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Glucosidase

Glucosidases are glycoside hydrolase enzymes.

α-glucosidase is a glucosidase located in the brush border of the small intestine that acts upon α(1→4) bonds. α-Glucosidase inhibitor is a new type of antidiabetics. By reducing the postprandial blood sugar concentration, it can effectively control the blood sugar levels, thereby reducing the occurrence of diabetic complications.

β-glucosidase catalyzes the hydrolysis of the glycosidic bonds to terminal non-reducing residues in β-D-glucosides and oligosaccharides, with release of glucose. β-Glucosidase has attracted substantial attention in the scientific community because of its pivotal role in cellulose degradation, glycoside transformation and many other industrial processes. β-glucosidases catalyze the final step of cellulose hydrolysis and are essential in cellulose degradation.

Products for  Glucosidase

  1. Cat.No. Product Name Information
  2. GC70181 α-Glucosidase-IN-22

    Alpha-glucosidase-IN-22 (compound 7i) is a benzimidazole, an effective inhibitor of alpha-glucosidase with an IC50 of 0.64 μM. Alpha-glucosidase-IN-22 is an effective anti-diabetic active molecule with potential for use in type 2 diabetes (T2DM) research.

    α-Glucosidase-IN-22  Chemical Structure
  3. GC62551 β-Hydroxypropiovanillone β-Hydroxypropiovanillone, a natural compound, shows significant concentration-dependent inhibitory effects on α-glucosidase with an IC50 of 257.8 μg/mL. β-Hydroxypropiovanillone  Chemical Structure
  4. GC39795 (+)-Afzelechin (+)-Afzelechin, isolated from rhizomes of Bergenia ligulata, is an alpha-glucosidase activity inhibitor with an ID50 (50% inhibition dose) value of 0.13 mM. (+)-Afzelechin  Chemical Structure
  5. GC68525 (2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid

    (2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid is a saponin that can be isolated from Rubus ellipticus var. obcordatus. It inhibits α-Glucosidase with an IC50 of 1.68 mM.

    (2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid  Chemical Structure
  6. GN10317 1-Deoxynojirimycin 1-Deoxynojirimycin  Chemical Structure
  7. GC41992 1-Deoxynojirimycin (hydrochloride) 1-Deoxynojirimycin (1-dNM) (hydrochloride), produced by Bacillus species, is a glucose analog that potently inhibits α-glucosidase I and II. 1-Deoxynojirimycin (hydrochloride)  Chemical Structure
  8. GC30277 4',5-Dihydroxyflavone 4',5-Dihydroxyflavone is a soybean LOX-1 and yeast α-Glucosidase inhibitor, with an Ki of 102.6 μM for soybean LOX-1 and an IC50 of 66 μM for yeast α-glucosidase. 4',5-Dihydroxyflavone  Chemical Structure
  9. GC35553 Brevifolincarboxylic acid Brevifolincarboxylic acid is extracted from Polygonum capitatum, has inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarboxylic acid  Chemical Structure
  10. GC39233 Butyl isobutyl phthalate Butyl isobutyl phthalate is isolated from the rhizoid of Laminaria japonica. Butyl isobutyl phthalate  Chemical Structure
  11. GC38279 Cedryl acetate Cedryl acetate is a tricyclic sesquiterpene isolated from the plant Psidium caudatum. Cedryl acetate  Chemical Structure
  12. GC31580 Cefetrizole Ceftezole is an α-Glucosidase inhibitor with an IC50 and a Ki of 2.1 μM and 0.578 μM, respectively. Cefetrizole  Chemical Structure
  13. GC32191 Celgosivir (MBI 3253) Celgosivir (MBI 3253) (MBI 3253; MDL 28574; MX3253) is an α-glucosidase I inhibitor; inhibits bovine viral diarrhoea virus (BVDV) with an IC50 of 1.27 μM in in vitro assay. Celgosivir (MBI 3253)  Chemical Structure
  14. GC32074 Celgosivir hydrochloride (MBI 3253 (hydrochloride)) Celgosivir hydrochloride (MBI 3253 (hydrochloride)) (MBI 3253 hydrochloride; MDL 28574 hydrochloride; MX3253 hydrochloride) is an α-glucosidase I inhibitor; inhibits bovine viral diarrhoea virus (BVDV) with an IC50 of 1.27 μM in in vitro assay. Celgosivir hydrochloride (MBI 3253 (hydrochloride))  Chemical Structure
  15. GC60706 Chrysophanol triglucoside Chrysophanol triglucoside is an anthraquinone isolated from Cassia obtusifolia, inhibits protein tyrosine phosphatases 1B (PTP1B) and α-glucosidase with IC50s of 80.17 and 197.06 ?M, respectively. Chrysophanol triglucoside  Chemical Structure
  16. GC18058 Conduritol B epoxide β-glucosidase inhibitor Conduritol B epoxide  Chemical Structure
  17. GC60802 Eleutherol Eleutherol is a naphthalene isolated from E. Eleutherol  Chemical Structure
  18. GC62984 Ganoderic acid Y Ganoderic acid Y is a α-glucosidase inhibitor with an IC50 of 170 μM for yeast α-glucosidase. Ganoderic acid Y  Chemical Structure
  19. GC64202 Ganoderlactone D Ganoderlactone D shows inhibitory effects of yeast α-Glucosidase with IC50 values of 41.7 μM. Ganoderlactone D  Chemical Structure
  20. GC38046 Gitogenin Gitogenin is a natural steroid isolated from the whole plant of Tribulus longipetalus. Gitogenin  Chemical Structure
  21. GC36165 Glycyrrhisoflavone Glycyrrhisoflavone, an active prenylflavonoid, inhibits α-glucosidase. Glycyrrhisoflavone  Chemical Structure
  22. GC36347 Isotanshinone I Isotanshinone I has inhibitory activity against α-glucosidase and formation of AGE, with IC50s of 1.13 μM and 0.432 μM for α-glucosidase and AGE, respectively. Isotanshinone I  Chemical Structure
  23. GC36375 Kaempferol 3-O-gentiobioside Kaempferol 3-O-gentiobioside is a flavonoid isolated from C. Kaempferol 3-O-gentiobioside  Chemical Structure
  24. GC64519 Kaempferol-3,7-di-O-β-glucoside Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside), a flavonol, possesses enzyme inhibition property towards α-amylase, α-glucosidase and Acetylcholinesterase. Kaempferol-3,7-di-O-β-glucoside  Chemical Structure
  25. GC61635 Kaempferol-7-O-rhamnoside Kaempferol-7-O-rhamnoside, isolated from Chimonanthus nitens Oliv. Kaempferol-7-O-rhamnoside  Chemical Structure
  26. GN10551 Licochalcone C Licochalcone C  Chemical Structure
  27. GC64507 ML198 ML198 is a glucocerebrosidase (GCase) modulator with an EC50 of 0.4 μM. ML198  Chemical Structure
  28. GC63442 N-Caffeoyl O-methyltyramine N-Caffeoyl O-methyltyramine is a class of alkaloid isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase (IC50 of 103.58 μM). N-Caffeoyl O-methyltyramine  Chemical Structure
  29. GC30637 N-Methylmoranoline (MOR 14) N-Methylmoranoline (MOR 14) (MOR 14) is an α-glucosidase inhibitor. N-Methylmoranoline (MOR 14)  Chemical Structure
  30. GC61697 Naringinase Naringinase, a hydrolytic enzymatic complex, possesses the activity of both α-L-rhamnosidase and β-D-glucosidase. Naringinase  Chemical Structure
  31. GC63099 NCGC00092410 NCGC00092410 is a potent, selective, and nonsugar glucocerebrosidase (GC) inhibitor, with an IC50 of 31 nM. NCGC00092410  Chemical Structure
  32. GC67983 Norathyriol Norathyriol  Chemical Structure
  33. GN10114 Oroxin A Oroxin A  Chemical Structure
  34. GC65271 p-Hydroxyphenethyl trans-ferulate p-Hydroxyphenethyl trans-ferulate has anti-hyperglycemic(yeast α-glucosidase,IC50 19.24 ± 1.73 ?mol L-1), antioxidant, and anti-inflammatory activities. p-Hydroxyphenethyl trans-ferulate  Chemical Structure
  35. GC38995 Panasenoside Panasenoside is a flavonoid isolated from Lilium pumilum D. Panasenoside  Chemical Structure
  36. GN10011 Rebaudioside A Rebaudioside A   Chemical Structure
  37. GC61242 Resveratroloside Resveratroloside is a competitive inhibitior of α-glucosidase with an IC50 of 22.9 μM. Resveratroloside  Chemical Structure
  38. GC34835 Terphenyllin

    A fungal metabolite with antibacterial properties

    Terphenyllin  Chemical Structure
  39. GC18007 Voglibose α-glucosidases inhibitor Voglibose  Chemical Structure

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