AMPK
AMPK (5'AMP-activated protein kinase) acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of GLUT4 (glucose transporter 4) and mitochondria.
Products for AMPK
- Cat.No. Product Name Information
- GC35124 3α-Hydroxymogrol 3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle, acts as a potent AMPK activator, and enhances AMPK phosphorylation.
- GC13992 3-Guanidinopropionic Acid RGX-202 (3-Guanidinopropionic acid) is an oral small-molecule SLC6A8 transporter inhibitor. RGX-202 robustly inhibits creatine import in vitro and in vivo, reduces intracellular phosphocreatine and ATP levels, and induces tumor apoptosis. RGX-202 can be used for the research of cancer and duchenne muscular dystrophy.
- GN10093 6-gingerol
- GC31348 7-Methoxyisoflavone A synthetic isoflavone
- GC11234 A-769662 A direct activator of AMPK
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GC10518
AICAR
An activator of AMPK
- GC10580 AICAR phosphate AMPK activator
- GC66024 Aldometanib Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib can activate lysosomal adenosine monophosphate-activated protein kinase (AMPK) and decreases blood glucose. Aldometanib can be used for the research of metabolic homeostasis.
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GC42776
Amarogentin
A secoiridoid glycoside with diverse biological activities
- GC11190 AMPK activator AMPK activator is a cell penetrant AMPK activator and partially inhibits the mitochondrial complex I. In multiple myeloma cells, AMPK activator inhibits cell growth.
- GC35327 AMPK activator 1 AMPK activator 1 is an AMPK activator extracted from patent WO2013116491A1, compound No.1-75, has an EC50 of <0.1μM.
- GC62841 AMPK activator 4 AMPK activator 4 is a potent AMPK activator without inhibition of mitochondrial complex I.
- GC67961 AMPK-IN-3
- GC16534 Ampkinone AMPK activator
- GC67772 BAY-3827
- GC62135 BC1618 BC1618, an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling (via preventing activated pAmpkα from Fbxo48-mediated degradation).
- GC42987 Buformin (hydrochloride) Buformin is a biguanide derivative with antihyperglycemic activity.
- GC31383 Chitosan oligosaccharide COS
- GN10222 Cimigenol-3-O-α-L-arabinoside
- GC62548 COH-SR4 COH-SR4 is an AMPK activator.
- GC30056 Danthron (Dantron) Danthron (Dantron) is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron (Dantron) functions in regulating glucose and lipid metabolism by activating AMPK.
- GC38101 Demethyleneberberine Demethyleneberberine (DMB), as a natural active component of medicinal plant Cortex phellodendri chinensis, has favorable bioactivity.
- GC17243 Dorsomorphin (Compound C) Dorsomorphin (Compound C) (Compound C) is a selective and ATP-competitive AMPK inhibitor (Ki=109 nM in the absence of AMP). Dorsomorphin (Compound C) (BML-275) selectively inhibits BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin (Compound C) induces autophagy.
- GC12560 Dorsomorphin (Compound C) 2HCl Dorsomorphin (Compound C) 2HCl (BML-275 dihydrochloride; Compound C dihydrochloride) is a potent, selective and ATP-competitive AMPK inhibitor, with a Ki of 109 nM. Dorsomorphin (Compound C) 2HCl inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin (Compound C) 2HCl induces autophagy.
- GC17567 Doxorubicin (Adriamycin) HCl Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent.
- GC39377 EB-3D EB-3D is a potent and selective choline kinase α (ChoKα) inhibitor, with an IC50 of 1 μM for ChoKα1. EB-3D exerts effects on ChoKα expression, AMPK activation, apoptosis, endoplasmic reticulum stress and lipid metabolism. EB-3D exhibits a potent antiproliferative activity in a panel of T-leukemia cell lines. Anti-cancer activity.
- GC38422 Euphorbiasteroid A tricyclic diterpene
- GC31411 EX229 A potent and allosteric activator of AMPK
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GC13466
Flufenamic acid
TRPC activator
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GC61855
Galegine hydrochloride
Galegine hydrochloride, a guanidine derivative, contributes to weight loss in mice.
- GN10473 Ginkgolide C
- GC36178 Gomisin J A lignan with diverse biological activities
- GC11724 GSK621 AMPK agonist
- GC13696 GSK690693 GSK690693 is an ATP-competitive, low nanomolar inhibitor of Akt kinases with IC50 values of 2, 13, and 9 nM for Akt1, 2, and 3, respectively.
- GC13185 HTH-01-015 NUAK1 inhibitor,highly specific and selective
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GC10576
Imeglimin
Antidiabetic agent
- GC10956 Imeglimin hydrochloride Antidiabetic agent
- GC38209 Kahweol A natural diterpene with antiinflammatory and antiangiogenic properties
- GC63934 Karanjin Karanjin is a major active furanoflavonol constituent of Fordia cauliflora. Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Karanjin can induce cancer cell death through cell cycle arrest and enhance apoptosis.
- GC61029 Marein A glucoside chalcone with diverse biological activities
- GC61045 Metformin D6 hydrochloride An internal standard for the quantification of metformin
- GC17443 Metformin HCl Metformin HCl (1,1-Dimethylbiguanide hydrochloride) inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research.
- GC38815 Methyl cinnamate Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound.
- GC31361 MK-3903 MK-3903 is a potent and selective AMP-activated protein kinase (AMPK) activator with an EC50 of 8 nM.
- GC31470 MK8722 MK8722 is a potent and systemic pan-AMPK activator.
- GC25648 MOTS-c MOTS-c, a mitochondria-derived peptide (MDP), exerts antinociceptive and anti-inflammatory effects through activating AMPK pathway and inhibiting MAP kinases-c-fos signaling pathway.
- GC60258 MT 63-78 MT 63-78 is a specific and potent direct AMPK activator with an EC50 of 25 μM. MT 63–78 also induces cell mitotic arrest and apoptosis. MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathways. MT 63-78 has antitumor effects.
- GC38567 Nepodin A naphthol with diverse biological activities
- GC19269 O-304 O-304 is a small molecule AMPK activator.
- GC33765 Palmitelaidic Acid (9-trans-Hexadecenoic acid) Palmitelaidic Acid (9-trans-Hexadecenoic acid) (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid.
- GC19286 PF-06409577 PF-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 isoform with an EC50 of 7 nM.
- GC66002 PF-06685249 PF-06685249 (PF-249) is a potent and orally active allosteric AMPK activator with an EC50 of 12 nM for recombinant AMPK α1β1γ1. PF-06685249 can be used for diabetic nephropathy research.
- GC10461 Phenformin HCl Phenformin HCl is an anti-diabetic drug from the biguanide class, can activate AMPK activity.
- GN10592 Platycodin D
- GC17204 PT 1 AMPK activator, selective
- GC12324 RSVA 405 AMPK activator
- GC12364 SAMS Peptide SAMS Peptide peptide is a specific substrate for the AMP-activated protein kinase (AMPK).
- GC37694 STO-609 A CaMKK inhibitor
- GC38679 Urolithin B A metabolite of ellagic acid
- GC16549 WZ4003 NUAK1/2 inhibitor, potent and selective
- GC61382 Xanthoangelol Xanthoangelol, extracted from Angelica keiskei, suppresses obesity-induced inflammatory responses.
- GC18208 YLF-466D YLF-466D is an orally bioavailable activator of AMP-activated protein kinase (AMPK), an enzyme involved in regulation of cellular energy homeostasis.
- GC37970 ZLN024 An allosteric activator of AMPK
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GC12162
ZLN024 hydrochloride
novel AMPK allosteric activator