ROR/RAR/RXR
RAR/RXR is a heterodimer of RAR (retinoic acid receptor) and RXR (retinoid X receptor) that cause dissociation of corepressor and recruitment of coactivator protein that, in turn, promotes transcription of the downstream target gene into mRNA and eventually protein.
Products for ROR/RAR/RXR
- Cat.No. Product Name Information
- GC50708 (±)-ML 209 An RORγt antagonist
- GC34960 (+)-Talarozole (+)-Talarozole is a potent inhibitor of retinoic acid metabolism extracted from patent WO 1997049704 A1.
- GC18632 6-hydroxy Bexarotene 6-hydroxy Bexarotene is an oxidative metabolite of bexarotene , a high-affinity ligand for retinoid X receptors (RXRs).
- GC46740 7β,27-dihydroxy Cholesterol An oxysterol and agonist of RORγ and RORγt
- GC40464 9(R)-HETE 9(R)-HETE is an enantiomer which makes up 50% of (±)9-HETE.
- GC40465 9(S)-HETE 9(S)-HETE is an enantiomer which makes up 50% of (±)9-HETE.
- GC14596 9-cis-Retinoic Acid 9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist.
- GC11852 AC 261066 Potent RARβ2 agonist
- GC10871 AC 55649 RARβ2 agonist, potent and selective
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GC17094
Acitretin
Metabolite of etretinate
- GC17113 Acitretin sodium Second-generation, systemic retinoid
- GC10610 Adapalene RARβ and RARγ agonist
- GC14379 Adapalene sodium salt Retinoic acid receptor agonist
- GC46798 Adapalene-d3 An internal standard for the quantification of adapalene
- GC13959 Adarotene An atypical retinoid
- GC32817 AGN 193109 AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively.
- GC33315 AGN 194078 AGN 194078 is a selective RARα agonist with a Kd and EC50 of 3 and 112 nM, respectively.
- GC12598 AGN 194310 pan-RAR antagonist
- GC35265 AGN 195183 AGN 195183 (IRX-5183) is a potent and selective agonist of RARα (Kd=3 nM) with improved binding selectivity relative to AGN 193836. AGN 195183 has no activity on RARβ/γ.
- GC35266 AGN 196996 AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM).
- GC35267 AGN 205327 AGN 205327 is a potent synthetic RARs agonist with EC50 of 3766/734/32 nM for RARα/β/γ respectively; no inhibition on RXR.
- GC35268 AGN 205728 AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM; no inhibiton on RARα and RARβ.
- GC39584 AGN194204 AGN194204 (IRX4204) is an orally active and selective RXR agonist with Kd values 0.4 nM, 3.6 nM and 3.8 nM and EC50s of 0.2 nM, 0.8 nM and 0.08 nM for RXRα, RXRβ and RXRγ, respectively.
- GC14511 all-trans Retinal converted to retinoic acid in vivo
- GC42769 all-trans Retinoyl β-D-Glucuronide all-trans Retinoyl β-D-glucuronide is a metabolite of all-trans retinoic acid formed by the UDP-glucuronosyltransferase (UGT) system.
- GC49393 all-trans-13,14-Dihydroretinol A metabolite of all-trans retinoic acid
- GC18482 all-trans-5,6-epoxy Retinoic Acid all-trans-5,6-epoxy Retinoic acid (5,6-epoxy RA) is an agonist of all isoforms of the retinoic acid receptor (RAR; EC50s = 77, 35, and 4 nM for RARα, RARβ, and RARγ, respectively).
- GC13664 AM580 Selective RARα agonist
- GC63932 Amsilarotene Amsilarotene (TAC-101; Am 555S), an orally active synthetic retinoid, has selective affinity for retinoic acid receptor α (RAR-α) binding with Ki of 2.4, 400 nM for RAR-α and RAR-β. Amsilarotene induces the apoptotic of human gastric cancer, hepatocellular carcinoma and ovarian carcinoma cells. Amsilarotene can be used for the research of cancer.
- GC19035 AR7 A retinoic acid receptor α (RARα) antagonist
- GC46892 ATRA-BA Hybrid A prodrug form of all-trans retinoic acid and butyric acid
- GC10037 Bexarotene Retinoid Receptor agonist
- GC46923 Bexarotene-d4 A neuropeptide with diverse biological activities
- GC60076 Bigelovin Bigelovin, a sesquiterpene lactone isolated from Inula helianthus-aquatica, is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation.
- GC11504 BMS 195614 BMS 195614 (BMS 614) is a neutral RARα-selective antagonist with a Ki of 2.5 nM.
- GC49654 BMS 270394 A RARγ agonist
- GC10656 BMS 453 RAR agonist
- GC15648 BMS 493 Pan-RAR inverse agonist
- GC14185 BMS 753 RARα-selective agonist
- GC17382 BMS 961 Selective RARγ agonist
- GC46104 Butyric Acid-d7 An internal standard for the quantification of sodium butyrate
- GC11794 CD 1530 RAR receptor agonist
- GC10080 CD 2314 RARβ agonist,potent and selective
- GC12072 CD 2665 Selective RARβ/γ antagonist
- GC17730 CD 3254 RXRα agonist,potent and selective
- GC11464 CD 437 RARγ-selective agonist,potent and cell-permeable
- GC11053 Ch 55 RAR agonist
- GC11676 EC 23 retinoic acid receptors agonist
- GC12577 ER 50891 RARα receptor antagonist
- GC17143 Fenretinide A synthetic retinoic acid derivative
-
GC11694
Fluorobexarotene
RXR agonist
- GC10064 Flurizan A COX-inactive enantiomer of flurbiprofen
- GC49306 Isopimaric Acid A diterpenoid resin acid
- GC15382 Isotretinoin A retinoid
- GC12294 LE 135 RARβ antagonist
- GC44059 LG 100268 LG 100268 is an agonist of retinoid X receptors (RXRs; Kd = 3 nM).
- GC34173 LG-100064 LG-100064 is a retinoid-X-receptor (RXR) agonist, with EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ; LG-100064 can be used in the research of cancer.
- GC15483 Luffariellolide agonist for the RA receptors RAR α, β, and γ
- GC19232 LY2955303 LY2955303 is a potent and selective retinoic acid receptor gamma (RARγ) antagonist with a Ki of 1.09 nM.
- GN10301 Magnolol
- GC52325 MeTC7 A vitamin D receptor antagonist
-
GC10212
MM 11253
RARγ antagonist
-
GC14304
Palovarotene
Selective retinoic acid receptor gamma(RAR-γ) agonist
- GC32107 Peretinoin (NIK333) Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR).
- GC17433 Phytol activator of retinoid X receptors (RXRs)
- GC34740 PROTAC RAR Degrader-1 PROTAC RAR Degrader-1 comprises a IAP ligand binding group, a linker and a RAR ligand binding group. PROTAC RAR Degrader-1 is an RAR degrader. Maximal RAR degradation at 30 μM concentration in HT1080 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs).
- GC66433 Ro 41-5253 Ro 41-5253 is an orally active selective retinoic acid receptor alpha (RARα) antagonist. Ro 41-5253 can bind RARα without inducing transcription or affecting RAR/RXR heterodimerization and DNA binding. Ro 41-5253 can inhibit cancer cell proliferation and induce apoptosis, has antitumor activity.
- GC45567 SR 1903
- GC17063 Talarozole
- GC13984 Tamibarotene A selective RARα agonist
- GC15459 Tazarotene Topical retinoid;antiproliferative;inducer of TIG3 tumor suppressor
- GC45001 Tazarotenic Acid Tazarotenic acid is an active metabolite of tazarotene, an acetylenic retinoid prodrug that induces epidermal hyperplasia with an ED50 value of 100 nM.
- GC18147 Tretinoin (Aberela) Tretinoin (Aberela) is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Tretinoin (Aberela) is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Tretinoin (Aberela) bind to PPARβ/δ with Kd of 17 nM. Tretinoin (Aberela) acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.
- GC31935 Trifarotene (CD5789) Trifarotene (CD5789) (CD5789) is a potent and selective RARγ agonist.
- GC14273 TTNPB (Arotinoid Acid) TTNPB (Arotinoid Acid) is a highly potent RAR agonist. Competitive binding assays using human RARs yield IC50s of α=5.1 nM, β= 4.5 nM, and γ=9.3 nM, respectively.
- GC13199 UVI 3003 RXR antagonist
- GC52242 V-125 An RXR agonist
- GC37913 Vitamin A An intermediate in retinol metabolism 325,000 IU/g
- GC34862 WYC-209 WYC-209, a synthetic retinoid, is a retinoic acid receptor (RAR) agonist. WYC-209 induces apoptosis primarily via the caspase 3 pathway (IC50=0.19?μM for inmalignant murine melanoma TRCs), and has long-term effects with little toxicity.
-
GC70155
YCT529
YCT529 is an effective, selective, and orally active RAR-α inhibitor.