HIV Integrase
Human immunodeficiency virus (HIV) integrase is a Mr 32000 protein encoded by the pol gene of HIV that catalyzes an essential step in the viral replicative cycle to integrate the viral DNA into the host DNA. HIV integrase catalyzes two temporally and spatially separated reactions, including process, where a CA dinucleotide from the 3’-ends of the double stranded viral DNA is cleaved by HIV integrase in cytoplasm generating a double-stranded DNA with a two-base overhang, and strand transfer, where the HIV integrase-and-DNA complex is transferred in to the nucleus. The most well studied HIV integrase is HIV-1 integrase characterized by containing three domains, including the N-terminal domain, the C-terminal domain and the core domain.
Products for HIV Integrase
- Cat.No. Product Name Information
- GC34961 (±)-BI-D (±)-BI-D is a potent ALLINI(An allosteric IN inhibitor) that binds integrase at the LEDGF/p75 binding site.
- GC35510 BI 224436 BI 224436 is a novel HIV-1 noncatalytic site integrase inhibitor with EC50 values of less than 15 nM against different HIV-1 laboratory strains.
- GC32060 Bictegravir (GS-9883) Bictegravir (GS-9883) (GS-9883) is a potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.
- GC68478 Bictegravir sodium
- GC11923 BMS-707035
- GC14996 Elvitegravir (GS-9137) An inhibitor of HIV-1 integrase
- GC10572 Equisetin HIV-1 integrase inhibitor
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GC14466
Fluorouracil (Adrucil)
A prodrug form of FdUMP
- GC14057 GSK1349572 sodiuM salt GSK1349572 sodiuM salt (S/GSK1349572 sodium) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer.
- GC16215 GSK744 (S/GSK1265744) GSK744 (S/GSK1265744) (GSK-1265744) is a orally active and long-acting HIV integrase inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC50 values of 2.5 nM, 0.41 μM and 0.81 μM for HIVADA, OAT3 and OAT1, respectively.
- GC12998 HIV-1 integrase inhibitor
- GC36233 HIV-1 integrase inhibitor 2 HIV-1 integrase inhibitor 2 (CX05168) is a quinoline-based protein-protein interaction inhibitor of LEDGF/p75 and HIV integrase.
- GC36234 HIV-1 integrase inhibitor 3 HIV-1 integrase inhibitor 3 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 2.7 nM.
- GC36235 HIV-1 integrase inhibitor 4 HIV-1 integrase inhibitor 4 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 3.7 nM.
- GC63399 HIV-1 integrase inhibitor 8 HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8.
- GC12339 Ivermectin NAChR/purinergic P2X4 receptor modulator
- GC60978 L-Chicoric Acid A dicaffeoyl ester with diverse biological activities
- GC45494 Lavendustin B
- GC15561 MK-2048
- GC17709 Nelfinavir HIV-1 protease inhibitor
- GC14084 Nelfinavir Mesylate An HIV-1 protease inhibitor
- GC11956 Raltegravir (MK-0518)
- GC15036 Raltegravir potassium salt Raltegravir (MK 0518) potassium is a potent integrase (IN) inhibitor, used to treat HIV infection.
- GC61576 Robinetin Robinetin (3,3',4',5',7-Pentahydroxyflavone), a naturally occurring flavonoid with remarkable ‘two color’ intrinsic fluorescence properties, has antifungal, antiviral, antibacterial, antimutagenesis, and antioxidant activity.
- GC17906 S/GSK1349572 A potent inhibitor of HIV integrase
- GC18016 Salicylanilide Antiviral,antibacterial,antifungal reagent
- GC67697 XZ426