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Home >> Signaling Pathways >> Others >> Imidazoline Receptors

Imidazoline Receptors

Imidazoline receptors are the primary receptors on which clonidine and other imidazolines act. There are three classes of imidazoline receptors: I1 receptor – mediates the sympatho-inhibitory actions of imidazolines to lower blood pressure, (NISCH or IRAS, imidazoline receptor antisera selected), I2 receptor - an allosteric binding site of monoamine oxidase and is involved in pain modulation and neuroprotection, I3 receptor - regulates insulin secretion from pancreatic beta cells. Activated I1-imidazoline receptors trigger the hydrolysis of phosphatidylcholine into DAG. Elevated DAG levels in turn trigger the synthesis of second messengers arachidonic acid and downstreameicosanoids. In addition, the sodium-hydrogen antiporter is inhibited, and enzymes of catecholamine synthesis are induced. The I1-imidazoline receptor may belong to the neurocytokine receptorfamily, since its signaling pathways are similar to those of interleukins.

Products for  Imidazoline Receptors

  1. Cat.No. Product Name Information
  2. GC11588 2-BFI hydrochloride I2 ligand 2-BFI hydrochloride Chemical Structure
  3. GC16831 Agmatine sulfate

    NIH 11035

     α2-adrenergic receptor ligand Agmatine sulfate Chemical Structure
  4. GC14934 AGN 192403 hydrochloride I1 imidazoline receptor AGN 192403 hydrochloride Chemical Structure
  5. GN10492 Allantoin

    (±)-Allantoin, NSC 7606, SD 101, 5-Ureidohydantoin

     Allantoin Chemical Structure
  6. GC74240 Allantoin-13C2,15N4

    5-Ureidohydantoin-13C2,15N4

     Allantoin-13C2,15N4 is the 13C and 15N labeled Allantoin. Allantoin-13C2,15N4 Chemical Structure
  7. GC15700 BU 224 hydrochloride Antagonist of I2 Imidazoline receptor,potent and selective BU 224 hydrochloride Chemical Structure
  8. GC15202 BU 226 hydrochloride Ligand at I2 imidazoline sites,high affinity and selectivity BU 226 hydrochloride Chemical Structure
  9. GC11580 BU 239 hydrochloride Imidazoline receptors-selective antagonist BU 239 hydrochloride Chemical Structure
  10. GC31094 CR4056 CR4056 Chemical Structure
  11. GC15384 Harmane

    1-Methyl-β-Carboline, NSC 54439

     endogenous ligand for imidazoline binding sites Harmane Chemical Structure
  12. GC69206 Harmane-d

    Harmane-d is the deuterated form of Harmane. Harmane, a beta-carboline alkaloid, is an effective neurotoxin that can cause severe motor tremors and psychiatric symptoms. Harmane has a 1000-fold selectivity for I1-imidazoline receptors (IC50=30 nM) over alpha-2 adrenergic receptors (IC50=18 μM). It is also an effective and selective monoamine oxidase inhibitor with IC50 values of 0.5 μM and 5 μM for MAO A/B, respectively.

     Harmane-d Chemical Structure
  13. GC63754 Harmane-d1 Harmane-d1 is the deuterium labeled Harmane. Harmane-d1 Chemical Structure
  14. GC38192 Idazoxan hydrochloride Idazoxan hydrochloride Chemical Structure
  15. GC12629 Moxonidine

    LY326869

     An imidazoline I1 and α2A-adrenergic receptor agonist Moxonidine Chemical Structure
  16. GC11198 Moxonidine hydrochloride Mixed I1 imidazoline receptor and α2-adrenergic agonist Moxonidine hydrochloride Chemical Structure
  17. GC60325 Rilmenidine

    Oxaminozoline, NSC 664312

     An antihypertensive agent Rilmenidine Chemical Structure
  18. GC13017 Rilmenidine Phosphate antihypertensive drug targets the imidazoline receptor Rilmenidine Phosphate Chemical Structure
  19. GC14958 RS 45041-190 hydrochloride Highly selective I2 imidazoline receptor ligand RS 45041-190 hydrochloride Chemical Structure

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