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PI3K/Akt/mTOR Signaling

Products for  PI3K/Akt/mTOR Signaling

  1. Cat.No. Product Name Information
  2. GC17984 FPA 124

    Akt/PKB inhibitor

    FPA 124  Chemical Structure
  3. GC38551 FPA-124 FPA-124  Chemical Structure
  4. GC17457 FRATide GSK-3 inhibitor FRATide  Chemical Structure
  5. GC33355 FT-1518 FT-1518 is a new generation selective, potent and oral bioavailable mTORC1 and mTORC2 inhibitor, and exhibits antitumor activity. FT-1518  Chemical Structure
  6. GC61855 Galegine hydrochloride

    Galegine hydrochloride, a guanidine derivative, contributes to weight loss in mice.

    Galegine hydrochloride  Chemical Structure
  7. GC17967 GDC-0032 GDC-0032 (GDC-0032) is a potent PI3K inhibitor targets PIK3CA mutations, with Kis of 0.12 nM, 0.29 nM, 0.97 nM, and 9.1 nM for PI3Kδ, PI3Kα, PI3Kγ and PI3Kβ, respectively. GDC-0032  Chemical Structure
  8. GC11214 GDC-0068 (RG7440) GDC-0068 (RG7440)  Chemical Structure
  9. GC32710 GDC-0077 (RG6114) GDC-0077 (RG6114) is a potent, orally available, and selective PI3Kα inhibitor (IC50=0.038 nM). GDC-0077 (RG6114) exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. GDC-0077 (RG6114) is more selective for mutant versus wild-type PI3Kα. GDC-0077 (RG6114)  Chemical Structure
  10. GC10228 GDC-0084 PI3K and mTOR inhibitor, brain-permeable GDC-0084  Chemical Structure
  11. GC19161 GDC-0326 GDC-0326 is a potent and selective PI3Kα inhibitor with a Ki of 0.2 nM. GDC-0326  Chemical Structure
  12. GC12021 GDC-0349 MTOR inhibitor GDC-0349  Chemical Structure
  13. GC16154 GDC-0941 dimethanesulfonate A pan inhibitor of class I PI3K isoforms GDC-0941 dimethanesulfonate  Chemical Structure
  14. GC11177 GDC-0980 (RG7422) GDC-0980 (RG7422) (GDC-0980; GNE 390; RG 7422) is a selective, potent, orally bioavailable Class I PI3 kinase and mTOR kinase (TORC1/2) inhibitor with IC50s of 5 nM/27 nM/7 nM/14 nM for PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ, and with aKiof 17 nM for mTOR. GDC-0980 (RG7422)  Chemical Structure
  15. GC10900 GDC-mTOR inhibitor GDC-mTOR inhibitor  Chemical Structure
  16. GC64778 Gilmelisib Gilmelisib is an antineoplastic. Gilmelisib is a PI3K inhibitor (IC50 <1 nM for PI3K p110α) extracted from WO2017101847 A1, compound 1. Gilmelisib  Chemical Structure
  17. GN10473 Ginkgolide C Ginkgolide C  Chemical Structure
  18. GN10584 Ginsenoside Rk1 Ginsenoside Rk1  Chemical Structure
  19. GC38606 Glaucocalyxin A Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect. Glaucocalyxin A  Chemical Structure
  20. GC17338 GNE-317 potent, brain-penetrant PI3K inhibitor GNE-317  Chemical Structure
  21. GC10340 GNE-477 dual PI3K/mTOR inhibitor GNE-477  Chemical Structure
  22. GC68429 GNE-490 GNE-490  Chemical Structure
  23. GC15423 GNE-493 Pan-PI3K/mTOR inhibitor GNE-493  Chemical Structure
  24. GC38787 GNF4877 GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6?nM and 16?nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50 of 0.66?μM for mouse β (R7T1) cells). GNF4877  Chemical Structure
  25. GC36178 Gomisin J A lignan with diverse biological activities Gomisin J  Chemical Structure
  26. GC36186 GS-9901 GS-9901 is a highly selective and orally active PI3Kδ inhibitor, with an IC50 of 1 nM. GS-9901  Chemical Structure
  27. GC36190 GSK-3 inhibitor 1 GSK-3 inhibitor 1 is an inhibitor of GSK-3. GSK-3 inhibitor 1  Chemical Structure
  28. GC14987 GSK-3 Inhibitor IX (BIO) GSK-3 Inhibitor IX (BIO) (6-Bromoindirubin-3'-oxime; BIO) is a potent, selective, reversible and ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex with IC50s of 5 nM/320 nM/80 nM for (GSK-3α/β)/CDK1/CDK5, respectively. GSK-3 Inhibitor IX (BIO)  Chemical Structure
  29. GC36193 GSK-3β inhibitor 1 GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC50 of 4.9 nM. GSK-3β inhibitor 1  Chemical Structure
  30. GC66032 GSK-3β inhibitor 11 GSK-3β inhibitor 11 (compound 21) is a glycogen synthase kinase-3β (GSK-3β) inhibitor (IC50=10.02 μM). GSK-3β inhibitor 11 can be used in neurodegenerative disease research. GSK-3β inhibitor 11  Chemical Structure
  31. GC62338 GSK-3β inhibitor 3 GSK-3β inhibitor 3 is a potent, selective, irreversible and covalent inhibitor of Glycogen Synthase Kinase 3β (GSK-3β), with an IC50 of 6.6 μM. GSK-3β inhibitor 3 can be used for the research of acute promyelocytic leukemia. GSK-3β inhibitor 3  Chemical Structure
  32. GC62423 GSK-3/CDK5/CDK2-IN-1 GSK-3/CDK5/CDK2-IN-1, an imidazole derivative, is an inhibitor of cdk5, cdk2, and GSK-3 extracted from patent WO2002010141A1, example 9a. GSK-3/CDK5/CDK2-IN-1  Chemical Structure
  33. GC16187 GSK-3β Inhibitor II GSK-3β inhibitor GSK-3β Inhibitor II  Chemical Structure
  34. GC65309 GSK-F1 GSK-F1 (Compound F1) is an orally active PI4KA inhibitor with pIC50 values of 8.0, 5.9, 5.8, 5.9, 5.9 and 6.4 against PI4KA, PI4KB, PI3KA, PI3KB, PI3KG and PI3KD, respectively. GSK-F1  Chemical Structure
  35. GC11018 GSK1059615 PI3K and mTOR inhibitor,potent and reversible GSK1059615  Chemical Structure
  36. GC33135 GSK2110183 GSK2110183 is the structural analogue of GSK2110183. GSK2110183  Chemical Structure
  37. GC33010 GSK2110183 hydrochloride GSK2110183 hydrochloride is the structural analogue of GSK2110183. GSK2110183 hydrochloride  Chemical Structure
  38. GC15072 GSK2126458 GSK2126458 (GSK2126458) is an orally active and highly selective inhibitor of PI3K with Kis of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2, respectively. GSK2126458 has anti-cancer activity. GSK2126458  Chemical Structure
  39. GC12305 GSK2141795 GSK2141795 (GSK2141795) is a potent and selective pan-Akt inhibitor with IC50 values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively. GSK2141795  Chemical Structure
  40. GC15595 GSK2269557 inhibitor of PI3Kδ GSK2269557  Chemical Structure
  41. GC15679 GSK2292767 PI3Kδ inhibitor,potent and selective GSK2292767  Chemical Structure
  42. GC12275 GSK2334470 PDK1 inhibitor,highly specific and potent GSK2334470  Chemical Structure
  43. GC64612 GSK251 GSK251 is a highly potent, highly selective, orally bioavailable inhibitor of PI3Kδ with a novel binding mode. GSK251  Chemical Structure
  44. GC17109 GSK2636771

    GSK2636771 is a potent adenosine triphosphate competitive oral inhibitor of PI3Kβ, with an IC50 of 5.

    GSK2636771  Chemical Structure
  45. GC43790 GSK3 Inhibitor XIII GSK3 Inhibitor XIII is an aminopyrazole ATP-competitive inhibitor of glycogen synthase kinase 3 (GSK3), with 34% inhibition when used at a concentration of 2.5 μM. GSK3 Inhibitor XIII  Chemical Structure
  46. GC66035 GSK3-IN-1 GSK3-IN-1 (compound 11) is a GSK-3 inhibitor with an IC50 value of 12 μM. GSK3-IN-1 can be used in the research of diabetes. GSK3-IN-1  Chemical Structure
  47. GC18810 GSK3β Inhibitor XI GSK3β inhibitor XI is a potent inhibitor of glycogen synthase kinase 3β (GSK3β; Ki = 25 nM). GSK3β Inhibitor XI  Chemical Structure
  48. GC11724 GSK621 AMPK agonist GSK621  Chemical Structure
  49. GC13696 GSK690693

    GSK690693 is an ATP-competitive, low nanomolar inhibitor of Akt kinases with IC50 values of 2, 13, and 9 nM for Akt1, 2, and 3, respectively.

    GSK690693  Chemical Structure
  50. GC17658 Guggulsterone Broad spectrum steroid receptor ligand Guggulsterone  Chemical Structure
  51. GA10282 H-Leu-OH H-Leu-OH  Chemical Structure
  52. GC65460 HDACs/mTOR Inhibitor 1 HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα, respectively. HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induce tumor cell apoptosis with low toxicity in vivo. HDACs/mTOR Inhibitor 1  Chemical Structure
  53. GC38088 Hederacolchiside A1 Hederacolchiside A1  Chemical Structure
  54. GC39266 Hematein Hematein is a oxidation product of hematoxylin acted as a dye. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells. Hematein  Chemical Structure
  55. GC38168 Heterophyllin B Heterophyllin B is an active cyclic peptide isolated from Pseudostellaria heterophylla. Heterophyllin B provides a novel strategy for the treatment of esophageal cancer. Heterophyllin B  Chemical Structure
  56. GC64035 Hirsutenone Hirsutenone is an active botanical diarylheptanoid present in Alnus species and exhibits many biological activities, including anti-inflammatory, anti-tumor promoting and anti-atopic dermatitis effects. Hirsutenone  Chemical Structure
  57. GN10664 Honokiol Honokiol  Chemical Structure
  58. GC16713 HS-173 novel PI3K inhibitor HS-173  Chemical Structure
  59. GC62572 hSMG-1 inhibitor 11e hSMG-1 inhibitor 11e is a potent and selective hSMG-1 kinase inhibitor with an IC50 of 900-fold selectivity over mTOR (IC50 of 45 nM), PI3Kα/γ (IC50s of 61 nM and 92 nM) and CDK1/CDK2 (IC50s of 32 μM and 7.1 μM). hSMG-1 inhibitor 11e  Chemical Structure
  60. GC61925 hSMG-1 inhibitor 11j hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1, with an IC50 of 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 μM). hSMG-1 inhibitor 11j can be used for the research of cancer. hSMG-1 inhibitor 11j  Chemical Structure
  61. GC13185 HTH-01-015 NUAK1 inhibitor,highly specific and selective HTH-01-015  Chemical Structure
  62. GC15540 IC-87114 PI3Kδ inhibitor IC-87114  Chemical Structure
  63. GC62465 Idelalisib D5 Idelalisib D5 is a deuterium labeled Idelalisib. Idelalisib is a highly selective and orally bioavailable p110δ inhibitor. Idelalisib D5  Chemical Structure
  64. GC63017 IHMT-PI3Kδ-372 IHMT-PI3Kδ-372 is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM. IHMT-PI3Kδ-372  Chemical Structure
  65. GC19411 IITZ-01 IITZ-01 is a potent lysosomotropic autophagy inhibitor with single-agent antitumor activity, with an IC50 of 2.62 μM for PI3Kγ. IITZ-01  Chemical Structure
  66. GC16617 IM-12 GSK-3β inhibitor, potent IM-12  Chemical Structure
  67. GC13503 iMDK PI3K and endogenous midkine (MDK) expression inhibitor iMDK  Chemical Structure
  68. GC62376 iMDK quarterhydrate iMDK quarterhydrate is a potent PI3K inhibitor and inhibits the growth factor MDK (also known as midkine or MK). iMDK quarterhydrate suppresses non-small cell lung cancer (NSCLC) cooperatively with A MEK inhibitor without harming normal cells and mice. iMDK quarterhydrate  Chemical Structure
  69. GC10576 Imeglimin

    Antidiabetic agent

    Imeglimin  Chemical Structure
  70. GC10956 Imeglimin hydrochloride Antidiabetic agent Imeglimin hydrochloride  Chemical Structure
  71. GC12975 Indirubin A cyclin-dependent kinases and GSK-3β inhibitor Indirubin  Chemical Structure
  72. GC12661 Indirubin-3'-oxime Indirubin-3'-oxime is a potent GSK-3β inhibitor, and weakly inhibits 5-Lipoxygenase, with IC50s of 22 nM and 7.8-10 μM, respectively; Indirubin-3'-oxime also shows inhibitory activities against CDK5/p25 and CDK1/cyclin B, with IC50s of 100 and 180 nM. Indirubin-3'-oxime  Chemical Structure
  73. GC36312 Indirubin-3'-monoxime-5-sulphonic acid Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively. Indirubin-3'-monoxime-5-sulphonic acid  Chemical Structure
  74. GC36313 Indirubin-5-sulfonate Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively. Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β. Indirubin-5-sulfonate  Chemical Structure
  75. GC10969 INK 128(MLN0128) INK 128 (MLN0128) (INK-128; MLN0128; TAK-228) is an orally available, ATP-dependent mTOR1/2 inhibitor with an IC50 of 1 nM for mTOR kinase. INK 128(MLN0128)  Chemical Structure
  76. GC12416 INK1117 INK1117 (MLN1117) is a selective p110α inhibitor with an IC50 of 15 nM. INK1117  Chemical Structure
  77. GC65559 INY-03-041 INY-03-041 is a potent, highly selective and PROTAC-based pan-AKT degrader consisting of the ATP-competitive AKT inhibitor GDC-0068 conjugated to Lenalidomide (Cereblon ligand). INY-03-041 inhibits AKT1, AKT2 and AKT3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively. INY-03-041  Chemical Structure
  78. GC32794 Ipatasertib dihydrochloride (GDC-0068 (dihydrochloride)) Ipatasertib dihydrochloride (GDC-0068 (dihydrochloride)) (GDC-0068 dihydrochloride) is a highly selective and ATP-competitive pan-Akt inhibitor with IC50s of 5, 18 and 8 nM for Akt1, Akt2 and Akt3, respectively. Ipatasertib dihydrochloride (GDC-0068 (dihydrochloride))  Chemical Structure
  79. GC10749 IPI-145 (INK1197) IPI-145 (INK1197) (IPI-145) is a selectivite p100δ inhibitor with IC50 of 2.5 nM, 27.4 nM, 85 nM and 1602 nM for p110δ, P110γ, p110β and p110α, respectively. IPI-145 (INK1197)  Chemical Structure
  80. GC31756 IPI-3063 IPI-3063 is a potent and selective PI3K p110δ inhibitor with an IC50 of 2.5?±?1.2 nM. IPI-3063  Chemical Structure
  81. GC19202 IPI549 IPI549 (IPI549) is a potent and selective PI3Kγ inhibitor with an IC50 of 16 nM. IPI549 shows >100-fold selectivity over other lipid and protein kinases. IPI549  Chemical Structure
  82. GC13795 Isobavachalcone A chalcone and flavonoid with diverse biological activities Isobavachalcone  Chemical Structure
  83. GN10023 Isorhamnetin Isorhamnetin  Chemical Structure
  84. GC32995 JNJ-47117096 hydrochloride (MELK-T1 hydrochloride) JNJ-47117096 hydrochloride (MELK-T1 hydrochloride) is potent and selective MELK inhibitor, with an IC50 of 23 nM, also effectively inhibits Flt3, with an IC50 of 18 nM. JNJ-47117096 hydrochloride (MELK-T1 hydrochloride)  Chemical Structure
  85. GC34909 JR-AB2-011 A selective mTORC2 inhibitor JR-AB2-011  Chemical Structure
  86. GC33357 K-80003 (TX-803) K-80003 (TX-803) is a potent inhibitor of tRXRα-dependent Akt activation and cancer cell growth. K-80003 (TX-803)  Chemical Structure
  87. GC48507 Kaempferol 3-O-galactoside Kaempferol 3-O-galactoside (Trifolin) is a derivative of flavonoid, which is isolated from the aerial part of Consolida oliveriana. Kaempferol 3-O-galactoside  Chemical Structure
  88. GC38209 Kahweol A natural diterpene with antiinflammatory and antiangiogenic properties Kahweol  Chemical Structure
  89. GC63934 Karanjin Karanjin is a major active furanoflavonol constituent of Fordia cauliflora. Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Karanjin can induce cancer cell death through cell cycle arrest and enhance apoptosis. Karanjin  Chemical Structure
  90. GC32118 KDU691 An antimalarial compound KDU691  Chemical Structure
  91. GC38033 KDU731 KDU731, an orally active C. KDU731  Chemical Structure
  92. GC14182 Kenpaullone CDK1/cyclin B and GSK-3β inhibitor Kenpaullone  Chemical Structure
  93. GC15553 KP372-1 specific Akt inhibitor KP372-1  Chemical Structure
  94. GC14346 KU-0060648 Dual DNA-PK/PI3-K inhibitor, ATP-competitive KU-0060648  Chemical Structure
  95. GC15167 KU-0063794 MTORC1 and mTORC2 inhibitor KU-0063794  Chemical Structure
  96. GC68037 L-Leucine-1-13C,15N L-Leucine-1-13C,15N  Chemical Structure
  97. GC68219 L-Leucine-13C L-Leucine-13C  Chemical Structure
  98. GC63833 L-Leucine-15N L-Leucine-15N  Chemical Structure
  99. GC66357 L-Leucine-d2 L-Leucine-d2 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway. L-Leucine-d2  Chemical Structure
  100. GC64188 L-Leucine-d3 L-Leucine-d3 is the deuterium labeled L-Leucine. L-Leucine-d3  Chemical Structure
  101. GC10573 L803-mts Selective peptide inhibitor of glycogen synthase kinase-3 (GSK-3) L803-mts  Chemical Structure

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