Nampt
Nampt (nicotinamide phosphoribosyltransferase) catalyzes the nicotinamide condensation with 5-phosphoribosyl-1-pyrophosphate to produce nicotinamide mononucleotide during the nicotinamide adenine dinucleotide biosynthesis. It is involved in the metabolism, stress response and aging.
Products for Nampt
- Cat.No. Product Name Information
- GC16709 CB 300919
- GC15207 CB30865
- GC14308 FK866 (APO866) Inhibitor of nicotinamide phosphoribosyltransferase
- GC14815 GMX1778 (CHS828) GMX1778 (CHS828) (GMX1778) is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), with an IC50 less than 25 nM. GMX1778 (CHS828) (GMX1778) exerts a cytotoxic effect by decreasing the cellular level of NAD+ and exhibits a potent anticancer activity.
- GC16041 GNE-617 NAMPT inhibitor
- GC15967 GNE-617 hydrochloride NAMPT inhibitor, potent and competitive
- GC41308 GPP 78 Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide into nicotinamide mononucleotide (NMN), which is subsequently converted to NAD+ by NMN adenyltransferase.
- GC14615 KPT-9274 Orally acitve allosteric inhibitor of PAK4
- GC36429 LB-60-OF61 LB-60-OF61 is a NAMPT inhibitor and is a cytotoxic compound with a selectivity towards MYC overexpressing cell lines.
-
GC69535
Nampt activator-1
Nampt activator-1 (compound 1) is an effective nicotinamide phosphoribosyltransferase (NAMPT) activator with an EC50 of 3.3-3.7 μM.
-
GC69536
Nampt activator-2
Nampt activator-2 (compound 34) is an effective NAMPT activator with an EC50 of 0.023 μM. Nampt activator-2 exhibits moderate activity against CYP2C9 (0.060 μM), 2D6 (0.41 μM), and 2C19 (0.59 μM).
- GC32818 Nampt-IN-1 (LSN3154567) Nampt-IN-1 (LSN3154567) (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 (LSN3154567) inhibits purified NAMPT with an IC50 of 3.1 nM.
-
GC69537
Nampt-IN-10 TFA
Nampt-IN-10 TFA (compound 4) is an inhibitor of nicotinamide phosphoribosyltransferase (NAMPT). Nampt-IN-10 TFA has cellular potency against A2780 and CORL23, with IC50 values of 5 and 19 nM, respectively. Nampt-IN-10 TFA can be used as a non-mitotic payload for ADCs.
- GC36690 Nampt-IN-3 Nampt-IN-3 (Compound 35) simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC50s of 31 nM and 55 nM, respectively. Nampt-IN-3 effectively induces cell apoptosis and autophagy and ultimately leads to cell death.
- GC62476 Nampt-IN-5 Nampt-IN-5 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-5 also inhibits CYP3A4 activity and has cellular IC50s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively.
- GC67797 NAT
- GC14692 P7C3 NAMPT activator
- GC37602 SBI-797812 SBI-797812 is an orally active nicotinamide phosphoribosyltransferase (NAMPT) activator.
- GC17096 STF-118804 NAMPT inhibitor
- GC61622 Teglarinad chloride Teglarinad chloride (GMX1777) is a prodrug of GMX1778 (a nicotinamide phosphoribosyl transferase inhibitor). Teglarinad chloride exhibits antitumor activity in mice can be attributed to inhibition of NAMPT. Teglarinad chloride also enhances radiation efficacy, mediated by interference with DNA repair and antiangiogenesis.