DHFR
Dihydrofolate reductase (DHFR) is an enzyme that catalyzes the reduction of dihydrofolate (H2F) to tetrahydrofolate (H4F) utilizing nicotinamide adenine dinucleotide phosphate (NADPH) as the hydride (H-) donor, in which the pro-R hydrogen of NADPH is transferred to C6 of the pteridine ring with concomitant protonation at the N5 position. The functional DHFR gene (approximately 30 kb with six exons and five introns) has been identified to encode DHFR enzyme. Human DHFR enzyme is a monomeric protein of 186 amino acids, which is characterized by containing a highly conserved dinucleotide-binding domain consisting of seven parallel and one antiparallel β-strands intercalated by α-helices.
Products for DHFR
- Cat.No. Product Name Information
- GC16333 Cycloguanil (hydrochloride) inhibitor of dihydrofolate reductase (DHFR)
-
GC10405
Methotrexate
Methotrexate, a folate antagonist, is a potent anti-inflammatory agent when used weekly in low concentrations, the anti-phlogistic action of which is due to increased adenosine release at inflamed sites.
- GC11610 Pemetrexed An antifolate with anticancer activity
- GC17694 Pemetrexed disodium hemipenta hydrate
- GC12919 Pralatrexate A dihydrofolate reductase inhibitor
- GC17867 Pyrimethamine A dihydrofolate reductase inhibitor