-phosphate dehydrogenase (GPDH) inhibitor with an IC50 of 4.1 μM.
- GC49216 ADL 08-0011 (hydrochloride) An active metabolite of alvimopan
- GC42736 ADP-Glucose (sodium salt) An intermediate in polysaccharide synthesis
- GC15601 AG-120 AG-120 (AG-120) is an orally active inhibitor of isocitrate dehydrogenase 1 mutant (mIDH1) enzyme, it exhibits profound d-2-hydroxyglutatrate (2-HG) lowering in vivo.
- GC25039 AG-120 (racemic) AG-120 (racemic), the racemic mixture of AG-120, is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity.
- GC13147 AG-221 (Enasidenib) AG-221 (Enasidenib) is an oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes, with IC50s of 100 and 400 nM against IDH2R140Q and IDH2R172K, respectively.
- GC62470 AG-636 AG-636 is a potent, reversible, selective and orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 17 nM. AG-636 has strong anticancer effects.
- GC10531 AGI-5198 A potent, selective inhibitor of IDH1 mutations
- GC14757 AGI-6780 A potent, selective inhibitor of mutant IDH2
- GN10413 Agrimol B
-
GC16597
Alda 1
ALDH2 activator
- GC42766 Aldicarb Sulfoxide Aldicarb sulfoxide is a metabolite and degradation product of the carbamate pesticide aldicarb.
- GC35281 Aleglitazar Aleglitazar (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively.
- GC16575 Alizarin A CYP450 inhibitor
- GC41541 Alizarin-3-methyliminodiacetic Acid Alizarin-3-methyliminodiacetic Acid is a calcium-tracer and a chelating agent.
- GC42769 all-trans Retinoyl β-D-Glucuronide all-trans Retinoyl β-D-glucuronide is a metabolite of all-trans retinoic acid formed by the UDP-glucuronosyltransferase (UGT) system.
- GC49393 all-trans-13,14-Dihydroretinol A metabolite of all-trans retinoic acid
- GC18539 all-trans-4-hydroxy Retinoic Acid all-trans-4-hydroxy Retinoic acid is a metabolite of all-trans retinoic acid formed by the cytochrome P450 (CYP) isoforms CYP26A1, B1, and C1.
- GC18482 all-trans-5,6-epoxy Retinoic Acid all-trans-5,6-epoxy Retinoic acid (5,6-epoxy RA) is an agonist of all isoforms of the retinoic acid receptor (RAR; EC50s = 77, 35, and 4 nM for RARα, RARβ, and RARγ, respectively).
- GC46831 Alloisolithocholic Acid Alloisolithocholic Acid (3β-Hydroxy-5α-cholanic acid), a derivative of Lithocholic acid, is a T cell regulator.
- GC61689 Alminoprofen Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylpropionic acid class.
- GC35298 Aloe-emodin-8-O-β-D-glucopyranoside Aloe-emodin-8-O-β-D-glucopyranoside, a compound isolated from Saussrurea lappa, is a moderate inhibitor of human protein tyrosine phosphatase 1B (hPTP1B) with an IC50 of 26.6 μM.
- GC15130 Alogliptin (SYR-322)
- GC46085 Alphitonin A flavonoid
- GC35308 Alpinetin Alpinetin is a flavonoid isolated from Alpinia katsumadai Hayata, activates activates PPAR-γ, with potent anti-inflammatory activity.
-
GC40024
Altenusin
Altenusin is a polyphenol fungal metabolite originally isolated from the fungus Alternaria that has diverse biological activities.
- GC49262 Alytesin (trifluoroacetate salt) A neuropeptide with diverse biological activities
- GC18214 AM2394 A glucokinase activator
- GC52361 AMARA Peptide (trifluoroacetate salt) A peptide substrate for AMPK
- GC48611 Ambroxol-d5 An internal standard for the quantification of ambroxol
- GC31213 AMG 579 AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM.
- GC19029 AMG-3969 AMG-3969 is a potent glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor with an IC50 of 4 nM.
- GC17669 AMG-47A destabilizer of the KRAS oncoprotein
- GC62836 AMG131 AMG131 (INT131), a potent and highly selective PPARγ partial agonist, binds to PPARγ and displaces Rosiglitazone with a Ki of ~10 nM.
- GC11675 Amidepsine A DGAT inhibitor
- GC17013 Amidepsine D DGAT inhibitor
- GC10859 Amino Tadalafil analog of tadalafil, a potent inhibitor of phosphodiesterase 5
- GC67997 Aminopeptidase-IN-1
- GC12764 Aminophylline A phosphodiesterase inhibitor and adenosine receptor antagonist
- GC61895 Ammonium iron(III) citrate Ammonium iron(III) citrate (Ammonium ferric citrate), a physiological form of nonetransferrin-bound iron, induces intracellular iron overload to cause ferroptosis. Ammonium iron(III) citrate can enhance protein production.
- GC10905 Amodiaquine dihydrochloride dihydrate histamine N-methyl transferase inhibitor
- GC40636 Amorfrutin A Amorfrutin A is an isoprenoid-substituted benzoic acid natural product found in the fruit of A.
- GC42791 Amorfrutin B Amorfrutin B is a partial agonist of the peroxisome proliferator-activated receptor γ (PPARγ; Ki = 19 nM and EC50 = 73 nM) that was first isolated from A.
-
GC31229
AMPD2 inhibitor 1
AMPD2 inhibitor 1 is an adenosine monophosphate deaminase 2 (AMPD2) inhibitor, used in the research of sugar craving, salt craving, umami craving, and addictions including drug, tobacco, nicotine and alcohol addictions.
- GC42792 Amrinone Amrinone is an inhibitor of phosphodiesterase 3 (PDE3; IC50 = 19.5 μM).
- GC46852 Amylose A polysaccharide
- GC11472 AN-2728 A selective PDE4 inhibitor
- GC31728 AN3199 AN3199 is a PDE4 inhibitor with an IC50 of 94.5 nM.
- GC17520 Anacetrapib (MK-0859) A CETP inhibitor
- GC11273 Anagrelide HCl A PDE3 inhibitor
- GC46854 Anastrozole-d12 An internal standard for the quantification of anastrozole
-
GC68657
Andolast free base
Andolast (CR 2039) (free base) is an anti-allergic agent. Andolast can inhibit cAMP-phosphodiesterase with an IC50 value of 50 μM. Andolast can be used for research on asthma.
- GC35349 Angeloylgomisin H Angeloylgomisin H, as a major lignin extract of Schisandra rubriflora, has the potential to improve insulin-stimulated glucose uptake by activating PPAR-γ.
- GC49419 Aniline-d5 An internal standard for the quantification of aniline
- GC35358 Ankaflavin Ankaflavin, isolated from Monascus-Fermented red rice, is an orally active PPARγ agonist.
- GC42815 Ansatrienin A Ansatrienin A is an ansamycin antibiotic and antifungal agent first isolated from S.
- GC46859 Antide (acetate) A GnRHR antagonist
- GC31141 Antihistamine-1 Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively.
- GC15544 AP-III-a4 enolase inhibitor
- GC35371 AP-III-a4 hydrochloride AP-III-a4 (ENOblock) hydrochloride is a nonsubstrate analogue enolase inhibitor with an IC50 of 0.576 uM.
- GC65035 Apatorsen Apatorsen?is?an?antisense?oligonucleotide?designed?to?bind?to?Hsp27?mRNA,?resulting?in?the?inhibition of?the?production?of?Hsp27?protein.
- GN10150 Apigenin Apigenin (API) is a competitive CYP2C9 inhibitor with a Ki of 2 µM..
- GC13130 Apixaban An inhibitor of Factor Xa
- GC46863 Apixaban-13C-d3 An internal standard for the quantification of apixaban
- GC14411 Apoptozole inhibitor of heat shock protein 70 (Hsp70)
- GC65004 Apostatin-1 Apostatin-1 (Apt-1) is a potent TRADD inhibitor.
- GC10420 Apremilast (CC-10004) An orally available PDE4 inhibitor
- GC46867 Apremilast-d5 An internal standard for the quantification of apremilast
- GC25097 AQX-016A AQX-016A is a potent agonist of SHIP1. AQX-016A inhibits DNFB induced inflammation in a mouse ear edema/cutaneous anaphylaxis model.
- GC62846 AR453588 AR453588 is a potent and orally bioavailable anti-diabetic glucokinase activator, with an EC50 of 42 nM.
- GC45385 Ara-G
- GC16770 Arachidonic Acid Leelamide phospholipase A2 inhibitor
- GC42843 Arachidonoyl thio-PC Arachidonoyl Thio-PC is a substrate for many phospholipase A2s (PLA2s) including sPLA2, cPLA2, and iPLA2.
- GC65163 Ardisiacrispin B Ardisiacrispin B displays cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death.
- GC46879 Argatroban-d3 (hydrochloride) An internal standard for the quantification of argatroban
- GC42852 Arginine Vasotocin (trifluoroacetate salt) Arginine vasotocin is a nonapeptide hormone agonist of the AVT receptor (EC50 = 13 nM for eliciting membrane currents in X.
- GC31462 Arhalofenate (MBX 102) Arhalofenate (MBX 102) (MBX 102) is a selective partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ, used for the treatment of type 2 diabetes.