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HCV Protease

Hepatitis C virus (HCV) protease is an enzyme, either viral or cellular, that catalyzes the hydrolysis of the long polyprotein precursor (approximately 3000 amino acids) encoded by HCV genome into at least ten individual proteins, including four structural proteins (C, E1, E2 and p7) and six nonstructural (NS) proteins (NS2, NS3, NS4A, NS4B, NS5A and NS5B). The commonly studied HCV proteases are two virally encode proteases involved in the viral replication of HCV, including HCV NS2/3 protease, a highly hydrophobic protease responsible for the cleavage of NS2 and NS3, and HCV NS3-4A serine protease, a covalent heterodimer responsible for cleavage at four sites of the HCV polyprotein.

  1. Cat.No. Product Name Information
  2. GC32305 ACH-806 (GS9132)
  3. GC14937 Anguizole

    Inhibitor of HCV replication

  4. GC14458 Asunaprevir (BMS-650032) NS3 protease inhibitor
  5. GC10930 Balapiravir Polymerase inhibitor,anti-HCV
  6. GC12236 BMS-790052 dihydrochloride HCV NS5A inhibitor
  7. GC10959 Boceprevir HCV protease inhibitor,potent and selective
  8. GC12444 Clemizole H1 histamine receptor antagonist
  9. GC17701 Clemizole hydrochloride H1 histamine receptor antagonist
  10. GC12057 Daclatasvir (BMS-790052) HCV NS5A inhibitor
  11. GC12879 Danoprevir (RG7227)

    HCV NS3/4A protease inhibitor

  12. GC19165 Glecaprevir Glecaprevir is a novel HCV NS3/4A protease inhibitor, with IC50 values ranging from 3.5 to 11.3 nM.
  13. GC13312 HZ-1157 HCV NS3/4A protease inhibitor
  14. GC18004 MK-5172

    HCV NS3/4a protease inhibitor

  15. GC16098 MK-5172 hydrate HCV NS3/4a protease inhibitor
  16. GC17114 MK-5172 potassium salt HCV NS3/4a protease inhibitor
  17. GC11463 MK-5172 sodium salt HCV NS3/4a protease inhibitor
  18. GC14074 Narlaprevir HCV NS3 protease inhibitor
  19. GC15891 Nesbuvir NS5B polymerase inhibitor
  20. GC16901 PSI-6206

    Inhibitor of HCV RNA polymerase,potent and selective

  21. GC17270 Simeprevir Inhibitor of HCV NS3/4A protease

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