PIKfyve

PIKfyve (1-phosphatidylinositol 3-phosphate 5-kinase) catalyzes the production of PtdIns5P and PtdIns(3,5)biphosphate from the phosphorylation o f D-5 position in PtdIns and phosphatidylinositol-3-phosphate. It is involved in endosome carrier vesicle biogenesis in early endosomes and endomembrane homeostasis.

Products for PIKfyve

Cat.No. Product Name Information
GC31661 APY0201 APY0201 is a potent PIKfyve inhibitor, which inhibits the conversion of PtdIns3P to PtdIns(3,5)P2 in the presence of in the presence of [33P]ATP with an IC50 of 5.2 nM.
GC66013 MOMIPP MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB).
GC73606 PIK5-12d PIK5-12d is a PROTAC PIKfyve degrader (DC50: 1.48 nM).
GC69711 PIKfyve-IN-1
PIKfyve-IN-1 is an efficient and cell-active chemical probe that can inhibit phosphoinositide 3-phosphate 5-kinase (PIKfyve) with an IC50 value of 6.9 nM. PIKfyve-IN-1 can be used for the study of PIKfyve in virology.
GC74025 PIKfyve-IN-3 PIKfyve-IN-3 (compound L22) has a remarkable interaction with PIKfyve kinase with a Kd value of 0.47 nM.
GC10982 YM201636 PIKfyve inhibitor,potent and selective