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Home >> Signaling Pathways >> Others >> Carbonic Anhydrase

Carbonic Anhydrase

Carbonic anhydrases (CAs) are a family of zinc containing metalloproteins that catalyze the reversible conversion of carbon dioxide (CO2) to bicarbonate with the releasing of a proton.  Being encoded by three distinct and evolutionarily unrelated gene families, CA enzymes are divided into three subfamilies, α-CAs (in vertebrates, eubacteria, algae and cytoplasm of green plants), β-CAs (in eubacteria, algae and chloroplasts of both mono- and di-cotyledons) and γ-CAs (in Archaea and some eubacteria). Through extensive studies, fourteen different CA isozymes have been identified in mammals, including four cytosolic isozymes (CA I-III and CA VII), four membrane-bound isozymes (CA IV, CA IX, CA XII and CA XIV), one mitochondrial isozyme (CA V) and one secreted isozyme (CA VI).

Products for  Carbonic Anhydrase

  1. Cat.No. Product Name Information
  2. GC34186 2-Aminobenzenesulfonamide (Orthanilamide) 2-Aminobenzenesulfonamide (Orthanilamide) is a carbonic anhydrase IX inhibitor. 2-Aminobenzenesulfonamide (Orthanilamide) Chemical Structure
  3. GC20095 5,7-Dihydroxy-4-methylcoumarin

    NSC 5302

    5,7-Dihydroxy-4-methylcoumarin is a coumarin derivative from Mexican tarragon. 5,7-Dihydroxy-4-methylcoumarin possesses antifungal and antibacterial activities.

     5,7-Dihydroxy-4-methylcoumarin Chemical Structure
  4. GC11567 Acetazolamide

    L-579,486, NSC 145177

    carbonic anhydrase (CA) inhibitor

     Acetazolamide Chemical Structure
  5. GC33491 Acetazolamide D3 Acetazolamide D3 is deuterium labeled Acetazolamide, which is a potent carbonic anhydrase (CA) inhibitor. Acetazolamide D3 Chemical Structure
  6. GC65612 Acetazolamide sodium Acetazolamide sodium is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Acetazolamide sodium has diuretic, antihypertensive and anti-gonococcal activities. Acetazolamide sodium Chemical Structure
  7. GC64734 Benzenesulphonamide Benzenesulphonamide (compound 1) is a potent carbonic anhydrase inhibitor. Benzenesulphonamide shows CA II inhibitory activity. Benzenesulphonamide Chemical Structure
  8. GC32634 Benzthiazide Benzthiazide is a long-acting diuretic and a hypertension agent. Benzthiazide Chemical Structure
  9. GC71502 CA/MAO-B-IN-1 CA/MAO-B-IN-1 (Compound 78) is a dual inhibitor for human brain carbonic anhydrases (CA) and Monoamine Oxidase-B (MAO-B), with IC50s of 8.8 and 7.0 nM, respectively. CA/MAO-B-IN-1 Chemical Structure
  10. GC71498 Carbonic anhydrase inhibitor 16 Carbonic anhydrase inhibitor 16 (compound 1) is a dengue protease inhibitor with inhibitory activity against carbonic anhydrase hCA I and hCA II (Ki: 28.5 nM, 2.2 nM). Carbonic anhydrase inhibitor 16 Chemical Structure
  11. GC68830 Carbonic anhydrase inhibitor 2

    Carbonic anhydrase inhibitor 2 (compound 7c) is a carbonic anhydrase II inhibitor that can reduce intraocular pressure in rabbits with glaucoma.

     Carbonic anhydrase inhibitor 2 Chemical Structure
  12. GC17454 Dichlorphenamide

    Diclofenamide

     Carbonic anhydrase inhibitor Dichlorphenamide Chemical Structure
  13. GC13932 Dorzolamide Carbonic anhydrase inhibitor Dorzolamide Chemical Structure
  14. GC47267 Dorzolamide-d5 (hydrochloride)

    L-671,152-d5, MK-507-d5

     A neuropeptide with diverse biological activities Dorzolamide-d5 (hydrochloride) Chemical Structure
  15. GC73371 Enpp/Carbonic anhydrase-IN-2 Enpp/Carbonic andrase-IN-2 (compound 1i) is a potent Enpp and carbonic andrase inhibitor with IC50s of 1.13, 1.07, 0.74, 0.33, 0.68 for NPP1, NPP2, NPP3, CA-IX, CA-XII respectively. Enpp/Carbonic anhydrase-IN-2 Chemical Structure
  16. GC31710 Ethoxzolamide (Redupresin) Ethoxzolamide (Redupresin) is a carbonic anhydrase inhibitor with Ki of 1 nM. Ethoxzolamide (Redupresin) Chemical Structure
  17. GC66360 Girentuximab

    G250; cG250

     Girentuximab (G250) is a chimeric monoclonal antibody that binds carbonic anhydrase IX (CAIX), a cell surface glycoprotein ubiquitously expressed in clear cell renal cell carcinoma (ccRCC). Girentuximab Chemical Structure
  18. GC73573 hCA/Wnt/β-catenin-IN-1

    hCA/Wnt/β-catenin-IN-1 (Compd 15) is an inhibitor of hCA (Ki: 33.6, 24.1, 6.8 nM for hCA II, hCA IX, hCA XII). hCA/Wnt/β-catenin-IN-1 reduces P-gp activity.

     hCA/Wnt/β-catenin-IN-1 Chemical Structure
  19. GC66029 hCAI/II-IN-6 hCAI/II-IN-6 is an orally active human carbonic anhydrase (CA) inhibitor. hCAI/II-IN-6 selectively inhibits hCA II and hCA VII isoforms with Ki values of 220, 4.9, 6.5 and ＞50000 nM for hCA I, hCA II , hCA VII and hCA XII respectively. hCAI/II-IN-6 shows anticonvulsant activity and anti maximal electroshock (MES) activity in vivo. hCAI/II-IN-6 can be used for the research of epilepsy. hCAI/II-IN-6 Chemical Structure
  20. GC69209 hCAII-IN-8

    hCAII-IN-8 is an amide and a highly selective inhibitor of carbonic anhydrase (CA), with an IC50 value of 0.18 μM against hCA II.

     hCAII-IN-8 Chemical Structure
  21. GC73227 hCAIX-IN-18

    hCAIX-IN-18 (compound 30) is an inhibitor of carbonic andrase (CA), with Kis of 3.5 nM, 9.4 nM, 43.0 nM and 8.2 nM for hCAI, hCAII, hCAIX, hCAXII, respectively.

     hCAIX-IN-18 Chemical Structure
  22. GC65549 Indisulam

    E-7070

     Indisulam (E 7070) is a carbonic anhydrase inhibitor with anticancer activity. Indisulam (E 7070) is a sulfonamide agent that targets the G1 phase of the cell cycle. Indisulam (E 7070) causes a blockade in the G1/S transition through inhibition of the activation of both CDK2 and cyclin E. Indisulam (E 7070) targets splicing by inducing RBM39 degradation via recruitment to DCAF15. Indisulam Chemical Structure
  23. GC91667 NSC 44625

    Bendroflumethiazide Impurity A,2,4-Disulfamyl-5-trifluoromethylaniline

     NSC 44625 is an inhibitor of carbonic anhydrase II (CAII; Ki = 63 nM for the human enzyme). NSC 44625 Chemical Structure
  24. GC91296 p-Carboxyphenyl Sulfate

    A sulfated phenolic acid

     p-Carboxyphenyl Sulfate Chemical Structure
  25. GC30899 Sultiame

    Sultiame

    Sultiame is a carbonic anhydrase inhibitor, widely used as an antiepileptic drug.

     Sultiame Chemical Structure

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