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HCV Protease

Hepatitis C virus (HCV) protease is an enzyme, either viral or cellular, that catalyzes the hydrolysis of the long polyprotein precursor (approximately 3000 amino acids) encoded by HCV genome into at least ten individual proteins, including four structural proteins (C, E1, E2 and p7) and six nonstructural (NS) proteins (NS2, NS3, NS4A, NS4B, NS5A and NS5B). The commonly studied HCV proteases are two virally encode proteases involved in the viral replication of HCV, including HCV NS2/3 protease, a highly hydrophobic protease responsible for the cleavage of NS2 and NS3, and HCV NS3-4A serine protease, a covalent heterodimer responsible for cleavage at four sites of the HCV polyprotein.

Products for  HCV Protease

  1. Cat.No. Product Name Information
  2. GC32305 ACH-806 (GS9132) ACH-806 (GS9132) is an NS4A antagonist which can inhibit Hepatitis C Virus (HCV) replication with an EC50 of 14 nM. ACH-806 (GS9132)  Chemical Structure
  3. GC14937 Anguizole Anguizole  Chemical Structure
  4. GC14458 Asunaprevir (BMS-650032) An HCV NS3/4A protease inhibitor Asunaprevir (BMS-650032)  Chemical Structure
  5. GC25117 Azvudine Azvudine (RO-0622) is a novel nucleoside reverse transcriptase inhibitor with antiviral activity against human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV), potently inhibits HIV-1 (EC50 range 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). Azvudine  Chemical Structure
  6. GC10930 Balapiravir Balapiravir  Chemical Structure
  7. GC65345 BI 653048 BI 653048 is a selective and orally active nonsteroidal?glucocorticoid (GC)?agonist with an IC50 value of 55 nM. BI 653048  Chemical Structure
  8. GC10959 Boceprevir An NS3/4A protease inhibitor Boceprevir  Chemical Structure
  9. GC11840 Ciluprevir (BILN-2061) Inhibitor of HCV NS3 protease Ciluprevir (BILN-2061)  Chemical Structure
  10. GC12444 Clemizole An antihistamine and TRPC5 channel blocker Clemizole  Chemical Structure
  11. GC17701 Clemizole hydrochloride An antihistamine and TRPC5 channel blocker Clemizole hydrochloride  Chemical Structure
  12. GC64065 Coblopasvir Coblopasvir (KW-136) is a pangenotypic non-structural protein 5A (NS5A) inhibitor. Coblopasvir  Chemical Structure
  13. GC64066 Coblopasvir dihydrochloride Coblopasvir (KW-136) dihydrochloride is a pangenotypic non-structural protein 5A (NS5A) inhibitor. Coblopasvir dihydrochloride  Chemical Structure
  14. GC12057 Daclatasvir (BMS-790052) HCV NS5A inhibitor Daclatasvir (BMS-790052)  Chemical Structure
  15. GC12236 Daclatasvir dihydrochloride An NS5A inhibitor Daclatasvir dihydrochloride  Chemical Structure
  16. GC12879 Danoprevir (RG7227) An HCV NS3/4A protease inhibitor Danoprevir (RG7227)  Chemical Structure
  17. GC19165 Glecaprevir Glecaprevir is a novel HCV NS3/4A protease inhibitor, with IC50 values ranging from 3.5 to 11.3 nM. Glecaprevir  Chemical Structure
  18. GP10026 Hepatitis C virus Hepatitis C virus, (C48H88N10O13S), a peptide with the sequence H2N-Leu-Leu-Ala-Leu-Leu-Ser-Cys-Leu-Thr-Val-OH, MW= 1045.34. Hepatitis C virus  Chemical Structure
  19. GC13312 HZ-1157 HCV NS3/4A protease inhibitor HZ-1157  Chemical Structure
  20. GC60947 Isoeuphorbetin Isoeuphorbetin, a dimeric coumarin isolated from Viola philippica, is a potent HCV protease inhibitor with an IC50 of 3.63 ?g/mL. Isoeuphorbetin  Chemical Structure
  21. GC68453 ITMN 4077 ITMN 4077  Chemical Structure
  22. GC18004 MK-5172 An NS3/4A protease inhibitor MK-5172  Chemical Structure
  23. GC16098 MK-5172 hydrate MK-5172 hydrate  Chemical Structure
  24. GC17114 MK-5172 potassium salt MK-5172 potassium salt  Chemical Structure
  25. GC11463 MK-5172 sodium salt MK-5172 sodium salt  Chemical Structure
  26. GC14074 Narlaprevir Narlaprevir  Chemical Structure
  27. GC15891 Nesbuvir Nesbuvir  Chemical Structure
  28. GC16901 PSI-6206 An inactive derivative of a HCV NS5B inhibitor PSI-6206  Chemical Structure
  29. GC64016 Samatasvir Samatasvir (IDX71) is a potent, orally active NS5A inhibitor of HCV replication. Samatasvir  Chemical Structure
  30. GC17270 Simeprevir A potent NS3/4A protease inhibitor Simeprevir  Chemical Structure
  31. GC64038 Simeprevir-13C,d3 Simeprevir-13C,d3 (TMC435-13C,d3) is the 13C- and deuterium labeled Simeprevir. Simeprevir-13C,d3  Chemical Structure
  32. GC16887 Tegobuvir A non-nucleoside inhibitor of HCV NS5B Tegobuvir  Chemical Structure
  33. GC12299 Telaprevir (VX-950) An HCV NS3/4A protease inhibitor Telaprevir (VX-950)  Chemical Structure
  34. GC10155 Vaniprevir Vaniprevir  Chemical Structure
  35. GC37921 Voxilaprevir A pan-genotypic HCV NS3/4A protease inhibitor Voxilaprevir  Chemical Structure
  36. GC10832 VX-222 (VCH-222, Lomibuvir) An HCV polymerase inhibitor VX-222 (VCH-222, Lomibuvir)  Chemical Structure

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