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Home >> Signaling Pathways >> PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

Products for  PI3K/Akt/mTOR Signaling

  1. Cat.No. Product Name Information
  2. GC36426 LAS191954 LAS191954 is a potent, selective and orally active PI3Kδ inhibitor for inflammatory diseases treatment, with an IC50 of 2.6 nM. LAS191954 Chemical Structure
  3. GC19471 Leniolisib

    A potent and selective PI3Kδ inhibitor

     Leniolisib Chemical Structure
  4. GC36447 Licochalcone E Licochalcone E, a flavonoid compound isolated from Glycyrrhiza inflate, inhibits NF-κB and AP-1 transcriptional activity through the inhibition of AKT and MAPK activation. Licochalcone E Chemical Structure
  5. GC36456 Licoricidin Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin Chemical Structure
  6. GC16039 LJH685 RSK (p90 ribosomal S6 kinase) inhibitor LJH685 Chemical Structure
  7. GC16601 LJI308

    pan-RSK inhibitor

     LJI308 Chemical Structure
  8. GC30770 LM22B-10 An activator of TrkB and TrkC LM22B-10 Chemical Structure
  9. GC32510 Loureirin A Loureirin A is a flavonoid extracted from Dragon's Blood, can inhibit Akt phosphorylation, and has antiplatelet activity. Loureirin A Chemical Structure
  10. GC50276 LTURM 36 PI 3-kinase δ inhibitor LTURM 36 Chemical Structure
  11. GC19227 LTURM34

    LTURM34 is a specific DNA-PK inhibitor with an IC50 of 0.034 uM.

     LTURM34 Chemical Structure
  12. GC30884 LX2343 An inhibitor of BACE1 and PI3K LX2343 Chemical Structure
  13. GC12045 LY 303511 An inhibitor of cell proliferation LY 303511 Chemical Structure
  14. GC17187 LY2090314 A potent and selective inhibitor of GSK3 LY2090314 Chemical Structure
  15. GC12089 LY2584702 LY2584702 is a selective ATP competitive inhibitor of p70S6K with an IC50 of 4 nM. In S6K1 enzyme assay, the IC50 of LY-2584702 is 2 nM. LY2584702 Chemical Structure
  16. GC14371 LY3023414 LY3023414 (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, DNA-PK and mTOR, respectively. LY3023414 potently inhibits mTORC1/2 at low nanomolar concentrations. LY3023414 Chemical Structure
  17. GC61029 Marein A glucoside chalcone with diverse biological activities Marein Chemical Structure
  18. GC48707 MDK34597 MDK34597 (compound 35) is a potent PI3K p110α inhibitor with an pIC50 of 6.85. MDK34597 Chemical Structure
  19. GC25626 MELK-8a Dihydrochloride MELK-8a Dihydrochloride is a novel inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC50 of 2 nM. MELK-8a Dihydrochloride Chemical Structure
  20. GC32736 MELK-8a hydrochloride MELK-8a hydrochloride is a novel maternal embryonic leucine zipper kinase (MELK) inhibitor with an IC50 of 2 nM. MELK-8a hydrochloride Chemical Structure
  21. GC66065 MELK-IN-1 MELK-IN-1 is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC50 and a Ki of 3 nM and 0.39 nM, respectively. MELK-IN-1 Chemical Structure
  22. GC61045 Metformin D6 hydrochloride An internal standard for the quantification of metformin Metformin D6 hydrochloride Chemical Structure
  23. GC17443 Metformin HCl Metformin HCl (1,1-Dimethylbiguanide hydrochloride) inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research. Metformin HCl Chemical Structure
  24. GC38815 Methyl cinnamate Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate Chemical Structure
  25. GC64402 MHY-1685 MHY-1685, a novel mammalian target of rapamycin (mTOR) inhibitor, provides opportunities to improve hCSC-based myocardial regeneration. MHY-1685 Chemical Structure
  26. GC13790 MHY1485

    MHY1485 is a potent activator of mTOR, which inhibits autophagy and the fusion between autophagosomes and lysosomes.

     MHY1485 Chemical Structure
  27. GC10811 Miltefosine PI3K/Akt inhibitor Miltefosine Chemical Structure
  28. GC25638 Miransertib (ARQ 092) HCl Miransertib (ARQ 092) HCl is a novel, orally bioavailable and selective AKT pathway inhibitor exhibiting a manageable safety profile among patients with advanced solid tumors. Miransertib (ARQ 092) HCl Chemical Structure
  29. GC16304 MK-2206 dihydrochloride

    An allosteric Akt inhibitor

     MK-2206 dihydrochloride Chemical Structure
  30. GC31361 MK-3903 MK-3903 is a potent and selective AMP-activated protein kinase (AMPK) activator with an EC50 of 8 nM. MK-3903 Chemical Structure
  31. GC31470 MK8722 MK8722 is a potent and systemic pan-AMPK activator. MK8722 Chemical Structure
  32. GC65143 MKC-1 MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family. MKC-1 Chemical Structure
  33. GC49440 ML-9 A PKB/Akt inhibitor ML-9 Chemical Structure
  34. GC62109 MMV390048 MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 ?M). MMV390048 Chemical Structure
  35. GC66013 MOMIPP MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB). MOMIPP Chemical Structure
  36. GC25648 MOTS-c MOTS-c, a mitochondria-derived peptide (MDP), exerts antinociceptive and anti-inflammatory effects through activating AMPK pathway and inhibiting MAP kinases-c-fos signaling pathway. MOTS-c Chemical Structure
  37. GC65466 MS170 MS170 is a potent and selective PROTAC AKT degrader. MS170 depletes cellular total AKT (T-AKT) with the DC50 value of 32 nM. MS170 binds to AKT1, AKT2, and AKT3 with Kds of 1.3 nM, 77 nM, and 6.5 nM, respectively. MS170 Chemical Structure
  38. GC60258 MT 63-78 MT 63-78 is a specific and potent direct AMPK activator with an EC50 of 25 μM. MT 63–78 also induces cell mitotic arrest and apoptosis. MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathways. MT 63-78 has antitumor effects. MT 63-78 Chemical Structure
  39. GC64304 MTI-31 MTI-31 is a potent, orally active and highly selective inhibitor of mTORC1 and mTORC2. MTI-31 Chemical Structure
  40. GC65115 mTOR inhibitor-1 mTOR inhibitor-1 is a novel mTOR pathway inhibitor which can suppress cells proliferation and inducing autophagy. mTOR inhibitor-1 Chemical Structure
  41. GC62339 mTOR inhibitor-8 mTOR inhibitor-8 is an mTOR inhibitor and autophagy inducer. mTOR inhibitor-8 inhibits the activity of mTOR via FKBP12 and induces autophagy of A549 human lung cancer cells. mTOR inhibitor-8 Chemical Structure
  42. GC19256 MTX-211 MTX-211 is a dual inhibitor of EGFR and PI3K, used for the treatment of cancer and other diseases. MTX-211 Chemical Structure
  43. GC65442 Musk ketone Musk ketone (MK) is a widely used artificial fragrance. Musk ketone Chemical Structure
  44. GC60262 N-Feruloyloctopamine N-Feruloyloctopamine is an antioxidant constituent. N-Feruloyloctopamine significantly decreases thephosphorylationlevels of Akt and p38MAPK. N-Feruloyloctopamine Chemical Structure
  45. GC31536 N-Oleoyl glycine

    A putative substrate for peptidyl glycine αamidating enzyme

     N-Oleoyl glycine Chemical Structure
  46. GC36714 Nemiralisib Nemiralisib (GSK2269557 free base) is a potent and highly selective PI3Kδ inhibitor with a pKi of 9.9. Nemiralisib Chemical Structure
  47. GC38567 Nepodin A naphthol with diverse biological activities Nepodin Chemical Structure
  48. GC18089 Nordihydroguaiaretic acid A non-selective LO inhibitor Nordihydroguaiaretic acid Chemical Structure
  49. GC11907 NSC 210902 NSC 210902 is a CK2 inhibitor, with an IC50 of 150 nM. NSC 210902 Chemical Structure
  50. GC33014 NSC781406 A dual inhibitor of PI3K and mTOR NSC781406 Chemical Structure
  51. GC12332 NU 7026 DNPK inhibitor,ATP-competitive and potent NU 7026 Chemical Structure
  52. GC11251 NU7441 (KU-57788) NU7441 (KU-57788) (NU7441) is a highly potent and selective DNA-PK inhibitor with an IC50 of 14 nM. NU7441 (KU-57788) is an NHEJ pathway inhibitor. NU7441 (KU-57788) also inhibits PI3K and mTOR with IC50s of 5.0 and 1.7 μM, respectively. NU7441 (KU-57788) Chemical Structure
  53. GC63121 NV-5138 NV-5138, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 Chemical Structure
  54. GC63122 NV-5138 hydrochloride NV-5138 hydrochloride, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 hydrochloride Chemical Structure
  55. GC13725 NVP-BAG956 A dual PDK1 and class I PI3K inhibitor NVP-BAG956 Chemical Structure
  56. GC16145 NVP-BGT226 BGT226 (NVP-NVP-BGT226) is a PI3K (with IC50s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and PI3Kγ) /mTOR dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells. NVP-BGT226 Chemical Structure
  57. GC14504 NVP-BKM120 Hydrochloride An inhibitor of class I PI3K isoforms NVP-BKM120 Hydrochloride Chemical Structure
  58. GC36786 NVP-QAV-572 NVP-QAV-572 is a PI3K inhibitor extracted from patent US7998990B2, Compound Example 8, has an IC50 of 10 nM. NVP-QAV-572 Chemical Structure
  59. GC62141 NVS-PI3-4 NVS-PI3-4 is a specific PI3Kγ inhibitor. NVS-PI3-4 Chemical Structure
  60. GC19269 O-304 O-304 is a small molecule AMPK activator. O-304 Chemical Structure
  61. GC36807 ON 146040 ON 146040 is a potent PI3Kα and PI3Kδ (IC50≈14 and 20 nM, respectively) inhibitor. ON 146040 also inhibits Abl1 (IC50<150 nM). ON 146040 Chemical Structure
  62. GN10692 Oridonin

    A diterpenoid with anti-inflammatory and anticancer properties

     Oridonin Chemical Structure
  63. GN10732 Oroxin B Oroxin B Chemical Structure
  64. GC14071 OSI-027 MTORC1/ mTORC2 inhibitor OSI-027 Chemical Structure
  65. GC15742 OSU-03012 (AR-12) Potent PDK1 inhibitor OSU-03012 (AR-12) Chemical Structure
  66. GC10201 OTSSP167 MELK inhibitor OTSSP167 Chemical Structure
  67. GC12155 OTSSP167 hydrochloride MELK inhibitor,highly potent and selective OTSSP167 hydrochloride Chemical Structure
  68. GC15740 OXA-01 mTORC1 and mTORC2 inhibitor OXA-01 Chemical Structure
  69. GC36832 P110δ-IN-1 P110δ-IN-1 is a potent and selective inhibitor of P110δ extracted from patent WO 2014055647 A1, with an IC50 of 8.4 nM. P110δ-IN-1 Chemical Structure
  70. GN10752 Pachymic acid Pachymic acid Chemical Structure
  71. GC33765 Palmitelaidic Acid (9-trans-Hexadecenoic acid) Palmitelaidic Acid (9-trans-Hexadecenoic acid) (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitelaidic Acid (9-trans-Hexadecenoic acid) Chemical Structure
  72. GC12773 Palomid 529

    PI3K/Akt/mTOR inhibitor

     Palomid 529 Chemical Structure
  73. GC36855 Paris saponin VII Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia. Paris saponin VII Chemical Structure
  74. GC32916 Parsaclisib (INCB050465) Parsaclisib (INCB050465) (INCB050465) is a potent, selective and orally active inhibitor of PI3Kδ, with an IC50 of 1 nM at 1 mM ATP. Parsaclisib (INCB050465) shows approximately 20000-fold selectivity over other PI3K class I isoforms. Parsaclisib (INCB050465) can be used for the research of relapsed or refractory B-cell malignancies. Parsaclisib (INCB050465) Chemical Structure
  75. GC62593 Parsaclisib hydrochloride Parsaclisib hydrochloride (INCB050465 hydrochloride) is a potent, selective and orally active inhibitor of PI3Kδ, with an IC50 of 1 nM at 1 mM ATP. Parsaclisib hydrochloride shows approximately 20000-fold selectivity over other PI3K class I isoforms. Parsaclisib hydrochloride can be used for the research of relapsed or refractory B-cell malignancies. Parsaclisib hydrochloride Chemical Structure
  76. GC12866 PDK1 inhibitor PDK1 inhibitor Chemical Structure
  77. GC66474 PDK1-IN-RS2 PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1. PDK1-IN-RS2 Chemical Structure
  78. GC44587 PDMP (hydrochloride) PDMP is a ceramide analog first prepared in a search for inhibitors of glucosylceramide synthase. PDMP (hydrochloride) Chemical Structure
  79. GC15680 Perifosine Akt inhibitor Perifosine Chemical Structure
  80. GC16417 PF-04691502 PI3K/mTOR (FRAP) inhibitor PF-04691502 Chemical Structure
  81. GC63446 PF-04802367 PF-04802367 (PF-367) is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay. PF-04802367 Chemical Structure
  82. GC19283 PF-04979064 PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with Kis of 0.13 nM and 1.42 nM for PI3Kα and mTOR, respectively. PF-04979064 Chemical Structure
  83. GC15653 PF-05212384 (PKI-587) PF-05212384 (PKI-587) (PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ, and mTOR with IC50s of 0.4 nM, 5.4 nM and 1.6 nM, respectively. PF-05212384 (PKI-587) is equally effective in both complexes of mTOR, mTORC1 and mTORC2. PF-05212384 (PKI-587) Chemical Structure
  84. GC19286 PF-06409577 PF-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 isoform with an EC50 of 7 nM. PF-06409577 Chemical Structure
  85. GC66002 PF-06685249 PF-06685249 (PF-249) is a potent and orally active allosteric AMPK activator with an EC50 of 12 nM for recombinant AMPK α1β1γ1. PF-06685249 can be used for diabetic nephropathy research. PF-06685249 Chemical Structure
  86. GC62556 PF-06843195 PF-06843195 is a highly selective PI3Kα inhibitor with an IC50 of 18 nM in Rat1 fibroblasts. The Kis of PF-06843195 for PI3Kα and PI3Kδ in biochemical kinase assay are less than 0.018 nM and 0.28 nM, respectively. PF-06843195 has great suppression of the PI3K/mTOR signaling pathway and durable antitumor efficacy. PF-06843195 Chemical Structure
  87. GC62660 PF-07104091 PF-07104091 is a CDK2/cyclin E1 inhibitor, a selective ATP-site inhibitor targeting the cyclin-bound activated state of the kinase [1]. PF-07104091 Chemical Structure
  88. GC62661 PF-07104091 hydrate PF-07104091 hydrate Chemical Structure
  89. GC10689 PF-4708671

    PF-4708671, is a novel cell-permeable inhibitor of S6K1, specifically inhibits the S6K1 isoform with a Ki of 20 nM and IC50 of 160 nM.

     PF-4708671 Chemical Structure
  90. GC12375 PF-4989216 Selective oral PI3K inhibitor PF-4989216 Chemical Structure
  91. GC32892 PF-AKT400 (AKT protein kinase inhibitor) PF-AKT400 (AKT protein kinase inhibitor) is a broadly selective, potent, ATP-competitive Akt inhibitor, displays 900-fold greater selectivity for PKBα (IC50=0.5 nM) than PKA (IC50=450 nM). PF-AKT400 (AKT protein kinase inhibitor) Chemical Structure
  92. GC38170 Phellodendrine Phellodendrine Chemical Structure
  93. GC10461 Phenformin HCl Phenformin HCl is an anti-diabetic drug from the biguanide class, can activate AMPK activity. Phenformin HCl Chemical Structure
  94. GC65375 Phospho-Glycogen Synthase Peptide-2(substrate) TFA Phospho-Glycogen Synthase Peptide-2 (substrate) is peptide substrate?for glycogen synthase kinase-3 (GSK-3) and can be used for affinity purification of protein-serine kinases. Phospho-Glycogen Synthase Peptide-2(substrate) TFA Chemical Structure
  95. GC12094 PHT-427 Akt and PDPK1 inhibitor PHT-427 Chemical Structure
  96. GC10386 PI 828

    PI 3-Kinase inhibitor

     PI 828 Chemical Structure
  97. GC11165 PI-103 Class I PI3K, mTOR and DNA-PK inhibitor PI-103 Chemical Structure
  98. GC16379 PI-103 Hydrochloride A potent, cell-permeable PI3K inhibitor PI-103 Hydrochloride Chemical Structure
  99. GC39155 PI-273 PI-273 is a first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC50 of 0.47 μM. PI-273 can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis. PI-273 Chemical Structure
  100. GC15310 PI-3065 P110δkinase inhibitor PI-3065 Chemical Structure
  101. GC38578 PI-828 A PI3K inhibitor PI-828 Chemical Structure

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