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Home >> Signaling Pathways >> PI3K/Akt/mTOR Signaling >> PDK-1

PDK-1

PDK-1 (3-phosphoinositide dependent protein kinase-1) is a master kinase, which is crucial for the activation of AKT/PKB and many other AGC kinases including PKC, S6K, SGK.

Products for  PDK-1

  1. Cat.No. Product Name Information
  2. GC63802 (R)-PS210 (R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC50 value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of?PDK1. PIF: The protein kinase C-related kinase 2 (PRK2)-interacting fragment. (R)-PS210 Chemical Structure
  3. GC16818 BX-912 PDK1 inhibitor,potent and ATP-competitive BX-912 Chemical Structure
  4. GC15615 BX517(PDK1 inhibitor2) BX517(PDK1 inhibitor2) is a potent and selective inhibitor of PDK1 with IC50 of 6 nM. BX517(PDK1 inhibitor2) Chemical Structure
  5. GC11573 BX795 A multi-kinase inhibitor BX795 Chemical Structure
  6. GC12275 GSK2334470 PDK1 inhibitor,highly specific and potent GSK2334470 Chemical Structure
  7. GC13725 NVP-BAG956 A dual PDK1 and class I PI3K inhibitor NVP-BAG956 Chemical Structure
  8. GC15742 OSU-03012 (AR-12) Potent PDK1 inhibitor OSU-03012 (AR-12) Chemical Structure
  9. GC12866 PDK1 inhibitor PDK1 inhibitor Chemical Structure
  10. GC66474 PDK1-IN-RS2 PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1. PDK1-IN-RS2 Chemical Structure
  11. GC69714 PKD-IN-1 dihydrochloride

    PKD-IN-1 dihydrochloride (compound 32) is an aminoethylaminobenzyl (AEAA) compound that can be used as a PKD-1 inhibitor. PKD-IN-1 can be used in research on diseases mediated by protein kinase D (PKD).

     PKD-IN-1 dihydrochloride Chemical Structure
  12. GN10709 Polyphyllin A Polyphyllin A Chemical Structure
  13. GC13920 PS 48

    PDK1 activator

     PS 48 Chemical Structure
  14. GC63155 PS47 PS47 is an inactive E-isomer of PS48. PS47 Chemical Structure
  15. GC10857 UCN-01 inhibitor of Akt, protein kinase C, PDK1 and cyclin-dependent kinases UCN-01 Chemical Structure

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