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Home >> Signaling Pathways >> Metabolism >> HMG-CoA Reductase

HMG-CoA Reductase

HMG-CoA Reductase (HMGR) catalyzes the rate-limiting step of the sterol and isoprenoid biosynthesis. It is required for normal cellular functions and a target for hypocholesterolemic drug.

Products for  HMG-CoA Reductase

  1. Cat.No. Product Name Information
  2. GC60396 (3S,5R)-Fluvastatin sodium (3S,5R)-Fluvastatin sodium ((3S,5R)-XU 62-320) is the (3S,5R)-enantiomer?of Fluvastatin. (3S,5R)-Fluvastatin sodium Chemical Structure
  3. GC68317 (3S,5R)-Fluvastatin-d6 sodium (3S,5R)-Fluvastatin-d6 sodium Chemical Structure
  4. GC13751 (3S,5S)-Atorvastatin (sodium salt) negetive control of Atorvastatin, HMG-CoA reductase inhibitor (3S,5S)-Atorvastatin (sodium salt) Chemical Structure
  5. GC61548 (Rac)-5-Keto Fluvastatin (Rac)-5-Keto Fluvastatin (3-Hydroxy-5-Keto Fluvastatin) is an impurity of Fluvastatin (XU 62320). (Rac)-5-Keto Fluvastatin Chemical Structure
  6. GC35419 Atorvastatin Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids[1]. Atorvastatin Chemical Structure
  7. GC14038 Atorvastatin Calcium An HMG-CoA reductase inhibitor Atorvastatin Calcium Chemical Structure
  8. GC42868 Atorvastatin lactone Atorvastatin lactone is a prodrug form of atorvastatin, an HMG-CoA reductase inhibitor used to lower blood cholesterol levels. Atorvastatin lactone Chemical Structure
  9. GC43231 Cerivastatin (sodium salt) Cerivastatin (sodium salt) is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin (sodium salt) Chemical Structure
  10. GC15810 Clinofibrate HMGCR inhibitor Clinofibrate Chemical Structure
  11. GC13535 Fluvastatin An HMG-CoA reductase inhibitor Fluvastatin Chemical Structure
  12. GC36061 Fluvastatin D6 sodium Fluvastatin D6 sodium (XU 62-320 D6) is deuterium labeled Fluvastatin sodium. Fluvastatin D6 sodium Chemical Structure
  13. GC15541 Fluvastatin Sodium An HMG-CoA reductase inhibitor Fluvastatin Sodium Chemical Structure
  14. GC60189 Hesperetin 7-O-glucoside A flavanone glucoside with diverse biological activities Hesperetin 7-O-glucoside Chemical Structure
  15. GC11633 Lovastatin An inhibitor of HMG-CoA reductase Lovastatin Chemical Structure
  16. GC44082 Lovastatin Hydroxy Acid (sodium salt) Lovastatin Hydroxy Acid (sodium salt) (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM. Lovastatin Hydroxy Acid (sodium salt) Chemical Structure
  17. GC34035 Meglutol (Dicrotalic acid) Meglutol (Dicrotalic acid) is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids, and inhibits the activity of hydroxymethylglutarryl CoA reductases, which is the rate limiting enzyme in the biosynthesis of cholesterol. Meglutol (Dicrotalic acid) Chemical Structure
  18. GC11895 Mevastatin HMG-CoA reductase inhibitor Mevastatin Chemical Structure
  19. GC31586 Monacolin J (Antibiotic MB 530A) Monacolin J (Antibiotic MB 530A) is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase. Monacolin J (Antibiotic MB 530A) Chemical Structure
  20. GC11332 Pitavastatin

    HMG-CoA reductase inhibitor

     Pitavastatin Chemical Structure
  21. GC12116 Pitavastatin Calcium Enzyme HMGCR inhibitor Pitavastatin Calcium Chemical Structure
  22. GC36930 Pitavastatin D4 Pitavastatin D4 (NK-104 D4) is deuterium labeled Pitavastatin. Pitavastatin D4 Chemical Structure
  23. GC13870 Pravastatin HMG-CoA reductase inhibitor against sterol synthesis Pravastatin Chemical Structure
  24. GC14538 Pravastatin sodium A potent HMG-CoA reductase inhibitor Pravastatin sodium Chemical Structure
  25. GC16359 Rosuvastatin Competitive inhibitor of HMG-CoA reductase Rosuvastatin Chemical Structure
  26. GC15736 Rosuvastatin Calcium HMG-CoA reductase inhibitor Rosuvastatin Calcium Chemical Structure
  27. GC61251 Rosuvastatin D3 Rosuvastatin D3 (ZD 4522 D3) is a deuterium labeled Rosuvastatin. Rosuvastatin D3 Chemical Structure
  28. GC37559 Rosuvastatin D3 Sodium Rosuvastatin D3 Sodium is deuterium labeled Rosuvastatin, which is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM. Rosuvastatin D3 Sodium Chemical Structure
  29. GC37560 Rosuvastatin D6 Calcium Rosuvastatin D6 Calcium Chemical Structure
  30. GC37561 Rosuvastatin D6 Sodium Rosuvastatin D6 Sodium is deuterium labeled Rosuvastatin, which is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM. Rosuvastatin D6 Sodium Chemical Structure
  31. GC69833 Rosuvastatin Sodium

    Rosuvastatin Sodium is a competitive inhibitor of HMG-CoA reductase (HMGCR), with an IC50 of 11 nM. It effectively blocks hERG currents, with an IC50 of 195 nM. Rosuvastatin Sodium reduces the expression of mature hERG and the interaction between heat shock protein 70 (Hsp70) and hERG protein. Rosuvastatin Sodium effectively lowers levels of low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein.

     Rosuvastatin Sodium Chemical Structure
  32. GC67661 S-2E S-2E is an orally active and noncompetitive HMG-CoA reductase and acetyl-CoA carboxylase inhibitor. S-2E has an anti-hyperlipidemic action. S-2E has the potential for familial hypercholesterolemia and mixed hyperlipidemia research. S-2E Chemical Structure
  33. GC12285 Simvastatin (sodium salt) Simvastatin hydroxy acid (Tenivastatin) sodium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin (sodium salt) Chemical Structure
  34. GC10585 Simvastatin (Zocor) Simvastatin (Zocor) (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. Simvastatin (Zocor) Chemical Structure
  35. GC10092 SR 12813 Pregnane X receptor (PXR) agonist SR 12813 Chemical Structure

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