PDE
PDE (phosphodiesterases) catalyze the hydrolysis of cGMP and/or cAMP. Stimulus such as light, neurotransmitter and hormone trigger PDE to regulate various biological response including vascular smooth muscle proliferation/contraction, hormone secretion and plate aggregation etc.
Products for PDE
- Cat.No. Product Name Information
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GC13495
Trequinsin hydrochloride
PDE3 inhibitor
- GC31668 TYK2-IN-2 TyK2-IN-2 (Compoud 18) is a potent and selective TYK2 inhibitor with IC50s of 7 nM, 0.1 μM and 0.05 μM for TYK2 JH2, IL-23 and IFNα, respectively.
- GC13287 Udenafil PDE5 inhibitor
- GC15242 Vardenafil PDE5 inhibitor
- GC10588 Vardenafil HCl Trihydrate An inhibitor of PDE5 and PDE6
- GC37888 Vardenafil hydrochloride Vardenafil hydrochloride is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM.
- GC32110 Vesnarinone (OPC-8212) Vesnarinone (OPC-8212) (OPC-8212) is an orally active phosphodiesterase 3 (PDE3) inhibitor.
- GC16658 Vinpocetine PDE inhibitor
- GC37923 VP3.15 VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively.
- GC37924 VP3.15 dihydrobromide VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively.
- GC31814 WAY127093B racemate WAY127093B racemate is the racemate of WAY127093B.
- GC31327 Win 58237 Win 58237 is a cyclic nucleotide phosphodiesterase (PDE) inhibitor, with Ki of 170 nM for PDE V, possessing vasorelaxant activity.
- GC32659 Win-62005 Win-62005 is a cyclic AMP phosphodiesterase III (PDE III) inhibitor with Kis of 25 and 26 nM for rat heart and canine aorta, respectively.
- GC12059 YM 976 PDE4 inhibitor, orally active
- GC12909 Zaprinast phosphodiesterase inhibitor and GPR35 agonist
- GC16426 Zardaverine A dual inhibitor of PDE3 and PDE4