Home >> Signaling Pathways >> Metabolism >> Dihydroorotate Dehydrogenase

Dihydroorotate Dehydrogenase

Dihydroorotate dehydrogenase (DHODH) is the fourth enzyme in the de novo pyrimidine biosynthesis pathway, serving as the catalyst to oxidize the dihydroorotate to orotic acid in the biosynthesis of uridine monophosphate (UMP). DHODH is a known target for autoimmune diseases as well as an important target for malaria.

Based on localization and electron acceptor, DHODHs have classified into two families: Family 1 members are soluble proteins localized to the cytosol, while family 2 members are membrane proteins localized to the inner mitochondrial membrane. Family 1 is further subdivided into family 1A and family 1B, which use fumarate and NAD+ (respectively) as electron acceptors. Family 2 DHODH enzymes use respiratory quinones as electron acceptors.

Products for  Dihydroorotate Dehydrogenase

  1. Cat.No. Product Name Information
  2. GC62470 AG-636 AG-636 is a potent, reversible, selective and orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 17 nM. AG-636 has strong anticancer effects. AG-636  Chemical Structure
  3. GC62336 CHIKV-IN-2 CHIKV-IN-2 is a potent inhibitor against Chikungunya virus (CHIKV), with excellent cellular antiviral activity (EC90=270 nM) and improved liver microsomal stability. CHIKV-IN-2  Chemical Structure
  4. GC60763 DHODH-IN-11 DHODH-IN-11 (Compound 14b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03. DHODH-IN-11  Chemical Structure
  5. GC63547 DHODH-IN-16 DHODH-IN-16 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 0.396 nM for human DHODH. DHODH-IN-16  Chemical Structure
  6. GC63418 DHODH-IN-17 DHODH-IN-17, a 2-anilino nicotinic acid, is a human DHODH inhibitor (IC50=0.40 μM). DHODH-IN-17 can be used for theresearch of acute myeloid leukemia (AML). DHODH-IN-17  Chemical Structure
  7. GC39234 DHODH-IN-2 DHODH-IN-2  Chemical Structure
  8. GC39374 DHODH-IN-5 DHODH-IN-5  Chemical Structure
  9. GC63533 DSM502 DSM502 is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM502  Chemical Structure
  10. GC64074 DSM705 hydrochloride DSM705 hydrochloride, an orally active antimalarial compound, is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM705 hydrochloride  Chemical Structure
  11. GC39632 Laflunimus Laflunimus (HR325) is an immunosuppressive agent and an analogue of the Leflunomide-active metabolite A77 1726. Laflunimus  Chemical Structure
  12. GC65335 PTC299 PTC299 is an orally active inhibitor of VEGFA mRNA translation that selectively inhibits VEGF protein synthesis at the post-transcriptional level. PTC299 is also a potent inhibitor of dihydroorotate dehydrogenase (DHODH). PTC299 shows good oral bioavailability and lack of off-target kinase inhibition and myelosuppression. PTC299 can be useful for the research of hematologic malignancies. PTC299  Chemical Structure

11 Item(s)

per page

Set Descending Direction