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Home >> Signaling Pathways >> Others >> BCRP

BCRP

BCRP(breast cancer resistance protein), also called ABCG2 (ATP-binding cassette subfamily G member 2) is expressed in MDR (multi-drug resistance) diverse cancer cells. It protects cell from toxic xenobiotic substance in intestine, biliary tract, placenta, blood-testis barrier and blood-brain barriers.

Products for  BCRP

  1. Cat.No. Product Name Information
  2. GC68596 Ac32Az19

    Ac32Az19 is an effective, non-toxic, and highly selective BCRP inhibitor with an EC50 value of 13 nM in HEK293/R2 cells overexpressing BCRP.

     Ac32Az19 Chemical Structure
  3. GC33099 BCRP-IN-1 BCRP-IN-1 is a breast cancer resistance protein (BCRP) inhibitor with an IC50 of 0.6 μM on BCRP efflux transporter. BCRP-IN-1 Chemical Structure
  4. GC69042 Efflux inhibitor-1

    Efflux inhibitor-1 (compound 2) is a pyrazolo[1,5-a]pyrimidine efflux inhibitor. Efflux inhibitor-1 selectively targets ABCG2 over ABCB1 with IC50 values of 0.45 μM and 2.17 μM, respectively.

     Efflux inhibitor-1 Chemical Structure
  5. GC17215 Elacridar

    GF120918, GG918, GW0918

     An inhibitor of MRP-1 and BCRP Elacridar Chemical Structure
  6. GC36034 FD 12-9

    Ac12Az9

     FD 12-9 is a flavonoid dimer, acts as a dual inhibitor of P-gp and BCRP, with EC50s of 285 nM and 0.9 nM, respectively. Anti-glioblastoma activity. FD 12-9 Chemical Structure
  7. GC10874 Fumitremorgin C

    Tryptoquivaline

     multidrug transporter inhibitor Fumitremorgin C Chemical Structure
  8. GC12711 Ko 143 Ko 143 is a potent and selective inhibitor of breast cancer resistance protein (BCRP; ABCG2) with an IC50 value of 23nM. Ko 143 Chemical Structure
  9. GC14688 KS 176 inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter KS 176 Chemical Structure
  10. GC38129 ML753286

    ML753286 is an orally active and selective BCRP (Breast cancer resistance protein) inhibitor with an IC50 of 0.6 μM. ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions, and is stable in plasma cross species.

     ML753286 Chemical Structure
  11. GC70762 Triclabendazole sulfoxide Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide Chemical Structure
  12. GC18163 YHO-13177

    A potent and specific inhibitor of BCRP

     YHO-13177 Chemical Structure
  13. GC32114 YHO-13351 YHO-13351 is the prodrug of YHO-13177, which is a potent and specific inhibitor of BCRP. YHO-13351 Chemical Structure
  14. GC33056 YHO-13351 free base YHO-13351 free base is the prodrug of YHO-13177, which is a potent and specific inhibitor of BCRP. YHO-13351 free base Chemical Structure
  15. GC32593 Zamicastat (BIA 5-1058)

    BIA 5-1058

     Zamicastat (BIA 5-1058) (BIA 5-1058) is a dopamine β-hydroxylase (DBH) inhibitor and can cross the blood-brain barrier (BBB) to cause central as well as peripheral effects. Zamicastat (BIA 5-1058) Chemical Structure

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