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Home >> Signaling Pathways >> Metabolism >> SGLT

SGLT

SGLT (sodium-glucose linked transporter) uses the energy from the downhill sodium ion gradient created by the ATPase pump to transport glucose across the apical membrane against an uphill glucose gradient.

Products for  SGLT

  1. Cat.No. Product Name Information
  2. GC19065 Bexagliflozin Bexagliflozin is a potent and selective SGLT2 inhibitor with IC50 value of 5.6 uM /2 nM in SGLT1 /SGLT2 respectively. Bexagliflozin Chemical Structure
  3. GC13771 Canagliflozin SGLT2 inhibitor,potent and selective Canagliflozin Chemical Structure
  4. GC39178 Canagliflozin D4 Canagliflozin D4 is a deuterium labeled Canagliflozin. Canagliflozin D4 Chemical Structure
  5. GC35603 Canagliflozin hemihydrate Canagliflozin hemihydrate (JNJ28431754 hemihydrate) is a selective SGLT2 inhibitor with IC50s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively. Canagliflozin hemihydrate Chemical Structure
  6. GC15530 Dapagliflozin

    Dapagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, is a novel antidiabetic agent that is approved for the treatment of T2DM by based on its ability to inhibit SGLT2-mediated renal glucose reabsorption.

     Dapagliflozin Chemical Structure
  7. GC35809 Dapagliflozin ((2S)-1,2-propanediol, hydrate) Dapagliflozin ((2S)-1,2-propanediol, hydrate) is the S-enantiomer of Dapagliflozin 1,2-propanediol, hydrate. Dapagliflozin ((2S)-1,2-propanediol, hydrate) Chemical Structure
  8. GC16212 Empagliflozin (BI 10773) An SGLT2 inhibitor Empagliflozin (BI 10773) Chemical Structure
  9. GC64266 Enavogliflozin Enavogliflozin (DWP-16001), an antidiabetic agent, is an orally active, best-in-class and selective sodium-glucose cotransporter-2 (SGLT-2) inhibitor. Enavogliflozin Chemical Structure
  10. GC36004 Ertugliflozin L-pyroglutamic acid Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2. Ertugliflozin L-pyroglutamic acid Chemical Structure
  11. GC16697 fluoro-Dapagliflozin selective sodium-glucose cotransporter (SGLT) inhibitor fluoro-Dapagliflozin Chemical Structure
  12. GC17190 galacto-Dapagliflozin potent inhibitor of human SGLT2 galacto-Dapagliflozin Chemical Structure
  13. GC16469 Ipragliflozin SGLT2 inhibitor Ipragliflozin Chemical Structure
  14. GC36326 Ipragliflozin L-Proline Ipragliflozin L-Proline is a highly potent and selective SGLT2 inhibitor with an IC50 of 2.8 nM; little and NO potency for SGLT1/3/4/5/6. Ipragliflozin L-Proline Chemical Structure
  15. GC31366 Licogliflozin (LIK066) Licogliflozin (LIK066) is a sodium glucose cotransporter (SGLT1 and SGLT2) inhibitor. Licogliflozin (LIK066) Chemical Structure
  16. GC15088 LX-4211 An SGLT inhibitor LX-4211 Chemical Structure
  17. GC36498 LX2761 LX2761 is chemically stable and potent inhibitor against sodium-dependent glucose cotransporter 1 (SGLT1) and SGLT2 in vitro with IC50s of 2.2 nM and 2.7nM for hSGLT1 and hSGLT2, but displays specific SGLT1 inhibition in the gastrointestinal (GI) tract. LX2761 Chemical Structure
  18. GC60249 Mizagliflozin Mizagliflozin (DSP-3235 free base) is a potent, orally active and selective SGLT1 inhibitor, with a Ki of 27 nM for human SGLT1. Mizagliflozin Chemical Structure
  19. GC16012 PF-04971729 An SGLT2 inhibitor PF-04971729 Chemical Structure
  20. GC17976 Phloretin A natural inhibitor of various transporters Phloretin Chemical Structure
  21. GN10029 Phloridzin Phloridzin Chemical Structure
  22. GC31461 Tofogliflozin (CSG452) Tofogliflozin (CSG452)(CSG-452) is a potent and highly specific sodium/glucose cotransporter 2(SGLT2) inhibitor with Ki values of 2.9, 14.9, and 6.4 nM for human, rat, and mouse SGLT2. Tofogliflozin (CSG452) Chemical Structure
  23. GC31377 Tofogliflozin hydrate (CSG-452 hydrate) Tofogliflozin hydrate (CSG-452 hydrate) is a potent and highly specific sodium/glucose cotransporter 2 (SGLT2) inhibitor with an IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SGLT2. Tofogliflozin hydrate (CSG-452 hydrate) Chemical Structure
  24. GC41374 Trilobatin Trilobatin is a dihydrochalcone glucoside and derivative of phloretin that has been found in Rooibos (A. Trilobatin Chemical Structure
  25. GC31593 Velagliflozin

    Velagliflozin is an orally available sodium-glucose cotransporter 2 (SGLT2) inhibitor, with anti-diabetic activity.

     Velagliflozin Chemical Structure
  26. GC70113 Velagliflozin proline

    Velagliflozin proline is an orally administered sodium-glucose co-transporter 2 (SGLT2) inhibitor with anti-diabetic activity. Specifically, Velagliflozin proline reduces renal glucose reabsorption, promotes glucosuria, and thereby lowers blood glucose and insulin concentrations.

     Velagliflozin proline Chemical Structure

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