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MAGL

Monoacylglycerol lipase (MGL) is a 33 kDa serine hydrolase that catalyses the hydrolysis of monoacylglycerols to their corresponding fatty acids. The enzyme is found both in the brain and in peripheral tissues such as the kidney, ovary, testis, adrenal gland, adipose tissue and heart. The three-dimensional structure of MGL has been elucidated by X-ray crystallography, and the enzyme has been shown to be a dimeric molecule with amphitropic properties, that is, it can exist both in a soluble form and associated with the membrane lipid bilayers. Mutagenesis studies have demonstrated the importance of the catalytic triad of ser122, asp239 and his269 that the enzyme shares with other enzymes in the α/β hydrolase superfamily. The substrate is recruited via a wide hydrophobic tunnel, where it can then interact with the catalytic triad at the end of the tunnel.

MGL inhibitors have lagged behind, but have a potential advantage over FAAH inhibitors in terms of eCB specificity of action given that the N-acylethanolamines are a class of compounds with multiple biological actions.

Products for  MAGL

  1. Cat.No. Product Name Information
  2. GC62821 AA38-3 AA38-3 is a serine hydrolase (SH) inhibitor. AA38-3  Chemical Structure
  3. GC19412 ABX-1431 ABX-1431 is a highly potent, selective, and orally available, CNS-penetrant monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 14 nM. ABX-1431  Chemical Structure
  4. GC34327 DO-264 An ABHD12 inhibitor DO-264  Chemical Structure
  5. GC38638 Euphol

    Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active.

    Euphol  Chemical Structure
  6. GC10162 JJKK 048 monoacylglycerol lipase (MAGL) inhibitor JJKK 048  Chemical Structure
  7. GC17304 JW 642 monoacylglycerol lipase (MAGL) inhibitor JW 642  Chemical Structure
  8. GC12693 JZL 195 Dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) JZL 195  Chemical Structure
  9. GC14390 JZL184 MAGL inhibitor, potent and selective JZL184  Chemical Structure
  10. GC34640 JZP-430 JZP-430 is a potent, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) with an IC50 of 44 nM, exhibits ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL). JZP-430  Chemical Structure
  11. GC17385 KML 29

    KML 29 is reported to display IC50 values of 43, 15, and 5.9 nM toward rat, mouse, and human monoacylglycerol lipase (MAGL), respectively.

    KML 29  Chemical Structure
  12. GC16756 KT182 ABHD6 (a/b-Hydrolase Domain Containing 6) inhibitor KT182  Chemical Structure
  13. GC36401 KT185 KT185 is an orally-bioavailable, brain-penetrant and selective ABHD6 inhibitor, with an IC50 0.21 nM in Neuro2A cells. KT185  Chemical Structure
  14. GC13763 KT203 ABHD6 inhibitor KT203  Chemical Structure
  15. GC63055 MAGL-IN-4 MAGL-IN-4 is an orally active, selective and reversible monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 6.2 nM. MAGL-IN-4  Chemical Structure
  16. GC38135 MJN110 A selective MAGL inhibitor MJN110  Chemical Structure
  17. GC14079 MJN110 MAGL inhibitor MJN110  Chemical Structure
  18. GC17855 SA 57 FAAH inhibitor SA 57  Chemical Structure
  19. GC15074 WWL 70 α/β-hydrolase domain 6 inhibitor WWL 70  Chemical Structure

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