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Home >> Signaling Pathways >> Others >> Glucosidase

Glucosidase

Glucosidases are glycoside hydrolase enzymes.

α-glucosidase is a glucosidase located in the brush border of the small intestine that acts upon α(1→4) bonds. α-Glucosidase inhibitor is a new type of antidiabetics. By reducing the postprandial blood sugar concentration, it can effectively control the blood sugar levels, thereby reducing the occurrence of diabetic complications.

β-glucosidase catalyzes the hydrolysis of the glycosidic bonds to terminal non-reducing residues in β-D-glucosides and oligosaccharides, with release of glucose. β-Glucosidase has attracted substantial attention in the scientific community because of its pivotal role in cellulose degradation, glycoside transformation and many other industrial processes. β-glucosidases catalyze the final step of cellulose hydrolysis and are essential in cellulose degradation.

Products for  Glucosidase

  1. Cat.No. Product Name Information
  2. GC70181 α-Glucosidase-IN-22

    Alpha-glucosidase-IN-22 (compound 7i) is a benzimidazole, an effective inhibitor of alpha-glucosidase with an IC50 of 0.64 μM. Alpha-glucosidase-IN-22 is an effective anti-diabetic active molecule with potential for use in type 2 diabetes (T2DM) research.

     α-Glucosidase-IN-22 Chemical Structure
  3. GC72710 α-Glucosidase-IN-35 α-Glucosidase-IN-35 (compound 1) is a kind of chromene. α-Glucosidase-IN-35 Chemical Structure
  4. GC62551 β-Hydroxypropiovanillone β-Hydroxypropiovanillone, a natural compound, shows significant concentration-dependent inhibitory effects on α-glucosidase with an IC50 of 257.8 μg/mL. β-Hydroxypropiovanillone Chemical Structure
  5. GC39795 (+)-Afzelechin (+)-Afzelechin, isolated from rhizomes of Bergenia ligulata, is an alpha-glucosidase activity inhibitor with an ID50 (50% inhibition dose) value of 0.13 mM. (+)-Afzelechin Chemical Structure
  6. GC68525 (2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid

    (2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid is a saponin that can be isolated from Rubus ellipticus var. obcordatus. It inhibits α-Glucosidase with an IC50 of 1.68 mM.

     (2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid Chemical Structure
  7. GN10317 1-Deoxynojirimycin

    BAY-h-5955, D-1-Deoxynojirimycin, 1-DNJ, 1-dNM, Moranoline

     1-Deoxynojirimycin Chemical Structure
  8. GC41992 1-Deoxynojirimycin (hydrochloride)

    1-DNJ, 1-dNM, Moranoline

     1-Deoxynojirimycin (1-dNM) (hydrochloride), produced by Bacillus species, is a glucose analog that potently inhibits α-glucosidase I and II. 1-Deoxynojirimycin (hydrochloride) Chemical Structure
  9. GC71909 2,7"-Phloroglucinol-6,6'-bieckol 2,7"-Phloroglucinol-6,6'-bieckol is an orally active dual α-amylase/α-glucosidase inhibitor with IC50 values of 6.94 μM and 23.35 μM respectively. 2,7"-Phloroglucinol-6,6'-bieckol Chemical Structure
  10. GC72494 2-Hydroxyquinoline 2-Hydroxyquinoline is a potent α-glucosidase inhibitor with IC50 values of 64.4, 130.5 µg/mL for α-glucosidase and α-amylase, respectively. 2-Hydroxyquinoline Chemical Structure
  11. GC30277 4',5-Dihydroxyflavone 4',5-Dihydroxyflavone is a soybean LOX-1 and yeast α-Glucosidase inhibitor, with an Ki of 102.6 μM for soybean LOX-1 and an IC50 of 66 μM for yeast α-glucosidase. 4',5-Dihydroxyflavone Chemical Structure
  12. GC35553 Brevifolincarboxylic acid

    Brevifolin Carboxylic Acid

     Brevifolincarboxylic acid is extracted from Polygonum capitatum, has inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarboxylic acid Chemical Structure
  13. GC39233 Butyl isobutyl phthalate Butyl isobutyl phthalate is isolated from the rhizoid of Laminaria japonica. Butyl isobutyl phthalate Chemical Structure
  14. GC71869 Caffeoyltryptophan Caffeoyltryptophan is a competitive PTP1B inhibitor, with an IC50 of 16.99 μM. Caffeoyltryptophan Chemical Structure
  15. GC72043 Casuarictin Casuarictin is a potent and competitive α-glucosidase inhibitor with an IC50 of 0.21 μg/mL. Casuarictin Chemical Structure
  16. GC38279 Cedryl acetate Cedryl acetate is a tricyclic sesquiterpene isolated from the plant Psidium caudatum. Cedryl acetate Chemical Structure
  17. GC31580 Cefetrizole Ceftezole is an α-Glucosidase inhibitor with an IC50 and a Ki of 2.1 μM and 0.578 μM, respectively. Cefetrizole Chemical Structure
  18. GC32191 Celgosivir (MBI 3253)

    MBI 3253; MDL 28574; MX3253

     Celgosivir (MBI 3253) (MBI 3253; MDL 28574; MX3253) is an α-glucosidase I inhibitor; inhibits bovine viral diarrhoea virus (BVDV) with an IC50 of 1.27 μM in in vitro assay. Celgosivir (MBI 3253) Chemical Structure
  19. GC32074 Celgosivir hydrochloride (MBI 3253 (hydrochloride))

    MBI 3253 hydrochloride; MDL 28574 hydrochloride; MX3253 hydrochloride

     Celgosivir hydrochloride (MBI 3253 (hydrochloride)) (MBI 3253 hydrochloride; MDL 28574 hydrochloride; MX3253 hydrochloride) is an α-glucosidase I inhibitor; inhibits bovine viral diarrhoea virus (BVDV) with an IC50 of 1.27 μM in in vitro assay. Celgosivir hydrochloride (MBI 3253 (hydrochloride)) Chemical Structure
  20. GC60706 Chrysophanol triglucoside Chrysophanol triglucoside is an anthraquinone isolated from Cassia obtusifolia, inhibits protein tyrosine phosphatases 1B (PTP1B) and α-glucosidase with IC50s of 80.17 and 197.06 ?M, respectively. Chrysophanol triglucoside Chemical Structure
  21. GC18058 Conduritol B epoxide

    CBE

     β-glucosidase inhibitor Conduritol B epoxide Chemical Structure
  22. GC71410 Cyclophellitol aziridine Cyclophellitol aziridine is a cyclophenol analogue and a potent β-glucosidase inhibitor. Cyclophellitol aziridine Chemical Structure
  23. GC71877 Diphlorethohydroxycarmalol Diphlorethohydroxycarmalol, a kind of phlorotannin, is an orally active α-glucosidase and α-amylase inhibitor with IC50s of 0.16 mM and 0.53 mM, respectively. Diphlorethohydroxycarmalol Chemical Structure
  24. GC60802 Eleutherol Eleutherol is a naphthalene isolated from E. Eleutherol Chemical Structure
  25. GC62984 Ganoderic acid Y Ganoderic acid Y is a α-glucosidase inhibitor with an IC50 of 170 μM for yeast α-glucosidase. Ganoderic acid Y Chemical Structure
  26. GC64202 Ganoderlactone D Ganoderlactone D shows inhibitory effects of yeast α-Glucosidase with IC50 values of 41.7 μM. Ganoderlactone D Chemical Structure
  27. GC69155 Gcase activator 2

    Gcase activator 2 (compound 14) is a pyrrolo[2,3-b]pyridine and a beta-glucocerebrosidase (Gcase) activator with an EC50 of 3.8 μM. Gcase activator 2 induces Gcase dimerization (including k-type and v-type). Gcase activator 2 has low metabolic clearance in humans and mice.

     Gcase activator 2 Chemical Structure
  28. GC38046 Gitogenin

    NSC 147752, 5α-hydroxy Tigogenin

     Gitogenin is a natural steroid isolated from the whole plant of Tribulus longipetalus. Gitogenin Chemical Structure
  29. GC36165 Glycyrrhisoflavone Glycyrrhisoflavone, an active prenylflavonoid, inhibits α-glucosidase. Glycyrrhisoflavone Chemical Structure
  30. GC70830 IHVR-17028 IHVR-17028 is a potent and broad-spectrum antiviral agent. IHVR-17028 Chemical Structure
  31. GC36347 Isotanshinone I Isotanshinone I has inhibitory activity against α-glucosidase and formation of AGE, with IC50s of 1.13 μM and 0.432 μM for α-glucosidase and AGE, respectively. Isotanshinone I Chemical Structure
  32. GC36375 Kaempferol 3-O-gentiobioside Kaempferol 3-O-gentiobioside is a flavonoid isolated from C. Kaempferol 3-O-gentiobioside Chemical Structure
  33. GC64519 Kaempferol-3,7-di-O-β-glucoside Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside), a flavonol, possesses enzyme inhibition property towards α-amylase, α-glucosidase and Acetylcholinesterase. Kaempferol-3,7-di-O-β-glucoside Chemical Structure
  34. GC61635 Kaempferol-7-O-rhamnoside Kaempferol-7-O-rhamnoside, isolated from Chimonanthus nitens Oliv. Kaempferol-7-O-rhamnoside Chemical Structure
  35. GN10551 Licochalcone C Licochalcone C Chemical Structure
  36. GC64507 ML198 ML198 is a glucocerebrosidase (GCase) modulator with an EC50 of 0.4 μM. ML198 Chemical Structure
  37. GC63442 N-Caffeoyl O-methyltyramine N-Caffeoyl O-methyltyramine is a class of alkaloid isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase (IC50 of 103.58 μM). N-Caffeoyl O-methyltyramine Chemical Structure
  38. GC30637 N-Methylmoranoline (MOR 14)

    N-Methyl-1-Deoxynojirimycin, N-methyl DNJ, N-methyl dNM, N-Methylmoranoline, MOR 14

     N-Methylmoranoline (MOR 14) (MOR 14) is an α-glucosidase inhibitor. N-Methylmoranoline (MOR 14) Chemical Structure
  39. GC61697 Naringinase Naringinase, a hydrolytic enzymatic complex, possesses the activity of both α-L-rhamnosidase and β-D-glucosidase. Naringinase Chemical Structure
  40. GC63099 NCGC00092410 NCGC00092410 is a potent, selective, and nonsugar glucocerebrosidase (GC) inhibitor, with an IC50 of 31 nM. NCGC00092410 Chemical Structure
  41. GC67983 Norathyriol

    Mangiferitin

     Norathyriol Chemical Structure
  42. GN10114 Oroxin A

    Baicalein-7-O-Glucoside

     Oroxin A Chemical Structure
  43. GC65271 p-Hydroxyphenethyl trans-ferulate p-Hydroxyphenethyl trans-ferulate has anti-hyperglycemic（yeast α-glucosidase，IC50 19.24 ± 1.73 ?mol L-1）, antioxidant, and anti-inflammatory activities. p-Hydroxyphenethyl trans-ferulate Chemical Structure
  44. GC38995 Panasenoside Panasenoside is a flavonoid isolated from Lilium pumilum D. Panasenoside Chemical Structure
  45. GN10011 Rebaudioside A

    Glycoside A3 (from S. Rebaudiana), Reb A, Stevioside A3

     Rebaudioside A Chemical Structure
  46. GC61242 Resveratroloside Resveratroloside is a competitive inhibitior of α-glucosidase with an IC50 of 22.9 μM. Resveratroloside Chemical Structure
  47. GC34835 Terphenyllin

    NSC 299114

    A fungal metabolite with antibacterial properties

     Terphenyllin Chemical Structure
  48. GC18007 Voglibose

    AO-128

     α-glucosidases inhibitor Voglibose Chemical Structure

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