Transferase
Transferases are a collection of a large and diverse group of enzymes that specifically catalyze the transfer of one or more functional groups from one molecule (the donor) to another (the acceptor). A few transferases involved in this category include farnesyltransferase (FTase), diacylglycerol acyltransferase (DGAT) and catechol-O-methyltransferase (COMT). Ftase catalyzes the transfer of a farnesyl moiety to the cysteine terminal residue (the sulfhydryl cysteine of the CAAS motif)) of substrate proteins. DGAT catalyzes the final step of the triacylglycerol (TG) biosynthetic pathway, where diacylglycerol is esterified to produce TG. COMT catalyzes the methylation of catechol substrates utilizing S-adenosyl-L-methionine (SAM) as a methyl donor and generating O-methylated catechol and S-adenosyl-L-homocysteine.
Products for Transferase
- Cat.No. Product Name Information
- GC15614 A922500 A diacylglycerol acyltransferase 1 inhibitor
- GC10905 Amodiaquine dihydrochloride dihydrate histamine N-methyl transferase inhibitor
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GC12912
BCATc Inhibitor 2
cytosolic BCAT (BCATc) inhibitor
- GC11524 Cystamine dihydrochloride transglutaminase inhibitor
- GC14308 FK866 (APO866) Inhibitor of nicotinamide phosphoribosyltransferase
- GC17780 FTase Inhibitor II Ftase inhibitor
- GC16310 FTI 277 HCl FTI 277 HCl is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling.
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GC16612
GGsTop
γ-glutamyl transpeptidase (GGT) inhibitor, novel and irreversible
-
GC11884
GPP 78 hydrochloride
NAMPT inhibitor
- GC10170 LB42708 Selective FTase inhibitor
- GC10330 Lonafarnib A farnesyltransferase inhibitor with antitumor activity
- GC16129 LY 78335 phenylethanolamine-N-methyltransferase (PNMT) inhibitor
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GC10265
Manumycin A
farnesyltransferase inhibitor
- GC10106 OR-486 OR-486 (OR-486) is a potent catechol-O-methyltransferase inhibitor, with an IC50 of 12 nM.
- GC12981 OU749 γ-Glutamyl transferase (GGT) inhibitor
- GC15274 PF-04620110 A potent, bioavailable inhibitor of DGAT-1
- GC12449 SKF 91488 dihydrochloride histamine N-methyltransferase inhibitor
- GC15442 Tipifarnib (Zarnestra) A farnesyltransferase inhibitor with antitumor activity
- GC17921 Tolcapone A reversible COMT inhibitor
- GC17046 Tris DBA N-myristoyltransferase-1 (NMT-1) inhibitor
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GC16738
Tunicamycin Mixture
Antibiotic,inhibits GlcNAc phosphotransferase (GPT)