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Metabolism

Products for  Metabolism

  1. Cat.No. Product Name Information
  2. GC14781 ABT (1-Aminobenzotriazole) ABT (1-Aminobenzotriazole) is a nonspecific and irreversible inhibitor of cytochrome P450 (P450). ABT (1-Aminobenzotriazole)  Chemical Structure
  3. GC46777 AC-262536 A selective androgen receptor modulator AC-262536  Chemical Structure
  4. GC42690 Acecainide (hydrochloride) Acecainide is an active metabolite of the class III antiarrhythmic procainamide. Acecainide (hydrochloride)  Chemical Structure
  5. GC42691 Aceclofenac ethyl ester A potential impurity found in commercial preparations of aceclofenac Aceclofenac ethyl ester  Chemical Structure
  6. GC42692 Aceclofenac methyl ester A potential impurity in commercial preparations of aceclofenac Aceclofenac methyl ester  Chemical Structure
  7. GC49614 Acenocoumarol-d4 Acenocoumarol-d4 is deuterium labeled Acenocoumarol. Acenocoumarol-d4  Chemical Structure
  8. GC46780 Acesulfame-d4 (potassium salt) An internal standard for the quantification of acesulfame Acesulfame-d4 (potassium salt)  Chemical Structure
  9. GC42693 Acetaminophen Glucuronide (sodium salt) Acetaminophen glucuronide is an inactive metabolite of the analgesic and antipyretic agent acetaminophen. Acetaminophen Glucuronide (sodium salt)  Chemical Structure
  10. GC42694 Acetaminophen sulfate (potassium salt) Acetaminophen sulfate is a metabolite of acetaminophen. Acetaminophen sulfate (potassium salt)  Chemical Structure
  11. GC11567 Acetazolamide

    carbonic anhydrase (CA) inhibitor

    Acetazolamide  Chemical Structure
  12. GC33491 Acetazolamide D3 Acetazolamide D3 is deuterium labeled Acetazolamide, which is a potent carbonic anhydrase (CA) inhibitor. Acetazolamide D3  Chemical Structure
  13. GC65612 Acetazolamide sodium Acetazolamide sodium is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Acetazolamide sodium has diuretic, antihypertensive and anti-gonococcal activities. Acetazolamide sodium  Chemical Structure
  14. GC41269 Acetildenafil Acetildenafil is an analog of the phosphodiesterase inhibitor sildenafil, named for a substitution of an acetyl group for a sulfonyl group. Acetildenafil  Chemical Structure
  15. GC42695 Acetoacetyl Coenzyme A (sodium salt hydrate)

    Acetoacetyl coenzyme A (acetoacetyl-CoA) is a precursor to HMG-CoA in the isoprenoid pathway.

    Acetoacetyl Coenzyme A (sodium salt hydrate)  Chemical Structure
  16. GC46782 Acetochlor An herbicide Acetochlor  Chemical Structure
  17. GC11786 Acetylcysteine

    Acetylcysteine is the N-acetyl derivative of CYSTEINE.

    Acetylcysteine  Chemical Structure
  18. GC35236 Acetylshikonin Acetylshikonin, derived from the root of Lithospermum erythrorhizon, has anti-cancer and antiinflammation activity. Acetylshikonin  Chemical Structure
  19. GC49406 ACT-373898 A metabolite of macitentan ACT-373898  Chemical Structure
  20. GC16350 Actinonin

    Peptidomimetic antibiotic that inhibits aminopeptidases

    Actinonin  Chemical Structure
  21. GC31693 Adelmidrol Adelmidrol exerts important anti-inflammatory effects that are partly dependent on PPARγ. Adelmidrol  Chemical Structure
  22. GC42734 Adenosine 5'-phosphosulfate (sodium salt) Adenosine 5'-phosphosulfate is an ATP and sulfate competitive inhibitor of ATP sulfurylase in humans, S. Adenosine 5'-phosphosulfate (sodium salt)  Chemical Structure
  23. GC35250 Adenosine deaminase

    Involved in metabolism of purines

    Adenosine deaminase  Chemical Structure
  24. GC11969 Adenosine-5'-diphosphate Agonist of purinergic receptors Adenosine-5'-diphosphate  Chemical Structure
  25. GC42735 Adipostatin A Adipostatin A (Adipostatin A) is a glycerol-3-phosphate dehydrogenase (GPDH) inhibitor with an IC50 of 4.1 μM. Adipostatin A  Chemical Structure
  26. GC49216 ADL 08-0011 (hydrochloride) An active metabolite of alvimopan ADL 08-0011 (hydrochloride)  Chemical Structure
  27. GC42736 ADP-Glucose (sodium salt) An intermediate in polysaccharide synthesis ADP-Glucose (sodium salt)  Chemical Structure
  28. GC15601 AG-120 AG-120 (AG-120) is an orally active inhibitor of isocitrate dehydrogenase 1 mutant (mIDH1) enzyme, it exhibits profound d-2-hydroxyglutatrate (2-HG) lowering in vivo. AG-120  Chemical Structure
  29. GC25039 AG-120 (racemic) AG-120 (racemic), the racemic mixture of AG-120, is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity. AG-120 (racemic)  Chemical Structure
  30. GC13147 AG-221 (Enasidenib) AG-221 (Enasidenib) is an oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes, with IC50s of 100 and 400 nM against IDH2R140Q and IDH2R172K, respectively. AG-221 (Enasidenib)  Chemical Structure
  31. GC62470 AG-636 AG-636 is a potent, reversible, selective and orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 17 nM. AG-636 has strong anticancer effects. AG-636  Chemical Structure
  32. GC10531 AGI-5198 A potent, selective inhibitor of IDH1 mutations AGI-5198  Chemical Structure
  33. GC14757 AGI-6780 A potent, selective inhibitor of mutant IDH2 AGI-6780  Chemical Structure
  34. GN10413 Agrimol B Agrimol B  Chemical Structure
  35. GC16597 Alda 1

    ALDH2 activator

    Alda 1  Chemical Structure
  36. GC42766 Aldicarb Sulfoxide Aldicarb sulfoxide is a metabolite and degradation product of the carbamate pesticide aldicarb. Aldicarb Sulfoxide  Chemical Structure
  37. GC35281 Aleglitazar Aleglitazar (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively. Aleglitazar  Chemical Structure
  38. GC16575 Alizarin A CYP450 inhibitor Alizarin  Chemical Structure
  39. GC41541 Alizarin-3-methyliminodiacetic Acid Alizarin-3-methyliminodiacetic Acid is a calcium-tracer and a chelating agent. Alizarin-3-methyliminodiacetic Acid  Chemical Structure
  40. GC42769 all-trans Retinoyl β-D-Glucuronide all-trans Retinoyl β-D-glucuronide is a metabolite of all-trans retinoic acid formed by the UDP-glucuronosyltransferase (UGT) system. all-trans Retinoyl β-D-Glucuronide  Chemical Structure
  41. GC49393 all-trans-13,14-Dihydroretinol A metabolite of all-trans retinoic acid all-trans-13,14-Dihydroretinol  Chemical Structure
  42. GC18539 all-trans-4-hydroxy Retinoic Acid all-trans-4-hydroxy Retinoic acid is a metabolite of all-trans retinoic acid formed by the cytochrome P450 (CYP) isoforms CYP26A1, B1, and C1. all-trans-4-hydroxy Retinoic Acid  Chemical Structure
  43. GC18482 all-trans-5,6-epoxy Retinoic Acid all-trans-5,6-epoxy Retinoic acid (5,6-epoxy RA) is an agonist of all isoforms of the retinoic acid receptor (RAR; EC50s = 77, 35, and 4 nM for RARα, RARβ, and RARγ, respectively). all-trans-5,6-epoxy Retinoic Acid  Chemical Structure
  44. GC46831 Alloisolithocholic Acid Alloisolithocholic Acid (3β-Hydroxy-5α-cholanic acid), a derivative of Lithocholic acid, is a T cell regulator. Alloisolithocholic Acid  Chemical Structure
  45. GC61689 Alminoprofen Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylpropionic acid class. Alminoprofen  Chemical Structure
  46. GC35298 Aloe-emodin-8-O-β-D-glucopyranoside Aloe-emodin-8-O-β-D-glucopyranoside, a compound isolated from Saussrurea lappa, is a moderate inhibitor of human protein tyrosine phosphatase 1B (hPTP1B) with an IC50 of 26.6 μM. Aloe-emodin-8-O-β-D-glucopyranoside  Chemical Structure
  47. GC15130 Alogliptin (SYR-322) Alogliptin (SYR-322)  Chemical Structure
  48. GC46085 Alphitonin A flavonoid Alphitonin  Chemical Structure
  49. GC35308 Alpinetin Alpinetin is a flavonoid isolated from Alpinia katsumadai Hayata, activates activates PPAR-γ, with potent anti-inflammatory activity. Alpinetin  Chemical Structure
  50. GC40024 Altenusin

    Altenusin is a polyphenol fungal metabolite originally isolated from the fungus Alternaria that has diverse biological activities.

    Altenusin  Chemical Structure
  51. GC49262 Alytesin (trifluoroacetate salt) A neuropeptide with diverse biological activities Alytesin (trifluoroacetate salt)  Chemical Structure
  52. GC18214 AM2394 A glucokinase activator AM2394  Chemical Structure
  53. GC52361 AMARA Peptide (trifluoroacetate salt) A peptide substrate for AMPK AMARA Peptide (trifluoroacetate salt)  Chemical Structure
  54. GC48611 Ambroxol-d5 An internal standard for the quantification of ambroxol Ambroxol-d5  Chemical Structure
  55. GC31213 AMG 579 AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM. AMG 579  Chemical Structure
  56. GC19029 AMG-3969 AMG-3969 is a potent glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor with an IC50 of 4 nM. AMG-3969  Chemical Structure
  57. GC17669 AMG-47A destabilizer of the KRAS oncoprotein AMG-47A  Chemical Structure
  58. GC62836 AMG131 AMG131 (INT131), a potent and highly selective PPARγ partial agonist, binds to PPARγ and displaces Rosiglitazone with a Ki of ~10 nM. AMG131  Chemical Structure
  59. GC11675 Amidepsine A DGAT inhibitor Amidepsine A  Chemical Structure
  60. GC17013 Amidepsine D DGAT inhibitor Amidepsine D  Chemical Structure
  61. GC10859 Amino Tadalafil analog of tadalafil, a potent inhibitor of phosphodiesterase 5 Amino Tadalafil  Chemical Structure
  62. GC67997 Aminopeptidase-IN-1 Aminopeptidase-IN-1  Chemical Structure
  63. GC12764 Aminophylline A phosphodiesterase inhibitor and adenosine receptor antagonist Aminophylline  Chemical Structure
  64. GC61895 Ammonium iron(III) citrate Ammonium iron(III) citrate (Ammonium ferric citrate), a physiological form of nonetransferrin-bound iron, induces intracellular iron overload to cause ferroptosis. Ammonium iron(III) citrate can enhance protein production. Ammonium iron(III) citrate  Chemical Structure
  65. GC10905 Amodiaquine dihydrochloride dihydrate histamine N-methyl transferase inhibitor Amodiaquine dihydrochloride dihydrate  Chemical Structure
  66. GC40636 Amorfrutin A Amorfrutin A is an isoprenoid-substituted benzoic acid natural product found in the fruit of A. Amorfrutin A  Chemical Structure
  67. GC42791 Amorfrutin B Amorfrutin B is a partial agonist of the peroxisome proliferator-activated receptor γ (PPARγ; Ki = 19 nM and EC50 = 73 nM) that was first isolated from A. Amorfrutin B  Chemical Structure
  68. GC31229 AMPD2 inhibitor 1

    AMPD2 inhibitor 1 is an adenosine monophosphate deaminase 2 (AMPD2) inhibitor, used in the research of sugar craving, salt craving, umami craving, and addictions including drug, tobacco, nicotine and alcohol addictions.

    AMPD2 inhibitor 1  Chemical Structure
  69. GC42792 Amrinone Amrinone is an inhibitor of phosphodiesterase 3 (PDE3; IC50 = 19.5 μM). Amrinone  Chemical Structure
  70. GC46852 Amylose A polysaccharide Amylose  Chemical Structure
  71. GC11472 AN-2728 A selective PDE4 inhibitor AN-2728  Chemical Structure
  72. GC31728 AN3199 AN3199 is a PDE4 inhibitor with an IC50 of 94.5 nM. AN3199  Chemical Structure
  73. GC17520 Anacetrapib (MK-0859) A CETP inhibitor Anacetrapib (MK-0859)  Chemical Structure
  74. GC11273 Anagrelide HCl A PDE3 inhibitor Anagrelide HCl  Chemical Structure
  75. GC46854 Anastrozole-d12 An internal standard for the quantification of anastrozole Anastrozole-d12  Chemical Structure
  76. GC68657 Andolast free base

    Andolast (CR 2039) (free base) is an anti-allergic agent. Andolast can inhibit cAMP-phosphodiesterase with an IC50 value of 50 μM. Andolast can be used for research on asthma.

    Andolast free base  Chemical Structure
  77. GC35349 Angeloylgomisin H Angeloylgomisin H, as a major lignin extract of Schisandra rubriflora, has the potential to improve insulin-stimulated glucose uptake by activating PPAR-γ. Angeloylgomisin H  Chemical Structure
  78. GC49419 Aniline-d5 An internal standard for the quantification of aniline Aniline-d5  Chemical Structure
  79. GC35358 Ankaflavin Ankaflavin, isolated from Monascus-Fermented red rice, is an orally active PPARγ agonist. Ankaflavin  Chemical Structure
  80. GC42815 Ansatrienin A Ansatrienin A is an ansamycin antibiotic and antifungal agent first isolated from S. Ansatrienin A  Chemical Structure
  81. GC46859 Antide (acetate) A GnRHR antagonist Antide (acetate)  Chemical Structure
  82. GC31141 Antihistamine-1 Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively. Antihistamine-1  Chemical Structure
  83. GC15544 AP-III-a4 enolase inhibitor AP-III-a4  Chemical Structure
  84. GC35371 AP-III-a4 hydrochloride AP-III-a4 (ENOblock) hydrochloride is a nonsubstrate analogue enolase inhibitor with an IC50 of 0.576 uM. AP-III-a4 hydrochloride  Chemical Structure
  85. GC65035 Apatorsen Apatorsen?is?an?antisense?oligonucleotide?designed?to?bind?to?Hsp27?mRNA,?resulting?in?the?inhibition of?the?production?of?Hsp27?protein. Apatorsen  Chemical Structure
  86. GN10150 Apigenin

    Apigenin is a competitive CYP2C9 inhibitor with a Ki of 2 μM.

    Apigenin  Chemical Structure
  87. GC13130 Apixaban An inhibitor of Factor Xa Apixaban  Chemical Structure
  88. GC46863 Apixaban-13C-d3 An internal standard for the quantification of apixaban Apixaban-13C-d3  Chemical Structure
  89. GC14411 Apoptozole inhibitor of heat shock protein 70 (Hsp70) Apoptozole  Chemical Structure
  90. GC65004 Apostatin-1 Apostatin-1 (Apt-1) is a potent TRADD inhibitor. Apostatin-1  Chemical Structure
  91. GC10420 Apremilast (CC-10004) An orally available PDE4 inhibitor Apremilast (CC-10004)  Chemical Structure
  92. GC46867 Apremilast-d5 An internal standard for the quantification of apremilast Apremilast-d5  Chemical Structure
  93. GC25097 AQX-016A AQX-016A is a potent agonist of SHIP1. AQX-016A inhibits DNFB induced inflammation in a mouse ear edema/cutaneous anaphylaxis model. AQX-016A  Chemical Structure
  94. GC62846 AR453588 AR453588 is a potent and orally bioavailable anti-diabetic glucokinase activator, with an EC50 of 42 nM. AR453588  Chemical Structure
  95. GC45385 Ara-G   Ara-G  Chemical Structure
  96. GC16770 Arachidonic Acid Leelamide phospholipase A2 inhibitor Arachidonic Acid Leelamide  Chemical Structure
  97. GC42843 Arachidonoyl thio-PC Arachidonoyl Thio-PC is a substrate for many phospholipase A2s (PLA2s) including sPLA2, cPLA2, and iPLA2. Arachidonoyl thio-PC  Chemical Structure
  98. GC65163 Ardisiacrispin B Ardisiacrispin B displays cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death. Ardisiacrispin B  Chemical Structure
  99. GC46879 Argatroban-d3 (hydrochloride) An internal standard for the quantification of argatroban Argatroban-d3 (hydrochloride)  Chemical Structure
  100. GC42852 Arginine Vasotocin (trifluoroacetate salt) Arginine vasotocin is a nonapeptide hormone agonist of the AVT receptor (EC50 = 13 nM for eliciting membrane currents in X. Arginine Vasotocin (trifluoroacetate salt)  Chemical Structure
  101. GC31462 Arhalofenate (MBX 102) Arhalofenate (MBX 102) (MBX 102) is a selective partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ, used for the treatment of type 2 diabetes. Arhalofenate (MBX 102)  Chemical Structure

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