Home >> Signaling Pathways >> Others >> Imidazoline Receptors

Imidazoline Receptors

Imidazoline receptors are the primary receptors on which clonidine and other imidazolines act. There are three classes of imidazoline receptors: I1 receptor – mediates the sympatho-inhibitory actions of imidazolines to lower blood pressure, (NISCH or IRAS, imidazoline receptor antisera selected), I2 receptor - an allosteric binding site of monoamine oxidase and is involved in pain modulation and neuroprotection, I3 receptor - regulates insulin secretion from pancreatic beta cells. Activated I1-imidazoline receptors trigger the hydrolysis of phosphatidylcholine into DAG. Elevated DAG levels in turn trigger the synthesis of second messengers arachidonic acid and downstreameicosanoids. In addition, the sodium-hydrogen antiporter is inhibited, and enzymes of catecholamine synthesis are induced. The I1-imidazoline receptor may belong to the neurocytokine receptorfamily, since its signaling pathways are similar to those of interleukins.

  1. Cat.No. Product Name Information
  2. GC11588 2-BFI hydrochloride I2 ligand
  3. GC16831 Agmatine sulfate α2-adrenergic receptor ligand
  4. GC14934 AGN 192403 hydrochloride I1 imidazoline receptor
  5. GN10492 Allantoin Extracted from Dioscorea opposite Thunb. dried tubers;Store the product in sealed, cool and dry condition
  6. GC15700 BU 224 hydrochloride Antagonist of I2 Imidazoline receptor,potent and selective
  7. GC15202 BU 226 hydrochloride Ligand at I2 imidazoline sites,high affinity and selectivity
  8. GC11580 BU 239 hydrochloride Imidazoline receptors-selective antagonist
  9. GC31094 CR4056
  10. GC38192 Idazoxan hydrochloride
  11. GC12629 Moxonidine I1R/α2AR agonist
  12. GC11198 Moxonidine hydrochloride Mixed I1 imidazoline receptor and α2-adrenergic agonist
  13. GC13017 Rilmenidine Phosphate antihypertensive drug targets the imidazoline receptor
  14. GC14958 RS 45041-190 hydrochloride Highly selective I2 imidazoline receptor ligand

13 Item(s)

per page

Set Descending Direction