P450
Cytochrome P450 are a family of heme-containing monoxygenases catalyzing the metabolism of xenobiotics in the body where P450 enzymes use O2 and two electrons provided by NAD(P)H with the help of redox partner flavoproteins and iron-sulfur proteins to catalyze the monooxygenation of a variety of substrates. Based on how electrons from NAD(P)H are delivered to the catalytic site, P450 enzymes are divided into four classes, including Class I requiring both an FAD-containing reductase and an iron sulfur redoxin, Class II requiring only an FAD/FMN-containg P450 reductase, Class III requiring no electron donor and Class IV requiring electrons directly from NAD(P)H.
Products for P450
- Cat.No. Product Name Information
- GC37632 Seviteronel racemate Seviteronel racemate (VT-464 racemate) is the racemate form of Seviteronel (VT-464), which is a potent CYP17 lyase inhibitor(h-Lyase IC50=nM)inhibition.
- GC16259 SKF 525A (hydrochloride) SKF 525A (hydrochloride) is a Cytochrome P450 inhibitor (IC50 = 19μM).
- GC16951 Stiripentol An LDH inhibitor
- GC11638 Sulfaphenazole CYP2C9 inhibitor
- GC17063 Talarozole
- GC37727 Talarozole R enantiomer Talarozole R enantiomer is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne.
- GC32160 Tebuconazole A triazole fungicide
- GC33833 Tetrahydrocurcumin (HZIV 81-2) Tetrahydrocurcumin (HZIV 81-2) is a Curcuminoid found in turmeric (Curcuma longa) that is produced by the reduction of Curcumin.
- GC15244 Thienyldecyl Isothiocyanate cytochrome P450 inhibitor
- GC15445 TMS cytochrome P450 1B1 inhibitor
- GC13362 TOK-001 TOK-001 (TOK-001) is a multifunctional antiandrogen and CYP17 inhibitor (IC50=47 nM) in castration resistant prostate cancer (CRPC).
- GC45582 trans-ε-Viniferin ε-Viniferin, the dimer of Resveratrol and isolated from Vitis vinifera, displays a potent inhibitory for all the CYP activities, with Ki values from 0.5-20 μM.
- GC17112 Uniconazole cytochrome P450 707As inhibitor
- GC31791 Veledimex (INXN-1001) Veledimex (INXN-1001) (INXN-1001), a synthetic analog of the insect molting hormone ecdysone, is an orally active activator ligand for a proprietary gene therapy promoter system.
- GC33870 Veledimex racemate (RG-115932 racemate) Veledimex racemate (RG-115932 racemate) (INXN-1001 racemate) is the racemate of veledimex.
- GC30705 Veledimex S enantiomer (INXN-1001 S enantiome) Veledimex S enantiomer (INXN-1001 S enantiomer) is the S enantiomer of veledimex. Veledimex is an oral activator ligand for a proprietary gene therapy promoter system, and a moderate inhibitor of and substrate for CYP3A4/5.
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GC15056
β-Nicotyrine
cytochrome P450 (CYP) isoforms, CYP2A6 and CYP2A13 inhibitor