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Home >> Signaling Pathways >> Metabolism >> Transferase

Transferase

Transferases are a collection of a large and diverse group of enzymes that specifically catalyze the transfer of one or more functional groups from one molecule (the donor) to another (the acceptor). A few transferases involved in this category include farnesyltransferase (FTase), diacylglycerol acyltransferase (DGAT) and catechol-O-methyltransferase (COMT). Ftase catalyzes the transfer of a farnesyl moiety to the cysteine terminal residue (the sulfhydryl cysteine of the CAAS motif)) of substrate proteins. DGAT catalyzes the final step of the triacylglycerol (TG) biosynthetic pathway, where diacylglycerol is esterified to produce TG. COMT catalyzes the methylation of catechol substrates utilizing S-adenosyl-L-methionine (SAM) as a methyl donor and generating O-methylated catechol and S-adenosyl-L-homocysteine.

Products for  Transferase

  1. Cat.No. Product Name Information
  2. GC15614 A922500

    (1R,2R)2(4'(3phenylureido)biphenylcarbonyl)cyclopentanecarboxylic acid

     A diacylglycerol acyltransferase 1 inhibitor A922500 Chemical Structure
  3. GC10905 Amodiaquine dihydrochloride dihydrate histamine N-methyl transferase inhibitor Amodiaquine dihydrochloride dihydrate Chemical Structure
  4. GC12912 BCATc Inhibitor 2

    Cytosolic Branched-Chain Amino Acid Transferase Inhibitor 2

    cytosolic BCAT (BCATc) inhibitor

     BCATc Inhibitor 2 Chemical Structure
  5. GC11524 Cystamine dihydrochloride transglutaminase inhibitor Cystamine dihydrochloride Chemical Structure
  6. GC14308 FK866 (APO866)

    K 22.175

    FK866 (APO866) is an inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase).

     FK866 (APO866) Chemical Structure
  7. GC17780 FTase Inhibitor II

    Farnesyltransferase Inhibitor II,FTI-II

     Ftase inhibitor FTase Inhibitor II Chemical Structure
  8. GC16310 FTI 277 HCl FTI 277 HCl is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI 277 HCl Chemical Structure
  9. GC16612 GGsTop

    Nahlsgen

    γ-glutamyl transpeptidase (GGT) inhibitor, novel and irreversible

     GGsTop Chemical Structure
  10. GC11884 GPP 78 hydrochloride

    NAMPT inhibitor

     GPP 78 hydrochloride Chemical Structure
  11. GC10170 LB42708 Selective FTase inhibitor LB42708 Chemical Structure
  12. GC10330 Lonafarnib

    Sarasar, SCH 66336

     A farnesyltransferase inhibitor with antitumor activity Lonafarnib Chemical Structure
  13. GC16129 LY 78335 phenylethanolamine-N-methyltransferase (PNMT) inhibitor LY 78335 Chemical Structure
  14. GC10265 Manumycin A

    NSC 62214, UCF 1C

    farnesyltransferase inhibitor

     Manumycin A Chemical Structure
  15. GC10106 OR-486

    OR-486

     OR-486 (OR-486) is a potent catechol-O-methyltransferase inhibitor, with an IC50 of 12 nM. OR-486 Chemical Structure
  16. GC12981 OU749 γ-Glutamyl transferase (GGT) inhibitor OU749 Chemical Structure
  17. GC15274 PF-04620110

    PF 04620110,PF04620110

     A potent, bioavailable inhibitor of DGAT-1 PF-04620110 Chemical Structure
  18. GC12449 SKF 91488 dihydrochloride histamine N-methyltransferase inhibitor SKF 91488 dihydrochloride Chemical Structure
  19. GC15442 Tipifarnib (Zarnestra)

    R 115777

     A farnesyltransferase inhibitor with antitumor activity Tipifarnib (Zarnestra) Chemical Structure
  20. GC17921 Tolcapone

    Ro 40-7592

     A reversible COMT inhibitor Tolcapone Chemical Structure
  21. GC17046 Tris DBA N-myristoyltransferase-1 (NMT-1) inhibitor Tris DBA Chemical Structure
  22. GC16738 Tunicamycin Mixture Tunicamycin Mixture is a mixture of homologous nucleoside antibiotics that inhibits N-glycosylation and blocks GlcNAc phosphotransferase (GPT). Tunicamycin Mixture Chemical Structure

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