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Home >> Signaling Pathways >> Others >> MDR multidrug resistance

MDR multidrug resistance

MDR (multidrug resistance) is a property that first identified in tumor cell, hat the resistance of tumor cell is to a variety of chemotherapy agent due to active efflux via transporter proteins.

Products for  MDR multidrug resistance

  1. Cat.No. Product Name Information
  2. GC45246 (-)-Chaetominine

    (-)-Chaetominine

     (-)-Chaetominine is a cytotoxic alkaloid originally isolated from Chaetomium sp. (-)-Chaetominine Chemical Structure
  3. GC41865 10'-Desmethoxystreptonigrin 10'-Desmethoxystreptonigrin is an antibiotic originally isolated from Streptomyces and a derivative of the antibiotic streptonigrin. 10'-Desmethoxystreptonigrin Chemical Structure
  4. GC45324 2,5-dimethyl Celecoxib

    DMC

       2,5-dimethyl Celecoxib Chemical Structure
  5. GC91154 33-BCRP Inhibitor

    A BCRP inhibitor

     33-BCRP Inhibitor Chemical Structure
  6. GC91135 4-(3,4-Difluorobenzo)curcumin

    A semisynthetic coumarin with antiparasitic and anticancer activities

     4-(3,4-Difluorobenzo)curcumin Chemical Structure
  7. GC42616 7-oxo Staurosporine

    BMY 41950, RK-1409

    7-oxo Staurosporine is an antibiotic originally isolated from S.

     7-oxo Staurosporine Chemical Structure
  8. GC49275 8-Oxycoptisine

    8-Oxocoptisine

     8-Oxycoptisine is a natural protoberberine alkaloid with anti-cancer activity. 8-Oxycoptisine Chemical Structure
  9. GC46809 Afatinib-d6

    BIBW 2992 D6

     An internal standard for the quantification of afatinib Afatinib-d6 Chemical Structure
  10. GC42806 Andrastin A

    NSC 697452

     Andrastin A is a meroterpenoid farnesyltransferase inhibitor. Andrastin A Chemical Structure
  11. GC43004 C10 Ceramide (d18:1/10:0)

    N-decanoyl-D-erythro-Sphingosine

    C10 ceramide is an endogenous, bioactive sphingolipid produced by ceramide synthase.

     C10 Ceramide (d18:1/10:0) Chemical Structure
  12. GC43060 C2 Adamantanyl Globotriaosylceramide (d18:1/2:0) C2 Adamantanyl globotriaosylceramide (AdaGb3) is a bioactive sphingolipid and water-soluble form of globotriaosylceramide that contains an adamantanyl group in place of the fatty acyl chain. C2 Adamantanyl Globotriaosylceramide (d18:1/2:0) Chemical Structure
  13. GC45395 Cabazitaxel-d9

    XRP6258-d9; RPR-116258A-d9; taxoid XRP6258-d9

     Cabazitaxel-d9 is deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel-d9 Chemical Structure
  14. GC45679 Carubicin

    Antibiotic R 588A, Carminomycin, NCI 180024, NSC 180024

     An anthracycline with anticancer activity Carubicin Chemical Structure
  15. GC40795 CAY10503 CAY10503 is a proapoptotic, antiproliferative compound that is able to arrest cell cycle progression in the G0-G1 phase. CAY10503 Chemical Structure
  16. GC18901 CAY10647 CAY10647 is an aryl-benzoyl-imidazole which prevents proliferation of multidrug resistant cancer cells in vitro (IC50 = 28-63 nM) and inhibits melanoma xenograph tumor growth in vivo (10-30 mg/kg). CAY10647 Chemical Structure
  17. GC45792 Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)

    Iron Salophene Complex, N,N'-o-Phenylenebis(salicylideneaminato)iron(III) Chloride

     An inducer of ferroptosis Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) Chemical Structure
  18. GC90543 EGFR Peptide (human, mouse) (myristoylated) (trifluoroacetate salt)

    A PKC inhibitor

     EGFR Peptide (human, mouse) (myristoylated) (trifluoroacetate salt) Chemical Structure
  19. GC46004 Evoxanthine

    NSC 407812

     An alkaloid Evoxanthine Chemical Structure
  20. GC91152 Flavokawain 1i

    A flavokawain derivative with anticancer and antiviral activities

     Flavokawain 1i Chemical Structure
  21. GC90660 Fz25

    A triazole-modified sterol and an anticancer agent

     Fz25 Chemical Structure
  22. GC49106 Gentisein

    NSC 329491

     A xanthone with diverse biological activities Gentisein Chemical Structure
  23. GC47409 Glycocholic Acid-d4

    Cholylglycine-d4, GCA-d4

     A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications Glycocholic Acid-d4 Chemical Structure
  24. GC91057 HP661

    A mitochondrial complex I inhibitor

     HP661 Chemical Structure
  25. GC91403 HR68

    PP21

     HR68 is an anticancer agent and a derivative of the peroxisome proliferator-activated receptor (PPAR) agonist fenofibric acid . HR68 Chemical Structure
  26. GC49670 Indium (III) thiosemicarbazone 5b An anticancer agent Indium (III) thiosemicarbazone 5b Chemical Structure
  27. GC44129 MC 70 A P-glycoprotein inhibitor MC 70 Chemical Structure
  28. GC48479 Migrastatin

    (+)-Migrastatin

     A fungal metabolite with antimuscarinic and anticancer activities Migrastatin Chemical Structure
  29. GC44195 Milbemycin A4 oxime

    5-Ketomilbemycin A4 oxime, 5-Oxomilbemycin A4 5-oxime

     Milbemycin A4 oxime is a derivative of milbemycin A4 and a component of milbemycin oxime, compounds that both have insecticidal and nematocidal activity. Milbemycin A4 oxime Chemical Structure
  30. GC41564 MPT0B014 An inhibitor of tubulin polymerization MPT0B014 Chemical Structure
  31. GC19270 Olmutinib Olmutinib (HM61713; BI-1482694) is an irreversible EGFR tyrosine kinase inhibitor that binds to a cysteine residue near the kinase domain. Olmutinib Chemical Structure
  32. GC45784 ONT-093

    OC 144093

     A P-glycoprotein inhibitor ONT-093 Chemical Structure
  33. GC49251 Oxaliplatin-d10

    Lipoxal-d10

     An internal standard for the quantification of oxaliplatin Oxaliplatin-d10 Chemical Structure
  34. GC44613 PF-6274484 PF-6274484 is an inhibitor of the EGF receptor (EGFR; IC50s = 0.18 and 0.14 nM for wild-type EGFR and inhibitor-resistant EGFRL858R/T790M, respectively). PF-6274484 Chemical Structure
  35. GC44615 PGP-4008 PGP-4008 is a selective inhibitor of P-glycoprotein (P-gp) that does not affect the activity of multidrug resistance-related protein 1 (MRP1). PGP-4008 Chemical Structure
  36. GC41629 Piperafizine A Piperafizine A is a natural methylated diketopiperazine first isolated from an actinomycete, Streptoverticillium. Piperafizine A Chemical Structure
  37. GC52455 Pixantrone-d8 (maleate) An internal standard for the quantification of pixantrone Pixantrone-d8 (maleate) Chemical Structure
  38. GC52104 Ponatinib (hydrochloride)

    AP 24534

     An inhibitor of native and mutant Bcr-Abl Ponatinib (hydrochloride) Chemical Structure
  39. GC17403 Pyronaridine Tetraphosphate

    PND

    An antimalarial agent

     Pyronaridine Tetraphosphate Chemical Structure
  40. GC44821 Reversin 121 Reversin 121 is a hydrophobic peptide chemosensitizer that can reverse P-glycoprotein-mediated multidrug resistance. Reversin 121 Chemical Structure
  41. GC91096 S-72

    An inhibitor of microtubule polymerization

     S-72 Chemical Structure
  42. GC45688 STX140

    2-Methoxyestradiol-bis-sulphamate

     An estrogen sulfamate STX140 Chemical Structure
  43. GC48119 Suprafenacine

    SML1493

     An inhibitor of tubulin polymerization with anticancer activity Suprafenacine Chemical Structure
  44. GC48219 Ulipristal Acetate-d6

    CDB-2914-d6

     An internal standard for the quantification of ulipristal acetate Ulipristal Acetate-d6 Chemical Structure
  45. GC49308 Ungeremine

    Lycobetaine

     A betaine-type alkaloid with diverse biological activities Ungeremine Chemical Structure
  46. GC91435 YCH1899 YCH1899 is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (IC50s = 1 It is selective for PARP1 and PARP2 over PARP3, -4, -5A, -5B, -6, -7, -10, and -12 (IC50s = 1-14.1 nM). YCH1899 Chemical Structure

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