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Home >> Signaling Pathways >> Others >> PDHK

PDHK

PDHK (pyruvate dehydrogenase kinase) is a kinase enzyme which acts to inactivate the enzyme pyruvate dehydrogenase by phosphorylating it using ATP.

Products for  PDHK

  1. Cat.No. Product Name Information
  2. GC13669 AZD7545 PDHK inhibitor,potent and selective AZD7545 Chemical Structure
  3. GC16795 DCA DCA is a metabolic regulator in cancer cells' mitochondria with anticancer activity. DCA inhibits PDHK, resulting in decreased lactic acid in the tumor microenvironment. DCA increases reactive oxygen species (ROS) generation and promotes cancer cell apoptosis. DCA also works as NKCC inhibitor. DCA Chemical Structure
  4. GC15350 Dicoumarol

    NSC 17860, NSC 41834, NSC 221570

     competitive NADH quinone oxidoreductase (NQO1) inhibitor Dicoumarol Chemical Structure
  5. GC50280 JX 06

    NSC 402538

     Potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor JX 06 Chemical Structure
  6. GC36396 KPLH1130 KPLH1130 is a specific pyruvate dehydrogenase kinase (PDK) inhibitor, blocks macrophage polarization and attenuates proinflammatory responses. KPLH1130 Chemical Structure
  7. GC60232 M77976 M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms 4), with an IC50 of 648 μM. M77976 Chemical Structure
  8. GC73738 PDK-IN-3 PDK-IN-3 (compound 1) is a potent pan inhibitor of PDK with IC50s of 109.3, 135.8, 458.7 nM and 8.67 μM against PDK 1-4, respectively. PDK-IN-3 Chemical Structure
  9. GC39500 PDK4-IN-1 hydrochloride PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 value of 84 nM. PDK4-IN-1 hydrochloride Chemical Structure
  10. GC65502 TM-1 TM-1 is a potent inhibitor of pyruvate dehydrogenase kinase (PDHK1). TM-1 inhibits PDHK1 and PDHK2 with IC50s of 2.97 μM and 5.2 μM, respectively. TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation, and inhibits cell proliferation. TM-1 Chemical Structure
  11. GC32778 VER-246608 A pan-PDHK inhibitor VER-246608 Chemical Structure

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