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Home >> Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

Ligand for E3 Ligase

The PROTAC molecule consists of a ligand, which binds an E3 ubiquitin ligase, connected by a linker to another ligand that binds the target protein.

The association between a protein and an E3 ligase, as induced by a PROTAC molecule, will lead to the transfer of ubiquitin and degradation of the targeted protein.

Targets for  Ligand for E3 Ligase

Products for  Ligand for E3 Ligase

  1. Cat.No. Product Name Information
  2. GC70184 β-Naphthoflavone-CH2-Br

    Beta-naphthoflavone-CH2-Br is an aryl hydrocarbon receptor (AhR) ligand. It is used in the synthesis of PROTAC Beta-NF-JQ1.

     β-Naphthoflavone-CH2-Br Chemical Structure
  3. GC46008 (±)-Thalidomide-d4 An internal standard for the quantification of (±)-thalidomide (±)-Thalidomide-d4 Chemical Structure
  4. GC62283 (S,R,S)-AHPC (S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells. (S,R,S)-AHPC Chemical Structure
  5. GC38724 (S,R,S)-AHPC-propargyl (S,R,S)-AHPC-propargyl (VH032-propargyl) is a VHL ligand which is used in “click reaction” for PROTACs. (S,R,S)-AHPC-propargyl Chemical Structure
  6. GC68681 AR antagonist 1 hydrochloride

    AR antagonist 1 (compound 29) hydrochloride is an effective AR antagonist that binds to E3 ligand and has weak affinity for VHL protein. It is used in the synthesis of PROTAC ARD-266.

     AR antagonist 1 hydrochloride Chemical Structure
  7. GC38055 BC-1215 An inhibitor of FBXO3 BC-1215 Chemical Structure
  8. GC66442 CC-17369 CC-17369 (7-Hydroxy pomalidomide) is a metabolite of Pomalidomide. CC-17369 is the Pomalidomide -based cereblon (CRBN) ligand used in the recruitment of CRBN protein. CC-17369 can be connected to the ligand for protein by a linker to form PROTAC. CC-17369 Chemical Structure
  9. GC18862 CC-885 CC-885 is a modulator of the E3 ligase protein cereblon with antiproliferative effects on human myeloid leukemia cell lines. CC-885 Chemical Structure
  10. GC64851 CC-99282 CC-99282 is a potent and orally active cereblon (CRBN) E3 ligase modulator (CELMoD). CC-99282 co-opts CRBN to induce potent and targeted degradation of Ikaros and Aiolos. CC-99282 can be used for researching non-Hodgkin lymphomas. CC-99282 Chemical Structure
  11. GC64835 CFT7455 CFT7455 is an orally active zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3) degrader. CFT7455 is an anti-cancer agent that binds with high affinity to the cereblon E3 ligase (Kd of 0.9 nM) (WO2022032132A1; Compound 1). CFT7455 Chemical Structure
  12. GC50364 cis VH 298 Negative control for VH 298 cis VH 298 Chemical Structure
  13. GC62218 CRBN modulator-1 CRBN modulator-1, a Thalidomide analog and a CRBN modulator extracted from WO2020006262A1, compound 10, has an IC50 of 3.5 μM and a Ki of 0.98 μM. CRBN modulator-1 Chemical Structure
  14. GC32711 E3 ligase Ligand 1 E3 ligase Ligand 1 (VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. E3 ligase Ligand 1 can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM. E3 ligase Ligand 1 Chemical Structure
  15. GC34291 E3 ligase Ligand 1 dihydrochloride E3 ligase Ligand 1 dihydrochloride Chemical Structure
  16. GC35924 E3 ligase Ligand 10 E3 ligase Ligand 10 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 10 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins. E3 ligase Ligand 10 Chemical Structure
  17. GC35925 E3 ligase Ligand 11 E3 ligase Ligand 11 is the LCL161 derivative based IAP ligand. E3 ligase Ligand 11 can be connected to the ABL ligand for protein by a linker to form SNIPER. E3 ligase Ligand 11 Chemical Structure
  18. GC35926 E3 ligase Ligand 12 E3 ligase Ligand 12 is the LCL161 derivative based IAP ligand. E3 ligase Ligand 12 can be connected to the ABL ligand for protein by a linker to form SNIPER. E3 ligase Ligand 12 Chemical Structure
  19. GC35927 E3 ligase Ligand 13 E3 ligase Ligand 13 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 13 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins. E3 ligase Ligand 13 Chemical Structure
  20. GC35928 E3 ligase Ligand 14 E3 ligase Ligand 14 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 14 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins. E3 ligase Ligand 14 Chemical Structure
  21. GC35929 E3 ligase Ligand 15 E3 ligase Ligand 15 (MDM2 ligand 2) is the Nutlin 3-based MDM2 ligand. E3 ligase Ligand 15 can be connected to the ligand for protein by a linker to form PROTACs. E3 ligase Ligand 15 Chemical Structure
  22. GC35930 E3 ligase Ligand 16 E3 ligase Ligand 16 (MDM2 ligand 1) is the Nutlin 3-based MDM2 ligand. E3 ligase Ligand 16 can be connected to the ligand for protein by a linker to form PROTAC. E3 ligase Ligand 16 Chemical Structure
  23. GC35932 E3 ligase Ligand 18 E3 ligase Ligand 18 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 18 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins. E3 ligase Ligand 18 Chemical Structure
  24. GC33101 E3 ligase Ligand 1A E3 ligase Ligand 1A (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. E3 ligase Ligand 1A can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM. E3 ligase Ligand 1A Chemical Structure
  25. GC32848 E3 ligase Ligand 2 E3 ligase Ligand 2 (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. E3 ligase Ligand 2 (Cereblon ligand 2) can be connected to the ligand for protein by a linker to form PROTACs. E3 ligase Ligand 2 Chemical Structure
  26. GC30029 E3 ligase Ligand 3 E3 ligase Ligand 3 (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. E3 ligase Ligand 3 Chemical Structure
  27. GC30164 E3 ligase Ligand 4 E3 ligase Ligand 4 (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. E3 ligase Ligand 4 (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1. E3 ligase Ligand 4 Chemical Structure
  28. GC35933 E3 ligase Ligand 8 E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 8 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins. E3 ligase Ligand 8 Chemical Structure
  29. GC34566 E3 ligase Ligand 9 E3 ligase Ligand 9 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 9 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins. E3 ligase Ligand 9 Chemical Structure
  30. GC19195 Iberdomide Iberdomide (CC-220) is a cereblon modulator with an IC50 of 60 nM. Iberdomide Chemical Structure
  31. GC60963 KB02-COOH KB02-COOH is a fragment of synthesis of ubiquitin E3 ligase ligand KB02. KB02 can be used in the synthesis of PROTAC, such as KB02-JQ1 and KB02-SLF. KB02-COOH Chemical Structure
  32. GC14976 Lenalidomide (CC-5013) An analog of thalidomide Lenalidomide (CC-5013) Chemical Structure
  33. GC13473 Lenalidomide hemihydrate

    TNF-α secretion inhibitor

     Lenalidomide hemihydrate Chemical Structure
  34. GC14015 Lenalidomide hydrochloride An analog of thalidomide Lenalidomide hydrochloride Chemical Structure
  35. GC62624 Lenalidomide-4-OH Lenalidomide-4-OH is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-OH can be connected to the ligand for protein by a linker to form PROTAC. Lenalidomide-4-OH Chemical Structure
  36. GC63806 Lenalidomide-5-aminomethyl hydrochloride Lenalidomide-5-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC Lenalidomide-5-aminomethyl hydrochloride Chemical Structure
  37. GC62541 Lenalidomide-5-Br Lenalidomide-5-Br is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-Br can be connected to the ligand for protein by a linker to form PROTAC. Lenalidomide-5-Br Chemical Structure
  38. GC38579 Lenalidomide-Br Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC STAT3 degrader SD-36. Lenalidomide-Br Chemical Structure
  39. GC62147 Lenalidomide-I Lenalidomide-I (Compound 72), an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570. Lenalidomide-I Chemical Structure
  40. GC60223 Lenalidomide-OH Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620. Lenalidomide-OH Chemical Structure
  41. GC11697 Pomalidomide (CC-4047) An inhibitor of cereblon Pomalidomide (CC-4047) Chemical Structure
  42. GC19302 Protein degrader 1 hydrochloride (S,R,S)-AHPC (VH032-NH2) hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. Protein degrader 1 hydrochloride can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells. Protein degrader 1 hydrochloride Chemical Structure
  43. GC32433 Protein degrader 1 TFA (S,R,S)-AHPC (VH032-NH2) TFA is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. Protein degrader 1 TFA can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells. Protein degrader 1 TFA Chemical Structure
  44. GC69906 SJPYT-195

    SJPYT-195 is a cell-toxic degradation product of GSPT1 that can be used for synthesizing PROTAC.

     SJPYT-195 Chemical Structure
  45. GC33068 TD-106 TD-106 is a cereblon (CRBN) modulator, which can be used for targeted protein degradation. BRD4 PROTACs with TD-106 induce BRD4 degradation. TD-106 Chemical Structure
  46. GC17054 Thalidomide An immunomodulatory compound with diverse biological activities Thalidomide Chemical Structure
  47. GC60360 Thalidomide 5-fluoride Thalidomide 5-fluoride is Thalidomide-based cereblon ligand?that incorporates to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1. Thalidomide 5-fluoride Chemical Structure
  48. GC63392 Thalidomide-5,6-F Thalidomide-5,6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-F can be connected to the ligand for protein by a linker to form PROTACs. Thalidomide-5,6-F Chemical Structure
  49. GC63810 Thalidomide-5-NH2-CH2-COOH Thalidomide-5-NH2-CH2-COOH (compound 114) is a potent and selective inhibitor of tropomyosin receptor kinase (trk). Thalidomide-5-NH2-CH2-COOH Chemical Structure
  50. GC60361 Thalidomide-5-OH Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs. Thalidomide-5-OH Chemical Structure
  51. GC62378 Thalidomide-NH-CH2-COOH Thalidomide-NH-CH2-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-NH-CH2-COOH can be connected to the ligand for protein by a linker to form PROTACs, such as THAL-SNS-032. Thalidomide-NH-CH2-COOH Chemical Structure
  52. GC60362 Thalidomide-O-C8-Boc Thalidomide-O-C8-Boc is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-C8-Boc can be connected to the ligand for protein by a linker to form PROTACs. Thalidomide-O-C8-Boc Chemical Structure
  53. GC60363 Thalidomide-O-C8-COOH Thalidomide-O-C8-COOH is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-C8-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs. Thalidomide-O-C8-COOH Chemical Structure
  54. GC38862 Thalidomide-propargyl Thalidomide-propargyl is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-propargyl can be connected to the ligand for protein by a linker to form the IMiD containing PROTACs. Thalidomide-propargyl Chemical Structure
  55. GC50623 VH 101, phenol VH 101, phenol is the VH032-based VHL ligand. VH 101, phenol can be connected to the ligand for protein (e.g., SMARCA BD ligand) by a linker to form PROTACs (e.g., PROTAC 1). PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4. VH 101, phenol Chemical Structure
  56. GC19375 VH-298 VH-298 is a highly potent inhibitor of the VHL:HIF-α interaction with a Kd value of 80 to 90 nM, used in PROTAC technology. VH-298 Chemical Structure
  57. GC61452 VH032 VH032 is a VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. VH032 is a VHL/HIF-1α interaction inhibitor with a Kd VH032 Chemical Structure
  58. GC65392 VH032 thiol VH032 thiol (VHL ligand 6) is a VHL ligand, which binds to pan-BET inhibitor JQ1 via a linker to form PROTAC. VH032 thiol Chemical Structure
  59. GC34855 VL285 VL285 is a potent VHL ligand with an IC50 of 0.34 μM. VL285 Chemical Structure
  60. GC64969 ZXH-1-161 ZXH-1-161 is a potent cereblon (CRBN) modulator with an IC50 value of 39 nM in MM1.S wild type cells. ZXH-1-161 has selective degradation activity towards GSPT1. ZXH-1-161 can be used for researching multiple myeloma. ZXH-1-161 Chemical Structure

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