Search Site
  • 0
    My Cart

    Click Here to Find How Many Items You Have Added:)

    image loader

    Adding item(s) to cart......

Home >> Signaling Pathways >> Others >> Estrogen Receptor/ERR

Estrogen Receptor/ERR

Estrogen receptors are a group of proteins found inside cells. They are receptors that are activated by the hormone estrogen (17β-estradiol). Two classes of estrogen receptor exist: ER, which is a member of the nuclear hormone family of intracellular receptors, and GPER (GPR30), which is a member of the rhodopsin-like family of G protein-coupled receptors. The ER's helix 12 domain plays a crucial role in determining interactions with coactivators and corepressors and, therefore, the respective agonist or antagonist effect of the ligand. Different ligands may differ in their affinity for alpha and beta isoforms of the estrogen receptor: estradiol binds equally well to both receptors, estrone, and raloxifene bind preferentially to the alpha receptor, estriol, and genistein to the beta receptor. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.

Targets for  Estrogen Receptor/ERR

Products for  Estrogen Receptor/ERR

  1. Cat.No. Product Name Information
  2. GC11282 β-Estradiol

    β-Estradiol, Estradiol, 17β-Oestradiol, E2

    Sex hormone

     β-Estradiol Chemical Structure
  3. GC40753 α-Zearalanol

    MK-188, (-)-α-Zearalanol

     α-Zearalenol (α-zol) is a Mycotoxin with high affinity for the estrogen receptors (ER), α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects. α-Zearalanol Chemical Structure
  4. GC38008 β-Zearalenol

    β-trans-Zearalenol, (-)-β-Zearalenol

     A hepatic metabolite of zearalenone β-Zearalenol Chemical Structure
  5. GC45968 (±)-Liquiritigenin A flavonoid with anticancer activity (±)-Liquiritigenin Chemical Structure
  6. GC34962 (±)-Medicarpin (±)-Medicarpin, a pterocarpan, is a type of isoflavonoid isolated from several medicinal plant species with various biological effects, including Sophora japonica, Zollernia paraensis and Platymiscium yucatamun, Machaerium aristulatum, Platymiscium floribundum, and so on. (±)-Medicarpin potently inhibits osteoclastogenesis and promotes bone healing and increases bone mass by osteoblast differentiation with estrogen receptor (ER) β-mediated osteogenic action. (±)-Medicarpin Chemical Structure
  7. GC65885 (1S,3R)-GNE-502 (1S,3R)-GNE-502 (compound 179) is a potent ERα degrader with an EC50 value of 13 nM against ERα in MCF7 HCS. (1S,3R)-GNE-502 can be used to research cancer related with estrogen receptor. (1S,3R)-GNE-502 Chemical Structure
  8. GC34965 (20S)-Protopanaxatriol

    20(S)-APPT, 20(S)-PPT

     An active ginsenoside metabolite (20S)-Protopanaxatriol Chemical Structure
  9. GC34978 (E)-4-Hydroxytamoxifen (E)-4-Hydroxytamoxifen ((E)-Afimoxifene), the less active isomer of (Z)-4-hydroxytamoxifen, is an estrogen receptor modulator. (E)-4-Hydroxytamoxifen Chemical Structure
  10. GC39747 (E/Z)-GSK5182 (E/Z)-GSK5182 is a racemic compound of (E)-GSK5182 and (Z)-GSK5182 isomers. (E/Z)-GSK5182 Chemical Structure
  11. GC40643 (R)-Equol

    (+)-Equol, Isoequol

     Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzein by human intestinal microflora. (R)-Equol Chemical Structure
  12. GC61488 (Rac)-Acolbifene

    EM-343; (Rac)-EM-652

     (Rac)-Acolbifene (EM-343; (Rac)-EM-652) is the racemic form of EM652 (estrogen receptor?antagonist), has anti-estrogenic and estrogenic activities. (Rac)-Acolbifene (EM-343; (Rac)-EM-652) contains a piperidine ring, shows good pharmacological profile,relative binding affinity (RBA)=380. (Rac)-Acolbifene Chemical Structure
  13. GC38542 10β,17β-dihydroxyestra-1,4-dien-3-one

    DHED

     10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-targeting bioprecursor prodrug of the main human estrogen, 17β-estradiol, alleviates hot flushes in rat models of thermoregulatory dysfunction of the brain. 10β,17β-dihydroxyestra-1,4-dien-3-one Chemical Structure
  14. GC13887 25(R)-27-hydroxy Cholesterol

    (25R)-26-hydroxy cholesterol

     25(R)-27-hydroxy Cholesterol is a selective estrogen receptor modulator and an agonist of the liver X receptor. 25(R)-27-hydroxy Cholesterol Chemical Structure
  15. GC68533 3'-Hydroxymirificin

    3'-Hydroxymirificin (compound 3) is a natural product that can be obtained from the roots of Pueraria lobata. It has estrogenic and anti-proliferative activity against MCF-7 human breast cancer cells.

     3'-Hydroxymirificin Chemical Structure
  16. GC17803 4-Hydroxytamoxifen

    Afimoxifene, 4-OHT

     4-hydroxytamoxifen is a major metabolite of tamoxifen and selective estrogen receptor antagonist. 4-Hydroxytamoxifen Chemical Structure
  17. GC68553 4-Nonylphenol-d5

    4-n-Nonylphenol-2,3,5,6-d4,OD

    4-Nonylphenol-d5 is the deuterated form of 4-nonylphenol. 4-nonylphenol is the main degradation product of nonylphenol ethoxylates (NPEOs), a persistent organic pollutant with endocrine disrupting properties and estrogenic activity.

     4-Nonylphenol-d5 Chemical Structure
  18. GC18362 Acolbifene

    SCH 57068

     Acolbifene is a selective estrogen receptor modulator (SERM). Acolbifene Chemical Structure
  19. GC61514 Acolbifene hydrochloride

    EM-652 hydrochloride; SCH 57068 hydrochloride

     Acolbifene (EM-652) hydrochloride, an active metabolite of EM800, is an orally active, cancer-preventing selective estrogen receptor modulator (SERM). Acolbifene (EM-652) hydrochloride inhibits estradiol (E2)-induced transcriptional activity of ERα (IC50=2 nM) and ERβ (IC50=0.4 nM). Acolbifene (EM-652) hydrochloride exerts a potent and pure antiestrogenic action in the mammary gland and uterus. Anticarcinogenic properties. Acolbifene hydrochloride Chemical Structure
  20. GC62723 ARV-471

    ARV-471

     ARV-471 is an orally bioavailable estrogen receptor-targeted (ER-targeted) PROTAC for the treatment of patients with locally advanced or metastatic ER+/HER2- breast cancer. ARV-471 Chemical Structure
  21. GC33381 Arzoxifene hydrochloride (LY 353381 HCl) Arzoxifene (LY353381) hydrocloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen agonist to maintain bone density and lower serum cholesterol. Arzoxifene hydrochloride (LY 353381 HCl) Chemical Structure
  22. GC73046 AZ'6421 AZ'6421 acts as Protcolysis Targeting Chimera (PROTAC) to selectively degrade estrogen receptor alpha. AZ'6421 Chemical Structure
  23. GC14405 AZD9496 estrogen receptor inhibitor, orally active AZD9496 Chemical Structure
  24. GC35450 AZD9496 maleate AZD9496 maleate is a potent and selective estrogen receptor (ERα) antagonist with IC50 of 0.28 nM. AZD9496 maleate is an orally bioavailable selective oestrogen receptor degrader (SERD). AZD9496 maleate Chemical Structure
  25. GC17588 Bavachin

    Corylifolin

     estrogen receptors ERα and ERβ activator Bavachin Chemical Structure
  26. GC14883 Bazedoxifene Bazedoxifene Chemical Structure
  27. GC10852 Bazedoxifene acetate

    TSE 424

     A selective estrogen receptor modulator Bazedoxifene acetate Chemical Structure
  28. GC33011 BHPI An ERα antagonist BHPI Chemical Structure
  29. GC72696 Bisphenol AF-d4 Bisphenol AF-d4 is the isotope labelled analog of Bisphenol AF . Bisphenol AF-d4 Chemical Structure
  30. GC32782 Brilanestrant (ARN-810)

    GDC-0810, RG-6046

     Brilanestrant (ARN-810) (ARN-810; GDC-0810) is an orally bioavailable selective estrogen receptor degrader (SERD) with IC50 of 0.7 nM. Brilanestrant (ARN-810) Chemical Structure
  31. GC17398 Cholesterol

    NSC 8798, Provitamin D

    Major sterol in mammals

     Cholesterol Chemical Structure
  32. GC64477 Cholesterol-13C2 Cholesterol-13C2 is the 13C labeled Cholesterol. Cholesterol-13C2 Chemical Structure
  33. GC63843 Cholesterol-13C3 Cholesterol-13C3 Chemical Structure
  34. GC64334 Cholesterol-13C5 Cholesterol-13C5 Chemical Structure
  35. GC68864 Cholesterol-d4

    Cholesterol-d4 is the deuterated form of cholesterol. Cholesterol is a major sterol in mammals, comprising 20-25% of membrane structural components. The membrane has high permeability to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of transport proteins and signaling proteins. Cholesterol is also an endogenous estrogen-related receptor alpha (ERRα) agonist.

     Cholesterol-d4 Chemical Structure
  36. GN10028 Chrysin

    5,7-DHF, 5,7-Dihydroxyflavone, NSC 407436

     Chrysin Chemical Structure
  37. GC73261 CIDD-0149897 CIDD-0149897 is a potent, selective and brain-penetrant ERβ agonist. CIDD-0149897 Chemical Structure
  38. GC70175 citrate

    Zuclomiphene-d4 (citrate) is the deuterated form of Zuclomiphene citrate. Zuclomiphene citrate has anti-estrogenic effects and is more effective than its trans-isomer in inhibiting the secretion of luteinizing hormone (LH). It is also an orally active cholesterol-lowering agent.

     citrate Chemical Structure
  39. GC15366 Clomiphene citrate

    Clomifene, Omifin, NSC 35770

     Selective estrogen receptor modulator Clomiphene citrate Chemical Structure
  40. GC10002 Coumestrol

    NSC 22842

     competitive binder of the estrogen receptors ERα Coumestrol Chemical Structure
  41. GC17688 Diarylpropionitrile(DPN)

    diarylpropionitrile

     Diarylpropionitrile(DPN) (Diarylpropionitrile) is a non-steroidal estrogen receptor β (ERβ) selective ligand, with an EC50 of 0.85 nM. Diarylpropionitrile(DPN) Chemical Structure
  42. GC31008 Dienestrol

    Dienestrol is a synthetic, non-steroidal estrogen, is an estrogen receptor agonist, for the treatment of menopausal and postmenopausal symptoms.

     Dienestrol Chemical Structure
  43. GC11215 Diethylstilbestrol synthetic nonsteroidal estrogen Diethylstilbestrol Chemical Structure
  44. GC38098 Dihydroresveratrol

    3,4',5-Trihydroxybibenzyl, α,β-Dihydro-3,4',5-trihydroxystilbene

     Dihydroresveratrol, a potent phytoestrogen, is a hormone receptor modulator. Dihydroresveratrol exhibits proliferative effects in androgen-independent prostate and breast cancer cells at picomolar and nanomolar concentrations. Dihydroresveratrol Chemical Structure
  45. GC63988 DK1 DK1 is a potent modulator of estrogen related receptor. DK1 Chemical Structure
  46. GC63989 DK3 DK3 is a potent and selective estrogen-related receptor alpha (ERRα) agonist. DK3 Chemical Structure
  47. GC39707 Droloxifene

    FK-435, 3-Hydroxytamoxifen, K-060-E

     A selective estrogen receptor modulator Droloxifene Chemical Structure
  48. GC64652 DS20362725 DS20362725 is an estrogen-related receptor α (ERRα) agonist. DS20362725 Chemical Structure
  49. GC64533 DS45500853 DS45500853 is an estrogen-related receptor α (ERRα) agonist. DS45500853 Chemical Structure
  50. GC10394 DY131

    GSK 9089;DY-131;DY 131;GSK9089;GSK-9089

     An ERRβ/γ agonist DY131 Chemical Structure
  51. GC33349 E3 ligase Ligand 5 E3 ligase Ligand 5 is an estrogen-related receptor α (ERRα) antagonist with IC50s of 0.04 and 2.8 μM for ERRα and ERRγ, respectively. E3 ligase Ligand 5 Chemical Structure
  52. GC33025 Elacestrant (RAD1901)

    RAD1901

     Elacestrant (RAD1901) (RAD1901) is an orally available selective estrogen receptor degrader (SERD) with IC50s of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant (RAD1901) Chemical Structure
  53. GC62379 Elacestrant (S enantiomer)

    RAD1901 S enantiomer

     Elacestrant S enantiomer (RAD1901 S enantiomer) is an low activity enantiomer of elacestrant. Elacestrant (RAD1901) is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant (S enantiomer) Chemical Structure
  54. GC32696 Elacestrant dihydrochloride (RAD1901 dihydrochloride)

    RAD1901 dihydrochloride

     Elacestrant dihydrochloride (RAD1901 dihydrochloride) (RAD1901 dihydrochloride) is an orally available selective estrogen receptor degrader (SERD) with IC50s of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant dihydrochloride (RAD1901 dihydrochloride) Chemical Structure
  55. GC34293 Elacestrant S enantiomer (RAD1901 S enantiomer) Elacestrant S enantiomer (RAD1901 S enantiomer) Chemical Structure
  56. GC34294 Elacestrant S enantiomer dihydrochloride (RAD1901 S enantiomer dihydrochloride) Elacestrant S enantiomer dihydrochloride (RAD1901 S enantiomer dihydrochloride) Chemical Structure
  57. GC35985 Enclomiphene citrate

    trans-Clomiphene

     Enclomiphene ((E)-Clomiphene) citrate is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene citrate Chemical Structure
  58. GC60806 Enclomiphene D4 hydrochloride

    (E)-Clomiphene D4 hydrochloride; trans-Clomiphene D4 hydrochloride; Enclomifene D4 hydrochloride

     Enclomiphene D4 hydrochloride ((E)-Clomiphene D4 hydrochloride; trans-Clomiphene D4 hydrochloride; Enclomifene D4 hydrochloride)?is a deuterium labeled Enclomiphene. Enclomiphene D4 hydrochloride Chemical Structure
  59. GC12140 Endoxifen Endoxifen Z-isomer is the most important Tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha (ERα). Endoxifen Chemical Structure
  60. GC35988 Endoxifen E-isomer Endoxifen E-isomer (E-Endoxifen), an E-isomer of Endoxifen, is an impurity in Endoxifen Z-isomer drug substance. Endoxifen E-isomer exhibits antiestrogenic effects. Endoxifen E-isomer Chemical Structure
  61. GC35989 Endoxifen E-isomer hydrochloride

    E-Endoxifen hydrochloride

     Endoxifen E-isomer hydrochloride (E-Endoxifen hydrochloride), an E-isomer of Endoxifen, is an impurity in Endoxifen Z-isomer drug substance. Endoxifen E-isomer hydrochloride exhibits antiestrogenic effects. Endoxifen E-isomer hydrochloride Chemical Structure
  62. GC35990 Endoxifen hydrochloride Endoxifen hydrochloride is a key active metabolite of Tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen hydrochloride has the potential for breast cancer study. Endoxifen hydrochloride Chemical Structure
  63. GC35991 Endoxifen Z-isomer hydrochloride Endoxifen Z-isomer hydrochloride is the most important Tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha (ERα). Endoxifen Z-isomer hydrochloride Chemical Structure
  64. GC34006 Equilin (7-Dehydroestrone) Equilin (7-Dehydroestrone) (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone). Equilin (7-Dehydroestrone) Chemical Structure
  65. GC16292 Equol non-steroidal estrogen Equol Chemical Structure
  66. GC67927 ERα degrader-2 ERα degrader-2 Chemical Structure
  67. GC10389 ERB 041 ERB 041 (ERB-041) is a potent and selective estrogen receptor (ER) β agonist with IC50s of 5.4, 3.1 and 3.7 nM for human, rat and mouse ERβ, respectively. ERB 041 displays >200-fold selectivity for ERβ over ERα. ERB 041 is a potent skin cancer chemopreventive agent that acts by dampening the WNT/β-catenin signaling pathway. ERB 041 induces ovarian cancer apoptosis. ERB 041 Chemical Structure
  68. GC30650 ERB-196 (WAY-202196)

    WAY-202196

     ERB-196 (WAY-202196) is a nonsteroidal selective estrogen receptor-β (ERβ) agonist. ERB-196 (WAY-202196) Chemical Structure
  69. GC36001 ERD-308 ERD-308 is a highly potent von Hippel-Lindau-based PROTAC degrader of estrogen receptor (ER) for ER positive breast cancer treatment. ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines (DC50 (concentration causing 50% of protein degradation) of 0.17 nM and 0.43 nM in MCF-7 and T47D ER+ cells, respectively). ERD-308 Chemical Structure
  70. GC38777 ERRα antagonist-1 ERRα antagonist-1 (Compound A) is a selective and high affinity estrogen-related receptor α (ERRα) antagonist. ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC50 values are 170 nM and 180 nM, respectively. ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1. ERRα antagonist-1 Chemical Structure
  71. GC70943 ERRγ agonist-1 ERRγ agonist-1 is a potent ERRγ agonist. ERRγ agonist-1 Chemical Structure
  72. GC11822 Erteberel (LY500307)

    LY500307

     Erteberel (LY500307) (LY500307) is a potent and selective estrogen receptor beta (ERβ) agonist with Ki and EC50 of 1.54 nM and 3.61 nM, respectively. Erteberel (LY500307) Chemical Structure
  73. GC19478 Estetrol

    E4 15α-Hydroxyestriol

    An estrogen steroid hormone

     Estetrol Chemical Structure
  74. GC15245 Estradiol Benzoate

    β-Estradiol Benzoate, 17β-Estradiol 3-Benzoate, 17β-Oestradiol Benzoate, E2 Benzoate

     Estradiol Benzoate is a HBx protein inhibitor and inhibits androgen and hepatitis B virus (HBV) transcription, replication. Estradiol Benzoate shows antifertility effects, anti- Toxoplasma gondii activity and can improve memory behavior of Ovariectomy (Ovx) female mice. Estradiol Benzoate Chemical Structure
  75. GC69084 Estradiol benzoate-d3

    β-Estradiol 3-benzoate-d3; 17β-Estradiol 3-benzoate-d3

    Estradiol benzoate-d3 is the deuterated form of estradiol benzoate. Estradiol Benzoate (β-Estradiol 3-benzoate) is a precursor active molecule of estradiol, which is a type of steroid hormone. Estradiol Benzoate exhibits slight synthetic metabolic properties and increases blood clotting.

     Estradiol benzoate-d3 Chemical Structure
  76. GC10139 Estradiol Cypionate

    Estradiol 17β-Cyclopentanepropionate, Estradiol 17-Cypionate, NSC 3354

     Estrogen receptor inhibitor Estradiol Cypionate Chemical Structure
  77. GC60815 Estradiol dipropionate Estradiol dipropionate is a combined estrogen-progesterone, acts as an estrogen and progesterone agonist. Estradiol dipropionate Chemical Structure
  78. GC66878 Estradiol enanthate Estradiol enanthate is a shorter-acting estrogen. The combination of Estradiol enanthate and dihydroxyprogesterone acetophenide can be used as a monthly injectable contraceptive. Estradiol enanthate Chemical Structure
  79. GC11796 Estradiol valerate

    Estradiol 17β-valerate, NSC 17590

     Estradiol valerate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy drugs. Estradiol valerate Chemical Structure
  80. GC63643 Estradiol-d4 Estradiol-d4 (β-Estradiol-d4) is the deuterium labeled Estradiol. Estradiol-d4 Chemical Structure
  81. GC12182 Estriol

    E3, 16α-hydroxy-17β-Estradiol, 1,3,5(10)-Estratriene-3,16α,17β-triol

     Estrogen receptor antagonist Estriol Chemical Structure
  82. GC60816 Estrogen receptor modulator 1 Estrogen receptor modulator 1 (compound 18) is an orally active and selective estrogen receptor modulator (SERM), with a pIC50 of 0.46. Estrogen receptor modulator 1 induces regression of Tamoxifen-resistant, hormone independent xenograft tumors. Estrogen receptor modulator 1 Chemical Structure
  83. GC14385 Estrone

    E1

     Estrone is one of the three major endogenous estrogens, the others being estradiol and estriol. Estrone Chemical Structure
  84. GC64437 Estrone-d4 Estrone-d4 Chemical Structure
  85. GC16852 Estropipate

    Piperazine Estrone Sulfate

     Estrogen receptor agonist Estropipate Chemical Structure
  86. GC12148 Ethinyl Estradiol

    Ethynyl βEstradiol, Ethynyl 17βEstradiol, Ethynyl 17βOestradiol, Ethynyl E2

     Ethinyl Estradiol (17α-Ethynylestradiol;Ethynylestradiol) is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills. Ethinyl Estradiol Chemical Structure
  87. GC62484 FLTX1 FLTX1 is a fluorescent Tamoxifen derivative that can specifically label intracellular Tamoxifen-binding sites (estrogen receptors) under permeabilized and non-permeabilized conditions. FLTX1 exhibits the potent antiestrogenic properties of Tamoxifen in breast cancer cells. FLTX1 is devoid of the estrogenic agonistic effect on the uterus. FLTX1 Chemical Structure
  88. GC69133 FSHR agonist 1

    FSHR agonist 1 is a high-affinity and allosteric follicle-stimulating hormone receptor (FSHR) agonist with a pEC50 of 7.72. FSHR agonist 1 interacts extensively with the transmembrane domain to directly activate FSHR.

     FSHR agonist 1 Chemical Structure
  89. GC18000 Fulvestrant (ICI 182,780)

    ICI 182780

     Fulvestrant is a selective estrogen receptor (ER) antagonist. It binds, blocks and degrades estrogen receptor, then inhibits estrogen receptor(ER)-mediated transcriptional activity with an IC50 of 9.4 nM . Fulvestrant (ICI 182,780) Chemical Structure
  90. GC73961 Fumagilin-105 Fumagilin-105 is an autophagy targeting chimera (AUTOTAC) that induces p62 self-oligomerization with DC50 values of 0.7 μM for MetAP2 in HEK293 cells. Fumagilin-105 Chemical Structure
  91. GC12766 G-1 G-1 is a selective and potent agonist of GPR30 with EC50 value about 2 nM. G-1 Chemical Structure
  92. GC16618 G-15

    A GPER receptor antagonist

     G-15 Chemical Structure
  93. GC32920 GDC-0927 (SRN-927)

    SRN-927

     GDC-0927 (SRN-927) (SRN-927) is a potent, non-steroidal, orally bioavailable, selective estrogen receptor antagonist. GDC-0927 (SRN-927) Chemical Structure
  94. GC33193 GDC-0927 Racemate (SRN-927 Racemate)

    SRN-927 Racemate

     GDC-0927 Racemate (SRN-927 Racemate) (SRN-927 Racemate) is a degrader of estrogen receptor, potently inhibits ER-α activity, with an IC50 of 0.2 nM, and is used in the research of ER-related diseases. GDC-0927 Racemate (SRN-927 Racemate) Chemical Structure
  95. GC31746 Gestrinone (R 2323) An androgen and progesterone receptor ligand used to treat endometriosis Gestrinone (R 2323) Chemical Structure
  96. GC65609 Glicoricone Glicoricone, a phenolic compound, is isolated from a species of licorice. Glicoricone Chemical Structure
  97. GC69182 GNE-149

    GNE-149 is an effective and orally active estrogen receptor alpha (ERα; IC50=0.053 nM) antagonist. It is also a selective estrogen receptor degrader (SERD). GNE-149 can be used for research on breast cancer.

     GNE-149 Chemical Structure
  98. GC65606 GNE-274 GNE-274 is a non-degrader that is structurally related to GDC-0927 (ER degrader). GNE-274 does not induce ER turnover and functions as a partial ER agonist in breast cancer cell lines.?GNE-274 increase chromatin accessibility at ER-DNA binding sites, while GDC-0927 do not. GNE-274 is a potent inhibitor of ER-ligand binding domain (LBD). GNE-274 can be used for cancer research. GNE-274 Chemical Structure
  99. GC65590 GNE-502 GNE-502 is an orally active and potent degrader for estrogen receptor (ER). GNE-502 can be used for the research of breast cancer. GNE-502 Chemical Structure
  100. GC61817 GPR30 agonist-1 GPR30 agonist-1 is a G protein-coupled receptor 30 (GPR30) agonist. GPR30 agonist-1 Chemical Structure
  101. GC10558 GSK 4716 estrogen-related receptors ERRβ and ERRγ agonist GSK 4716 Chemical Structure

Items 1 to 100 of 169 total

per page
  1. 1
  2. 2

Set Descending Direction