HCV Protease
Hepatitis C virus (HCV) protease is an enzyme, either viral or cellular, that catalyzes the hydrolysis of the long polyprotein precursor (approximately 3000 amino acids) encoded by HCV genome into at least ten individual proteins, including four structural proteins (C, E1, E2 and p7) and six nonstructural (NS) proteins (NS2, NS3, NS4A, NS4B, NS5A and NS5B). The commonly studied HCV proteases are two virally encode proteases involved in the viral replication of HCV, including HCV NS2/3 protease, a highly hydrophobic protease responsible for the cleavage of NS2 and NS3, and HCV NS3-4A serine protease, a covalent heterodimer responsible for cleavage at four sites of the HCV polyprotein.
Products for HCV Protease
- Cat.No. Product Name Information
- GC32305 ACH-806 (GS9132) ACH-806 (GS9132) is an NS4A antagonist which can inhibit Hepatitis C Virus (HCV) replication with an EC50 of 14 nM.
- GC14937 Anguizole
- GC14458 Asunaprevir (BMS-650032) An HCV NS3/4A protease inhibitor
- GC25117 Azvudine Azvudine (RO-0622) is a novel nucleoside reverse transcriptase inhibitor with antiviral activity against human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV), potently inhibits HIV-1 (EC50 range 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).
- GC10930 Balapiravir
- GC65345 BI 653048 BI 653048 is a selective and orally active nonsteroidal?glucocorticoid (GC)?agonist with an IC50 value of 55 nM.
- GC10959 Boceprevir An NS3/4A protease inhibitor
- GC11840 Ciluprevir (BILN-2061) Inhibitor of HCV NS3 protease
- GC12444 Clemizole An antihistamine and TRPC5 channel blocker
- GC17701 Clemizole hydrochloride An antihistamine and TRPC5 channel blocker
- GC64065 Coblopasvir Coblopasvir (KW-136) is a pangenotypic non-structural protein 5A (NS5A) inhibitor.
- GC64066 Coblopasvir dihydrochloride Coblopasvir (KW-136) dihydrochloride is a pangenotypic non-structural protein 5A (NS5A) inhibitor.
- GC12057 Daclatasvir (BMS-790052) HCV NS5A inhibitor
- GC12236 Daclatasvir dihydrochloride An NS5A inhibitor
- GC12879 Danoprevir (RG7227) An HCV NS3/4A protease inhibitor
- GC19165 Glecaprevir Glecaprevir is a novel HCV NS3/4A protease inhibitor, with IC50 values ranging from 3.5 to 11.3 nM.
- GP10026 Hepatitis C virus Hepatitis C virus, (C48H88N10O13S), a peptide with the sequence H2N-Leu-Leu-Ala-Leu-Leu-Ser-Cys-Leu-Thr-Val-OH, MW= 1045.34.
- GC13312 HZ-1157 HCV NS3/4A protease inhibitor
- GC60947 Isoeuphorbetin Isoeuphorbetin, a dimeric coumarin isolated from Viola philippica, is a potent HCV protease inhibitor with an IC50 of 3.63 ?g/mL.
- GC68453 ITMN 4077
- GC18004 MK-5172 An NS3/4A protease inhibitor
- GC16098 MK-5172 hydrate
- GC17114 MK-5172 potassium salt
- GC11463 MK-5172 sodium salt
- GC14074 Narlaprevir
- GC15891 Nesbuvir
- GC16901 PSI-6206 An inactive derivative of a HCV NS5B inhibitor
- GC64016 Samatasvir Samatasvir (IDX71) is a potent, orally active NS5A inhibitor of HCV replication.
- GC17270 Simeprevir A potent NS3/4A protease inhibitor
- GC64038 Simeprevir-13C,d3 Simeprevir-13C,d3 (TMC435-13C,d3) is the 13C- and deuterium labeled Simeprevir.
- GC16887 Tegobuvir A non-nucleoside inhibitor of HCV NS5B
- GC12299 Telaprevir (VX-950) An HCV NS3/4A protease inhibitor
- GC10155 Vaniprevir
- GC37921 Voxilaprevir A pan-genotypic HCV NS3/4A protease inhibitor
- GC10832 VX-222 (VCH-222, Lomibuvir) An HCV polymerase inhibitor