Imidazoline Receptors
Imidazoline receptors are the primary receptors on which clonidine and other imidazolines act. There are three classes of imidazoline receptors: I1 receptor – mediates the sympatho-inhibitory actions of imidazolines to lower blood pressure, (NISCH or IRAS, imidazoline receptor antisera selected), I2 receptor - an allosteric binding site of monoamine oxidase and is involved in pain modulation and neuroprotection, I3 receptor - regulates insulin secretion from pancreatic beta cells. Activated I1-imidazoline receptors trigger the hydrolysis of phosphatidylcholine into DAG. Elevated DAG levels in turn trigger the synthesis of second messengers arachidonic acid and downstreameicosanoids. In addition, the sodium-hydrogen antiporter is inhibited, and enzymes of catecholamine synthesis are induced. The I1-imidazoline receptor may belong to the neurocytokine receptorfamily, since its signaling pathways are similar to those of interleukins.
Products for Imidazoline Receptors
- Cat.No. Product Name Information
- GC11588 2-BFI hydrochloride I2 ligand
- GC16831 Agmatine sulfate α2-adrenergic receptor ligand
- GC14934 AGN 192403 hydrochloride I1 imidazoline receptor
- GN10492 Allantoin
- GC15700 BU 224 hydrochloride Antagonist of I2 Imidazoline receptor,potent and selective
- GC15202 BU 226 hydrochloride Ligand at I2 imidazoline sites,high affinity and selectivity
- GC11580 BU 239 hydrochloride Imidazoline receptors-selective antagonist
- GC31094 CR4056
- GC15384 Harmane endogenous ligand for imidazoline binding sites
- GC63754 Harmane-d1 Harmane-d1 is the deuterium labeled Harmane.
- GC38192 Idazoxan hydrochloride
- GC12629 Moxonidine An imidazoline I1 and α2A-adrenergic receptor agonist
- GC11198 Moxonidine hydrochloride Mixed I1 imidazoline receptor and α2-adrenergic agonist
- GC60325 Rilmenidine An antihypertensive agent
- GC13017 Rilmenidine Phosphate antihypertensive drug targets the imidazoline receptor
- GC14958 RS 45041-190 hydrochloride Highly selective I2 imidazoline receptor ligand