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Proteases

Proteases is a general term for a class of enzymes that hydrolyze protein peptide chains. According to the way they degrade polypeptides, they are divided into two categories: endopeptidases and telopeptidases. The former can cut the large molecular weight polypeptide chain from the middle to form prions and peptones with smaller molecular weights; the latter can be divided into carboxypeptidase and aminopeptidase, which respectively remove the peptide from the free carboxyl terminus or free amino terminus of the polypeptide one by one. Chain hydrolysis produces amino acids.

A general term for a class of enzymes that hydrolyze peptide bonds in proteins. According to the way they hydrolyze polypeptides, they can be divided into endopeptidases and exopeptidases. Endopeptidase cleaves the interior of the protein molecule to form smaller molecular weight peptones and peptones. Exopeptidase hydrolyzes peptide bonds one by one from the end of the free amino group or carboxyl group of protein molecules, and frees amino acids, the former is aminopeptidase and the latter is carboxypeptidase. Proteases can be classified into serine proteases, sulfhydryl proteases, metalloproteases and aspartic proteases according to their active centers and optimum pH. According to the optimum pH value of its reaction, it is divided into acidic protease, neutral protease and alkaline protease. The proteases used in industrial production are mainly endopeptidases.

Proteases are widely found in animal offal, plant stems and leaves, fruits and microorganisms. Microbial proteases are mainly produced by molds and bacteria, followed by yeast and actinomycetes.

Enzymes that catalyze the hydrolysis of proteins. There are many kinds, the important ones are pepsin, trypsin, cathepsin, papain and subtilisin. Proteases have strict selectivity for the reaction substrates they act on. A protease can only act on certain peptide bonds in protein molecules, such as the peptide bonds formed by the hydrolysis of basic amino acids catalyzed by trypsin. Proteases are widely distributed, mainly in the digestive tract of humans and animals, and are abundant in plants and microorganisms. Due to limited animal and plant resources, the industrial production of protease preparations is mainly prepared by fermentation of microorganisms such as Bacillus subtilis and Aspergillus terrestris.

Targets for  Proteases

Products for  Proteases

  1. Cat.No. Product Name Information
  2. GC41282 2'-O-Methyladenosine 2'-O-Methyladenosine is an analog of adenosine used to prepare nucleoside derivatives as inhibitors of viral RNA translation and replication. 2'-O-Methyladenosine  Chemical Structure
  3. GC60452 2(5H)-Furanone 2(5H)-Furanone  Chemical Structure
  4. GC39686 2,2-Dihydroxyacetic acid 2,2-Dihydroxyacetic acid is an endogenous metabolite. 2,2-Dihydroxyacetic acid  Chemical Structure
  5. GC60457 2,3,5-Trimethylpyrazine 2,3,5-Trimethylpyrazine  Chemical Structure
  6. GC60458 2,3-Butanediol 2,3-Butanediol is a butanediol derived from the bioconversion of natural resources. 2,3-Butanediol  Chemical Structure
  7. GC38243 2,3-Diaminopropanoic acid hydrochloride 2,3-Diaminopropanoic acid hydrochloride is an endogenous metabolite. 2,3-Diaminopropanoic acid hydrochloride  Chemical Structure
  8. GC30672 2,3-Diaminopropionic acid

    2, 3-Diaminopropionic acid is a metabolite of b-oxalyl-L-a, b-diaminopropionic acid a neurotoxic amino acid (ODAP).

    2,3-Diaminopropionic acid  Chemical Structure
  9. GC60463 2,4-Di-tert-butylphenol 2,4-Di-tert-butylphenol  Chemical Structure
  10. GC39772 2,4-Dihydroxybenzaldehyde 2,4-Dihydroxybenzaldehyde is an endogenous metabolite. 2,4-Dihydroxybenzaldehyde  Chemical Structure
  11. GC33626 2,4-Dihydroxybenzoic acid 2,4-Dihydroxybenzoic acid is a degradation product of cyaniding glycoside from tart cheeries in cell culture. 2,4-Dihydroxybenzoic acid  Chemical Structure
  12. GC38367 2,4-Dihydroxypyrimidine-5-carboxylic Acid 2,4-Dihydroxypyrimidine-5-carboxylic Acid is an endogenous metabolite. 2,4-Dihydroxypyrimidine-5-carboxylic Acid  Chemical Structure
  13. GC33519 2,5-Dihydroxybenzoic acid A benzoic acid with diverse biological activities 2,5-Dihydroxybenzoic acid  Chemical Structure
  14. GC46057 2,5-Dihydroxycinnamic Acid phenethyl ester An inhibitor of 5-LO 2,5-Dihydroxycinnamic Acid phenethyl ester  Chemical Structure
  15. GC38729 2,5-Dimethylpyrazine 2,5-Dimethylpyrazine is an endogenous metabolite. 2,5-Dimethylpyrazine  Chemical Structure
  16. GC33637 2,5-Furandicarboxylic acid 2,5-Furandicarboxylic acid, detected in human urine, is an important renewable biotechnological building block because it serves as an environmentally friendly substitute for terephthalic acid in the production of polyesters. 2,5-Furandicarboxylic acid  Chemical Structure
  17. GA20387 2,6-Diaminopimelic acid 2,6-Diaminopimelic acid is an endogenous metabolite. 2,6-Diaminopimelic acid  Chemical Structure
  18. GC39773 2,6-Dibromophenol 2,6-Dibromophenol is an endogenous metabolite. 2,6-Dibromophenol  Chemical Structure
  19. GC39767 2,6-Dihydroxyacetophenone 2,6-Dihydroxyacetophenone is an endogenous metabolite. 2,6-Dihydroxyacetophenone  Chemical Structure
  20. GC33642 2,6-Dihydroxybenzoic acid 2,6-Dihydroxybenzoic acid is a secondary metabolite of salicylic acid which has been hydrolyzed by liver enzymes during phase I metabolism. 2,6-Dihydroxybenzoic acid  Chemical Structure
  21. GC33643 2,6-Dimethoxybenzoic acid 2,6-Dimethoxybenzoic acid is a member of organic compounds known as o-methoxybenzoic acids and derivatives. 2,6-Dimethoxybenzoic acid  Chemical Structure
  22. GC39768 2,6-Dimethylhydroquinone 2,6-Dimethylhydroquinone  Chemical Structure
  23. GC62766 2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate 2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate is an endogenous metabolite. 2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate  Chemical Structure
  24. GC65461 2,8-Dihydroxyadenine 2,8-Dihydroxyadenine, an endogenous metabolite, can cause the formation of urinary crystals and kidney stones. 2,8-Dihydroxyadenine  Chemical Structure
  25. GC30697 2-(1-Methyl-1H-imidazol-4-yl)ethan-1-amine 2-(1-Methyl-1H-imidazol-4-yl)ethan-1-amine is a histamine (Him) metabolite. 2-(1-Methyl-1H-imidazol-4-yl)ethan-1-amine  Chemical Structure
  26. GC49159 2-(1-Piperazinyl)pyrimidine An α2-AR antagonist and active metabolite of azapirones 2-(1-Piperazinyl)pyrimidine  Chemical Structure
  27. GC38301 2-(1H-Indol-3-yl)ethan-1-ol An indole with diverse biological activities 2-(1H-Indol-3-yl)ethan-1-ol  Chemical Structure
  28. GC62763 2-(2’,3’,4’-Trihydroxybutyl)quinoxaline 2-(2’,3’,4’-Trihydroxybutyl)quinoxaline is a food metabolite. 2-(2’,3’,4’-Trihydroxybutyl)quinoxaline  Chemical Structure
  29. GC49330 2-(2-Aminoethyl)-3-(4-chlorophenyl)-3-hydroxyisoindol-1-one (hydrochloride) A metabolite of mazindol 2-(2-Aminoethyl)-3-(4-chlorophenyl)-3-hydroxyisoindol-1-one (hydrochloride)  Chemical Structure
  30. GC33633 2-(2-Methylbenzamido)acetic acid 2-(2-Methylbenzamido)acetic acid is a metabolite detected in urine. 2-(2-Methylbenzamido)acetic acid  Chemical Structure
  31. GC68504 2-(2-Methylbenzamido)acetic acid-d7

    2-(2-Methylbenzamido)acetic acid-d7 is the deuterated form of 2-(2-Methylbenzamido)acetic acid. 2-(2-Methylbenzamido)acetic acid is a metabolite that can be detected in urine.

    2-(2-Methylbenzamido)acetic acid-d7  Chemical Structure
  32. GC34193 2-(4-Methoxyphenyl)acetic acid (4-Methoxyphenylacetic acid) 2-(4-Methoxyphenyl)acetic acid (4-Methoxyphenylacetic acid) is a plasma metabolite, with high sensitivity and specificity value as a biomarker for discriminating between NSCLC and healthy controls. 2-(4-Methoxyphenyl)acetic acid (4-Methoxyphenylacetic acid)  Chemical Structure
  33. GC33496 2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) 2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) (N2-Methylguanine) is a modified nucleoside. 2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine)  Chemical Structure
  34. GC12964 2-3-Dihydroxybenzoic acid 2-3-Dihydroxybenzoic acid is a normal human benzoic acid metabolite found in plasma, and has increased levels after aspirin ingestion. 2-3-Dihydroxybenzoic acid  Chemical Structure
  35. GC39844 2-Acetonaphthone 2-Acetonaphthone is an endogenous metabolite. 2-Acetonaphthone  Chemical Structure
  36. GC60469 2-Acetyl-3-ethylpyrazine 2-Acetyl-3-ethylpyrazine is an endogenous metabolite. 2-Acetyl-3-ethylpyrazine  Chemical Structure
  37. GC30718 2-Amino-1-phenylethanol 2-Amino-1-phenylethanol is an analogue of noradrenaline. 2-Amino-1-phenylethanol  Chemical Structure
  38. GC66717 2-Amino-2-(p-tolyl)acetic acid 2-Amino-2-(p-tolyl)acetic acid is used for optimizing azide skeleton, and is the intermediate in the synthesis of 1,3, 4-thiadiazole compounds. 1,3,4-thiadiazole compounds exhibit potential anti-cancer activity, and inhibit glutaminase (GLSI). 2-Amino-2-(p-tolyl)acetic acid  Chemical Structure
  39. GC62769 2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid is an endogenous metabolite. 2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid  Chemical Structure
  40. GC60470 2-Amino-5-phenylpyridine 2-Amino-5-phenylpyridine is a mutagenic heterocyclic aromatic amine that is formed by pyrolysis of phenylalanine in proteins. 2-Amino-5-phenylpyridine is in broiled sardines and is considered as potentially carcinogenic. 2-Amino-5-phenylpyridine  Chemical Structure
  41. GC62770 2-Amino-5-ureidopentanoic acid 2-Amino-5-ureidopentanoic acid is an endogenous metabolite. 2-Amino-5-ureidopentanoic acid  Chemical Structure
  42. GC38260 2-Aminobenzenesulfonic acid 2-Aminobenzenesulfonic acid is an endogenous metabolite. 2-Aminobenzenesulfonic acid  Chemical Structure
  43. GC52029 2-Aminoflubendazole 2-Aminoflubendazole  Chemical Structure
  44. GC38321 2-Aminopyrimidin-5-ol 2-Aminopyrimidin-5-ol  Chemical Structure
  45. GC16403 2-Arachidonoyl Glycerol

    An endogenous agonist of the cannabinoid (CB) receptors CB1 and CB2

    2-Arachidonoyl Glycerol  Chemical Structure
  46. GC60471 2-Benzylsuccinic acid 2-Benzylsuccinic acid (DL-Benzylsuccinic acid) is an potent inhibitor of carboxypeptidase A (CPA). 2-Benzylsuccinic acid  Chemical Structure
  47. GC46539 2-Chloroadenine A heterocyclic building block 2-Chloroadenine  Chemical Structure
  48. GC11553 2-cyano-Pyrimidine cathepsin K inhibitor 2-cyano-Pyrimidine  Chemical Structure
  49. GC10408 2-D08 Sumoylation inhibitor 2-D08  Chemical Structure
  50. GC40675 2-deoxy-Artemisinin 2-deoxy-Artemisinin is an inactive metabolite of the antimalarial agent artemisinin. 2-deoxy-Artemisinin  Chemical Structure
  51. GC12850 2-Deoxy-D-ribose 2-Deoxy-D-ribose is an endogenous metabolite. 2-Deoxy-D-ribose  Chemical Structure
  52. GC11642 2-Deoxyadenosine 2-Deoxyadenosine is a nucleoside adenosine derivative, pairing with deoxythymidine (T) in double-stranded DNA. 2-Deoxyadenosine  Chemical Structure
  53. GC17478 2-Deoxycytidine A deoxyribonucleoside 2-Deoxycytidine  Chemical Structure
  54. GC11581 2-Deoxyinosine A nucleoside form of hypoxanthine 2-Deoxyinosine  Chemical Structure
  55. GC13571 2-Deoxyuridine A pyrimidine nucleoside 2-Deoxyuridine  Chemical Structure
  56. GC60472 2-Ethylpyrazine 2-Ethylpyrazine  Chemical Structure
  57. GC31632 2-Furoic acid (Furan-2-carboxylic acid) 2-Furoic acid (Furan-2-carboxylic acid) (Furan-2-carboxylic acid) is an organic compound produced through furfural oxidation. 2-Furoic acid (Furan-2-carboxylic acid)  Chemical Structure
  58. GC33645 2-Guanidinoacetic acid 2-Guanidinoacetic acid (Guanidinoacetic acid), a precursor of creatine, is a replacement of dietary arginine and could support overall energy homeostasis of the bird. 2-Guanidinoacetic acid  Chemical Structure
  59. GC11804 2-Guanidinoethylmercaptosuccinic Acid 2-Guanidinoethylmercaptosuccinic Acid (2-Guanidinoethylmercaptosuccinic acid) is a potent specific inhibitor of carboxypeptidase B-like processing enzyme (encephalin convertase) with the Ki value of 8.8 nM. 2-Guanidinoethylmercaptosuccinic Acid  Chemical Structure
  60. GC12545 2-HBA indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway. 2-HBA  Chemical Structure
  61. GC35090 2-Hydroxy atorvastatin calcium salt An active metabolite of atorvastatin 2-Hydroxy atorvastatin calcium salt  Chemical Structure
  62. GC60474 2-Hydroxy atorvastatin lactone 2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. 2-Hydroxy atorvastatin lactone  Chemical Structure
  63. GC31544 2-Hydroxy-2-methylbutanoic acid 2-Hydroxy-2-methylbutanoic acid, an unusual metabolite, is associated with 2-hydroxyglutaric aciduria and maple syrup urine disease. 2-Hydroxy-2-methylbutanoic acid  Chemical Structure
  64. GC38281 2-Hydroxy-2-phenylacetic acid 2-Hydroxy-2-phenylacetic acid ((±)-2-Hydroxy-2-phenylacetic acid), an alpha-hydroxycarboxylic acid, has been widely used as an intermediate of pharmaceutical and fine chemicals. 2-Hydroxy-2-phenylacetic acid  Chemical Structure
  65. GC31222 2-Hydroxy-3-methylbutanoic acid 2-Hydroxy-3-methylbutanoic acid is a close structure analogue of GHB, which is a naturally occurring neurotransmitter and a psychoactive drug. 2-Hydroxy-3-methylbutanoic acid  Chemical Structure
  66. GC30564 2-Hydroxy-4-methoxybenzaldehyde A phenol with diverse biological activities 2-Hydroxy-4-methoxybenzaldehyde  Chemical Structure
  67. GC60475 2-Hydroxy-4-methylbenzaldehyde 2-Hydroxy-4-methylbenzaldehyde is an endogenous metabolite. 2-Hydroxy-4-methylbenzaldehyde  Chemical Structure
  68. GC30612 2-Hydroxyadipic acid 2-Hydroxyadipic acid is an organic acid, formed by the reduction of 2-ketoadipic acid. 2-Hydroxyadipic acid  Chemical Structure
  69. GC64336 2-Hydroxyemodin 2-Hydroxyemodin is an active metabolite of emodin in the hepatic microsomes. 2-Hydroxyemodin  Chemical Structure
  70. GC38190 2-Hydroxyhexanoic acid 2-Hydroxyhexanoic acid is an endogenous metabolite. 2-Hydroxyhexanoic acid  Chemical Structure
  71. GC19715 2-hydroxyisobutyrate 2-hydroxyisobutyrate is an endogenous metabolite. 2-hydroxyisobutyrate  Chemical Structure
  72. GC68519 2-Hydroxyisobutyric acid-d6

    2-Hydroxyisobutyric acid-d6 is the deuterated form of 2-Hydroxyisobutyric acid. 2-Hydroxyisobutyric acid is an endogenous metabolic product.

    2-Hydroxyisobutyric acid-d6  Chemical Structure
  73. GC60476 2-hydroxymethyl benzoic acid 2-Hydroxymethyl benzoic acid is an endogenous metabolite. 2-hydroxymethyl benzoic acid  Chemical Structure
  74. GC33742 2-Hydroxyphenylacetic acid 2-Hydroxyphenylacetic acid is a potential biomarker for the food products, and found to be associated with phenylketonuria (PKU). 2-Hydroxyphenylacetic acid  Chemical Structure
  75. GC30136 2-Ketoglutaric acid An intermediate in the citric acid cycle 2-Ketoglutaric acid  Chemical Structure
  76. GC39761 2-Mercaptobenzothiazole 2-Mercaptobenzothiazole  Chemical Structure
  77. GC34179 2-Methoxybenzoic acid (NSC 3778) 2-Methoxybenzoic acid (NSC 3778) (NSC 3778) is used as an internal standard of salicylic acid and its putative biosynthetic precursors in cucumber leaves. Another known use is in the synthesis of Benextramine. 2-Methoxybenzoic acid (NSC 3778)  Chemical Structure
  78. GC15084 2-Methoxyestradiol (2-MeOE2) 2-Methoxyestradiol (2-MeOE2/2-Me) is a HIF-1α inhibitor that inhibits HIF-1α accumulation and HIF transcriptional activity. 2-Methoxyestradiol can trigger p53-induced apoptosis and has potential antitumor activity.. 2-Methoxyestradiol (2-MeOE2)  Chemical Structure
  79. GC33810 2-Methoxyestrone An active metabolite of estrone 2-Methoxyestrone  Chemical Structure
  80. GC39776 2-Methylacetophenone 2-Methylacetophenone  Chemical Structure
  81. GC60477 2-Methylbenzaldehyde 2-Methylbenzaldehyde is an endogenous metabolite. 2-Methylbenzaldehyde  Chemical Structure
  82. GC60478 2-Methylbenzoxazole 2-Methylbenzoxazole  Chemical Structure
  83. GC60479 2-Methylcitric acid An endogenous tricarboxylic acid 2-Methylcitric acid  Chemical Structure
  84. GC60480 2-Methylcitric acid trisodium 2-Methylcitric acid trisodium (Methylcitric acid trisodium) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid trisodium  Chemical Structure
  85. GC62779 2-Methylcyclohexanone 2-Methylcyclohexanone  Chemical Structure
  86. GC30671 2-Methylpentanedioic acid

    2-Methylpentanedioic acid is a metabolite of succinic acid, a citric acid cycle intermediate.

    2-Methylpentanedioic acid  Chemical Structure
  87. GC31435 2-Methylsuccinic acid

    2-Methylsuccinic acid is a normal metabolite in human fluids and the main biochemical measurable features in ethylmalonic encephalopathy.

    2-Methylsuccinic acid  Chemical Structure
  88. GC60481 2-Methylvaleric acid 2-Methylvaleric acid (2-Methylpentanoic acid) is a short-chain fatty acid isolated from Campomanesia adamantium and dairy products. 2-Methylvaleric acid  Chemical Structure
  89. GC17937 2-MPPA glutamate carboxypeptidase II (GCP II) inhibitor 2-MPPA  Chemical Structure
  90. GC30720 2-Naphthol 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2). 2-Naphthol  Chemical Structure
  91. GC39845 2-Naphthoxyacetic acid 2-Naphthoxyacetic acid is an endogenous metabolite. 2-Naphthoxyacetic acid  Chemical Structure
  92. GC39527 2-O-Methylcytosine 2-O-Methylcytosine, an O-alkylated analogue a DNA adduct, is the damaged nucleobase. 2-O-Methylcytosine  Chemical Structure
  93. GC42189 2-oxo Clopidogrel 2-oxo Clopidogrel is an intermediary metabolite of clopidogrel. 2-oxo Clopidogrel  Chemical Structure
  94. GC30622 2-Oxo-3-phenylpropanoic acid 2-Oxo-3-phenylpropanoic acid is used in the synthesis of 3-phenyllactic acid (PLA) by lactate dehydrogenase. 2-Oxo-3-phenylpropanoic acid  Chemical Structure
  95. GC30629 2-Oxobutanoic acid

    2-Oxobutanoic acid is a product in the enzymatic cleavage of cystathionine.

    2-Oxobutanoic acid  Chemical Structure
  96. GC38276 2-Oxosuccinic acid 2-Oxosuccinic acid (2-Oxosuccinic acid) is a metabolic intermediate involved in several ways, such as citric acid cycle, gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis. 2-Oxosuccinic acid  Chemical Structure
  97. GC30713 2-Oxovaleric acid

    2-Oxovaleric acid is a keto acid that is found in human blood.

    2-Oxovaleric acid  Chemical Structure
  98. GC60018 2-Phenylacetaldehyde 2-Phenylacetaldehyde is an endogenous metabolite. 2-Phenylacetaldehyde  Chemical Structure
  99. GC60483 2-Phenylacetamide 2-Phenylacetamide  Chemical Structure
  100. GC62784 2-Phenylbutanoic acid 2-Phenylbutanoic acid is an endogenous metabolite. 2-Phenylbutanoic acid  Chemical Structure
  101. GC60485 2-Phenylglycine 2-Phenylglycine (DL-α-Phenylglycine) is a metabolite in breast milk during the W2 to W4 lactation period. 2-Phenylglycine  Chemical Structure

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