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Home >> Signaling Pathways >> Others >> Nampt

Nampt

Nampt (nicotinamide phosphoribosyltransferase) catalyzes the nicotinamide condensation with 5-phosphoribosyl-1-pyrophosphate to produce nicotinamide mononucleotide during the nicotinamide adenine dinucleotide biosynthesis. It is involved in the metabolism, stress response and aging.

Products for  Nampt

  1. Cat.No. Product Name Information
  2. GC73953 BRD4/NAMPT-IN-1 BRD4/NAMPT-IN-1 (Compound A2) shows strong inhibitory effects on NAMPT and BRD4 (IC50=35 nM (NAMPT) and 58 nM (BRD4)). BRD4/NAMPT-IN-1 Chemical Structure
  3. GC16709 CB 300919 CB 300919 Chemical Structure
  4. GC15207 CB30865

    ZM242421;CB-30865;CB 30865;ZM-242421;ZM 242421

     CB30865 Chemical Structure
  5. GC14308 FK866 (APO866)

    K 22.175

    FK866 (APO866) is an inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase).

     FK866 (APO866) Chemical Structure
  6. GC14815 GMX1778 (CHS828)

    GMX 1778

     GMX1778 (CHS828) (GMX1778) is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), with an IC50 less than 25 nM. GMX1778 (CHS828) (GMX1778) exerts a cytotoxic effect by decreasing the cellular level of NAD+ and exhibits a potent anticancer activity. GMX1778 (CHS828) Chemical Structure
  7. GC16041 GNE-617 NAMPT inhibitor GNE-617 Chemical Structure
  8. GC15967 GNE-617 hydrochloride NAMPT inhibitor, potent and competitive GNE-617 hydrochloride Chemical Structure
  9. GC41308 GPP 78

    CAY10618, NMPRTase Inhibitor

     Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide into nicotinamide mononucleotide (NMN), which is subsequently converted to NAD+ by NMN adenyltransferase. GPP 78 Chemical Structure
  10. GC14615 KPT-9274 Orally acitve allosteric inhibitor of PAK4 KPT-9274 Chemical Structure
  11. GC36429 LB-60-OF61 LB-60-OF61 is a NAMPT inhibitor and is a cytotoxic compound with a selectivity towards MYC overexpressing cell lines. LB-60-OF61 Chemical Structure
  12. GC69535 Nampt activator-1

    Nampt activator-1 (compound 1) is an effective nicotinamide phosphoribosyltransferase (NAMPT) activator with an EC50 of 3.3-3.7 μM.

     Nampt activator-1 Chemical Structure
  13. GC69536 Nampt activator-2

    Nampt activator-2 (compound 34) is an effective NAMPT activator with an EC50 of 0.023 μM. Nampt activator-2 exhibits moderate activity against CYP2C9 (0.060 μM), 2D6 (0.41 μM), and 2C19 (0.59 μM).

     Nampt activator-2 Chemical Structure
  14. GC71068 Nampt activator-3 NAMPT activator-3, a NAT derivative, is a NAMPT activator with an EC50 of 2.6 μM and a KD of 132 nM. Nampt activator-3 Chemical Structure
  15. GC73389 Nampt degrader-2 Nampt degrader-2 is a fluorescent PROTAC, which efficiently degrades NAMPT with an IC50 of 41.9 nM. Nampt degrader-2 Chemical Structure
  16. GC32818 Nampt-IN-1 (LSN3154567)

    LSN3154567, Nicotinamide Phosphoribosyltransferase-IN-1

     Nampt-IN-1 (LSN3154567) (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 (LSN3154567) inhibits purified NAMPT with an IC50 of 3.1 nM. Nampt-IN-1 (LSN3154567) Chemical Structure
  17. GC69537 Nampt-IN-10 TFA

    Nampt-IN-10 TFA (compound 4) is an inhibitor of nicotinamide phosphoribosyltransferase (NAMPT). Nampt-IN-10 TFA has cellular potency against A2780 and CORL23, with IC50 values of 5 and 19 nM, respectively. Nampt-IN-10 TFA can be used as a non-mitotic payload for ADCs.

     Nampt-IN-10 TFA Chemical Structure
  18. GC36690 Nampt-IN-3 Nampt-IN-3 (Compound 35) simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC50s of 31 nM and 55 nM, respectively. Nampt-IN-3 effectively induces cell apoptosis and autophagy and ultimately leads to cell death. Nampt-IN-3 Chemical Structure
  19. GC62476 Nampt-IN-5 Nampt-IN-5 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-5 also inhibits CYP3A4 activity and has cellular IC50s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively. Nampt-IN-5 Chemical Structure
  20. GC67797 NAT NAT Chemical Structure
  21. GC14692 P7C3 NAMPT activator P7C3 Chemical Structure
  22. GC37602 SBI-797812 SBI-797812 is an orally active nicotinamide phosphoribosyltransferase (NAMPT) activator. SBI-797812 Chemical Structure
  23. GC17096 STF-118804 NAMPT inhibitor STF-118804 Chemical Structure
  24. GC61622 Teglarinad chloride Teglarinad chloride (GMX1777) is a prodrug of GMX1778 (a nicotinamide phosphoribosyl transferase inhibitor). Teglarinad chloride exhibits antitumor activity in mice can be attributed to inhibition of NAMPT. Teglarinad chloride also enhances radiation efficacy, mediated by interference with DNA repair and antiangiogenesis. Teglarinad chloride Chemical Structure

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