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Home >> Signaling Pathways >> Endocrinology and Hormones >> ROR/RAR/RXR

ROR/RAR/RXR

RAR/RXR is a heterodimer of RAR (retinoic acid receptor) and RXR (retinoid X receptor) that cause dissociation of corepressor and recruitment of coactivator protein that, in turn, promotes transcription of the downstream target gene into mRNA and eventually protein.

Products for  ROR/RAR/RXR

  1. Cat.No. Product Name Information
  2. GC34960 (+)-Talarozole (+)-Talarozole is a potent inhibitor of retinoic acid metabolism extracted from patent WO 1997049704 A1. (+)-Talarozole Chemical Structure
  3. GC18632 6-hydroxy Bexarotene 6-hydroxy Bexarotene is an oxidative metabolite of bexarotene , a high-affinity ligand for retinoid X receptors (RXRs). 6-hydroxy Bexarotene Chemical Structure
  4. GC46740 7β,27-dihydroxy Cholesterol

    7β,27-DHC

     An oxysterol and agonist of RORγ and RORγt 7β,27-dihydroxy Cholesterol Chemical Structure
  5. GC40464 9(R)-HETE

    9(R)-Hydroxyeicosatetraenoic Acid

     9(R)-HETE is an enantiomer which makes up 50% of (±)9-HETE. 9(R)-HETE Chemical Structure
  6. GC40465 9(S)-HETE

    9(S)-Hydroxyeicosatetraenoic Acid

     9(S)-HETE is an enantiomer which makes up 50% of (±)9-HETE. 9(S)-HETE Chemical Structure
  7. GC46754 9(S)-HETE-d8

    9(S)-Hydroxyeicosatetraenoic Acid-d8

     A neuropeptide with diverse biological activities 9(S)-HETE-d8 Chemical Structure
  8. GC14596 9-cis-Retinoic Acid

    Alitretinoin, NSC 659772, Panretin, 9-cis RA

     9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic Acid Chemical Structure
  9. GC11852 AC 261066 Potent RARβ2 agonist AC 261066 Chemical Structure
  10. GC10871 AC 55649 RARβ2 agonist, potent and selective AC 55649 Chemical Structure
  11. GC17094 Acitretin

    all-trans Acitretin, Ro 10-1670, Ro 10-1670/000

    Metabolite of etretinate

     Acitretin Chemical Structure
  12. GC17113 Acitretin sodium Second-generation, systemic retinoid Acitretin sodium Chemical Structure
  13. GC10610 Adapalene

    CD 271

     RARβ and RARγ agonist Adapalene Chemical Structure
  14. GC14379 Adapalene sodium salt Retinoic acid receptor agonist Adapalene sodium salt Chemical Structure
  15. GC46798 Adapalene-d3 An internal standard for the quantification of adapalene Adapalene-d3 Chemical Structure
  16. GC13959 Adarotene

    ST1926

     An atypical retinoid Adarotene Chemical Structure
  17. GC68629 AGN 192870

    AGN 192870 is a RAR neutral antagonist with Kd values of 147, 33, and 42 nM for RARα, RARβ, and RARγ respectively. The IC50 values for AGN 192870 are 87 and 32 nM for RARα and RARγ respectively. AGN 192870 exhibits partial agonistic activity on RARβ.

     AGN 192870 Chemical Structure
  18. GC32817 AGN 193109 AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively. AGN 193109 Chemical Structure
  19. GC33315 AGN 194078 AGN 194078 is a selective RARα agonist with a Kd and EC50 of 3 and 112 nM, respectively. AGN 194078 Chemical Structure
  20. GC12598 AGN 194310

    VTP-194310

     pan-RAR antagonist AGN 194310 Chemical Structure
  21. GC35265 AGN 195183

    IRX-5183; VTP-195183; NRX-195183

     AGN 195183 (IRX-5183) is a potent and selective agonist of RARα (Kd=3 nM) with improved binding selectivity relative to AGN 193836. AGN 195183 has no activity on RARβ/γ. AGN 195183 Chemical Structure
  22. GC35266 AGN 196996 AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM). AGN 196996 Chemical Structure
  23. GC35267 AGN 205327 AGN 205327 is a potent synthetic RARs agonist with EC50 of 3766/734/32 nM for RARα/β/γ respectively; no inhibition on RXR. AGN 205327 Chemical Structure
  24. GC35268 AGN 205728 AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM; no inhibiton on RARα and RARβ. AGN 205728 Chemical Structure
  25. GC39584 AGN194204

    IRX4204; NRX194204; VTP 194204

     AGN194204 (IRX4204) is an orally active and selective RXR agonist with Kd values 0.4 nM, 3.6 nM and 3.8 nM and EC50s of 0.2 nM, 0.8 nM and 0.08 nM for RXRα, RXRβ and RXRγ, respectively. AGN194204 Chemical Structure
  26. GC14511 all-trans Retinal

    Retinaldehyde,Vitamin A aldehyde

     converted to retinoic acid in vivo all-trans Retinal Chemical Structure
  27. GC40094 all-trans Retinoic Acid-d5

    atRA-d5, RA-d5, Vitamin A Acid-d5

     all-trans Retinoic acid-d5 is intended for use as an internal standard for the quantification of all-trans retinoic acid by GC- or LC-MS. all-trans Retinoic Acid-d5 Chemical Structure
  28. GC42769 all-trans Retinoyl β-D-Glucuronide

    Retinoyl Glucuronide, Retinoyl β-D Glucuronide

     all-trans Retinoyl β-D-glucuronide is a metabolite of all-trans retinoic acid formed by the UDP-glucuronosyltransferase (UGT) system. all-trans Retinoyl β-D-Glucuronide Chemical Structure
  29. GC49393 all-trans-13,14-Dihydroretinol A metabolite of all-trans retinoic acid all-trans-13,14-Dihydroretinol Chemical Structure
  30. GC18482 all-trans-5,6-epoxy Retinoic Acid

    5,6-epoxy-atRA, 5,6-epoxy RA

     all-trans-5,6-epoxy Retinoic acid (5,6-epoxy RA) is an agonist of all isoforms of the retinoic acid receptor (RAR; EC50s = 77, 35, and 4 nM for RARα, RARβ, and RARγ, respectively). all-trans-5,6-epoxy Retinoic Acid Chemical Structure
  31. GC13664 AM580

    CD336, NSC 608001, Ro 406055

     Selective RARα agonist AM580 Chemical Structure
  32. GC63932 Amsilarotene Amsilarotene (TAC-101; Am 555S), an orally active synthetic retinoid, has selective affinity for retinoic acid receptor α (RAR-α) binding with Ki of 2.4, 400 nM for RAR-α and RAR-β. Amsilarotene induces the apoptotic of human gastric cancer, hepatocellular carcinoma and ovarian carcinoma cells. Amsilarotene can be used for the research of cancer. Amsilarotene Chemical Structure
  33. GC19035 AR7 A retinoic acid receptor α (RARα) antagonist AR7 Chemical Structure
  34. GC46892 ATRA-BA Hybrid A prodrug form of all-trans retinoic acid and butyric acid ATRA-BA Hybrid Chemical Structure
  35. GC10037 Bexarotene

    LG 100069, LGD 1069, Ro 264455, SR 11247

     Retinoid Receptor agonist Bexarotene Chemical Structure
  36. GC46923 Bexarotene-d4

    LGD1069 D4

     A neuropeptide with diverse biological activities Bexarotene-d4 Chemical Structure
  37. GC60076 Bigelovin Bigelovin, a sesquiterpene lactone isolated from Inula helianthus-aquatica, is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation. Bigelovin Chemical Structure
  38. GC11504 BMS 195614

    BMS 614

     BMS 195614 (BMS 614) is a neutral RARα-selective antagonist with a Ki of 2.5 nM. BMS 195614 Chemical Structure
  39. GC49654 BMS 270394 A RARγ agonist BMS 270394 Chemical Structure
  40. GC10656 BMS 453

    BMS 189453

     RAR agonist BMS 453 Chemical Structure
  41. GC15648 BMS 493

    BMS 204493

     Pan-RAR inverse agonist BMS 493 Chemical Structure
  42. GC14185 BMS 753 RARα-selective agonist BMS 753 Chemical Structure
  43. GC17382 BMS 961

    BMS 961

     Selective RARγ agonist BMS 961 Chemical Structure
  44. GC68781 BMS641

    BMS-209641

    BMS641 (BMS-209641) is a selective RARβ agonist. BMS641 has 100 times higher affinity for RARβ (Kd, 2.5 nM) than for RARα (Kd, 225 nM) or RARγ (Kd, 223 nM).

     BMS641 Chemical Structure
  45. GC46104 Butyric Acid-d7 An internal standard for the quantification of sodium butyrate Butyric Acid-d7 Chemical Structure
  46. GC11794 CD 1530 RAR receptor agonist CD 1530 Chemical Structure
  47. GC10080 CD 2314 RARβ agonist,potent and selective CD 2314 Chemical Structure
  48. GC12072 CD 2665 Selective RARβ/γ antagonist CD 2665 Chemical Structure
  49. GC17730 CD 3254 RXRα agonist,potent and selective CD 3254 Chemical Structure
  50. GC11464 CD 437

    CD437

     RARγ-selective agonist,potent and cell-permeable CD 437 Chemical Structure
  51. GC11053 Ch 55 RAR agonist Ch 55 Chemical Structure
  52. GC11676 EC 23

    AGN 190205, BASF 46928

     retinoic acid receptors agonist EC 23 Chemical Structure
  53. GC12577 ER 50891 RARα receptor antagonist ER 50891 Chemical Structure
  54. GC72808 ER 50891 quarterhydrate ER 50891 quarterdrate is a potent antagonist of retinoic acid receptor α(RARα). ER 50891 quarterhydrate Chemical Structure
  55. GC17143 Fenretinide

    4-HPR, 4-Hydroxy(phenyl)retinamide, MK-4016, Retinoic Acid p-hydroxyphenylamide, Ro 22-4667

     A synthetic retinoic acid derivative Fenretinide Chemical Structure
  56. GC50190 Fenretinide - d4

    4-HPR-d4, 4-Hydroxy(phenyl)retinamide-d4, Retinoic Acid p-hydroxyphenylamide-d4

     Fenretinide - d4 is the deuterium labeled Fenretinide. Fenretinide - d4 Chemical Structure
  57. GC11694 Fluorobexarotene

    RXR agonist

     Fluorobexarotene Chemical Structure
  58. GC10064 Flurizan

    E7869, Flurizan, Tarenflurbil

     A COX-inactive enantiomer of flurbiprofen Flurizan Chemical Structure
  59. GC49306 Isopimaric Acid

    7,15-Isopimaradien-18-oic Acid, (+)-Isopimaric Acid

     A diterpenoid resin acid Isopimaric Acid Chemical Structure
  60. GC15382 Isotretinoin

    AGN 190013, 13(Z)-Retinoic Acid, 13-cis-Vitamin A Acid

     A retinoid Isotretinoin Chemical Structure
  61. GC12294 LE 135 RARβ antagonist LE 135 Chemical Structure
  62. GC44059 LG 100268

    AGN 192620, CD3127

     LG 100268 is an agonist of retinoid X receptors (RXRs; Kd = 3 nM). LG 100268 Chemical Structure
  63. GC34173 LG-100064 LG-100064 is a retinoid-X-receptor (RXR) agonist, with EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ; LG-100064 can be used in the research of cancer. LG-100064 Chemical Structure
  64. GC15483 Luffariellolide agonist for the RA receptors RAR α, β, and γ Luffariellolide Chemical Structure
  65. GC19232 LY2955303 LY2955303 is a potent and selective retinoic acid receptor gamma (RARγ) antagonist with a Ki of 1.09 nM. LY2955303 Chemical Structure
  66. GN10301 Magnolol

    NSC 293099

     Magnolol Chemical Structure
  67. GC52325 MeTC7 A vitamin D receptor antagonist MeTC7 Chemical Structure
  68. GC10212 MM 11253

    RARγ antagonist

     MM 11253 Chemical Structure
  69. GC73494 MSU-42011 MSU-42011 is an orally active retinoid X receptor (RXR) agonist. MSU-42011 Chemical Structure
  70. GC14304 Palovarotene

    Ro 3300074

    Selective retinoic acid receptor gamma(RAR-γ) agonist

     Palovarotene Chemical Structure
  71. GC32107 Peretinoin (NIK333)

    NIK333

     Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin (NIK333) Chemical Structure
  72. GC17433 Phytol

    trans-Phytol

     activator of retinoid X receptors (RXRs) Phytol Chemical Structure
  73. GC34740 PROTAC RAR Degrader-1 PROTAC RAR Degrader-1 comprises a IAP ligand binding group, a linker and a RAR ligand binding group. PROTAC RAR Degrader-1 is an RAR degrader. Maximal RAR degradation at 30 μM concentration in HT1080 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs). PROTAC RAR Degrader-1 Chemical Structure
  74. GC31345 Retinol (Vitamin A1)

    all-trans Retinol, all-trans Vitamin A, NSC 122759, Vitamin A1 Alcohol

     Retinol, also known as vitamin A1, is a fat-soluble vitamin in the vitamin A family that is found in food and used as a dietary supplement[1]. Retinol (Vitamin A1) Chemical Structure
  75. GC66433 Ro 41-5253 Ro 41-5253 is an orally active selective retinoic acid receptor alpha (RARα) antagonist. Ro 41-5253 can bind RARα without inducing transcription or affecting RAR/RXR heterodimerization and DNA binding. Ro 41-5253 can inhibit cancer cell proliferation and induce apoptosis, has antitumor activity. Ro 41-5253 Chemical Structure
  76. GC70895 RXR antagonist 1 RXR antagonist 1 (compound 6a) is a retinoid X receptor (RXR) modulator. RXR antagonist 1 Chemical Structure
  77. GC45567 SR 1903   SR 1903 Chemical Structure
  78. GC17063 Talarozole Talarozole Chemical Structure
  79. GC13984 Tamibarotene

    Amnolake, NSC 608000, Retinobenzoic Acid, Tamibarotene

     A selective RARα agonist Tamibarotene Chemical Structure
  80. GC15459 Tazarotene

    AGN 190168

     Topical retinoid;antiproliferative;inducer of TIG3 tumor suppressor Tazarotene Chemical Structure
  81. GC45001 Tazarotenic Acid

    AGN 190299

     Tazarotenic acid is an active metabolite of tazarotene, an acetylenic retinoid prodrug that induces epidermal hyperplasia with an ED50 value of 100 nM. Tazarotenic Acid Chemical Structure
  82. GC18147 Tretinoin (Aberela)

    Trans Retinoic Acid

     Tretinoin (Aberela) is a vitamin A-derived, non-peptidic, small lipophilic molecule that acts as ligand for nuclear RA receptors (RARs), converting them from transcriptional repressors to activators. Tretinoin (Aberela) Chemical Structure
  83. GC31935 Trifarotene (CD5789) Trifarotene (CD5789) (CD5789) is a potent and selective RARγ agonist. Trifarotene (CD5789) Chemical Structure
  84. GC14273 TTNPB (Arotinoid Acid)

    AGN 191183, Arotinoid Acid, Ro 13-7410

     TTNPB (Arotinoid Acid) is a highly potent RAR agonist. Competitive binding assays using human RARs yield IC50s of α=5.1 nM, β= 4.5 nM, and γ=9.3 nM, respectively. TTNPB (Arotinoid Acid) Chemical Structure
  85. GC13199 UVI 3003 RXR antagonist UVI 3003 Chemical Structure
  86. GC52242 V-125 An RXR agonist V-125 Chemical Structure
  87. GC37913 Vitamin A

    all-trans Retinol, all-trans Vitamin A, NSC 122759, Vitamin A1 Alcohol

     An intermediate in retinol metabolism 325,000 IU/g Vitamin A Chemical Structure
  88. GC34862 WYC-209 WYC-209, a synthetic retinoid, is a retinoic acid receptor (RAR) agonist. WYC-209 induces apoptosis primarily via the caspase 3 pathway (IC50=0.19?μM for inmalignant murine melanoma TRCs), and has long-term effects with little toxicity. WYC-209 Chemical Structure
  89. GC73215 XS-060 XS-060 is a potent anticancer agent and RXRα antagonist. XS-060 Chemical Structure
  90. GC70155 YCT529

    YCT529 is an effective, selective, and orally active RAR-α inhibitor.

     YCT529 Chemical Structure

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