Elastase
Elastase is a serine protease that catalyzes not only the hydrolysis of peptide bonds of proteins but also the hydrolysis of amides and esters. Although it has similar functions as trypsin and chymotrypsin, elastase preferentially targets the protein elastin catalyzing cleavage at its neutral sites. Two major types of elastase have been identified, including pancreatic elastase and neutrophil elastase (PMN). While he pancreatic elastase is produced initially as an inactive protein requiring the activation by trypsin in the duodenum; PMN is found in relatively high levels in the azurophilic granules of circulating leukocytes and neutrophils. Both types of elastase exhibit similar activities but differ in substrate specificity and inhibitor profile.
Products for Elastase
- Cat.No. Product Name Information
- GC11847 (Z-Ala-Ala-Ala-Ala)2Rh110 fluorogenic elastase substrate
- GC32016 AE-3763 AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC50 of 29 nM.
- GC14785 Alvelestat NE inhibitor
- GC13487 ARP 100 A selective inhibitor of MMP-2
- GC12088 BAY-678 HNE inhibitor
- GC35476 BAY-678 racemate BAY-678 racemate is a racemate of BAY-678.
- GC31564 BAY-85-8501 BAY-85-8501 is a selective, reversible and potent inhibitor of Human Neutrophil Elastase (HNE), with an IC50 of 65 pM.
- GC35884 DMP 777 DMP 777 is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.
- GC61744 FK706 FK706 is a potent, slow-binding and competitive inhibitor of human neutrophil elastase with an IC50 of 83 nM and a Ki of 4.2 nM.
- GC60858 Freselestat quarterhydrate Freselestat quarterhydrate (ONO-6818 quarterhydrate) is a potent and orally active neutrophil elastase inhibitor with a Ki of 12.2 nM.
- GC11615 GW311616 inhibitor of human neutrophil elastase(HNE)
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GC13851
GW311616 hydrochloride
HNE inhibitor
- GC31494 Lodelaben (SC-39026) Lodelaben (SC-39026) is a human neutrophil elastase inhibitor with an IC50 and Ki of 0.5 and 1.5 μM, respectively.
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GC11981
Neutrophil Elastase Inhibitor
neutrophil elastase inhibitor
- GC50225 ONO 6818 ONO 6818 (ONO-6818) is a potent and orally active neutrophil elastase inhibitor with a Ki of 12.2 nM.
- GC37618 Secologanoside Secologanoside is a triterpenoid isolated from Poraqueiba sericea, weakly inhibits elastase with an IC50 of 164 μg/mL.
- GC16724 Sivelestat (ONO-5046) Sivelestat (ONO-5046) (EI546) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (ONO-5046) (EI546) has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.
- GC17247 Sivelestat sodium salt An inhibitor of neutrophil elastase
- GC10672 SSR 69071 A potent inhibitor of neutrophil elastase
- GC32628 ZD-0892 ZD-0892 is a selective and potent inhibitor of a neutrophil elastase with Kis of 6.7 and 200 nM for human neutrophil elastase and porcine pancreatic elastase, respectively.
- GC32005 ZD8321 ZD8321 is a potent inhibitor of human Neutrophil elastase (NE) with a Ki of 13±1.7 nM.