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Home >> Signaling Pathways >> Proteases >> Dipeptidyl Peptidase

Dipeptidyl Peptidase

Dipeptidyl Peptidase (DPP) is an antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation,signal transduction and apoptosis. DPP is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. The substrates of DPP are proline-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPP plays a major role in glucose metabolism. DPP is responsible for the degradation of incretins such as GLP-1. Furthermore, DPP appears to work as a suppressor in the development of cancer and tumours. DPP plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others.

Targets for  Dipeptidyl Peptidase

Products for  Dipeptidyl Peptidase

  1. Cat.No. Product Name Information
  2. GC39296 1G244 1G244 is a potent DPP8/9 inhibitor with IC50s of 12 nM and 84 nM, respectively. 1G244 does not inhibit DPPIV and DPPII. 1G244 induces apoptosis in multiple myeloma cells and has anti-myeloma effects. 1G244 Chemical Structure
  3. GC15130 Alogliptin (SYR-322) Alogliptin (SYR-322) Chemical Structure
  4. GC13949 Alogliptin Benzoate A DPP-4 inhibitor Alogliptin Benzoate Chemical Structure
  5. GC31341 Anagliptin (SK-0403) Anagliptin (SK-0403) (SK-0403) is a highly selective, potent, orally active inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC50 of 3.8 nM, and less selective at DPP-8 and DDP-9 with IC50s of 68 nM and 60 nM, respectively. Anagliptin (SK-0403) Chemical Structure
  6. GC60613 Azaleatin Azaleatin is an O-methylated flavonol isolated from Rhododendron species. Azaleatin Chemical Structure
  7. GC19052 AZD7986 AZD7986 (AZD7986) is an oral dipeptidyl peptidase 1 (DPP1) inhibitor with pIC50s of 6.85, 7.6, 7.7, 7.8, and 7.8 in human, mouse, rat, dog and rabbit, respectively. AZD7986 Chemical Structure
  8. GC19120 DBPR108 DBPR108 is a potent, selective, and orally bioavailable dipeptide-derived inhibitor of DPP4 with IC50 of 15 nM; no inhibition on DDP8 and DPP9. DBPR108 Chemical Structure
  9. GC45436 Diprotin A   Diprotin A Chemical Structure
  10. GC31414 Diprotin A TFA (Ile-Pro-Pro (TFA)) Diprotin A TFA (Ile-Pro-Pro (TFA)) (Ile-Pro-Ile TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV). Diprotin A TFA (Ile-Pro-Pro (TFA)) Chemical Structure
  11. GC31547 DPP-IV-IN-1 DPP-IV-IN-1 is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV), a highly specific serine protease, with an IC50 of 4.6 nM. DPP-IV-IN-1 Chemical Structure
  12. GC30877 DPP-IV-IN-2 DPP-IV-IN-2 is an inhibitor of both dipeptidyl peptidase IV (DPIV) and DP8/9 with IC50s of 0.1 and 0.95 μM, respectively. DPP-IV-IN-2 Chemical Structure
  13. GC31467 Dutogliptin Dutogliptin (PHX-1149 free base) is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus. Dutogliptin Chemical Structure
  14. GC60828 Evogliptin tartrate Evogliptin tartrate is a potent, orally bioavailable and selective dipeptidyl peptidase-4 (DPP-4) inhibitor, with antidiabetic activity. Evogliptin tartrate Chemical Structure
  15. GC33769 Gemigliptin (LC15-0444) Gemigliptin (LC15-0444) (LC15-0444 ) is a highly selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin (LC15-0444) Chemical Structure
  16. GC31463 Gosogliptin (PF-00734200) Gosogliptin (PF-00734200) is a potent and selective inhibitor of dipeptidyl peptidase-IV (DPP-IV). Gosogliptin (PF-00734200) Chemical Structure
  17. GC14827 Linagliptin (BI-1356) A potent DPP-4 inhibitor Linagliptin (BI-1356) Chemical Structure
  18. GC66355 Linagliptin-d4 Linagliptin-d4 is deuterium labeled Linagliptin. Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM. Linagliptin-d4 Chemical Structure
  19. GC17012 MK3102 MK3102 (MK-3102) is a potent, selective, orally active and cross the blood-brain barrier dipeptidyl peptidase 4 (DPP-4) inhibitor. MK3102 Chemical Structure
  20. GC10091 Nateglinide Insulin secretagog agent Nateglinide Chemical Structure
  21. GC47751 Nateglinide-d5 An internal standard for the quantification of nateglinide Nateglinide-d5 Chemical Structure
  22. GC44353 NDMC101 A salicylanilide derivative NDMC101 Chemical Structure
  23. GC32546 Prodipine hydrochloride Prodipine, a diphenyl-phosphonate derivative. Prodipine hydrochloride Chemical Structure
  24. GC10171 Puromycin aminonucleoside

    A glomerular epithelial cell toxin

     Puromycin aminonucleoside Chemical Structure
  25. GC63170 Retagliptin Retagliptin (SP2086) is a selective, competitive and orally active dipeptidyl peptidase-4 (DPP-4) inhibitor. Retagliptin Chemical Structure
  26. GC31472 Retagliptin Phosphate (SP 2086) Retagliptin Phosphate (SP 2086) (SP2086 phosphate) is a selective, competitive and orally active dipeptidyl peptidase-4 (DPP-4) inhibitor. Retagliptin Phosphate (SP 2086) Chemical Structure
  27. GC31444 Saikogenin A Saikogenin A, extracted from a Chinese herbal plant called Tsai-Fu, is a dipeptidyl peptidase-IV (DPP-IV) inhibitor. Saikogenin A Chemical Structure
  28. GC12895 Saxagliptin Selective DPP4 inhibitor Saxagliptin Chemical Structure
  29. GC44874 Saxagliptin (hydrochloride) Saxagliptin is a potent inhibitor of dipeptidyl peptidase 4 (DPP-4; Ki = 0.6 nM). Saxagliptin (hydrochloride) Chemical Structure
  30. GC37594 Saxagliptin hydrate Saxagliptin hydrate (BMS-477118 hydrate) is a potent, selective, reversible, competitive and orally active dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM) inhibitor. Saxagliptin hydrate Chemical Structure
  31. GC31317 Sitagliptin (MK0431) Sitagliptin (MK0431) (MK-0431) is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts. Sitagliptin (MK0431) Chemical Structure
  32. GC12235 Sitagliptin (phosphate) DPP-4 inhibitor Sitagliptin (phosphate) Chemical Structure
  33. GC69900 Sitagliptin fenilalanil

    Sitagliptin phenylalanine is a dipeptidyl peptidase-4 (DPP-4) inhibitor.

     Sitagliptin fenilalanil Chemical Structure
  34. GC69901 Sitagliptin fenilalanil hydrochloride

    Sitagliptin phenylalanine hydrochloride is a dipeptidyl peptidase-4 (DPP-4) inhibitor.

     Sitagliptin fenilalanil hydrochloride Chemical Structure
  35. GC10298 Sitagliptin phosphate monohydrate Sitagliptin phosphate monohydrate Chemical Structure
  36. GC63383 Sitagliptin-d4 phosphate Sitagliptin-d4 phosphate Chemical Structure
  37. GC33853 Talabostat (PT100)

    Talabostat (PT100) is an inhibitor of the dipeptidyl peptidase (DPP) family, with IC50 values of <4 nM for DPP-IV, 4 nM for DPP8, 11 nM for DPP9, 310 nM for QPP, 560 nM for FAP, and 390 nM for PEP. It exhibits anti-tumor activity and stimulatory effects on hematopoiesis.

     Talabostat (PT100) Chemical Structure
  38. GC10018 Talabostat mesylate

    Talabostat (PT100) is an inhibitor of the dipeptidyl peptidase (DPP) family, with IC50 values of <4 nM for DPP-IV, 4 nM for DPP8, 11 nM for DPP9, 310 nM for QPP, 560 nM for FAP, and 390 nM for PEP. It exhibits anti-tumor activity and stimulatory effects on hematopoiesis.

     Talabostat mesylate Chemical Structure
  39. GC31333 Teneligliptin (MP-513) Teneligliptin (MP-513) (MP-513) is a potent, orally available, competitive, and long-lasting DPP-4 inhibitor. Teneligliptin (MP-513) Chemical Structure
  40. GC62280 Teneligliptin D8 Teneligliptin D8 (MP-513 D8) a deuterium labeled Teneligliptin (MP-513). Teneligliptin D8 Chemical Structure
  41. GC15576 Teneligliptin hydrobromide A DPP-4 inhibitor Teneligliptin hydrobromide Chemical Structure
  42. GC37757 Teneligliptin hydrobromide hydrate A DPP-4 inhibitor Teneligliptin hydrobromide hydrate Chemical Structure
  43. GC16613 Trelagliptin A DDP-4 inhibitor Trelagliptin Chemical Structure
  44. GC17479 Trelagliptin succinate A DDP-4 inhibitor Trelagliptin succinate Chemical Structure
  45. GC12360 UAMC 00039 dihydrochloride

    dipeptidyl peptidase II (DPP-II) inhibitor

     UAMC 00039 dihydrochloride Chemical Structure
  46. GC16733 Vildagliptin (LAF-237) A DPP-4 inhibitor Vildagliptin (LAF-237) Chemical Structure
  47. GC31492 Vildagliptin dihydrate (LAF237 dihydrate) Vildagliptin dihydrate (LAF237 dihydrate) (LAF237 dihydrate) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin dihydrate (LAF237 dihydrate) Chemical Structure

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