Factor Xa
Factor Xa is a trypsin-like serine protease that catalyzes the cleavage of peptide bonds on the carboxyl side (P’1) of a basic amino acid residue with a preference to cleave peptide bonds of carboxyl function provided by an argininyl residue. Factor Xa plays an essential role in the coagulation cascade catalyzing the conversion of prothrombin to thrombin on surface of vascular cells to link the extrinsic and intrinsic pathways, in which it forms the Ca2+- and phospholipid-dependent prothrombinase complex with cofactor V/Va on activated platelets, monocytes or endothelial cells. Moreover, factor Xa has been found to mediate the stimulation of lymphocyte proliferation, induce the mitogenesis of endothelial and smooth muscle cells, and trigger acute inflammatory responses in vivo.
Products for Factor Xa
- Cat.No. Product Name Information
- GC49118 10-hydroxy Warfarin A metabolite of (R)-warfarin
- GC11101 5-R-Rivaroxaban
- GC49614 Acenocoumarol-d4 Acenocoumarol-d4 is deuterium labeled Acenocoumarol.
- GC13130 Apixaban An inhibitor of Factor Xa
- GC46863 Apixaban-13C-d3 An internal standard for the quantification of apixaban
- GC46879 Argatroban-d3 (hydrochloride) An internal standard for the quantification of argatroban
- GC65912 Asundexian Asundexian (BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an IC50 of 1 nM.
- GC17799 Betrixaban Factor Xa inhibitor
- GC61748 Betrixaban D6 Betrixaban D6 is a deuterium labeled Betrixaban.
- GC25137 Betrixaban maleate Betrixaban maleate is the maleate salt form of Betrixaban, which is a Factor Xa inhibitor that decreases prothrombinase activity and thrombin generation.
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GC68778
BMS-262084
BMS-262084 is an effective, selective, and irreversible inhibitor of factor XIa with an IC50 value of 2.8 nM for human factor XIa. BMS-262084 also inhibits human pancreatic trypsin (IC50=5 nM). BMS-262084 has anti-thrombotic properties.
- GC32614 BMS-654457 BMS-654457 is a small-molecule, reversible inhibitor of factor XIa (FXIa), binding with human and rabbit FXIa with Kis of 0.2 and 0.42 nM, respectively.
- GC35536 BMS-962212 BMS-962212 is a direct, reversible, selective factor XIa (FXIa) inhibitor .
- GC49684 Dabigatran-13C-d3 An internal standard for the quantification of dabigatran
- GC49682 Dabigatran-d3 An internal standard for the quantification of dabigatran
- GC62922 Darexaban Darexaban (YM150) is a potent, selective and orally active factor Xa (FXa) inhibitor with an IC50 of 54.6 nM.
- GC49131 Dehydro Warfarin A metabolite of (±)-warfarin
- GC11644 Edoxaban
- GC62298 Edoxaban impurity 4 Edoxaban impurity 4 is an impurity of Edoxaban.
- GC62439 Edoxaban impurity 6
- GC35962 Edoxaban tosylate Edoxaban (DU-176b) tosylate is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Kis of 0.561 and 2.98 nM for free human FXa and prothrombinase.
- GC12839 Edoxaban tosylate monohydrate A potent inhibitor of Factor Xa
- GC47280 Edoxaban-d6 An internal standard for the quantification of edoxaban
- GC68034 Enoxaparin
- GC65060 Fitusiran Fitusiran (ALN-AT3SC), an small interfering RNA, specifically targets antithrombin (AT) messenger RNA to lower production of AT in the liver.
- GC49518 Fluindione A vitamin K antagonist
- GC43696 Fondaparinux (sodium salt) Fondaparinux (sodium salt) is an antithrombin-dependent factor Xa inhibitor.
- GC36092 FXIa-IN-1 FXIa-IN-1 (compound EP-7041) is a potent β-lactam covalent heparin-derived factor XIa (fXIa) inhibitor.
- GC13711 Gabexate mesylate A serine protease inhibitor
- GC49322 GGACK (hydrochloride) A uPA and factor Xa inhibitor
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GC19766
Heparin sodium salt (MW 15kDa)
A polymer of Heparin with the molecular weight of 15kD
- GC63873 Milvexian Milvexian (BMS-986177), an effective antithrombotic agent, is an orally-bioavailable, reversible and direct inhibitor of human and rabbit factor XIa (FXIa) with Ki of 0.11, and 0.38 nM, respectively.
- GC17726 Otamixaban
- GC15757 Ozagrel A selective inhibitor of TXA synthase
- GC36831 Ozagrel sodium Ozagrel sodium (OKY-046 sodium) is a thromboxane A2 (TXA2) synthase inhibitor.
- GC13683 Rivaroxaban A selective inhibitor of Factor Xa
- GC60326 Rivaroxaban D4 An internal standard for the quantification of rivaroxaban
- GC32567 RWJ-445167 (3DP-10017) RWJ-445167 (3DP-10017) (3DP-10017) is a dual inhibitor of thrombin and factor Xa with Ki of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity.
- GC44966 Sucrose octasulfate (potassium salt) Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum-sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury.