Search Site
  • 0
    My Cart

    Click Here to Find How Many Items You Have Added:)

    image loader

    Adding item(s) to cart......

Home >> Signaling Pathways >> Others >> NAE

NAE

NAE (NEDD8-activating enzyme) catalyzes the initial step of the neddylation signaling that regulates CRLs (cullin-ring ubiquitin ligases) activities. Its downstream effect is linked to cancer cell growth and survival.

Products for  NAE

  1. Cat.No. Product Name Information
  2. GC15086 MLN4924

    Pevonedistat

    MLN4924 is a potent and selective small-molecule inhibitor of NEDD8-activating enzyme (NAE) (IC50 = 4 nM), and is selective relative to the closely related enzymes UAE, SAE, UBA6 and ATG7 (IC50 = 1.5, 8.2, 1.8 and >10 µM, respectively).

     MLN4924 Chemical Structure
  3. GC12175 MLN4924 HCl salt A selective inhibitor of NEDD8-activating enzyme MLN4924 HCl salt Chemical Structure

2 Item(s)

per page

Set Descending Direction