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Home >> Signaling Pathways >> Metabolism >> phosphatases

phosphatases

Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.

Products for  phosphatases

  1. Cat.No. Product Name Information
  2. GC14520 (-)-p-Bromotetramisole Oxalate ALP inhibitor, potent and non-specific (-)-p-Bromotetramisole Oxalate Chemical Structure
  3. GC18575 2-hydroxy Tricosanoic Acid methyl ester 2-hydroxy Tricosanoic acid methyl ester is a hydroxylated fatty acid methyl ester that has been found in ripe and unripe strawberry homogenates, Pseudosuberites and S. 2-hydroxy Tricosanoic Acid methyl ester Chemical Structure
  4. GC33059 3α-Aminocholestane 3α-Aminocholestane is a selective SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) inhibitor with an IC50 of ~2.5 μM. 3α-Aminocholestane Chemical Structure
  5. GC49169 3,8’-Biapigenin A biflavonoid with diverse biological activities 3,8’-Biapigenin Chemical Structure
  6. GC49494 4-Aminobenzylphosphonic Acid An alkaline phosphatase inhibitor 4-Aminobenzylphosphonic Acid Chemical Structure
  7. GC35298 Aloe-emodin-8-O-β-D-glucopyranoside Aloe-emodin-8-O-β-D-glucopyranoside, a compound isolated from Saussrurea lappa, is a moderate inhibitor of human protein tyrosine phosphatase 1B (hPTP1B) with an IC50 of 26.6 μM. Aloe-emodin-8-O-β-D-glucopyranoside Chemical Structure
  8. GC13516 AS 1949490 Selective SHIP2 inhibitor AS 1949490 Chemical Structure
  9. GC46897 AUTEN-99 AUTEN-99 (hydrobromide) is a novel inhibitor of the myotubularin phosphatase Jumpy (also called MTMR14). AUTEN-99 Chemical Structure
  10. GC38646 BCI

    BCI, as a selective dual-specificity phosphatase 6 (DUSP6) inhibitor, can inhibit tumor growth and macrophage inflammation.

     BCI Chemical Structure
  11. GC39160 BCI-215 BCI-215 is a potent and tumor cell-selective dual specificity MAPK phosphatase (DUSP-MKP) inhibitor. BCI-215 has cytotoxicity for tumor cells but not normal cells. BCI-215 Chemical Structure
  12. GC49403 Benzarone An active metabolite of benzbromarone Benzarone Chemical Structure
  13. GC33345 BN82002 BN82002 is a potent, selective and irreversible inhibitor of CDC25 phosphatase family. BN82002 inhibits CDC25A, CDC25B2, CDC25B3, CDC25C CDC25A, and 25C-cat with IC50 values of 2.4, 3.9, 6.3, 5.4, and 4.6 ?M, respectively. BN82002 displays ~20-fold greater selectivity over CD45 tyrosine phosphatase. BN82002 Chemical Structure
  14. GC18718 bpV(pic) (potassium hydrate) bpV(pic) is a bisperoxovanadium (bpV) compound that inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 31 nM). bpV(pic) (potassium hydrate) Chemical Structure
  15. GC38467 BTdCPU BTdCPU is a potent heme-regulated eIF2α kinase (HRI) activator. BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell. BTdCPU Chemical Structure
  16. GC16256 BVT 948 An inhibitor of protein tyrosine phosphatases BVT 948 Chemical Structure
  17. GC18106 Calyculin A Potent inhibitor of PP1 and PP2A Calyculin A Chemical Structure
  18. GC35627 CDC25B-IN-1 CDC25B-IN-1 (compound 4a) is a potent inhibitor of cell division cycle 25B (CDC25B) phosphatase, with a Ki of 8.5 μM. CDC25B-IN-1 potently inhibits cell proliferation and colony formation, causes an increase of the G2/M phase. CDC25B-IN-1 Chemical Structure
  19. GC18258 CpdA CpdA is a non-steroidal selective glucocorticoid receptor modulator. CpdA Chemical Structure
  20. GC50357 CX08005 Competitive PTP1B inhibitor CX08005 Chemical Structure
  21. GC35791 cyt-PTPε Inhibitor-1 cyt-PTPε Inhibitor-1 is a potent cytosolic protein tyrosine phosphatase epsilon (cyt-PTPε) inhibitor, binds to the catalytic domain of cyt-PTPε, blocks c-Src activation (dephosphorylation of c-Src), and exhibits anti-osteoclastic activity. cyt-PTPε Inhibitor-1 Chemical Structure
  22. GC17591 D-erythro-Sphingosine (synthetic) D-erythro-Sphingosine (synthetic) (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (synthetic) (Erythrosphingosine) is also a PP2A activator. D-erythro-Sphingosine (synthetic) Chemical Structure
  23. GC41305 DA-3003-2 Cdc25 dual-specific protein tyrosine phosphatases are important for cell cycle progression and often overexpressed in cancers. DA-3003-2 Chemical Structure
  24. GC38445 DPM-1001 DPM-1001 is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM. DPM-1001 Chemical Structure
  25. GC34562 DT-061 DT-061 is an orally bioavailable activator of protein phosphatase 2A (PP2A) and could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis. DT-061 Chemical Structure
  26. GC30664 Enocyanin Enocyanin is an anthocyanin extracted from grapes. Enocyanin Chemical Structure
  27. GC33816 Ertiprotafib (PTP 112) Ertiprotafib (PTP 112) is an inhibitor of PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist, with an IC50 of 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPARα/PPARβ. Ertiprotafib (PTP 112) Chemical Structure
  28. GC33227 F1063-0967 F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM. F1063-0967 Chemical Structure
  29. GC49074 Forphenicine A bacterial metabolite and an inhibitor of alkaline phosphatase Forphenicine Chemical Structure
  30. GC38783 Ginkgolic acid C17:1 Ginkgolic acid C17:1, extracted from Ginkgo biloba Leaves, suppresses constitutive and inducible STAT3 activation through induction of PTEN and SHP-1 tyrosine phosphatase. Ginkgolic acid C17:1 has anticancer effects. Ginkgolic acid C17:1 Chemical Structure
  31. GC38916 GNF362 GNF362 is a selective, potent, and orally bioavailable inhibitor of inositol trisphosphate 3’ kinase B (Itpkb) with an IC50 of 9 nM. GNF362 Chemical Structure
  32. GC12880 GSK 2830371

    Orally active, allosteric inhibitor of Wip1 phosphatase

     GSK 2830371 Chemical Structure
  33. GC12306 Imidazole Alkaline phosphatases inhibitor Imidazole Chemical Structure
  34. GC34178 Isocryptotanshinone Isocryptotanshinone Chemical Structure
  35. GC33791 Isotanshinone IIA Isotanshinone IIA, an abietane-type diterpene metabolite, could non-competitively inhibit Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC50 0f 11.4 μM. Isotanshinone IIA Chemical Structure
  36. GC31499 JTT 551 JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with Kis of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively; JTT 551 can be used in the research of type 2 diabetes mellitus. JTT 551 Chemical Structure
  37. GC38919 KY-226 KY-226 is a potent, selective, orally active and allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 0.25 μM, and without PPARγ agonist activity. KY-226 Chemical Structure
  38. GC16451 L-690,330 competitive inhibitor of inositol monophosphatase (IMPase) L-690,330 Chemical Structure
  39. GC12189 LB-100 protein phosphatase 2A(PP2A)inhibitor LB-100 Chemical Structure
  40. GC36448 Licoflavone A Licoflavone A is a flavonoid isolated from the roots of Glycyrrhiza uralensis, inhibits protein tyrosine phosphatase-1B (PTP1B), with an IC50 of 54.5 μM. Licoflavone A Chemical Structure
  41. GC19223 LMPTP INHIBITOR 1 dihydrochloride LMPTP INHIBITOR 1 (dihydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 uM LMPTP-A. LMPTP INHIBITOR 1 dihydrochloride Chemical Structure
  42. GC34353 LMPTP INHIBITOR 1 hydrochloride LMPTP inhibitor 1 hydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A. LMPTP INHIBITOR 1 hydrochloride Chemical Structure
  43. GC32852 LTV-1 LTV-1 is a potent lymphoid tyrosine phosphatase (LYP) inhibitor in T cells with an IC50 of 508 nM. LTV-1 Chemical Structure
  44. GC18859 Microcystin-LA Microcystins are hepatotoxic cyclic heptapeptide toxins produced by cyanobacteria. Microcystin-LA Chemical Structure
  45. GC36607 Microcystin-LR A potent protein phosphatase inhibitor Microcystin-LR Chemical Structure
  46. GC10850 ML-095 (hydrochloride) ML-095 (hydrochloride) is a biochemical inhibitor of PLAP. ML-095 (hydrochloride) Chemical Structure
  47. GC44226 MLS-0322825 Cmpd 23 MLS-0322825 Cmpd 23 is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A. MLS-0322825 Cmpd 23 Chemical Structure
  48. GC38486 Momordicoside A Momordicoside A is isolated from Momordica charantia L. Momordicoside A Chemical Structure
  49. GC32396 MSI-1436 (Trodusquemine) MSI-1436 (Trodusquemine) is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B), with an IC50 of appr 1 μM, 200-fold preference over TCPTP (IC50, 224 μM). MSI-1436 (Trodusquemine) Chemical Structure
  50. GC32397 MSI-1436 lactate (Trodusquemine lactate) MSI-1436 lactate (Trodusquemine lactate) is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B), with an IC50 of 1 μM, 200-fold preference over TCPTP (IC50 of 224 μM). MSI-1436 lactate (Trodusquemine lactate) Chemical Structure
  51. GC14875 NSC 663284 Cdc25 dual specificity phosphatases inhibitor NSC 663284 Chemical Structure
  52. GC10169 NSC 87877 A potent inhibitor of SHP-1 and SHP-2 NSC 87877 Chemical Structure
  53. GC11561 NSC 95397 Cdc25 dual specificity phosphatases inhibitor NSC 95397 Chemical Structure
  54. GC44637 PHPS1

    PHPS1 is a cell-permeable, phosphotyrosine mimetic that inhibits the Src homology region 2 domain-containing phosphatase (SHP)-2 (IC50 = 2.1 μM; Ki = 0.73 μM).

     PHPS1 Chemical Structure
  55. GC50568 PHPS1 sodium salt Shp2 (PTPN11) inhibitor PHPS1 sodium salt Chemical Structure
  56. GC44774 PTP Inhibitor III PTP Inhibitor III is an α-haloacetophenone derivative that acts as a photoreversible covalent inhibitor of protein tyrosine phosphatases (PTPs). PTP Inhibitor III Chemical Structure
  57. GC44775 PTP1B Inhibitor PTP1B Inhibitor is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B, with an IC50 of 8 μM. PTP1B Inhibitor Chemical Structure
  58. GC37037 PTP1B-IN-1 PTP1B-IN-1 is a potent protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 of 1.6 mM; 1,2,5-thiadiazolidin-3-one-1,1-dioxide scaffold for derivatives synthesis. PTP1B-IN-1 Chemical Structure
  59. GC31324 PTP1B-IN-2 PTP1B-IN-2 is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 50 nM. PTP1B-IN-2 Chemical Structure
  60. GC31635 PTP1B-IN-3 PTP1B-IN-3 is a potent and orally active PTP1B inhibitor with IC50s of 120 nM for both PTP1B and TCPTP. PTP1B-IN-3 Chemical Structure
  61. GC38189 Raphin1 Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 Chemical Structure
  62. GC38539 Raphin1 acetate Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 acetate Chemical Structure
  63. GC30834 Rilapladib (SB 659032) Rilapladib (SB 659032) (SB 659032) is a selective Lp-PLA2 (lipoprotein-associated phospholipase A2) inhibitor with an IC50 of 230 pM. Rilapladib (SB 659032) Chemical Structure
  64. GC33044 RMC-4550 A SHP-2 inhibitor RMC-4550 Chemical Structure
  65. GC32783 Rosiptor (AQX-1125) Rosiptor (AQX-1125) (AQX-1125) is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. Rosiptor (AQX-1125) (AQX-1125) inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro. Rosiptor (AQX-1125) Chemical Structure
  66. GC14321 Sal 003 An inhibitor of eIF2α dephosphorylation Sal 003 Chemical Structure
  67. GC17331 Salubrinal Selective eIF2α inhibitor Salubrinal Chemical Structure
  68. GC38846 SBI-425 SBI-425 is an orally active and potent TNAP (tissue-nonspecific alkaline phosphatase) inhibitor (IC50=16 nM). SBI-425 Chemical Structure
  69. GC10019 SF1670 PTEN inhibitor, potent and specific SF1670 Chemical Structure
  70. GC44887 SHP099 SHP099 is an orally bioavailable inhibitor of SHP2, a non-receptor protein tyrosine phosphatase (IC50 = 71 nM). SHP099 Chemical Structure
  71. GC19331 SHP099 hydrochloride SHP099 hydrochloride is a potent, selective and orally available SHP2 inhibitor with an IC50 of 70 nM. SHP099 hydrochloride Chemical Structure
  72. GC30754 SHP2 IN-1 SHP2 IN-1 (compound 13) is an allergic inhibitor of SHP2 (PTPN11), with an IC50 of 3 nM. SHP2 IN-1 Chemical Structure
  73. GN10140 Silydianin Silydianin Chemical Structure
  74. GC10594 sodium fluoride Acid phosphatases inhibitor sodium fluoride Chemical Structure
  75. GC16396 Sodium molybdate Acid and phosphoprotein phosphatases inhibitor Sodium molybdate Chemical Structure
  76. GC14368 Sodium Orthovanadate PTP inhibitor Sodium Orthovanadate Chemical Structure
  77. GC12093 Sodium tartrate Acid phosphatases inhibitor Sodium tartrate Chemical Structure
  78. GC46011 SPI 112 A cell-impermeable SHP-2 inhibitor SPI 112 Chemical Structure
  79. GC32709 Stibogluconate sodium (Sodium stibogluconate) Stibogluconate sodium (Sodium stibogluconate) (Stibogluconate trisodium nonahydrate) is a potent inhibitor of protein tyrosine phosphatase. Stibogluconate sodium (Sodium stibogluconate) inhibits 99% of SHP-1, SHP-2 and PTP1B activity at 10, 100, 100 μg/mL, respectively. Stibogluconate sodium (Sodium stibogluconate) Chemical Structure
  80. GC16233 Tacrolimus (FK506)

    Tacrolimus (FK506), a macrolide antibiotic with potent immunosuppressive effects was isolated from Streptomyces tsukubaensis and has been previously used to prevent allograft and for treatment of autoimmune disorders in humans.

     Tacrolimus (FK506) Chemical Structure
  81. GC17995 Tacrolimus monohydrate immunosuppressive drug Tacrolimus monohydrate Chemical Structure
  82. GC41443 TAN 1364B TAN 1364B, a racemate of RK-682, is a protein tyrosine phosphatases (PTPases) inhibitor. TAN 1364B inhibits protein tyrosine phosphatase 1B (PTP-1B), low molecular weight protein tyrosine phosphatases (LMW-PTP), and cell division cycle 25B (CDC-25B) with IC50s of 8.6 μM, 12.4 μM, and 0.7 μM, respectively. TAN 1364B Chemical Structure
  83. GC37741 Tartaric acid disodium dihydrate Tartaric acid disodium dihydrate is a Acid phosphatase inhibitor, is a sodium salt used in buffers for molecular biology and cell culture applications. Tartaric acid disodium dihydrate Chemical Structure
  84. GC31772 Tautomycin

    Tautomycin, an antifungal antibiotic isolated from the bacterium Streptomyces verticillatus, is a potent and specific inhibitor of protein phosphatases 1 and 2A and induces contraction of smooth muscle under Ca2+-free conditions, with Kiapp values of 0.16 nM and 0.4 nM for PP1 and PP2A, respectively.

     Tautomycin Chemical Structure
  85. GC12020 TCS 401 A selective PTP1B inhibitor TCS 401 Chemical Structure
  86. GC11352 Tetramisole HCl Tetramisole HCl is an inhibitor of alkaline phosphatases, is a high purity antiparasitic. Tetramisole HCl Chemical Structure
  87. GC39514 TNO155 TNO155 is a potent selective and orally active allosteric inhibitor of wild-type SHP2 (IC50=0.011 μM). TNO155 has the potential for the study of RTK-dependent malignancies, especially advanced solid tumors. TNO155 Chemical Structure
  88. GC18239 TPI-1 TPI-1 is an inhibitor of protein tyrosine phosphatases. TPI-1 Chemical Structure
  89. GC49401 Triptolide-d3 An internal standard for the quantification of triptolide Triptolide-d3 Chemical Structure
  90. GC45149 VK3-OCH3 VK3-OCH3 is an analog of vitamin K3 that that has antiproliferative activities in vitro. VK3-OCH3 Chemical Structure
  91. GC50041 VO-OHpic Potent PTEN inhibitor VO-OHpic Chemical Structure
  92. GC35024 [pTyr5] EGFR 988-993 [pTyr5] EGFR 988-993 is derived from the autophosphorylation site (Tyr992) of epidermal growth factor receptor (EGFR 988-993). [pTyr5] EGFR 988-993 Chemical Structure
  93. GC11806 β-Glycerophosphate (sodium salt hydrate) β-Glycerophosphate (sodium salt hydrate) is a phosphatase inhibitor. β-Glycerophosphate (sodium salt hydrate) Chemical Structure

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