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Aminoacyl-tRNA Synthetase

Aminoacyl-tRNA Synthetases (AARSs) are ubiquitous and evolutionarily conserved enzymes that catalyze the highly specific acylation of amino acids to cognate tRNAs. Aminoacyl-tRNA Synthetases are essential for accurate decoding of the triplet genetic code and for sustenance of all domains of life, including bacteria, archaea, and eukarya.

Aminoacyl-tRNA Synthetases also perform critical cellular activities unrelated to their primary function in aminoacylation. These noncanonical activities include regulation of gene transcription, mRNA translational control, angiogenesis, apoptosis, amino acid sensing, and cell signaling.

Targets for  Aminoacyl-tRNA Synthetase

Products for  Aminoacyl-tRNA Synthetase

  1. Cat.No. Product Name Information
  2. GC32149 Aminoacyl tRNA synthetase-IN-1 Aminoacyl tRNA synthetase-IN-1 is a bacterial aminoacyl tRNA synthetase (aaRS) inhibitor. Aminoacyl tRNA synthetase-IN-1  Chemical Structure
  3. GC30293 Arg-AMS Arg-AMS is a potent nanomolar inhibitor of arginyl tRNA synthetase, which displays tightly bound inhibitory characteristics for the A-domains in non-ribosomal peptide synthetases (NRPS) enzymes. Arg-AMS  Chemical Structure
  4. GC31432 Asp-AMS Asp-AMS, an analogue of aspartyl-adenylate, is an aspartyl-tRNA synthetase inhibitor and also a strong competitive inhibitor of the mitochondrial enzyme. Asp-AMS  Chemical Structure
  5. GC30683 Gln-AMS

    Gln-AMS is an aminoacyl-tRNA synthetases (AARS) inhibitor, which binds the A-domain within the NRPS enzymes.

    Gln-AMS  Chemical Structure
  6. GC34331 Gln-AMS TFA Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor. Gln-AMS TFA  Chemical Structure
  7. GC32366 GlyRS-IN-1 GlyRS-IN-1 is a glycyl-tRNA synthase (GlyRS) inhibitor extracted from patent WO 2017066459 A1. GlyRS-IN-1  Chemical Structure
  8. GC32121 Leu-AMS Leu-AMS (compound 6), a leucine analogue, is a potent inhibitor of leucyl-tRNA synthetase (LRS) with an IC50 of 22.34 nM, which inhibits the catalytic activity of LRS but did not affect the leucine-induced mTORC1 activation. Leu-AMS  Chemical Structure
  9. GC34358 Leu-AMS R enantiomer Leu-AMS R enantiomer is the R enatiomer of Leu-AMS. Leu-AMS R enantiomer  Chemical Structure
  10. GC65058 LysRs-IN-2 LysRs-IN-2 is a lysyl-tRNA synthetase (KRS) inhibitor with IC50s of 0.015 μM and 0.13 μM for Plasmodium falciparum lysyl-tRNA synthetase (PfKRS) and Cryptosporidium parvum lysyl-tRNA synthetase (CpKRS), respectively. LysRs-IN-2  Chemical Structure

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