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Home >> Signaling Pathways >> Others >> Myosin

Myosin

Myosin belongs to family of motor protein which transforms the chemical energy into mechanical energy via ATP hydrolysis. It is responsible for muscle contractions.

Products for  Myosin

  1. Cat.No. Product Name Information
  2. GC12341 (±)-Blebbistatin

    (S)Blebbistatin

     (±)-Blebbistatin is a racemic mixture containing two configurations, (+)-Blebbistatinb and (-)-Blebbistatin (Cat. No. GC13430). (±)-Blebbistatin can effectively inhibit the activity of non-muscle myosin II ATPase and the expression of various striated muscle myosins and non-muscle myosins in vertebrates. (±)-Blebbistatin Chemical Structure
  3. GC13430 (-)-Blebbistatin

    (S)Blebbistatin

     (-)-Blebbistatin is one of the configurations of the racemic mixture (±)-Blebbistatin (Cat. No. GC12341) and is the active form. (-)-Blebbistatin is a cell-permeable inhibitor of non-muscle myosin II ATPase, which effectively inhibits multiple striated muscle myosins as well as vertebrate non-muscle myosins with IC50 values ranging from 0.5-5μM, and only slightly inhibits smooth muscle myosin (IC50=80μM) . (-)-Blebbistatin Chemical Structure
  4. GC12996 (R)-(+)-Blebbistatin

    (R)-Blebbistatin

     (R)-(+)-Blebbistatin is the inactive enantiomer of (-)-Blebbistatin. (R)-(+)-Blebbistatin Chemical Structure
  5. GC71036 (R)-MPH-220 (R)-MPH-220 is the R isomer of MPH-220 . (R)-MPH-220 Chemical Structure
  6. GC63519 Aficamten

    CK-274, CK-3773274

     Aficamten (CK-274) is a potent cardiac myosin inhibitor with an IC50 of 1.4 μM. Aficamten Chemical Structure
  7. GC33254 ATM-3507 ATM-3507 is a potent tropomyosin inhibitor with IC50s from 3.83-6.84 μM in human melanoma cell lines. ATM-3507 Chemical Structure
  8. GC35418 ATM-3507 trihydrochloride ATM-3507 trihydrochloride is a potent tropomyosin inhibitor with IC50s from 3.83-6.84 μM in human melanoma cell lines. ATM-3507 trihydrochloride Chemical Structure
  9. GC16189 BTS

    N-Benzyl-p-toluenesulfonamide, NSC 37123

     potent inhibitor of Ca2+-stimulated myosin S1 ATPase BTS Chemical Structure
  10. GC11605 C-1 C-1 is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. C-1 also used as a ROCK inhibitor. C-1 Chemical Structure
  11. GC69307 JB002

    JB002 is a myosin II inhibitor with an IC50 value of ≤10 μM. JB002 can be used for research on muscle spasms, chronic musculoskeletal pain, and hypertrophic cardiomyopathy.

     JB002 Chemical Structure
  12. GC69308 JB061

    JB061 is a non-muscle myosin inhibitor with IC50 values of 4.4 μM (cardiac myosin), 9.1 μM (skeletal muscle myosin) and >100 μM (smooth muscle myosin II). JB061 has a low ability to inhibit ATPase activity (IC50>200 μM). JB061 exhibits cytotoxicity against COS-7 cells with an IC50 value of 39 μM.

     JB061 Chemical Structure
  13. GC71199 JB062 JB062 is a nonmuscle myosin inhibitor with IC50 values of 1.6, 5.4, and >100 μM for Skeletal muscle myosin, Cardiac muscle myosin, and Smooth muscle myosin II, respectively. JB062 Chemical Structure
  14. GC72814 Mavacamten-d5

    MYK461-d5; SAR439152-d5

     Mavacamten-d5 (MYK461-d5; SAR439152-d5) is deuterium labeled Mavacamten. Mavacamten-d5 Chemical Structure
  15. GC11404 ML 9 hydrochloride MLCK inhibitor ML 9 hydrochloride Chemical Structure
  16. GC11411 ML-7 hydrochloride A smooth muscle myosin light chain kinase inhibitor ML-7 hydrochloride Chemical Structure
  17. GC13520 MLCK inhibitor peptide inhibitor of myosin light chain kinase MLCK inhibitor peptide Chemical Structure
  18. GC17329 MLCK inhibitor peptide 18

    Myosin Light Chain Kinase Inhibitor Peptide 18

     Selective competitive inhibitor of myosin light chain kinase MLCK inhibitor peptide 18 Chemical Structure
  19. GC69494 MPH-220

    MPH-220 is a selective, orally active inhibitor of skeletal muscle myosin-2 that causes muscle relaxation. It is an antispasmodic agent and can be used in the research of spasms and muscle stiffness.

     MPH-220 Chemical Structure
  20. GC33214 MS-444 (BE-34776)

    BE-34776

     MS-444 (BE-34776) inhibits the activity of purified smooth muscle myosin light chain kinase (MLCK) with an IC50 value of 10 μM. MS-444 (BE-34776) Chemical Structure
  21. GC15858 MYK-461

    MYK-461, SAR439152

     MYK-461 (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively. MYK-461 Chemical Structure
  22. GC69520 Myosin V-IN-1

    Myosin V-IN-1 (compound 8) is an effective and selective inhibitor of Myosin V, with a Ki of 6 μM. Myosin V-IN-1 exhibits acute inhibitory effects on myosin V. It slows down the activation of myosin by specifically inhibiting the release of ADP from the actomyosin complex through inhibition of myosin V ATPase.

     Myosin V-IN-1 Chemical Structure
  23. GC12832 Omecamtiv mecarbil

    CK-1827452; CK1827452

     Cardiac myosin activator Omecamtiv mecarbil Chemical Structure
  24. GC63650 Pentachloropseudilin

    Antibiotic A 15104 Y; PClP

     Pentachloropseudilin (Antibiotic A 15104 Y; PClP) is a reversible and allosteric potent inhibitor of Myo1s (class 1 myosins) with IC50s range from 1 to 5 μM for mammalian class-1 myosins and greater than 90 μM for class-2 and class-5 myosins. Pentachloropseudilin is a potent inhibitor of transforming growth factor-β (TGF-β)-stimulated signaling, with an IC50 of 0.1 to 0.2 μM for TGF-β. Pentachloropseudilin Chemical Structure
  25. GC69881 Sevasemten

    Sevasemten is a conformational inhibitor of skeletal muscle myosin. Sevasemten selectively inhibits myosin with IC50 values of ≤ 10 μM (skeletal) or >100 μM (cardiac).

     Sevasemten Chemical Structure

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