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Home >> Signaling Pathways >> PI3K/Akt/mTOR Signaling >> Akt

Akt

Products for  Akt

  1. Cat.No. Product Name Information
  2. GC10350 TIC10 isomer

    Potent Akt/ERK inhibitor

     TIC10 isomer Chemical Structure
  3. GC62122 (E)-Akt inhibitor-IV (E)-Akt inhibitor-IV ((E)-AKTIV) is a PI3K-Akt inhibitor, with potent cytotoxic. (E)-Akt inhibitor-IV Chemical Structure
  4. GC35037 1,3-Dicaffeoylquinic acid 1,3-Dicaffeoylquinic acid is a caffeoylquinic acid derivative, and activates PI3K/Akt. 1,3-Dicaffeoylquinic acid Chemical Structure
  5. GC13006 10-DEBC hydrochloride Akt inhibitor 10-DEBC hydrochloride Chemical Structure
  6. GC64670 24-Methylenecycloartanyl ferulate 24-Methylenecycloartanyl ferulate is a γ-oryzanol compound. 24-Methylenecycloartanyl ferulate promotes parvin-beta expression in human breast cancer cells. 24-Methylenecycloartanyl ferulate is a potential ATP-competitive Akt1 inhibitor (EC50= 33.3μM). 24-Methylenecycloartanyl ferulate Chemical Structure
  7. GC12078 3CAI AKT inhibitor 3CAI Chemical Structure
  8. GC12502 A-443654 A pan Akt inhibitor A-443654 Chemical Structure
  9. GC11875 A-674563

    Akt1/PKA/CDK2 inhibitor,potent and selective

     A-674563 Chemical Structure
  10. GC35212 A-674563 hydrochloride A-674563 hydrochloride is a potent and selective Akt1 inhibitor with Ki of 11 nM. A-674563 hydrochloride Chemical Structure
  11. GC35242 Actein Actein is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in human bladder cancer. Actein has little toxicity in vivo. Actein Chemical Structure
  12. GC16475 Afuresertib pan-AKT inhibitor Afuresertib Chemical Structure
  13. GC42747 Afuresertib (hydrochloride) Afuresertib is a selective, orally bioavailable inhibitor of Akt1, 2, and 3 with Ki values of 0.08, 2, and 2.6 nM, respectively. Afuresertib (hydrochloride) Chemical Structure
  14. GC42759 Akt Inhibitor IV Akt inhibitor IV is an inhibitor of Akt activation that inhibits Akt-mediated nuclear export of Forkhead box class O transcription factor 1a (FOXO1a; IC50 = 625 nM) and reduces phosphorylation of Akt at Ser473 and Thr308 in a dose-dependent manner. Akt Inhibitor IV Chemical Structure
  15. GC11589 AKT inhibitor VIII A potent inhibitor of Akt1 and Akt2 AKT inhibitor VIII Chemical Structure
  16. GC16366 AKT Kinase Inhibitor

    AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity[1].

     AKT Kinase Inhibitor Chemical Structure
  17. GC67700 AKT Kinase Inhibitor hydrochloride AKT Kinase Inhibitor hydrochloride Chemical Structure
  18. GC33308 AKT-IN-1 AKT-IN-1 is an allosteric AKT inhibitor with an IC50 of 1.042 μM. AKT-IN-1 Chemical Structure
  19. GC35275 AKT-IN-3 AKT-IN-3 (compound E22) is a potent, orally active low hERG blocking Akt inhibitor, with 1.4 nM, 1.2 nM and 1.7 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1, P70S6K, and SGK. AKT-IN-3 (compound E22) induces apoptosis and inhibits metastasis of cancer cells. AKT-IN-3 Chemical Structure
  20. GC62190 AKT-IN-6 AKT-IN-6 (Example 13) is a potent Akt inhibitor. AKT-IN-6 inhibits Akt1, Akt2 and Akt3 with IC50s < 500nM, respectively. (patent WO2013056015A1). AKT-IN-6 Chemical Structure
  21. GC32939 Akt1 and Akt2-IN-1 Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50=3.5 nM) and Akt2 (IC50=42 nM), with potent and balanced activity. Akt1 and Akt2-IN-1 Chemical Structure
  22. GC18374 API-1 API-1 is an inhibitor of Akt that reduces the level of phosphorylated Akt (IC50 = ~0.8 uM in OVCAR3 cells) by binding to Akt and blocking its translocation to the cell membrane. API-1 Chemical Structure
  23. GC35395 Arnicolide D Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner. Arnicolide D Chemical Structure
  24. GC19036 ARQ-092 ARQ-092 (ARQ-092) is a potent, orally active, selective and allosteric Akt inhibitor with IC50s of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively. ARQ-092 Chemical Structure
  25. GN10647 Artemisinine Artemisinine Chemical Structure
  26. GC17712 AT13148 Multi-AGC kinase inhibitor,ATP-competitive AT13148 Chemical Structure
  27. GC12297 AT7867

    Akt1/2/3 and p70S6K/PKA inhibitor

     AT7867 Chemical Structure
  28. GC10918 AT7867 dihydrochloride A potent and orally bioavailable pan-Akt inhibitor AT7867 dihydrochloride Chemical Structure
  29. GC11752 AZD5363 AZD5363 (AZD5363) is an orally active and potent pan-AKT kinase inhibitor with IC50 of 3, 7 and 7 nM for Akt1,Akt2 and Akt3, respectively. AZD5363 Chemical Structure
  30. GC64377 Batatasin III Batatasin III, a stilbenoid, inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition (EMT) and FAK-AKT signals. Batatasin III has anti-cancer activities. Batatasin III Chemical Structure
  31. GC19484 BAY1125976

    A selective allosteric Akt1/Akt2 inhibitor

     BAY1125976 Chemical Structure
  32. GC65367 Borussertib Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt. Borussertib Chemical Structure
  33. GC43149 CAY10404

    Many non-steroidal anti-inflammatory drugs (NSAIDs) are potent but non-selective inhibitors of both COX-1 and COX-2 in humans.

     CAY10404 Chemical Structure
  34. GC15864 CCT128930 AKT inhibitor CCT128930 Chemical Structure
  35. GC63539 CCT128930 hydrochloride CCT128930 hydrochloride is a potent and selective inhibitor of AKT (IC50=6 nM). CCT128930 hydrochloride has 28-fold selectivity over the closely related PKA kinase (IC50=168 nM) through the targeting of Met282 of AKT (Met173 of PKA-AKT chimera), as well as 20-fold selectivity over p70S6K (IC50=120 nM). CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. Antitumor activity. CCT128930 hydrochloride Chemical Structure
  36. GC35651 Cenisertib Cenisertib (AS-703569) is an ATP-competitive multi-kinase inhibitor that blocks the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5 and FLT3. Cenisertib induces major growth-inhibitory effects by blocking the activity of several different molecular targets in neoplastic mast cells (MC). Cenisertib inhibits tumor growth in xenograft models of pancreatic, breast, colon, ovarian, and lung tumors and leukemia. Cenisertib Chemical Structure
  37. GC12532 CHPG mGlu5 metabotropic glutamate receptor agonist CHPG Chemical Structure
  38. GC17963 CHPG Sodium salt mGlu5 agonist CHPG Sodium salt Chemical Structure
  39. GC35747 Crebanine Crebanine, an alkaloid from Stephania venosa, induces G1 arrest and apoptosis in human cancer cells. Crebanine Chemical Structure
  40. GC30582 Crosstide Crosstide is a peptide analog of glycogen synthase kinase α/β fusion protein sequence which is a substrate for Akt. Crosstide Chemical Structure
  41. GC38419 Cyclovirobuxine D An alkaloid with diverse biological activities Cyclovirobuxine D Chemical Structure
  42. GC15484 Deguelin A potent antiproliferative rotenoid compound Deguelin Chemical Structure
  43. GC32254 Deltonin Deltonin, a steroidal saponin, isolated from Dioscorea zingiberensis Wright, with antitumor activity; Deltonin inhibits ERK1/2 and AKT activation. Deltonin Chemical Structure
  44. GC38236 Esculetin A coumarin with diverse actions Esculetin Chemical Structure
  45. GC17984 FPA 124

    Akt/PKB inhibitor

     FPA 124 Chemical Structure
  46. GC38551 FPA-124 FPA-124 Chemical Structure
  47. GC11214 GDC-0068 (RG7440)

    GDC-0068 (RG7440, Ipatasertib) is a novel highly selective ATP-competitive pan-Akt inhibitor that inhibits all three isoforms of Akt1, Akt2, and Akt3 at an IC50 of 5,18,8 nM, respectively.

     GDC-0068 (RG7440) Chemical Structure
  48. GC38606 Glaucocalyxin A Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect. Glaucocalyxin A Chemical Structure
  49. GC33135 GSK2110183 GSK2110183 is the structural analogue of GSK2110183. GSK2110183 Chemical Structure
  50. GC33010 GSK2110183 hydrochloride GSK2110183 hydrochloride is the structural analogue of GSK2110183. GSK2110183 hydrochloride Chemical Structure
  51. GC12305 GSK2141795 GSK2141795 (GSK2141795) is a potent and selective pan-Akt inhibitor with IC50 values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively. GSK2141795 Chemical Structure
  52. GC13696 GSK690693 GSK690693 is an ATP-competitive, low nanomolar inhibitor of Akt kinases with IC50 values of 2, 13, and 9 nM for Akt1, 2, and 3, respectively. GSK690693 Chemical Structure
  53. GC17658 Guggulsterone Broad spectrum steroid receptor ligand Guggulsterone Chemical Structure
  54. GC38088 Hederacolchiside A1 Hederacolchiside A1 Chemical Structure
  55. GC39266 Hematein Hematein is a oxidation product of hematoxylin acted as a dye. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells. Hematein Chemical Structure
  56. GN10664 Honokiol Honokiol Chemical Structure
  57. GC65559 INY-03-041 INY-03-041 is a potent, highly selective and PROTAC-based pan-AKT degrader consisting of the ATP-competitive AKT inhibitor GDC-0068 conjugated to Lenalidomide (Cereblon ligand). INY-03-041 inhibits AKT1, AKT2 and AKT3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively. INY-03-041 Chemical Structure
  58. GC32794 Ipatasertib dihydrochloride (GDC-0068 (dihydrochloride)) Ipatasertib dihydrochloride (GDC-0068 (dihydrochloride)) (GDC-0068 dihydrochloride) is a highly selective and ATP-competitive pan-Akt inhibitor with IC50s of 5, 18 and 8 nM for Akt1, Akt2 and Akt3, respectively. Ipatasertib dihydrochloride (GDC-0068 (dihydrochloride)) Chemical Structure
  59. GC13795 Isobavachalcone A chalcone and flavonoid with diverse biological activities Isobavachalcone Chemical Structure
  60. GC33357 K-80003 (TX-803) K-80003 (TX-803) is a potent inhibitor of tRXRα-dependent Akt activation and cancer cell growth. K-80003 (TX-803) Chemical Structure
  61. GC15553 KP372-1 specific Akt inhibitor KP372-1 Chemical Structure
  62. GC36447 Licochalcone E Licochalcone E, a flavonoid compound isolated from Glycyrrhiza inflate, inhibits NF-κB and AP-1 transcriptional activity through the inhibition of AKT and MAPK activation. Licochalcone E Chemical Structure
  63. GC36456 Licoricidin Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin Chemical Structure
  64. GC30770 LM22B-10 An activator of TrkB and TrkC LM22B-10 Chemical Structure
  65. GC32510 Loureirin A Loureirin A is a flavonoid extracted from Dragon's Blood, can inhibit Akt phosphorylation, and has antiplatelet activity. Loureirin A Chemical Structure
  66. GC10811 Miltefosine PI3K/Akt inhibitor Miltefosine Chemical Structure
  67. GC25638 Miransertib (ARQ 092) HCl Miransertib (ARQ 092) HCl is a novel, orally bioavailable and selective AKT pathway inhibitor exhibiting a manageable safety profile among patients with advanced solid tumors. Miransertib (ARQ 092) HCl Chemical Structure
  68. GC16304 MK-2206 dihydrochloride

    An allosteric Akt inhibitor

     MK-2206 dihydrochloride Chemical Structure
  69. GC65143 MKC-1 MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family. MKC-1 Chemical Structure
  70. GC49440 ML-9 A PKB/Akt inhibitor ML-9 Chemical Structure
  71. GC65466 MS170 MS170 is a potent and selective PROTAC AKT degrader. MS170 depletes cellular total AKT (T-AKT) with the DC50 value of 32 nM. MS170 binds to AKT1, AKT2, and AKT3 with Kds of 1.3 nM, 77 nM, and 6.5 nM, respectively. MS170 Chemical Structure
  72. GC65442 Musk ketone Musk ketone (MK) is a widely used artificial fragrance. Musk ketone Chemical Structure
  73. GC60262 N-Feruloyloctopamine N-Feruloyloctopamine is an antioxidant constituent. N-Feruloyloctopamine significantly decreases thephosphorylationlevels of Akt and p38MAPK. N-Feruloyloctopamine Chemical Structure
  74. GC31536 N-Oleoyl glycine

    A putative substrate for peptidyl glycine αamidating enzyme

     N-Oleoyl glycine Chemical Structure
  75. GN10692 Oridonin

    A diterpenoid with anti-inflammatory and anticancer properties

     Oridonin Chemical Structure
  76. GN10752 Pachymic acid Pachymic acid Chemical Structure
  77. GC12773 Palomid 529

    PI3K/Akt/mTOR inhibitor

     Palomid 529 Chemical Structure
  78. GC36855 Paris saponin VII Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia. Paris saponin VII Chemical Structure
  79. GC15680 Perifosine Akt inhibitor Perifosine Chemical Structure
  80. GC32892 PF-AKT400 (AKT protein kinase inhibitor) PF-AKT400 (AKT protein kinase inhibitor) is a broadly selective, potent, ATP-competitive Akt inhibitor, displays 900-fold greater selectivity for PKBα (IC50=0.5 nM) than PKA (IC50=450 nM). PF-AKT400 (AKT protein kinase inhibitor) Chemical Structure
  81. GC38170 Phellodendrine Phellodendrine Chemical Structure
  82. GC12094 PHT-427 Akt and PDPK1 inhibitor PHT-427 Chemical Structure
  83. GC69991 Pifusertib hydrochloride

    Pifusertib (TAS-117) hydrochloride is an effective, selective, and orally active isoform Akt inhibitor (with IC50 values of 4.8, 1.6, and 44 nM for Akt1, 2, and 3 respectively). Pifusertib hydrochloride stimulates anti-myeloma activity and enhances lethal endoplasmic reticulum stress induced by proteasome inhibition. Pifusertib hydrochloride induces apoptosis and autophagy in cells.

     Pifusertib hydrochloride Chemical Structure
  84. GC11690 PIT 1 Akt signaling inhibitor PIT 1 Chemical Structure
  85. GN10312 Polygalasaponin F Polygalasaponin F Chemical Structure
  86. GN10709 Polyphyllin A Polyphyllin A Chemical Structure
  87. GC33130 Recilisib (Ex-RAD) Recilisib (Ex-RAD) (ON 01210) is a radioprotectant, which can activate AKT, PI3K activities in cells. Recilisib (Ex-RAD) Chemical Structure
  88. GC38609 Rotundic acid Rotundic acid, a triterpenoid obtained from I. Rotundic acid Chemical Structure
  89. GC11985 SC 66

    Akt inhibitor

     SC 66 Chemical Structure
  90. GC11645 SC 79 SC 79 is an activator of osmotic Akt phosphorylation in the brain and an inhibitor of AKT-PH domain translocation. SC 79 Chemical Structure
  91. GN10624 Scutellarin Scutellarin Chemical Structure
  92. GC34053 SOLENOPSIN Solenopsin is an ATP-competitive AKT inhibitor with IC50 value of 10 μM . SOLENOPSIN Chemical Structure
  93. GN10681 Sophocarpine Sophocarpine Chemical Structure
  94. GC64223 Sophocarpine monohydrate Sophocarpine (monohydrate) is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. Sophocarpine monohydrate Chemical Structure
  95. GC17500 SU6656 Src tyrosine kinases inhibitor SU6656 Chemical Structure
  96. GC63210 TAS-117 TAS-117 is a potent, selective, orally active allosteric Akt inhibitor (with IC50s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively). TAS-117 triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. TAS-117 induces apoptosis and autophagy. TAS-117 Chemical Structure
  97. GC62630 TAS-117 hydrochloride TAS-117 hydrochloride is a potent, selective, orally active allosteric Akt inhibitor (with IC50s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively). TAS-117 hydrochloride triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. TAS-117 hydrochloride induces apoptosis and autophagy. TAS-117 hydrochloride Chemical Structure
  98. GC62342 TASP0415914 TASP0415914 is a potent and orally active PI3Kγ inhibitor with an IC50 of 29 nM. TASP0415914 Chemical Structure
  99. GC62191 TD52 TD52, an Erlotinib derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 has less p-EGFR inhibition and has potent anti-cancer activity. TD52 Chemical Structure
  100. GC64936 TD52 dihydrochloride TD52 dihydrochloride, an Erlotinib derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 dihydrochloride mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 dihydrochloride indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 dihydrochloride has less p-EGFR inhibition and has potent anti-cancer activity. TD52 dihydrochloride Chemical Structure
  101. GC41573 Theaflavin 3,3'-digallate

    Theaflavin-3,3'-digallate (TFDG) is a major polyphenol found in black tea with diverse biological activities.

     Theaflavin 3,3'-digallate Chemical Structure

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