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Home >> Signaling Pathways >> Others >> Aldose reductase

Aldose reductase

Aldose reductase catalyzes the NADPH-dependent reduction of glucose to sorbitol. It is involved in the progression of diabetic and glactosemic complications.

Products for  Aldose reductase

  1. Cat.No. Product Name Information
  2. GC25009 2-Chloro-1-(4-fluorobenzyl)benzimidazole 2-Chloro-1-(4-fluorobenzyl)benzimidazole is an aldose reductase (ALR2) inhibitor which is used for preparation of disubstituted benzimidazole derivative. 2-Chloro-1-(4-fluorobenzyl)benzimidazole Chemical Structure
  3. GC35179 6-Methoxytricin 6-Methoxytricin (Compound 6) is an flavonoid isolated from Artemisia iwayomogi. 6-Methoxytricin Chemical Structure
  4. GC68633 AKR1C3-IN-9

    AKR1C3-IN-9 is a selective inhibitor of aldo-keto reductase 1C3 (AKR1C3), with an IC50 of 8.92 nM. AKR1C3-IN-9 significantly reverses Doxorubicin (DOX) resistance in drug-resistant breast cancer cell lines.

     AKR1C3-IN-9 Chemical Structure
  5. GC31376 Aldose reductase-IN-1

    Caficrestat

     Aldose reductase-IN-1 (Aldose reductase-IN-1) is a inhibitor of aldose reductase with IC50 of 28.9 pM. Aldose reductase-IN-1 Chemical Structure
  6. GC68645 ALR2-IN-1

    ALR2-IN-1 is a potent and selective inhibitor of ALR2 (IC50=1.42 μM). It exhibits antioxidant and antiglycation properties. ALR2-IN-1 can be used for research on complications related to diabetes.

     ALR2-IN-1 Chemical Structure
  7. GC11756 Alrestatin

    AY 22284, NSC 299132

     aldose reductase inhibitor Alrestatin Chemical Structure
  8. GC35309 Alrestatin sodium Alrestatin sodium is an inhibitor of aldose reductase, an enzyme involved in the pathogenesis of complications of diabetes mellitus, including diabetic neuropathy. Alrestatin sodium Chemical Structure
  9. GC38584 AT-007 AT-007 is an orally active central nervous system (CNS) penetrant Aldose Reductase inhibitor for treatment of Galactosemia with an IC50 value of 100 pM. AT-007 Chemical Structure
  10. GC10332 EBPC

    NSC 229530

     aldose reductase inhibitor EBPC Chemical Structure
  11. GC10001 Epalrestat

    ONO2235

     aldose reductase inhibitor Epalrestat Chemical Structure
  12. GC31487 Fidarestat (SNK 860) Fidarestat (SNK 860) (SNK 860) is an inhibitor of aldose reductase, with IC50s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) (SNK 860) has the potential to treat diabetic disease. Fidarestat (SNK 860) Chemical Structure
  13. GC70526 IDD388 IDD388 is a selective aldose reductase (ALR2) inhibitor with an IC50 of 30 nM. IDD388 Chemical Structure
  14. GC31412 Imirestat (AL 1576) Imirestat (AL 1576) (AL 1576) is an aldose reductase inhibitor, used for the treatment of diabetes. Imirestat (AL 1576) Chemical Structure
  15. GN10088 Isoliquiritigenin

    GU 17, ILQ, ISL

     Isoliquiritigenin Chemical Structure
  16. GC38810 Lidorestat Lidorestat (IDD-676) is a potent, selective and orally active aldose reductase inhibitor with an IC50 of 5 nM. Lidorestat Chemical Structure
  17. GC70493 MK204 MK204 is an aldose reductase (AR) inhibitor that can be used in diabetes research. MK204 Chemical Structure
  18. GC37053 Quercetin 3-gentiobioside Quercetin 3-gentiobioside is isolated from A. Quercetin 3-gentiobioside Chemical Structure
  19. GC31359 Ranirestat (AS-3201) Ranirestat (AS-3201) (AS-3201) potent and orally active aldose reductase (AR) inhibitor with IC50s of 11 nM and 15 nM for rat lens AR and recombinant human AR, respectively, and a Ki of 0.38 nM for recombinant human AR. Ranirestat (AS-3201) Chemical Structure
  20. GC31474 Risarestat (CT 112)

    CT 112

     Risarestat (CT 112) (CT-112), an aldose reductase inhibitor, is developed for the treatment of diabetic complications. Risarestat (CT 112) Chemical Structure
  21. GC37666 Sorbinil Sorbinil, is an Aldose reductase inhibitor (ARI). Sorbinil Chemical Structure
  22. GC10958 Statil

    ICI 128436,MK-538,Ponalrestat

     Statil (ICI 128436) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Statil Chemical Structure
  23. GC37812 Tolrestat

    AY 27773

     Tolrestat is a potent, orally active aldose reductase inhibitor with IC50 of 35 nM. Tolrestat Chemical Structure
  24. GC63990 Zenarestat Zenarestat is a potent and orally active aldose reductase inhibitor. Zenarestat Chemical Structure

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