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Home >> Signaling Pathways >> Others >> COMT

COMT

COMT (catechol-O-methyltransferase) is one of several enzymes that degrade catecholamines such as dopamine, epinephrine, and norepinephrine.

Products for  COMT

  1. Cat.No. Product Name Information
  2. GC66369 3-O-Methyltolcapone D7

    Ro 40-7591 D7

     3-O-Methyltolcapone D7 (Ro 40-7591 D7) is a deuterium labeled 3-O-Methyltolcapone. 3-O-Methyltolcapone is a metabolite of Tolcapone. Tolcapone is an orally active, reversible, selective and potent COMT inhibitor. Tolcapone crosses the blood-brain barrier, and can be used for treatment of Parkinson's disease. 3-O-Methyltolcapone D7 Chemical Structure
  3. GC62809 5-Hydroxyferulic acid 5-Hydroxyferulic acid is a hydroxycinnamic acid and is a metabolite of the phenylpropanoid pathway. 5-Hydroxyferulic acid Chemical Structure
  4. GC17334 Entacapone

    OR-611

     Entacapone is a potent, reversible, peripherally acting and orally active inhibitor of catechol-O-methyltransferase (COMT), which effectively inhibits rat liver total COMT with IC50 and Ki values of 20.1nM and 10.7nM, respectively. Entacapone Chemical Structure
  5. GC18091 Entacapone sodium salt COMT inhibitor Entacapone sodium salt Chemical Structure
  6. GC12535 Flopropione 5-HT receptor antagonist Flopropione Chemical Structure
  7. GC71152 hMAO-B/MB-COMT-IN-1 hMAO-B/MB-COMT-IN-1 is a dual MAO-B/MB-COMT inhibitor (IC50s: 2.5 μΜ for hMAO-B, 3.84 μΜ for MB-COMT). hMAO-B/MB-COMT-IN-1 Chemical Structure
  8. GC65175 Nebicapone

    BIA 3-202

     Nebicapone (BIA 3-202), a reversible catechol-O-methyltransferase (COMT) inhibitor, is mainly metabolized by glucuronidation. Nebicapone Chemical Structure
  9. GC14223 Nitecapone

    OR-462

     S-COMT inhibitor Nitecapone Chemical Structure
  10. GC36811 Opicapone

    BIA 9-1067

     A COMT inhibitor Opicapone Chemical Structure
  11. GC14843 Serotonin HCl

    5-HT, 5-Hydroxytryptamine

    Serotonin HCl a neurotransmitter, is a key messenger that mediates several central and peripheral functions in the human body.

     Serotonin HCl Chemical Structure
  12. GC17921 Tolcapone

    Ro 40-7592

     A reversible COMT inhibitor Tolcapone Chemical Structure

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