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Transferase

Transferases are a collection of a large and diverse group of enzymes that specifically catalyze the transfer of one or more functional groups from one molecule (the donor) to another (the acceptor). A few transferases involved in this category include farnesyltransferase (FTase), diacylglycerol acyltransferase (DGAT) and catechol-O-methyltransferase (COMT). Ftase catalyzes the transfer of a farnesyl moiety to the cysteine terminal residue (the sulfhydryl cysteine of the CAAS motif)) of substrate proteins. DGAT catalyzes the final step of the triacylglycerol (TG) biosynthetic pathway, where diacylglycerol is esterified to produce TG. COMT catalyzes the methylation of catechol substrates utilizing S-adenosyl-L-methionine (SAM) as a methyl donor and generating O-methylated catechol and S-adenosyl-L-homocysteine.

  1. Cat.No. Product Name Information
  2. GC15614 A922500 DGAT-1 inhibitor
  3. GC10905 Amodiaquine dihydrochloride dihydrate histamine N-methyl transferase inhibitor
  4. GC12912 BCATc Inhibitor 2 cytosolic BCAT (BCATc) inhibitor
  5. GC11524 Cystamine dihydrochloride transglutaminase inhibitor
  6. GC14308 FK866 (APO866) NAMPT inhibitor,non-competitive, highly specific
  7. GC17780 FTase Inhibitor II Ftase inhibitor
  8. GC16310 FTI 277 HCl FTase inhibitor
  9. GC16612 GGsTop γ-glutamyl transpeptidase (GGT) inhibitor, novel and irreversible
  10. GC11884 GPP 78 hydrochloride

    NAMPT inhibitor

  11. GC10170 LB42708 Selective FTase inhibitor
  12. GC10330 Lonafarnib Ftase inhibitor,potent and selective
  13. GC16129 LY 78335 phenylethanolamine-N-methyltransferase (PNMT) inhibitor
  14. GC10265 Manumycin A

    farnesyltransferase inhibitor

  15. GC10106 OR-486 inhibitor of catechol-O-methyl-transferase
  16. GC12981 OU749 γ-Glutamyl transferase (GGT) inhibitor
  17. GC15274 PF-04620110 DGAT-1 inhibitor,potent and selective
  18. GC12449 SKF 91488 dihydrochloride histamine N-methyltransferase inhibitor
  19. GC15442 Tipifarnib (Zarnestra)

    Farnesyltransferase inhibitor,potent and specific

  20. GC17921 Tolcapone

    COMT inhibitor

  21. GC17046 Tris DBA N-myristoyltransferase-1 (NMT-1) inhibitor

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