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Home >> Signaling Pathways >> Others >> Guanylate Cyclase

Guanylate Cyclase

GC (guanylyl cyclaese) converts GTP into cGMP and pyrophosphate. sGC (soluble GC) is a nitric oxide receptor and pGC (transmembrance GC) is a natriiuritic peptide receptor. Its major functions include cell hyperplasia,hypertrophy, cell differentiation and tumor progression etc.

Products for  Guanylate Cyclase

  1. Cat.No. Product Name Information
  2. GC34045 (4-Acetamidocyclohexyl) nitrate (BM121307)

    BM121307

     (4-Acetamidocyclohexyl) nitrate (BM121307) (BM121307) is a guanylate cyclase activator. (4-Acetamidocyclohexyl) nitrate (BM121307) Chemical Structure
  3. GC64490 (Rac)-MGV354 (Rac)-MGV354 is the racemate of MGV354. (Rac)-MGV354 Chemical Structure
  4. GC11361 Ataciguat

    HMR 1766

    activator of the oxidized (heme-free) form of soluble guanylate cyclase (sGC)

     Ataciguat Chemical Structure
  5. GC10192 BAY 41-2272 Activator of soluble guanylyl cyclase (sGC) BAY 41-2272 Chemical Structure
  6. GC11426 BAY 41-8543 heme-dependent stimulator of soluble guanylate cyclase (sGC) BAY 41-8543 Chemical Structure
  7. GC65051 BAY 60-2770 BAY 60-2770 is a potent, selective, and orally active soluble guanylyl cyclase (sGC) activator. BAY 60-2770 Chemical Structure
  8. GC68741 BAY-747

    BAY 1165747

    BAY-747 (BAY 1165747) is an orally effective and brain-penetrant soluble guanylate cyclase (sGC) stimulator. BAY-747 reverses L-NAME-induced memory impairment and enhances cognition in rats. It also lowers conscious blood pressure in both normotensive and spontaneously hypertensive rats (SHR). Additionally, BAY-747 improves skeletal muscle function associated with Duchenne muscular dystrophy (DMD) in the mdx/mTRG2 mouse model.

     BAY-747 Chemical Structure
  9. GC10962 Cinaciguat

    BAY 58-2667

     An activator of sGC Cinaciguat Chemical Structure
  10. GC19459 Cinaciguat hydrochloride

    BAY 58-2667

     Cinaciguat hydrochloride is a potent soluble guanylate cyclase (GC) activator with EC50 of 15 nM in platelets. Cinaciguat hydrochloride Chemical Structure
  11. GC74357 Dolcanatide Dolcanatide is an orally active GC-C (guanylate cyclase-C) agonist. Dolcanatide Chemical Structure
  12. GC74390 Guanylin (mouse, rat) (TFA) Guanylin (mouse, rat) TFA, a petide, is composed of 15 amino acids. Guanylin (mouse, rat) (TFA) Chemical Structure
  13. GC61604 Guanylin(human) TFA Guanylin(human) TFA, a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator. Guanylin(human) TFA Chemical Structure
  14. GC69277 Indusatumab

    5F9 Monoclonal antibody

    Indusatumab (5F9 monoclonal antibody) is a monoclonal antibody that targets anti-human GUCY2C (Guanylate cyclase 2C).

     Indusatumab Chemical Structure
  15. GC30016 Linaclotide A peptide agonist of the guanylate cyclase C receptor Linaclotide Chemical Structure
  16. GC13857 LY83583

    inhibitor of soluble guanylate cyclase and of cGMP production

     LY83583 Chemical Structure
  17. GC30051 Methylene Blue (Basic Blue 9) Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene Blue (Basic Blue 9) Chemical Structure
  18. GC39603 Methylene blue trihydrate Methylene blue trihydrate (C. Methylene blue trihydrate Chemical Structure
  19. GC62616 MGV354 MGV354 is a soluble guanylate cyclase (sGC) activator with EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively. MGV354 Chemical Structure
  20. GC63294 MM 419447 MM 419447, a linaclotide metabolite, is a guanylate cyclase-C agonist. MM 419447 Chemical Structure
  21. GC32493 Nelociguat (BAY60-4552)

    BAY 60-4552, Desmethyl Riociguat

     Nelociguat (BAY60-4552) (BAY60-4552) is a nitric oxide sensitive soluble guanylate cyclase stimulator. Nelociguat (BAY60-4552) Chemical Structure
  22. GC16975 NS 2028

    soluble guanylyl cyclase (sGC) inhibitor

     NS 2028 Chemical Structure
  23. GC36801 Olinciguat

    IW-1701

     Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay. Olinciguat Chemical Structure
  24. GC33898 Plecanatide acetate

    SP-304

     Plecanatide acetate, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide acetate Chemical Structure
  25. GC65449 Praliciguat

    IW-1973

     Praliciguat (IW-1973) is a potent and orally active soluble guanylate cyclase stimulator, enhances NO signaling, acts as a vasodilator. Praliciguat Chemical Structure
  26. GC12887 Riociguat

    BAY 63-2521

     A stimulator of soluble guanylate cyclase Riociguat Chemical Structure
  27. GC65192 Runcaciguat

    BAY 1101042

     Runcaciguat is an orally active stimulator of soluble guanylate cyclase, and is used in the research of cardiovascular and renal diseases combined with selective partial adenosine A1 receptor agonists. Runcaciguat Chemical Structure
  28. GC32472 Vericiguat (BAY1021189)

    BAY-1021189, MK-1242

     Vericiguat (BAY1021189) (BAY1021189) is a potent, orally available and soluble guanylate cyclase stimulator. Vericiguat (BAY1021189) Chemical Structure
  29. GC16406 YC 1 Lificiguat (YC-1) is a no-dependent soluble guanylyl cyclase(sGC) activator and a Hypoxia-inducible faction-1alpha (HIF-1alpha) inhibitor. YC 1 Chemical Structure
  30. GC65182 Zagociguat Zagociguat is the stimulator of soluble guanylate cyclase. Zagociguat Chemical Structure

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