Pyruvate kinase

Pyruvate kinase is an enzyme that catalyzes the conversion of phosphoenolpyruvate and ADP to pyruvate and ATP in glycolysis and plays a role in regulating cell metabolism. There are four mammalian pyruvate kinase isoforms (PKM1, PKM2, PKR, PKL), and each isoform has had multiple designations over time in the literature. The M2 isoform of pyruvate kinase (PKM2) supports anabolic metabolism and is expressed both in cancer and normal tissue. The enzymatic activity of PKM2 is allosterically regulated by both intracellular signaling pathways and metabolites; PKM2 thus integrates signaling and metabolic inputs to modulate glucose metabolism according to the needs of the cell.

Products for Pyruvate kinase

Cat.No. Product Name Information
GC69796 (Rac)-Etavopivat
(Rac)-Etavopivat ((Rac)-FT-4202) is an isomer of Etavopivat. Etavopivat is an orally active activator of red blood cell pyruvate kinase-R (PKR), which can be used for research on sickle cell disease and other hemoglobin disorders.
GC12888 DASA-58 activator of pyruvate kinase M2 (PKM2)
GC64428 Etavopivat
Etavopivat is a potent, selective, orally bioavailable red blood cell (RBC) pyruvate kinase (PKR) activator.
GC19297 Mitapivat Mitapivat is a potent human R-type pyruvate kinase (PKR) inhibitor; also shows potency for mutant PKR including R510Q PKR, R532W PKR, T384W PKR etc.
GC11741 ML-265 ML-265 (ML-265) is a potent and selective pyruvate kinase M2 (PKM2) activator with an AC50 of 92 nM, showing little or no effect on PKM1, PKL and PKR.
GC69716 PKM2 activator 2
PKM2 activator 2 is an activator of pyruvate kinase M2 (PKM2) with anti-proliferative effects, with an AC50 of 66 nM. PKM2 activator 2 may have anti-tumor proliferation effects and alleviate the Warburg effect, as PKM2 activation can restore normal glucose metabolism in cells.
GC32738 PKM2-IN-1
PKM2-IN-1 is a pyruvate kinase M2 (PKM2) inhibitor with an IC50 of 2.95μM
GN10216 Shikonin