PDHK
PDHK (pyruvate dehydrogenase kinase) is a kinase enzyme which acts to inactivate the enzyme pyruvate dehydrogenase by phosphorylating it using ATP.
Products for PDHK
- Cat.No. Product Name Information
- GC13669 AZD7545 PDHK inhibitor,potent and selective
- GC16795 DCA DCA is a metabolic regulator in cancer cells' mitochondria with anticancer activity. DCA inhibits PDHK, resulting in decreased lactic acid in the tumor microenvironment. DCA increases reactive oxygen species (ROS) generation and promotes cancer cell apoptosis. DCA also works as NKCC inhibitor.
- GC15350 Dicoumarol competitive NADH quinone oxidoreductase (NQO1) inhibitor
- GC50280 JX 06 Potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor
- GC36396 KPLH1130 KPLH1130 is a specific pyruvate dehydrogenase kinase (PDK) inhibitor, blocks macrophage polarization and attenuates proinflammatory responses.
- GC60232 M77976 M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms 4), with an IC50 of 648 μM.
- GC39500 PDK4-IN-1 hydrochloride PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 value of 84 nM.
- GC65502 TM-1 TM-1 is a potent inhibitor of pyruvate dehydrogenase kinase (PDHK1). TM-1 inhibits PDHK1 and PDHK2 with IC50s of 2.97 μM and 5.2 μM, respectively. TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation, and inhibits cell proliferation.
- GC32778 VER-246608 A pan-PDHK inhibitor